Amino acid dipepetide frequency for Enterobius vermicularis (Human pinworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.738AlaAla: 5.738 ± 0.055	1.275AlaCys: 1.275 ± 0.019	3.358AlaAsp: 3.358 ± 0.027	4.677AlaGlu: 4.677 ± 0.044	2.891AlaPhe: 2.891 ± 0.025	3.435AlaGly: 3.435 ± 0.028	1.28AlaHis: 1.28 ± 0.019	3.61AlaIle: 3.61 ± 0.032	4.01AlaLys: 4.01 ± 0.033	6.221AlaLeu: 6.221 ± 0.042	1.426AlaMet: 1.426 ± 0.02	2.763AlaAsn: 2.763 ± 0.023	2.6AlaPro: 2.6 ± 0.034	2.41AlaGln: 2.41 ± 0.028	3.209AlaArg: 3.209 ± 0.031	5.101AlaSer: 5.101 ± 0.036	3.629AlaThr: 3.629 ± 0.031	5.238AlaVal: 5.238 ± 0.038	0.587AlaTrp: 0.587 ± 0.011	1.916AlaTyr: 1.916 ± 0.02	0.003AlaXaa: 0.003 ± 0.001
Cys	1.368CysAla: 1.368 ± 0.023	0.734CysCys: 0.734 ± 0.021	1.225CysAsp: 1.225 ± 0.023	1.372CysGlu: 1.372 ± 0.025	1.143CysPhe: 1.143 ± 0.018	1.489CysGly: 1.489 ± 0.022	0.509CysHis: 0.509 ± 0.012	1.301CysIle: 1.301 ± 0.019	1.266CysLys: 1.266 ± 0.021	2.09CysLeu: 2.09 ± 0.025	0.465CysMet: 0.465 ± 0.013	1.023CysAsn: 1.023 ± 0.02	1.149CysPro: 1.149 ± 0.037	0.844CysGln: 0.844 ± 0.018	1.318CysArg: 1.318 ± 0.019	2.069CysSer: 2.069 ± 0.03	1.162CysThr: 1.162 ± 0.023	1.453CysVal: 1.453 ± 0.027	0.24CysTrp: 0.24 ± 0.007	0.782CysTyr: 0.782 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.394AspAla: 3.394 ± 0.032	1.116AspCys: 1.116 ± 0.017	3.959AspAsp: 3.959 ± 0.053	4.42AspGlu: 4.42 ± 0.034	2.536AspPhe: 2.536 ± 0.024	3.513AspGly: 3.513 ± 0.042	0.999AspHis: 0.999 ± 0.017	2.946AspIle: 2.946 ± 0.027	2.739AspLys: 2.739 ± 0.029	4.788AspLeu: 4.788 ± 0.036	1.08AspMet: 1.08 ± 0.016	2.112AspAsn: 2.112 ± 0.023	2.174AspPro: 2.174 ± 0.019	1.694AspGln: 1.694 ± 0.018	2.686AspArg: 2.686 ± 0.026	4.092AspSer: 4.092 ± 0.031	2.392AspThr: 2.392 ± 0.025	3.676AspVal: 3.676 ± 0.03	0.638AspTrp: 0.638 ± 0.012	1.909AspTyr: 1.909 ± 0.023	0.001AspXaa: 0.001 ± 0.001
Glu	4.429GluAla: 4.429 ± 0.04	1.33GluCys: 1.33 ± 0.023	3.713GluAsp: 3.713 ± 0.033	6.334GluGlu: 6.334 ± 0.069	2.404GluPhe: 2.404 ± 0.022	3.254GluGly: 3.254 ± 0.034	1.373GluHis: 1.373 ± 0.016	3.917GluIle: 3.917 ± 0.037	5.736GluLys: 5.736 ± 0.049	5.985GluLeu: 5.985 ± 0.046	1.727GluMet: 1.727 ± 0.02	3.685GluAsn: 3.685 ± 0.033	2.323GluPro: 2.323 ± 0.029	2.767GluGln: 2.767 ± 0.031	4.09GluArg: 4.09 ± 0.042	4.399GluSer: 4.399 ± 0.036	3.717GluThr: 3.717 ± 0.038	4.273GluVal: 4.273 ± 0.036	0.745GluTrp: 0.745 ± 0.015	1.944GluTyr: 1.944 ± 0.021	0.003GluXaa: 0.003 ± 0.001
