Amino acid dipepetide frequency for Octadecabacter sp. SW4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.198AlaAla: 17.198 ± 0.23	1.095AlaCys: 1.095 ± 0.035	7.864AlaAsp: 7.864 ± 0.094	6.926AlaGlu: 6.926 ± 0.107	4.538AlaPhe: 4.538 ± 0.081	10.715AlaGly: 10.715 ± 0.099	2.317AlaHis: 2.317 ± 0.049	6.345AlaIle: 6.345 ± 0.09	3.938AlaLys: 3.938 ± 0.065	13.527AlaLeu: 13.527 ± 0.139	4.012AlaMet: 4.012 ± 0.06	2.958AlaAsn: 2.958 ± 0.061	5.754AlaPro: 5.754 ± 0.097	5.076AlaGln: 5.076 ± 0.083	8.62AlaArg: 8.62 ± 0.107	5.269AlaSer: 5.269 ± 0.064	6.6AlaThr: 6.6 ± 0.08	8.476AlaVal: 8.476 ± 0.098	1.402AlaTrp: 1.402 ± 0.038	2.55AlaTyr: 2.55 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.118CysAla: 1.118 ± 0.038	0.117CysCys: 0.117 ± 0.012	0.677CysAsp: 0.677 ± 0.026	0.452CysGlu: 0.452 ± 0.021	0.324CysPhe: 0.324 ± 0.016	0.969CysGly: 0.969 ± 0.033	0.277CysHis: 0.277 ± 0.014	0.452CysIle: 0.452 ± 0.02	0.219CysLys: 0.219 ± 0.016	0.827CysLeu: 0.827 ± 0.031	0.174CysMet: 0.174 ± 0.012	0.227CysAsn: 0.227 ± 0.015	0.517CysPro: 0.517 ± 0.023	0.236CysGln: 0.236 ± 0.017	0.488CysArg: 0.488 ± 0.024	0.397CysSer: 0.397 ± 0.02	0.425CysThr: 0.425 ± 0.023	0.599CysVal: 0.599 ± 0.023	0.122CysTrp: 0.122 ± 0.009	0.206CysTyr: 0.206 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.858AspAla: 7.858 ± 0.093	0.526AspCys: 0.526 ± 0.022	4.278AspAsp: 4.278 ± 0.088	3.423AspGlu: 3.423 ± 0.059	2.493AspPhe: 2.493 ± 0.057	6.103AspGly: 6.103 ± 0.098	1.493AspHis: 1.493 ± 0.044	3.688AspIle: 3.688 ± 0.063	1.86AspLys: 1.86 ± 0.044	6.875AspLeu: 6.875 ± 0.096	1.993AspMet: 1.993 ± 0.047	1.466AspAsn: 1.466 ± 0.043	3.785AspPro: 3.785 ± 0.066	2.219AspGln: 2.219 ± 0.052	4.273AspArg: 4.273 ± 0.076	2.38AspSer: 2.38 ± 0.044	3.569AspThr: 3.569 ± 0.077	4.803AspVal: 4.803 ± 0.078	1.237AspTrp: 1.237 ± 0.036	1.663AspTyr: 1.663 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.402GluAla: 6.402 ± 0.099	0.359GluCys: 0.359 ± 0.017	3.178GluAsp: 3.178 ± 0.062	2.743GluGlu: 2.743 ± 0.068	1.725GluPhe: 1.725 ± 0.037	4.288GluGly: 4.288 ± 0.069	0.973GluHis: 0.973 ± 0.037	3.424GluIle: 3.424 ± 0.063	1.927GluLys: 1.927 ± 0.052	4.449GluLeu: 4.449 ± 0.067	1.783GluMet: 1.783 ± 0.048	1.761GluAsn: 1.761 ± 0.037	2.069GluPro: 2.069 ± 0.046	1.771GluGln: 1.771 ± 0.043	3.635GluArg: 3.635 ± 0.064	2.115GluSer: 2.115 ± 0.041	3.597GluThr: 3.597 ± 0.07	4.188GluVal: 4.188 ± 0.067	0.663GluTrp: 