Amino acid dipepetide frequency for Vibrio virus vB_VspP_SBP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.26AlaAla: 7.26 ± 0.827
1.369AlaCys: 1.369 ± 0.557
4.895AlaAsp: 4.895 ± 0.439
5.849AlaGlu: 5.849 ± 0.521
3.36AlaPhe: 3.36 ± 0.307
5.766AlaGly: 5.766 ± 0.555
1.12AlaHis: 1.12 ± 0.226
4.812AlaIle: 4.812 ± 0.525
5.352AlaLys: 5.352 ± 0.498
8.256AlaLeu: 8.256 ± 0.562
2.572AlaMet: 2.572 ± 0.374
4.314AlaAsn: 4.314 ± 0.552
2.572AlaPro: 2.572 ± 0.312
4.024AlaGln: 4.024 ± 0.64
2.862AlaArg: 2.862 ± 0.377
4.314AlaSer: 4.314 ± 0.459
4.854AlaThr: 4.854 ± 0.476
5.144AlaVal: 5.144 ± 0.675
1.037AlaTrp: 1.037 ± 0.201
3.526AlaTyr: 3.526 ± 0.304
0.0AlaXaa: 0.0 ± 0.0
Cys
0.871CysAla: 0.871 ± 0.293
0.207CysCys: 0.207 ± 0.094
1.037CysAsp: 1.037 ± 0.23
0.871CysGlu: 0.871 ± 0.229
0.29CysPhe: 0.29 ± 0.118
0.581CysGly: 0.581 ± 0.21
0.415CysHis: 0.415 ± 0.142
0.788CysIle: 0.788 ± 0.371
0.83CysLys: 0.83 ± 0.24
0.996CysLeu: 0.996 ± 0.279
0.415CysMet: 0.415 ± 0.14
0.664CysAsn: 0.664 ± 0.205
0.622CysPro: 0.622 ± 0.232
0.456CysGln: 0.456 ± 0.166
0.373CysArg: 0.373 ± 0.168
0.622CysSer: 0.622 ± 0.257
0.913CysThr: 0.913 ± 0.286
0.747CysVal: 0.747 ± 0.25
0.124CysTrp: 0.124 ± 0.072
0.249CysTyr: 0.249 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
6.14AspAla: 6.14 ± 0.517
0.747AspCys: 0.747 ± 0.217
4.19AspAsp: 4.19 ± 0.635
4.563AspGlu: 4.563 ± 0.748
2.614AspPhe: 2.614 ± 0.388
4.563AspGly: 4.563 ± 0.521
1.12AspHis: 1.12 ± 0.25
4.149AspIle: 4.149 ± 0.423
4.066AspLys: 4.066 ± 0.384
5.269AspLeu: 5.269 ± 0.508
2.157AspMet: 2.157 ± 0.339
3.402AspAsn: 3.402 ± 0.374
2.655AspPro: 2.655 ± 0.495
2.074AspGln: 2.074 ± 0.359
2.282AspArg: 2.282 ± 0.271
3.526AspSer: 3.526 ± 0.424
4.149AspThr: 4.149 ± 0.405
3.817AspVal: 3.817 ± 0.419
0.954AspTrp: 0.954 ± 0.23
2.323AspTyr: 2.323 ± 0.303
0.0AspXaa: 0.0 ± 0.0
Glu
6.804GluAla: 6.804 ± 0.694
0.498GluCys: 0.498 ± 0.15
3.983GluAsp: 3.983 ± 0.515
5.227GluGlu: 5.227 ± 0.618
2.697GluPhe: 2.697 ± 0.381
3.319GluGly: 3.319 ± 0.315
1.659GluHis: 1.659 ± 0.272
3.734GluIle: 3.734 ± 0.452
3.277GluLys: 3.277 ± 0.408
6.679GluLeu: 6.679 ± 0.427
1.991GluMet: 1.991 ± 0.268
3.236GluAsn: 3.236 ± 0.342
2.116GluPro: 2.116 ± 0.397
3.153GluGln: 3.153 ± 0.494
3.485GluArg: 3.485 ± 0.404
3.734GluSer: 3.734 ± 0.474
3.983GluThr: 3.983 ± 0.472
4.605GluVal: 4.605 ± 0.565