Phe	2.976PheAla: 2.976 ± 0.027	1.274PheCys: 1.274 ± 0.017	2.577PheAsp: 2.577 ± 0.028	2.749PheGlu: 2.749 ± 0.026	2.609PhePhe: 2.609 ± 0.033	2.841PheGly: 2.841 ± 0.028	1.031PheHis: 1.031 ± 0.014	2.62PheIle: 2.62 ± 0.028	2.256PheLys: 2.256 ± 0.023	4.663PheLeu: 4.663 ± 0.047	0.988PheMet: 0.988 ± 0.014	1.881PheAsn: 1.881 ± 0.021	1.889PhePro: 1.889 ± 0.023	1.609PheGln: 1.609 ± 0.018	2.362PheArg: 2.362 ± 0.026	3.82PheSer: 3.82 ± 0.035	2.341PheThr: 2.341 ± 0.023	3.142PheVal: 3.142 ± 0.032	0.592PheTrp: 0.592 ± 0.011	1.697PheTyr: 1.697 ± 0.022	0.004PheXaa: 0.004 ± 0.001
Gly	3.26GlyAla: 3.26 ± 0.03	1.221GlyCys: 1.221 ± 0.023	3.015GlyAsp: 3.015 ± 0.03	3.459GlyGlu: 3.459 ± 0.04	2.672GlyPhe: 2.672 ± 0.032	3.739GlyGly: 3.739 ± 0.051	1.245GlyHis: 1.245 ± 0.018	3.296GlyIle: 3.296 ± 0.035	3.575GlyLys: 3.575 ± 0.034	4.549GlyLeu: 4.549 ± 0.044	1.216GlyMet: 1.216 ± 0.021	2.648GlyAsn: 2.648 ± 0.027	2.127GlyPro: 2.127 ± 0.043	1.886GlyGln: 1.886 ± 0.023	3.218GlyArg: 3.218 ± 0.029	4.578GlySer: 4.578 ± 0.037	3.264GlyThr: 3.264 ± 0.031	3.575GlyVal: 3.575 ± 0.033	0.665GlyTrp: 0.665 ± 0.012	2.04GlyTyr: 2.04 ± 0.028	0.003GlyXaa: 0.003 ± 0.001
His	1.149HisAla: 1.149 ± 0.016	0.628HisCys: 0.628 ± 0.014	0.945HisAsp: 0.945 ± 0.014	1.224HisGlu: 1.224 ± 0.018	1.159HisPhe: 1.159 ± 0.015	1.218HisGly: 1.218 ± 0.02	0.6HisHis: 0.6 ± 0.015	1.232HisIle: 1.232 ± 0.016	1.063HisLys: 1.063 ± 0.015	2.3HisLeu: 2.3 ± 0.025	0.495HisMet: 0.495 ± 0.01	0.86HisAsn: 0.86 ± 0.012	1.095HisPro: 1.095 ± 0.017	0.849HisGln: 0.849 ± 0.015	1.299HisArg: 1.299 ± 0.017	1.819HisSer: 1.819 ± 0.021	1.061HisThr: 1.061 ± 0.02	1.271HisVal: 1.271 ± 0.016	0.318HisTrp: 0.318 ± 0.008	0.867HisTyr: 0.867 ± 0.014	0.002HisXaa: 0.002 ± 0.001
Ile	3.889IleAla: 3.889 ± 0.031	1.431IleCys: 1.431 ± 0.024	3.082IleAsp: 3.082 ± 0.028	3.536IleGlu: 3.536 ± 0.031	2.751IlePhe: 2.751 ± 0.028	3.143IleGly: 3.143 ± 0.031	1.198IleHis: 1.198 ± 0.016	3.251IleIle: 3.251 ± 0.037	3.123IleLys: 3.123 ± 0.026	5.089IleLeu: 5.089 ± 0.042	1.175IleMet: 1.175 ± 0.017	2.492IleAsn: 2.492 ± 0.024	2.722IlePro: 2.722 ± 0.029	2.005IleGln: 2.005 ± 0.024	3.144IleArg: 3.144 ± 0.03	4.584IleSer: 4.584 ± 0.031	3.101IleThr: 3.101 ± 0.03	3.666IleVal: 3.666 ± 0.033	0.66IleTrp: 0.66 ± 0.012	1.859IleTyr: 1.859 ± 0.023	0.002IleXaa: 0.002 ± 0.001