0.663 ± 0.024	0.996GluTyr: 0.996 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.852PheAla: 4.852 ± 0.075	0.431PheCys: 0.431 ± 0.02	3.049PheAsp: 3.049 ± 0.055	2.148PheGlu: 2.148 ± 0.051	1.485PhePhe: 1.485 ± 0.046	3.932PheGly: 3.932 ± 0.076	0.718PheHis: 0.718 ± 0.027	1.81PheIle: 1.81 ± 0.039	0.986PheLys: 0.986 ± 0.031	3.39PheLeu: 3.39 ± 0.063	0.945PheMet: 0.945 ± 0.034	1.097PheAsn: 1.097 ± 0.033	1.566PhePro: 1.566 ± 0.036	1.086PheGln: 1.086 ± 0.034	2.036PheArg: 2.036 ± 0.047	2.014PheSer: 2.014 ± 0.043	2.233PheThr: 2.233 ± 0.044	2.899PheVal: 2.899 ± 0.063	0.602PheTrp: 0.602 ± 0.026	0.964PheTyr: 0.964 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.313GlyAla: 10.313 ± 0.112	0.842GlyCys: 0.842 ± 0.03	5.46GlyAsp: 5.46 ± 0.112	4.481GlyGlu: 4.481 ± 0.078	3.841GlyPhe: 3.841 ± 0.066	7.729GlyGly: 7.729 ± 0.133	1.868GlyHis: 1.868 ± 0.048	4.56GlyIle: 4.56 ± 0.072	3.144GlyLys: 3.144 ± 0.064	8.976GlyLeu: 8.976 ± 0.108	2.702GlyMet: 2.702 ± 0.054	2.295GlyAsn: 2.295 ± 0.071	3.412GlyPro: 3.412 ± 0.062	3.237GlyGln: 3.237 ± 0.06	5.403GlyArg: 5.403 ± 0.077	3.938GlySer: 3.938 ± 0.078	4.818GlyThr: 4.818 ± 0.098	6.708GlyVal: 6.708 ± 0.08	1.492GlyTrp: 1.492 ± 0.045	2.348GlyTyr: 2.348 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.047	0.225HisCys: 0.225 ± 0.016	1.393HisAsp: 1.393 ± 0.038	0.977HisGlu: 0.977 ± 0.031	0.838HisPhe: 0.838 ± 0.029	1.865HisGly: 1.865 ± 0.048	0.565HisHis: 0.565 ± 0.025	1.048HisIle: 1.048 ± 0.028	0.544HisLys: 0.544 ± 0.022	2.054HisLeu: 2.054 ± 0.054	0.58HisMet: 0.58 ± 0.023	0.49HisAsn: 0.49 ± 0.021	1.363HisPro: 1.363 ± 0.043	0.59HisGln: 0.59 ± 0.022	1.253HisArg: 1.253 ± 0.035	0.911HisSer: 0.911 ± 0.027	0.863HisThr: 0.863 ± 0.03	1.494HisVal: 1.494 ± 0.041	0.358HisTrp: 0.358 ± 0.021	0.566HisTyr: 0.566 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.988IleAla: 7.988 ± 0.104	0.677IleCys: 0.677 ± 0.028	3.956IleAsp: 3.956 ± 0.065	3.238IleGlu: 3.238 ± 0.06	1.849IlePhe: 1.849 ± 0.042	5.137IleGly: 5.137 ± 0.085	0.924IleHis: 0.924 ± 0.036	2.616IleIle: 2.616 ± 0.059	1.654IleLys: 1.654 ± 0.045	4.665IleLeu: 4.665 ± 0.071	1.243IleMet: 1.243 ± 0.033	1.581IleAsn: 1.581 ± 0.047	2.348IlePro: 2.348 ± 0.054	1.202IleGln: 1.202 ± 0.032	3.082IleArg: 3.082 ± 0.049	2.986IleSer: 2.986 ± 0.061	3.43IleThr: 3.43 ± 0.06	4.143IleVal: 4.143 ± 0.078	0.806IleTrp: 0.806 ± 0.032	1.285IleTyr: 1.285 