1.037GluTrp: 1.037 ± 0.193
2.78GluTyr: 2.78 ± 0.414
0.0GluXaa: 0.0 ± 0.0
Phe
2.365PheAla: 2.365 ± 0.326
0.415PheCys: 0.415 ± 0.164
2.489PheAsp: 2.489 ± 0.315
2.904PheGlu: 2.904 ± 0.338
1.245PhePhe: 1.245 ± 0.239
2.862PheGly: 2.862 ± 0.363
0.747PheHis: 0.747 ± 0.163
2.033PheIle: 2.033 ± 0.276
2.572PheLys: 2.572 ± 0.395
2.489PheLeu: 2.489 ± 0.406
0.705PheMet: 0.705 ± 0.189
2.697PheAsn: 2.697 ± 0.359
0.83PhePro: 0.83 ± 0.215
1.535PheGln: 1.535 ± 0.236
1.701PheArg: 1.701 ± 0.292
1.825PheSer: 1.825 ± 0.302
2.24PheThr: 2.24 ± 0.322
2.78PheVal: 2.78 ± 0.422
0.332PheTrp: 0.332 ± 0.165
0.996PheTyr: 0.996 ± 0.183
0.0PheXaa: 0.0 ± 0.0
Gly
4.895GlyAla: 4.895 ± 0.627
0.747GlyCys: 0.747 ± 0.248
4.024GlyAsp: 4.024 ± 0.566
3.941GlyGlu: 3.941 ± 0.388
2.531GlyPhe: 2.531 ± 0.389
4.48GlyGly: 4.48 ± 0.459
0.913GlyHis: 0.913 ± 0.197
4.688GlyIle: 4.688 ± 0.576
4.273GlyLys: 4.273 ± 0.467
4.646GlyLeu: 4.646 ± 0.462
2.033GlyMet: 2.033 ± 0.247
4.107GlyAsn: 4.107 ± 0.687
0.871GlyPro: 0.871 ± 0.179
2.199GlyGln: 2.199 ± 0.458
2.531GlyArg: 2.531 ± 0.31
3.236GlySer: 3.236 ± 0.355
4.854GlyThr: 4.854 ± 0.515
4.439GlyVal: 4.439 ± 0.416
1.12GlyTrp: 1.12 ± 0.233
3.028GlyTyr: 3.028 ± 0.347
0.0GlyXaa: 0.0 ± 0.0
His
1.328HisAla: 1.328 ± 0.179
0.29HisCys: 0.29 ± 0.148
1.286HisAsp: 1.286 ± 0.278
1.203HisGlu: 1.203 ± 0.295
0.622HisPhe: 0.622 ± 0.191
1.991HisGly: 1.991 ± 0.251
0.373HisHis: 0.373 ± 0.136
1.162HisIle: 1.162 ± 0.243
1.41HisLys: 1.41 ± 0.276
1.95HisLeu: 1.95 ± 0.303
0.788HisMet: 0.788 ± 0.217
0.954HisAsn: 0.954 ± 0.22
0.747HisPro: 0.747 ± 0.247
0.747HisGln: 0.747 ± 0.19
1.12HisArg: 1.12 ± 0.274
1.41HisSer: 1.41 ± 0.331
1.037HisThr: 1.037 ± 0.223
1.328HisVal: 1.328 ± 0.276
0.456HisTrp: 0.456 ± 0.146
1.41HisTyr: 1.41 ± 0.295
0.0HisXaa: 0.0 ± 0.0
Ile
4.688IleAla: 4.688 ± 0.421
0.954IleCys: 0.954 ± 0.229
4.066IleAsp: 4.066 ± 0.405
3.817IleGlu: 3.817 ± 0.498
1.659IlePhe: 1.659 ± 0.285
3.568IleGly: 3.568 ± 0.461
1.286IleHis: 1.286 ± 0.322
3.194IleIle: 3.194 ± 0.535
3.526IleLys: 3.526 ± 0.379
3.485IleLeu: 3.485 ± 0.376
1.41IleMet: 1.41 ± 0.243
3.609IleAsn: 3.609 ± 0.421
2.448IlePro: 2.448 ± 0.365
2.531IleGln: 2.531 ± 0.381
3.111IleArg: 3.111 ± 0.345
3.568IleSer: 3.568 ± 0.369
3.526IleThr: 3.526 ± 0.441
3.526IleVal: 3.526 ± 0.481
0.456IleTrp: 0.456 ± 0.141
1.867IleTyr: 1.867 ± 0.334
0.0IleXaa: 0.0 ± 0.0