Lys	3.841LysAla: 3.841 ± 0.036	1.372LysCys: 1.372 ± 0.024	3.108LysAsp: 3.108 ± 0.027	4.776LysGlu: 4.776 ± 0.044	2.478LysPhe: 2.478 ± 0.026	2.94LysGly: 2.94 ± 0.035	1.299LysHis: 1.299 ± 0.018	3.651LysIle: 3.651 ± 0.031	5.43LysLys: 5.43 ± 0.053	5.808LysLeu: 5.808 ± 0.042	1.53LysMet: 1.53 ± 0.018	3.286LysAsn: 3.286 ± 0.031	2.641LysPro: 2.641 ± 0.034	2.571LysGln: 2.571 ± 0.029	4.003LysArg: 4.003 ± 0.036	4.257LysSer: 4.257 ± 0.036	3.45LysThr: 3.45 ± 0.031	3.826LysVal: 3.826 ± 0.028	0.741LysTrp: 0.741 ± 0.013	2.057LysTyr: 2.057 ± 0.022	0.004LysXaa: 0.004 ± 0.001
Leu	5.984LeuAla: 5.984 ± 0.041	2.217LeuCys: 2.217 ± 0.028	4.585LeuAsp: 4.585 ± 0.035	6.067LeuGlu: 6.067 ± 0.052	4.353LeuPhe: 4.353 ± 0.04	4.358LeuGly: 4.358 ± 0.034	2.256LeuHis: 2.256 ± 0.025	5.149LeuIle: 5.149 ± 0.037	6.339LeuLys: 6.339 ± 0.037	9.71LeuLeu: 9.71 ± 0.072	2.162LeuMet: 2.162 ± 0.026	4.363LeuAsn: 4.363 ± 0.031	4.636LeuPro: 4.636 ± 0.037	4.096LeuGln: 4.096 ± 0.038	5.584LeuArg: 5.584 ± 0.04	7.744LeuSer: 7.744 ± 0.056	4.876LeuThr: 4.876 ± 0.037	5.546LeuVal: 5.546 ± 0.039	1.027LeuTrp: 1.027 ± 0.016	2.958LeuTyr: 2.958 ± 0.029	0.005LeuXaa: 0.005 ± 0.001
Met	1.549MetAla: 1.549 ± 0.021	0.444MetCys: 0.444 ± 0.011	1.137MetAsp: 1.137 ± 0.017	1.586MetGlu: 1.586 ± 0.017	0.943MetPhe: 0.943 ± 0.015	1.1MetGly: 1.1 ± 0.016	0.503MetHis: 0.503 ± 0.011	1.266MetIle: 1.266 ± 0.016	1.568MetLys: 1.568 ± 0.018	2.114MetLeu: 2.114 ± 0.026	0.704MetMet: 0.704 ± 0.021	1.052MetAsn: 1.052 ± 0.014	0.999MetPro: 0.999 ± 0.019	0.973MetGln: 0.973 ± 0.016	1.284MetArg: 1.284 ± 0.017	1.654MetSer: 1.654 ± 0.021	1.235MetThr: 1.235 ± 0.017	1.388MetVal: 1.388 ± 0.017	0.235MetTrp: 0.235 ± 0.006	0.635MetTyr: 0.635 ± 0.013	0.001MetXaa: 0.001 ± 0.0
Asn	3.104AsnAla: 3.104 ± 0.026	1.124AsnCys: 1.124 ± 0.018	2.552AsnAsp: 2.552 ± 0.028	3.247AsnGlu: 3.247 ± 0.034	2.265AsnPhe: 2.265 ± 0.024	3.078AsnGly: 3.078 ± 0.034	0.896AsnHis: 0.896 ± 0.015	2.695AsnIle: 2.695 ± 0.025	2.403AsnLys: 2.403 ± 0.023	4.224AsnLeu: 4.224 ± 0.032	0.986AsnMet: 0.986 ± 0.015	2.182AsnAsn: 2.182 ± 0.029	1.989AsnPro: 1.989 ± 0.022	1.619AsnGln: 1.619 ± 0.021	2.404AsnArg: 2.404 ± 0.023	3.775AsnSer: 3.775 ± 0.033	2.201AsnThr: 2.201 ± 0.022	3.118AsnVal: 3.118 ± 0.025	0.512AsnTrp: 0.512 ± 0.01	1.673AsnTyr: 1.673 ± 0.022	0.001AsnXaa: 0.001 ± 0.0
Pro	2.732ProAla: 2.732 ± 0.027	0.805ProCys: 0.805 ± 0.018	2.252ProAsp: 2.252 ± 0.022	3.042ProGlu: 3.042 ± 0.032	1.906ProPhe: 1.906 ± 0.022	2.564ProGly: 2.564 ± 0.081	0.944ProHis: 0.944 ± 0.015	2.146ProIle: 2.146 ± 0.021	2.554ProLys: 2.554 ± 0.029	4.091ProLeu: 4.091 ± 0.032	0.848ProMet: 0.848 ± 0.015	2.063ProAsn: 2.063 ± 0.024	3.214ProPro: 3.214 ± 0.068	1.796ProGln: 1.796 ± 0.025	2.107ProArg: 2.107 ± 0.023	4.119ProSer: 4.119 ± 0.043	2.56ProThr: 2.56 ± 0.031	3.2ProVal: 3.2 ± 0.033	0.414ProTrp: 0.414 ± 0.011	1.518ProTyr: 1.518 ± 0.02	0.002ProXaa: 0.002 ± 0.001
Gln	2.216GlnAla: 2.216 ± 0.027	0.959GlnCys: 0.959 ± 0.025	1.422GlnAsp: 1.422 ± 0.017	2.29GlnGlu: 2.29 ± 0.027	1.695GlnPhe: 1.695 ± 0.02	1.593GlnGly: 1.593 ± 0.023	0.88GlnHis: 0.88 ± 0.014	2.288GlnIle: 2.288 ± 0.022	2.813GlnLys: 2.813 ± 0.032	4.092GlnLeu: 4.092 ± 0.036	1.081GlnMet: 1.081 ± 0.016	1.953GlnAsn: 1.953 ± 0.021	1.784GlnPro: 1.784 ± 0.028	2.415GlnGln: 2.415 ± 0.05	2.383GlnArg: 2.383 ± 0.027	2.721GlnSer: 2.721 ± 0.029	2.053GlnThr: 2.053 ± 0.025	2.255GlnVal: 2.255 ± 0.024	0.479GlnTrp: 0.479 ± 0.01	1.267GlnTyr: 1.267 ± 0.015	0.001GlnXaa: 0.001 ± 0.001
Arg	3.071ArgAla: 3.071 ± 0.03	1.335ArgCys: 1.335 ± 0.022	2.664ArgAsp: 2.664 ± 0.028	3.522ArgGlu: 3.522 ± 0.041	2.555ArgPhe: 2.555 ± 0.025	2.729ArgGly: 2.729 ± 0.03	1.307ArgHis: 1.307 ± 0.018	3.336ArgIle: 3.336 ± 0.028	4.107ArgLys: 4.107 ± 0.036	5.456ArgLeu: 5.456 ± 0.041	1.291ArgMet: 1.291 ± 0.017	2.805ArgAsn: 2.805 ± 0.028	2.254ArgPro: 2.254 ± 0.025	2.341ArgGln: 2.341 ± 0.02	4.275ArgArg: 4.275 ± 0.043	4.418ArgSer: 4.418 ± 0.037	2.865ArgThr: 2.865 ± 0.027	3.174ArgVal: 3.174 ± 0.029	0.654ArgTrp: 0.654 ± 0.011	1.984ArgTyr: 1.984 ± 0.024	0.001ArgXaa: 0.001 ± 0.001
Ser	5.421SerAla: 5.421 ± 0.034	1.821SerCys: 1.821 ± 0.025	4.269SerAsp: 4.269 ± 0.036	5.169SerGlu: 5.169 ± 0.045	3.806SerPhe: 3.806 ± 0.031	4.859SerGly: 4.859 ± 0.037	1.622SerHis: 1.622 ± 0.021	3.88SerIle: 3.88 ± 0.031	4.565SerLys: 4.565 ± 0.033	7.555SerLeu: 7.555 ± 0.047	1.586SerMet: 1.586 ± 0.02	3.597SerAsn: 3.597 ± 0.032	3.697SerPro: 3.697 ± 0.042	2.9SerGln: 2.9 ± 0.029	4.28SerArg: 4.28 ± 0.034	8.731SerSer: 8.731 ± 0.072	4.657SerThr: 4.657 ± 0.038	5.606SerVal: 5.606 ± 0.04	0.837SerTrp: 0.837 ± 0.014	2.383SerTyr: 2.383 ± 0.025	0.004SerXaa: 0.004 ± 0.001
Thr	4.093ThrAla: 4.093 ± 0.036	1.178ThrCys: 1.178 ± 0.025	2.783ThrAsp: 2.783 ± 0.023	3.491ThrGlu: 3.491 ± 0.037	2.411ThrPhe: 2.411 ± 0.025	3.184ThrGly: 3.184 ± 0.03	1.063ThrHis: 1.063 ± 0.019	2.897ThrIle: 2.897 ± 0.029	2.985ThrLys: 2.985 ± 0.031	4.892ThrLeu: 4.892 ± 0.038	1.121ThrMet: 1.121 ± 0.016	2.318ThrAsn: 2.318 ± 0.023	2.663ThrPro: 2.663 ± 0.031	1.724ThrGln: 1.724 ± 0.024	2.461ThrArg: 2.461 ± 0.024	4.767ThrSer: 4.767 ± 0.041	3.627ThrThr: 3.627 ± 0.054	4.444ThrVal: 4.444 ± 0.037	0.515ThrTrp: 0.515 ± 0.012	1.603ThrTyr: 1.603 ± 0.02	0.003ThrXaa: 0.003 ± 0.001
Val	4.585ValAla: 4.585 ± 0.036	1.588ValCys: 1.588 ± 0.027	3.764ValAsp: 3.764 ± 0.025	4.46ValGlu: 4.46 ± 0.035	3.048ValPhe: 3.048 ± 0.031	3.54ValGly: 3.54 ± 0.036	1.432ValHis: 1.432 ± 0.019	3.864ValIle: 3.864 ± 0.033	3.921ValLys: 3.921 ± 0.034	6.14ValLeu: 6.14 ± 0.045	1.431ValMet: 1.431 ± 0.019	2.905ValAsn: 2.905 ± 0.026	3.134ValPro: 3.134 ± 0.028	2.49ValGln: 2.49 ± 0.025	3.417ValArg: 3.417 ± 0.031	5.153ValSer: 5.153 ± 0.036	3.8ValThr: 3.8 ± 0.028	4.919ValVal: 4.919 ± 0.042	0.71ValTrp: 0.71 ± 0.014	2.132ValTyr: 2.132 ± 0.023	0.004ValXaa: 0.004 ± 0.001
Trp	0.58TrpAla: 0.58 ± 0.012	0.244TrpCys: 0.244 ± 0.008	0.583TrpAsp: 0.583 ± 0.011	0.638TrpGlu: 0.638 ± 0.012	0.528TrpPhe: 0.528 ± 0.01	0.495TrpGly: 0.495 ± 0.009	0.258TrpHis: 0.258 ± 0.008	0.734TrpIle: 0.734 ± 0.014	0.839TrpLys: 0.839 ± 0.013	1.127TrpLeu: 1.127 ± 0.018	0.32TrpMet: 0.32 ± 0.009	0.615TrpAsn: 0.615 ± 0.013	0.42TrpPro: 0.42 ± 0.01	0.448TrpGln: 0.448 ± 0.01	0.676TrpArg: 0.676 ± 0.012	0.889TrpSer: 0.889 ± 0.017	0.617TrpThr: 0.617 ± 0.011	0.578TrpVal: 0.578 ± 0.012	0.17TrpTrp: 0.17 ± 0.007	0.379TrpTyr: 0.379 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.991TyrAla: 1.991 ± 0.023	0.905TyrCys: 0.905 ± 0.016	1.871TyrAsp: 1.871 ± 0.023	2.086TyrGlu: 2.086 ± 0.022	1.762TyrPhe: 1.762 ± 0.022	2.177TyrGly: 2.177 ± 0.027	0.757TyrHis: 0.757 ± 0.013	1.821TyrIle: 1.821 ± 0.019	1.773TyrLys: 1.773 ± 0.021	3.115TyrLeu: 3.115 ± 0.03	0.739TyrMet: 0.739 ± 0.014	1.446TyrAsn: 1.446 ± 0.02	1.364TyrPro: 1.364 ± 0.02	1.204TyrGln: 1.204 ± 0.017	1.942TyrArg: 1.942 ± 0.022	2.55TyrSer: 2.55 ± 0.024	1.612TyrThr: 1.612 ± 0.019	2.086TyrVal: 2.086 ± 0.024	0.404TyrTrp: 0.404 ± 0.009	1.327TyrTyr: 1.327 ± 0.021	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.004XaaArg: 0.004 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.003XaaTyr: 0.003 ± 0.001	0.896XaaXaa: 0.896 ± 0.069

Statistics based on 12840 proteins (4826947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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