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.653LysAla: 3.653 ± 0.075	0.176LysCys: 0.176 ± 0.013	1.798LysAsp: 1.798 ± 0.046	1.347LysGlu: 1.347 ± 0.044	0.936LysPhe: 0.936 ± 0.033	2.682LysGly: 2.682 ± 0.065	0.64LysHis: 0.64 ± 0.024	1.735LysIle: 1.735 ± 0.044	1.204LysLys: 1.204 ± 0.05	2.812LysLeu: 2.812 ± 0.058	0.923LysMet: 0.923 ± 0.031	0.79LysAsn: 0.79 ± 0.033	1.71LysPro: 1.71 ± 0.041	0.937LysGln: 0.937 ± 0.036	2.201LysArg: 2.201 ± 0.053	1.864LysSer: 1.864 ± 0.051	2.028LysThr: 2.028 ± 0.045	2.245LysVal: 2.245 ± 0.055	0.404LysTrp: 0.404 ± 0.021	0.63LysTyr: 0.63 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.775LeuAla: 12.775 ± 0.14	0.858LeuCys: 0.858 ± 0.028	6.149LeuAsp: 6.149 ± 0.088	4.821LeuGlu: 4.821 ± 0.064	3.62LeuPhe: 3.62 ± 0.077	8.444LeuGly: 8.444 ± 0.102	1.932LeuHis: 1.932 ± 0.041	5.521LeuIle: 5.521 ± 0.08	2.73LeuLys: 2.73 ± 0.059	8.44LeuLeu: 8.44 ± 0.122	2.691LeuMet: 2.691 ± 0.056	2.731LeuAsn: 2.731 ± 0.055	5.191LeuPro: 5.191 ± 0.074	2.752LeuGln: 2.752 ± 0.052	7.131LeuArg: 7.131 ± 0.087	5.964LeuSer: 5.964 ± 0.098	5.954LeuThr: 5.954 ± 0.077	6.766LeuVal: 6.766 ± 0.096	1.307LeuTrp: 1.307 ± 0.045	1.893LeuTyr: 1.893 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.759MetAla: 3.759 ± 0.068	0.182MetCys: 0.182 ± 0.013	1.644MetAsp: 1.644 ± 0.046	1.244MetGlu: 1.244 ± 0.038	0.896MetPhe: 0.896 ± 0.03	2.395MetGly: 2.395 ± 0.055	0.507MetHis: 0.507 ± 0.023	1.786MetIle: 1.786 ± 0.041	1.061MetLys: 1.061 ± 0.036	2.624MetLeu: 2.624 ± 0.055	0.837MetMet: 0.837 ± 0.029	0.902MetAsn: 0.902 ± 0.031	1.534MetPro: 1.534 ± 0.041	1.026MetGln: 1.026 ± 0.036	1.981MetArg: 1.981 ± 0.046	1.722MetSer: 1.722 ± 0.04	2.287MetThr: 2.287 ± 0.044	2.022MetVal: 2.022 ± 0.047	0.294MetTrp: 0.294 ± 0.015	0.364MetTyr: 0.364 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.361AsnAla: 3.361 ± 0.06	0.271AsnCys: 0.271 ± 0.017	1.732AsnAsp: 1.732 ± 0.052	1.182AsnGlu: 1.182 ± 0.036	1.052AsnPhe: 1.052 ± 0.036	2.659AsnGly: 2.659 ± 0.057	0.541AsnHis: 0.541 ± 0.022	1.472AsnIle: 1.472 ± 0.041	0.676AsnLys: 0.676 ± 0.026	2.517AsnLeu: 2.517 ± 0.047	0.759AsnMet: 0.759 ± 0.027	0.692AsnAsn: 0.692 ± 0.032	1.898AsnPro: 1.898 ± 0.038	0.703AsnGln: 0.703 ± 0.026	1.689AsnArg: 1.689 ± 0.046	1.171AsnSer: 1.171 ± 0.036	1.49AsnThr: 1.49 ± 0.048	1.91AsnVal: 1.91 ± 0.046	0.476AsnTrp: 0.476 ± 0.023	0.676AsnTyr: 0.676 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.809ProAla: 