Lys
5.352LysAla: 5.352 ± 0.655
0.664LysCys: 0.664 ± 0.198
4.149LysAsp: 4.149 ± 0.54
5.186LysGlu: 5.186 ± 0.512
1.867LysPhe: 1.867 ± 0.308
3.526LysGly: 3.526 ± 0.563
1.991LysHis: 1.991 ± 0.351
2.406LysIle: 2.406 ± 0.308
4.19LysLys: 4.19 ± 0.64
6.181LysLeu: 6.181 ± 0.51
2.033LysMet: 2.033 ± 0.343
2.531LysAsn: 2.531 ± 0.306
2.738LysPro: 2.738 ± 0.442
3.236LysGln: 3.236 ± 0.435
2.572LysArg: 2.572 ± 0.384
3.568LysSer: 3.568 ± 0.318
3.526LysThr: 3.526 ± 0.389
4.605LysVal: 4.605 ± 0.482
0.913LysTrp: 0.913 ± 0.218
3.153LysTyr: 3.153 ± 0.429
0.0LysXaa: 0.0 ± 0.0
Leu
6.513LeuAla: 6.513 ± 0.531
0.664LeuCys: 0.664 ± 0.173
5.476LeuAsp: 5.476 ± 0.55
5.518LeuGlu: 5.518 ± 0.528
2.78LeuPhe: 2.78 ± 0.306
4.356LeuGly: 4.356 ± 0.452
1.742LeuHis: 1.742 ± 0.306
4.605LeuIle: 4.605 ± 0.441
5.02LeuLys: 5.02 ± 0.57
5.352LeuLeu: 5.352 ± 0.619
3.194LeuMet: 3.194 ± 0.504
4.646LeuAsn: 4.646 ± 0.386
4.149LeuPro: 4.149 ± 0.499
3.651LeuGln: 3.651 ± 0.339
4.314LeuArg: 4.314 ± 0.403
4.605LeuSer: 4.605 ± 0.505
5.766LeuThr: 5.766 ± 0.431
5.103LeuVal: 5.103 ± 0.446
0.913LeuTrp: 0.913 ± 0.179
2.531LeuTyr: 2.531 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
2.738MetAla: 2.738 ± 0.374
0.622MetCys: 0.622 ± 0.184
1.618MetAsp: 1.618 ± 0.301
2.157MetGlu: 2.157 ± 0.31
0.996MetPhe: 0.996 ± 0.22
1.701MetGly: 1.701 ± 0.261
0.664MetHis: 0.664 ± 0.146
1.618MetIle: 1.618 ± 0.306
1.825MetLys: 1.825 ± 0.372
2.199MetLeu: 2.199 ± 0.376
0.788MetMet: 0.788 ± 0.182
2.074MetAsn: 2.074 ± 0.326
1.493MetPro: 1.493 ± 0.233
1.037MetGln: 1.037 ± 0.221
1.618MetArg: 1.618 ± 0.303
1.991MetSer: 1.991 ± 0.235
2.323MetThr: 2.323 ± 0.312
1.784MetVal: 1.784 ± 0.259
0.332MetTrp: 0.332 ± 0.11
0.622MetTyr: 0.622 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
5.31AsnAla: 5.31 ± 0.563
0.747AsnCys: 0.747 ± 0.189
2.862AsnAsp: 2.862 ± 0.322
2.448AsnGlu: 2.448 ± 0.496
2.282AsnPhe: 2.282 ± 0.35
3.526AsnGly: 3.526 ± 0.479
1.328AsnHis: 1.328 ± 0.269
3.028AsnIle: 3.028 ± 0.352
3.402AsnLys: 3.402 ± 0.518
4.231AsnLeu: 4.231 ± 0.464
1.784AsnMet: 1.784 ± 0.279
3.111AsnAsn: 3.111 ± 0.37
3.07AsnPro: 3.07 ± 0.323
2.697AsnGln: 2.697 ± 0.34
3.153AsnArg: 3.153 ± 0.313
3.07AsnSer: 3.07 ± 0.341
3.941AsnThr: 3.941 ± 0.597
2.489AsnVal: 2.489 ± 0.376
0.29AsnTrp: 0.29 ± 0.117
1.991AsnTyr: 1.991 ± 0.29
0.0AsnXaa: 0.0 ± 0.0
Pro