5.809 ± 0.092	0.363ProCys: 0.363 ± 0.02	4.17ProAsp: 4.17 ± 0.06	3.322ProGlu: 3.322 ± 0.058	1.972ProPhe: 1.972 ± 0.044	3.48ProGly: 3.48 ± 0.056	1.097ProHis: 1.097 ± 0.036	2.334ProIle: 2.334 ± 0.051	1.632ProLys: 1.632 ± 0.045	4.639ProLeu: 4.639 ± 0.071	1.38ProMet: 1.38 ± 0.036	1.404ProAsn: 1.404 ± 0.037	2.086ProPro: 2.086 ± 0.052	1.677ProGln: 1.677 ± 0.042	2.578ProArg: 2.578 ± 0.052	2.308ProSer: 2.308 ± 0.046	2.576ProThr: 2.576 ± 0.055	4.172ProVal: 4.172 ± 0.062	0.656ProTrp: 0.656 ± 0.03	1.163ProTyr: 1.163 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.144GlnAla: 4.144 ± 0.067	0.229GlnCys: 0.229 ± 0.014	1.933GlnAsp: 1.933 ± 0.044	1.407GlnGlu: 1.407 ± 0.043	1.223GlnPhe: 1.223 ± 0.035	2.844GlnGly: 2.844 ± 0.053	0.628GlnHis: 0.628 ± 0.02	2.259GlnIle: 2.259 ± 0.048	0.993GlnLys: 0.993 ± 0.032	2.828GlnLeu: 2.828 ± 0.057	1.16GlnMet: 1.16 ± 0.034	0.93GlnAsn: 0.93 ± 0.03	1.55GlnPro: 1.55 ± 0.041	1.11GlnGln: 1.11 ± 0.035	2.197GlnArg: 2.197 ± 0.05	1.881GlnSer: 1.881 ± 0.047	2.053GlnThr: 2.053 ± 0.044	2.521GlnVal: 2.521 ± 0.044	0.427GlnTrp: 0.427 ± 0.024	0.627GlnTyr: 0.627 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.456ArgAla: 8.456 ± 0.096	0.467ArgCys: 0.467 ± 0.024	4.579ArgAsp: 4.579 ± 0.069	3.462ArgGlu: 3.462 ± 0.069	2.583ArgPhe: 2.583 ± 0.055	4.491ArgGly: 4.491 ± 0.078	1.429ArgHis: 1.429 ± 0.044	3.746ArgIle: 3.746 ± 0.055	2.147ArgLys: 2.147 ± 0.057	6.592ArgLeu: 6.592 ± 0.087	1.961ArgMet: 1.961 ± 0.041	1.79ArgAsn: 1.79 ± 0.044	2.941ArgPro: 2.941 ± 0.06	2.139ArgGln: 2.139 ± 0.049	4.512ArgArg: 4.512 ± 0.08	2.861ArgSer: 2.861 ± 0.062	2.977ArgThr: 2.977 ± 0.061	4.606ArgVal: 4.606 ± 0.075	0.922ArgTrp: 0.922 ± 0.03	1.538ArgTyr: 1.538 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.477SerAla: 5.477 ± 0.077	0.464SerCys: 0.464 ± 0.024	3.412SerAsp: 3.412 ± 0.064	2.56SerGlu: 2.56 ± 0.048	2.123SerPhe: 2.123 ± 0.052	5.148SerGly: 5.148 ± 0.08	0.974SerHis: 0.974 ± 0.03	2.46SerIle: 2.46 ± 0.059	1.441SerLys: 1.441 ± 0.04	4.801SerLeu: 4.801 ± 0.083	1.313SerMet: 1.313 ± 0.034	1.282SerAsn: 1.282 ± 0.037	2.367SerPro: 2.367 ± 0.042	1.59SerGln: 1.59 ± 0.036	2.901SerArg: 2.901 ± 0.051	2.246SerSer: 2.246 ± 0.051	2.445SerThr: 2.445 ± 0.054	3.599SerVal: 3.599 ± 0.056	0.642SerTrp: 0.642 ± 0.029	1.294SerTyr: 1.294 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.592ThrAla: 6.592 ± 0.077	0.515ThrCys: 0.515 ± 0.024	3.618ThrAsp: 3.618 ± 0.066	2.585ThrGlu: 2.585 ± 0.057	2.205ThrPhe: 2.205 ± 0.047	5.623ThrGly: 5.623 ± 0.08	1.215ThrHis: 1.215 ± 0.032	3.026ThrIle: 3.026 ± 0.062	1.579ThrLys: 1.579 ± 0.042	6.418ThrLeu: 6.418 ± 0.081	1.371ThrMet: 1.371 ± 0.039	1.398ThrAsn: 1.398 ± 0.038	3.524ThrPro: 3.524 ± 0.067	1.887ThrGln: 1.887 ± 0.048	3.54ThrArg: 3.54 ± 0.073	2.703ThrSer: 2.703 ± 0.059	3.185ThrThr: 3.185 ± 0.065	4.418ThrVal: 4.418 ± 0.064	0.713ThrTrp: 0.713 ± 0.031	1.439ThrTyr: 1.439 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.098ValAla: 9.098 ± 0.102	0.638ValCys: 0.638 ± 0.025	4.538ValAsp: 4.538 ± 0.07	3.893ValGlu: 3.893 ± 0.062	3.031ValPhe: 3.031 ± 0.056	5.712ValGly: 5.712 ± 0.081	1.322ValHis: 1.322 ± 0.039	4.751ValIle: 4.751 ± 0.074	2.051ValLys: 2.051 ± 0.052	7.409ValLeu: 7.409 ± 0.11	2.272ValMet: 2.272 ± 0.049	2.047ValAsn: 2.047 ± 0.042	3.43ValPro: 3.43 ± 0.067	2.32ValGln: 2.32 ± 0.048	4.056ValArg: 4.056 ± 0.071	3.929ValSer: 3.929 ± 0.063	5.093ValThr: 5.093 ± 0.078	5.755ValVal: 5.755 ± 0.091	1.014ValTrp: 1.014 ± 0.034	1.503ValTyr: 1.503 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.452TrpAla: 1.452 ± 0.045	0.143TrpCys: 0.143 ± 0.012	0.865TrpAsp: 0.865 ± 0.031	0.668TrpGlu: 0.668 ± 0.023	0.579TrpPhe: 0.579 ± 0.023	1.077TrpGly: 1.077 ± 0.034	0.341TrpHis: 0.341 ± 0.018	0.756TrpIle: 0.756 ± 0.028	0.4TrpLys: 0.4 ± 0.019	1.577TrpLeu: 1.577 ± 0.047	0.428TrpMet: 0.428 ± 0.023	0.438TrpAsn: 0.438 ± 0.019	0.705TrpPro: 0.705 ± 0.029	0.619TrpGln: 0.619 ± 0.023	1.088TrpArg: 1.088 ± 0.033	0.744TrpSer: 0.744 ± 0.032	0.759TrpThr: 0.759 ± 0.025	0.975TrpVal: 0.975 ± 0.03	0.242TrpTrp: 0.242 ± 0.017	0.285TrpTyr: 0.285 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.052	0.244TyrCys: 0.244 ± 0.015	1.688TyrAsp: 1.688 ± 0.038	1.166TyrGlu: 1.166 ± 0.037	0.93TyrPhe: 0.93 ± 0.03	2.274TyrGly: 2.274 ± 0.05	0.54TyrHis: 0.54 ± 0.026	1.024TyrIle: 1.024 ± 0.033	0.53TyrLys: 0.53 ± 0.022	2.251TyrLeu: 2.251 ± 0.047	0.537TyrMet: 0.537 ± 0.025	0.647TyrAsn: 0.647 ± 0.028	1.065TyrPro: 1.065 ± 0.031	0.769TyrGln: 0.769 ± 0.031	1.536TyrArg: 1.536 ± 0.044	1.133TyrSer: 1.133 ± 0.033	1.173TyrThr: 1.173 ± 0.035	1.566TyrVal: 1.566 ± 0.04	0.363TyrTrp: 0.363 ± 0.02	0.619TyrTyr: 0.619 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3350 proteins (1034289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---