2.572ProAla: 2.572 ± 0.287
0.373ProCys: 0.373 ± 0.119
3.277ProAsp: 3.277 ± 0.494
3.402ProGlu: 3.402 ± 0.434
1.493ProPhe: 1.493 ± 0.309
1.784ProGly: 1.784 ± 0.243
0.498ProHis: 0.498 ± 0.13
1.659ProIle: 1.659 ± 0.262
2.655ProLys: 2.655 ± 0.384
2.821ProLeu: 2.821 ± 0.346
0.954ProMet: 0.954 ± 0.182
2.199ProAsn: 2.199 ± 0.294
1.12ProPro: 1.12 ± 0.264
1.12ProGln: 1.12 ± 0.231
1.784ProArg: 1.784 ± 0.279
1.825ProSer: 1.825 ± 0.321
2.78ProThr: 2.78 ± 0.395
2.24ProVal: 2.24 ± 0.304
0.415ProTrp: 0.415 ± 0.123
1.245ProTyr: 1.245 ± 0.261
0.0ProXaa: 0.0 ± 0.0
Gln
4.19GlnAla: 4.19 ± 0.664
0.498GlnCys: 0.498 ± 0.19
2.199GlnAsp: 2.199 ± 0.377
2.738GlnGlu: 2.738 ± 0.413
1.493GlnPhe: 1.493 ± 0.201
2.448GlnGly: 2.448 ± 0.338
1.037GlnHis: 1.037 ± 0.233
1.991GlnIle: 1.991 ± 0.356
3.568GlnLys: 3.568 ± 0.511
3.941GlnLeu: 3.941 ± 0.421
1.203GlnMet: 1.203 ± 0.245
1.784GlnAsn: 1.784 ± 0.212
1.037GlnPro: 1.037 ± 0.199
2.448GlnGln: 2.448 ± 0.411
2.406GlnArg: 2.406 ± 0.32
2.116GlnSer: 2.116 ± 0.298
2.78GlnThr: 2.78 ± 0.343
3.028GlnVal: 3.028 ± 0.385
0.747GlnTrp: 0.747 ± 0.244
2.074GlnTyr: 2.074 ± 0.247
0.0GlnXaa: 0.0 ± 0.0
Arg
3.651ArgAla: 3.651 ± 0.518
0.622ArgCys: 0.622 ± 0.171
2.78ArgAsp: 2.78 ± 0.346
2.697ArgGlu: 2.697 ± 0.336
1.369ArgPhe: 1.369 ± 0.19
2.614ArgGly: 2.614 ± 0.367
1.203ArgHis: 1.203 ± 0.226
2.24ArgIle: 2.24 ± 0.291
3.277ArgLys: 3.277 ± 0.448
4.231ArgLeu: 4.231 ± 0.381
1.576ArgMet: 1.576 ± 0.285
2.697ArgAsn: 2.697 ± 0.41
1.12ArgPro: 1.12 ± 0.237
2.116ArgGln: 2.116 ± 0.299
2.697ArgArg: 2.697 ± 0.411
1.908ArgSer: 1.908 ± 0.3
3.858ArgThr: 3.858 ± 0.403
3.485ArgVal: 3.485 ± 0.329
0.622ArgTrp: 0.622 ± 0.147
1.867ArgTyr: 1.867 ± 0.24
0.0ArgXaa: 0.0 ± 0.0
Ser
4.273SerAla: 4.273 ± 0.613
0.456SerCys: 0.456 ± 0.143
4.066SerAsp: 4.066 ± 0.512
3.983SerGlu: 3.983 ± 0.524
1.784SerPhe: 1.784 ± 0.287
4.231SerGly: 4.231 ± 0.604
1.162SerHis: 1.162 ± 0.225
3.319SerIle: 3.319 ± 0.342
3.319SerLys: 3.319 ± 0.354
4.439SerLeu: 4.439 ± 0.656
1.908SerMet: 1.908 ± 0.292
2.448SerAsn: 2.448 ± 0.409
1.701SerPro: 1.701 ± 0.21
2.116SerGln: 2.116 ± 0.334
2.406SerArg: 2.406 ± 0.334
3.277SerSer: 3.277 ± 0.372
3.609SerThr: 3.609 ± 0.327
3.111SerVal: 3.111 ± 0.393
0.788SerTrp: 0.788 ± 0.197
1.784SerTyr: 1.784 ± 0.351
0.0SerXaa: 0.0 ± 0.0
Thr
5.269ThrAla: 5.269 ± 0.663
0.83ThrCys: 0.83 ± 0.293
4.19ThrAsp: 4.19 ± 0.423
3.402ThrGlu: 3.402 ± 0.39
2.489ThrPhe: 2.489 ± 0.332
5.103ThrGly: 5.103 ± 0.653
1.576ThrHis: 1.576 ± 0.361
4.19ThrIle: 4.19 ± 0.376
4.356ThrLys: 4.356 ± 0.426
4.771ThrLeu: 4.771 ± 0.516
1.369ThrMet: 1.369 ± 0.213
3.775ThrAsn: 3.775 ± 0.385
3.36ThrPro: 3.36 ± 0.442
3.194ThrGln: 3.194 ± 0.494
2.489ThrArg: 2.489 ± 0.285
3.36ThrSer: 3.36 ± 0.614
4.231ThrThr: 4.231 ± 0.7
4.522ThrVal: 4.522 ± 0.42
0.83ThrTrp: 0.83 ± 0.203
2.738ThrTyr: 2.738 ± 0.339
0.0ThrXaa: 0.0 ± 0.0
Val
5.103ValAla: 5.103 ± 0.402
0.705ValCys: 0.705 ± 0.23
4.605ValAsp: 4.605 ± 0.509
4.729ValGlu: 4.729 ± 0.597
2.24ValPhe: 2.24 ± 0.332
3.692ValGly: 3.692 ± 0.392
1.328ValHis: 1.328 ± 0.312
3.983ValIle: 3.983 ± 0.479
4.48ValLys: 4.48 ± 0.427
4.397ValLeu: 4.397 ± 0.379
1.701ValMet: 1.701 ± 0.296
3.817ValAsn: 3.817 ± 0.357
2.074ValPro: 2.074 ± 0.328
3.402ValGln: 3.402 ± 0.442
3.111ValArg: 3.111 ± 0.406
3.36ValSer: 3.36 ± 0.388
4.771ValThr: 4.771 ± 0.527
4.024ValVal: 4.024 ± 0.418
0.871ValTrp: 0.871 ± 0.207
2.945ValTyr: 2.945 ± 0.342
0.0ValXaa: 0.0 ± 0.0
Trp
0.913TrpAla: 0.913 ± 0.249
0.249TrpCys: 0.249 ± 0.131
0.996TrpAsp: 0.996 ± 0.172
0.871TrpGlu: 0.871 ± 0.212
0.415TrpPhe: 0.415 ± 0.145
0.83TrpGly: 0.83 ± 0.208
0.373TrpHis: 0.373 ± 0.124
0.498TrpIle: 0.498 ± 0.165
0.622TrpLys: 0.622 ± 0.152
1.286TrpLeu: 1.286 ± 0.258
0.332TrpMet: 0.332 ± 0.137
0.871TrpAsn: 0.871 ± 0.217
0.249TrpPro: 0.249 ± 0.098
0.456TrpGln: 0.456 ± 0.148
0.622TrpArg: 0.622 ± 0.142
0.581TrpSer: 0.581 ± 0.183
0.664TrpThr: 0.664 ± 0.159
1.369TrpVal: 1.369 ± 0.258
0.083TrpTrp: 0.083 ± 0.059
0.581TrpTyr: 0.581 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.028TyrAla: 3.028 ± 0.373
0.415TyrCys: 0.415 ± 0.148
2.614TyrAsp: 2.614 ± 0.289
2.489TyrGlu: 2.489 ± 0.235
1.535TyrPhe: 1.535 ± 0.239
2.614TyrGly: 2.614 ± 0.317
1.079TyrHis: 1.079 ± 0.253
2.199TyrIle: 2.199 ± 0.239
2.365TyrLys: 2.365 ± 0.258
3.277TyrLeu: 3.277 ± 0.353
1.245TyrMet: 1.245 ± 0.209
1.825TyrAsn: 1.825 ± 0.28
1.245TyrPro: 1.245 ± 0.306
1.535TyrGln: 1.535 ± 0.273
1.991TyrArg: 1.991 ± 0.304
2.282TyrSer: 2.282 ± 0.377
2.24TyrThr: 2.24 ± 0.333
3.194TyrVal: 3.194 ± 0.494
0.539TyrTrp: 0.539 ± 0.154
1.742TyrTyr: 1.742 ± 0.277
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 112 proteins (24106 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski