Amino acid dipepetide frequency for Pseudocercospora eumusae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.676AlaAla: 9.676 ± 0.058	1.159AlaCys: 1.159 ± 0.015	4.474AlaAsp: 4.474 ± 0.032	5.615AlaGlu: 5.615 ± 0.042	3.303AlaPhe: 3.303 ± 0.024	5.978AlaGly: 5.978 ± 0.035	1.95AlaHis: 1.95 ± 0.019	4.375AlaIle: 4.375 ± 0.029	4.632AlaLys: 4.632 ± 0.035	7.838AlaLeu: 7.838 ± 0.045	2.132AlaMet: 2.132 ± 0.019	3.18AlaAsn: 3.18 ± 0.026	5.029AlaPro: 5.029 ± 0.043	3.902AlaGln: 3.902 ± 0.032	5.236AlaArg: 5.236 ± 0.034	7.673AlaSer: 7.673 ± 0.047	5.546AlaThr: 5.546 ± 0.037	5.431AlaVal: 5.431 ± 0.037	1.246AlaTrp: 1.246 ± 0.015	2.343AlaTyr: 2.343 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.015	0.257CysCys: 0.257 ± 0.007	0.683CysAsp: 0.683 ± 0.012	0.654CysGlu: 0.654 ± 0.013	0.549CysPhe: 0.549 ± 0.008	0.942CysGly: 0.942 ± 0.015	0.354CysHis: 0.354 ± 0.008	0.714CysIle: 0.714 ± 0.013	0.578CysLys: 0.578 ± 0.011	1.22CysLeu: 1.22 ± 0.015	0.296CysMet: 0.296 ± 0.007	0.45CysAsn: 0.45 ± 0.01	0.655CysPro: 0.655 ± 0.011	0.456CysGln: 0.456 ± 0.01	0.769CysArg: 0.769 ± 0.013	0.958CysSer: 0.958 ± 0.014	0.742CysThr: 0.742 ± 0.011	0.765CysVal: 0.765 ± 0.012	0.209CysTrp: 0.209 ± 0.007	0.397CysTyr: 0.397 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.041AspAla: 5.041 ± 0.034	0.667AspCys: 0.667 ± 0.011	4.461AspAsp: 4.461 ± 0.049	4.615AspGlu: 4.615 ± 0.037	2.325AspPhe: 2.325 ± 0.021	4.088AspGly: 4.088 ± 0.034	1.356AspHis: 1.356 ± 0.017	2.875AspIle: 2.875 ± 0.027	2.351AspLys: 2.351 ± 0.026	5.006AspLeu: 5.006 ± 0.035	1.34AspMet: 1.34 ± 0.015	1.792AspAsn: 1.792 ± 0.017	3.131AspPro: 3.131 ± 0.028	2.078AspGln: 2.078 ± 0.018	3.119AspArg: 3.119 ± 0.032	4.07AspSer: 4.07 ± 0.037	2.975AspThr: 2.975 ± 0.025	3.667AspVal: 3.667 ± 0.03	0.917AspTrp: 0.917 ± 0.015	1.612AspTyr: 1.612 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.606GluAla: 5.606 ± 0.038	0.635GluCys: 0.635 ± 0.012	4.358GluAsp: 4.358 ± 0.037	5.396GluGlu: 5.396 ± 0.04	1.779GluPhe: 1.779 ± 0.017	3.629GluGly: 3.629 ± 0.03	1.654GluHis: 1.654 ± 0.019	2.907GluIle: 2.907 ± 0.024	3.829GluLys: 3.829 ± 0.034	5.243GluLeu: 5.243 ± 0.04	1.483GluMet: 1.483 ± 0.016	2.24GluAsn: 2.24 ± 0.019	2.802GluPro: 2.802 ± 0.029	2.883GluGln: 2.883 ± 0.031	4.115GluArg: 4.115 ± 0.039	4.121GluSer: 4.121 ± 0.031	3.243GluThr: 3.243 ± 0.028	3.522GluVal: 3.522 ± 0.027	0.883GluTrp: 0.883 ± 0.012	1.633GluTyr: 1.633 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.247PheAla: 3.247 ± 0.028	0.561PheCys: 0.561 ± 0.011	2.27PheAsp: 2.27 ± 0.019	2.16PheGlu: 2.16 ± 0.021	1.535PhePhe: 1.535 ± 0.022	2.885PheGly: 2.885 ± 0.028	0.876PheHis: 0.876 ± 0.014	1.615PheIle: 1.615 ± 0.02	1.491PheLys: 1.491 ± 0.017	3.212PheLeu: 3.212 ± 0.029	0.783PheMet: 0.783 ± 0.013	1.383PheAsn: 1.383 ± 0.016	1.775PhePro: 1.775 ± 0.017	1.335PheGln: 1.335 ± 0.016	1.89PheArg: 1.89 ± 0.02	2.755PheSer: 2.755 ± 0.028	2.093PheThr: 2.093 ± 0.021	2.26PheVal: 2.26 ± 0.025	0.661PheTrp: 0.661 ± 0.011	1.048PheTyr: 1.048 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.331GlyAla: 5.331 ± 0.034	0.879GlyCys: 0.879 ± 0.014	3.584GlyAsp: 3.584 ± 0.027	3.605GlyGlu: 3.605 ± 0.027	2.707GlyPhe: 2.707 ± 0.025	5.671GlyGly: 5.671 ± 0.052	1.725GlyHis: 1.725 ± 0.019	3.434GlyIle: 3.434 ± 0.027	3.572GlyLys: 3.572 ± 0.03	5.762GlyLeu: 5.762 ± 0.037	1.673GlyMet: 1.673 ± 0.02	2.571GlyAsn: 2.571 ± 0.027	3.182GlyPro: 3.182 ± 0.026	2.634GlyGln: 2.634 ± 0.024	4.095GlyArg: 4.095 ± 0.032	5.498GlySer: 5.498 ± 0.039	3.911GlyThr: 3.911 ± 0.028	4.091GlyVal: 4.091 ± 0.03	1.134GlyTrp: 1.134 ± 0.016	2.162GlyTyr: 2.162 ± 0.023	0.001GlyXaa: 0.001 ± 0.0
His	2.184HisAla: 2.184 ± 0.022	0.373HisCys: 0.373 ± 0.008	1.513HisAsp: 1.513 ± 0.019	1.516HisGlu: 1.516 ± 0.02	0.979HisPhe: 0.979 ± 0.014	1.791HisGly: 1.791 ± 0.018	0.948HisHis: 0.948 ± 0.018	1.253HisIle: 1.253 ± 0.017	1.006HisLys: 1.006 ± 0.015	2.273HisLeu: 2.273 ± 0.024	0.524HisMet: 0.524 ± 0.01	0.884HisAsn: 0.884 ± 0.013	1.627HisPro: 1.627 ± 0.018	1.092HisGln: 1.092 ± 0.016	1.597HisArg: 1.597 ± 0.018	1.943HisSer: 1.943 ± 0.021	1.414HisThr: 1.414 ± 0.016	1.541HisVal: 1.541 ± 0.017	0.371HisTrp: 0.371 ± 0.008	0.729HisTyr: 0.729 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.379IleAla: 4.379 ± 0.032	0.759IleCys: 0.759 ± 0.01	2.915IleAsp: 2.915 ± 0.019	2.858IleGlu: 2.858 ± 0.021	1.86IlePhe: 1.86 ± 0.021	3.122IleGly: 3.122 ± 0.029	1.185IleHis: 1.185 ± 0.014	2.253IleIle: 2.253 ± 0.023	2.122IleLys: 2.122 ± 0.022	4.175IleLeu: 4.175 ± 0.035	1.027IleMet: 1.027 ± 0.016	1.776IleAsn: 1.776 ± 0.018	2.849IlePro: 2.849 ± 0.023	1.785IleGln: 1.785 ± 0.017	2.66IleArg: 2.66 ± 0.022	3.639IleSer: 3.639 ± 0.028	2.793IleThr: 2.793 ± 0.025	3.021IleVal: 3.021 ± 0.026	0.726IleTrp: 0.726 ± 0.013	1.342IleTyr: 1.342 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.766LysAla: 4.766 ± 0.036	0.523LysCys: 0.523 ± 0.011	2.942LysAsp: 2.942 ± 0.025	3.41LysGlu: 3.41 ± 0.032	1.424LysPhe: 1.424 ± 0.016	2.899LysGly: 2.899 ± 0.028	1.328LysHis: 1.328 ± 0.017	2.233LysIle: 2.233 ± 0.024	3.544LysLys: 3.544 ± 0.047	4.113LysLeu: 4.113 ± 0.03	1.101LysMet: 1.101 ± 0.014	1.758LysAsn: 1.758 ± 0.018	2.785LysPro: 2.785 ± 0.027	2.232LysGln: 2.232 ± 0.025	3.688LysArg: 3.688 ± 0.032	3.566LysSer: 3.566 ± 0.028	2.9LysThr: 2.9 ± 0.023	2.765LysVal: 2.765 ± 0.023	0.717LysTrp: 0.717 ± 0.012	1.353LysTyr: 1.353 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.894LeuAla: 7.894 ± 0.042	1.196LeuCys: 1.196 ± 0.017	5.023LeuAsp: 5.023 ± 0.035	5.385LeuGlu: 5.385 ± 0.038	3.045LeuPhe: 3.045 ± 0.03	5.566LeuGly: 5.566 ± 0.035	2.331LeuHis: 2.331 ± 0.023	3.661LeuIle: 3.661 ± 0.031	4.158LeuLys: 4.158 ± 0.032	7.913LeuLeu: 7.913 ± 0.055	1.736LeuMet: 1.736 ± 0.017	3.08LeuAsn: 3.08 ± 0.024	5.501LeuPro: 5.501 ± 0.036	3.966LeuGln: 3.966 ± 0.031	5.716LeuArg: 5.716 ± 0.035	6.678LeuSer: 6.678 ± 0.04	4.609LeuThr: 4.609 ± 0.033	4.942LeuVal: 4.942 ± 0.035	1.165LeuTrp: 1.165 ± 0.019	2.27LeuTyr: 2.27 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.361MetAla: 2.361 ± 0.021	0.264MetCys: 0.264 ± 0.008	1.258MetAsp: 1.258 ± 0.016	1.248MetGlu: 1.248 ± 0.015	0.733MetPhe: 0.733 ± 0.013	1.365MetGly: 1.365 ± 0.018	0.564MetHis: 0.564 ± 0.011	0.987MetIle: 0.987 ± 0.014	1.034MetLys: 1.034 ± 0.014	1.979MetLeu: 1.979 ± 0.021	0.591MetMet: 0.591 ± 0.011	0.843MetAsn: 0.843 ± 0.013	1.472MetPro: 1.472 ± 0.019	1.01MetGln: 1.01 ± 0.013	1.364MetArg: 1.364 ± 0.018	1.921MetSer: 1.921 ± 0.021	1.309MetThr: 1.309 ± 0.017	1.214MetVal: 1.214 ± 0.016	0.271MetTrp: 0.271 ± 0.006	0.545MetTyr: 0.545 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.587AsnAla: 3.587 ± 0.023	0.435AsnCys: 0.435 ± 0.01	2.111AsnAsp: 2.111 ± 0.019	2.05AsnGlu: 2.05 ± 0.019	1.398AsnPhe: 1.398 ± 0.016	3.216AsnGly: 3.216 ± 0.03	0.91AsnHis: 0.91 ± 0.013	1.937AsnIle: 1.937 ± 0.021	1.534AsnLys: 1.534 ± 0.018	3.061AsnLeu: 3.061 ± 0.022	0.866AsnMet: 0.866 ± 0.013	1.5AsnAsn: 1.5 ± 0.023	2.221AsnPro: 2.221 ± 0.023	1.34AsnGln: 1.34 ± 0.017	1.903AsnArg: 1.903 ± 0.021	2.699AsnSer: 2.699 ± 0.024	2.306AsnThr: 2.306 ± 0.025	2.347AsnVal: 2.347 ± 0.022	0.558AsnTrp: 0.558 ± 0.011	1.012AsnTyr: 1.012 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	5.575ProAla: 5.575 ± 0.048	0.53ProCys: 0.53 ± 0.009	3.129ProAsp: 3.129 ± 0.022	3.743ProGlu: 3.743 ± 0.03	1.954ProPhe: 1.954 ± 0.018	3.875ProGly: 3.875 ± 0.033	1.418ProHis: 1.418 ± 0.017	2.447ProIle: 2.447 ± 0.021	2.837ProLys: 2.837 ± 0.024	4.445ProLeu: 4.445 ± 0.029	1.105ProMet: 1.105 ± 0.015	2.231ProAsn: 2.231 ± 0.02	5.333ProPro: 5.333 ± 0.063	2.629ProGln: 2.629 ± 0.03	3.392ProArg: 3.392 ± 0.029	5.802ProSer: 5.802 ± 0.05	3.989ProThr: 3.989 ± 0.033	3.269ProVal: 3.269 ± 0.031	0.726ProTrp: 0.726 ± 0.011	1.575ProTyr: 1.575 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.948GlnAla: 3.948 ± 0.031	0.504GlnCys: 0.504 ± 0.009	2.259GlnAsp: 2.259 ± 0.022	2.554GlnGlu: 2.554 ± 0.022	1.196GlnPhe: 1.196 ± 0.016	2.408GlnGly: 2.408 ± 0.02	1.348GlnHis: 1.348 ± 0.018	1.884GlnIle: 1.884 ± 0.02	2.196GlnLys: 2.196 ± 0.024	3.532GlnLeu: 3.532 ± 0.029	0.967GlnMet: 0.967 ± 0.015	1.72GlnAsn: 1.72 ± 0.019	2.759GlnPro: 2.759 ± 0.034	2.934GlnGln: 2.934 ± 0.041	2.936GlnArg: 2.936 ± 0.024	3.327GlnSer: 3.327 ± 0.032	2.477GlnThr: 2.477 ± 0.021	2.173GlnVal: 2.173 ± 0.02	0.61GlnTrp: 0.61 ± 0.011	1.304GlnTyr: 1.304 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.906ArgAla: 4.906 ± 0.028	0.74ArgCys: 0.74 ± 0.013	3.477ArgAsp: 3.477 ± 0.032	3.848ArgGlu: 3.848 ± 0.035	2.052ArgPhe: 2.052 ± 0.02	3.569ArgGly: 3.569 ± 0.027	1.716ArgHis: 1.716 ± 0.019	2.882ArgIle: 2.882 ± 0.023	3.78ArgLys: 3.78 ± 0.031	5.324ArgLeu: 5.324 ± 0.034	1.422ArgMet: 1.422 ± 0.017	2.354ArgAsn: 2.354 ± 0.021	3.65ArgPro: 3.65 ± 0.034	2.928ArgGln: 2.928 ± 0.028	5.214ArgArg: 5.214 ± 0.046	4.954ArgSer: 4.954 ± 0.04	3.391ArgThr: 3.391 ± 0.027	3.107ArgVal: 3.107 ± 0.025	0.924ArgTrp: 0.924 ± 0.013	1.648ArgTyr: 1.648 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.049SerAla: 7.049 ± 0.051	0.905SerCys: 0.905 ± 0.014	4.191SerAsp: 4.191 ± 0.032	4.162SerGlu: 4.162 ± 0.031	2.823SerPhe: 2.823 ± 0.025	5.458SerGly: 5.458 ± 0.037	1.953SerHis: 1.953 ± 0.021	3.917SerIle: 3.917 ± 0.029	3.843SerLys: 3.843 ± 0.035	6.569SerLeu: 6.569 ± 0.039	1.815SerMet: 1.815 ± 0.018	3.07SerAsn: 3.07 ± 0.028	5.343SerPro: 5.343 ± 0.049	3.328SerGln: 3.328 ± 0.03	5.085SerArg: 5.085 ± 0.043	8.535SerSer: 8.535 ± 0.082	5.703SerThr: 5.703 ± 0.05	4.187SerVal: 4.187 ± 0.028	1.125SerTrp: 1.125 ± 0.016	2.031SerTyr: 2.031 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.565ThrAla: 5.565 ± 0.036	0.8ThrCys: 0.8 ± 0.013	2.757ThrAsp: 2.757 ± 0.025	2.987ThrGlu: 2.987 ± 0.023	2.262ThrPhe: 2.262 ± 0.022	4.0ThrGly: 4.0 ± 0.035	1.333ThrHis: 1.333 ± 0.015	3.109ThrIle: 3.109 ± 0.026	2.672ThrLys: 2.672 ± 0.022	5.072ThrLeu: 5.072 ± 0.042	1.248ThrMet: 1.248 ± 0.015	2.198ThrAsn: 2.198 ± 0.022	4.409ThrPro: 4.409 ± 0.036	2.189ThrGln: 2.189 ± 0.023	3.174ThrArg: 3.174 ± 0.023	5.581ThrSer: 5.581 ± 0.042	4.438ThrThr: 4.438 ± 0.045	3.408ThrVal: 3.408 ± 0.028	0.87ThrTrp: 0.87 ± 0.013	1.641ThrTyr: 1.641 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.202ValAla: 5.202 ± 0.033	0.793ValCys: 0.793 ± 0.014	3.542ValAsp: 3.542 ± 0.029	3.762ValGlu: 3.762 ± 0.03	2.237ValPhe: 2.237 ± 0.022	3.774ValGly: 3.774 ± 0.032	1.396ValHis: 1.396 ± 0.015	2.642ValIle: 2.642 ± 0.023	2.961ValLys: 2.961 ± 0.023	5.216ValLeu: 5.216 ± 0.034	1.254ValMet: 1.254 ± 0.017	2.172ValAsn: 2.172 ± 0.021	3.361ValPro: 3.361 ± 0.024	2.443ValGln: 2.443 ± 0.021	3.327ValArg: 3.327 ± 0.029	4.269ValSer: 4.269 ± 0.031	3.26ValThr: 3.26 ± 0.025	3.943ValVal: 3.943 ± 0.033	0.869ValTrp: 0.869 ± 0.011	1.599ValTyr: 1.599 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.096TrpAla: 1.096 ± 0.016	0.217TrpCys: 0.217 ± 0.007	0.842TrpAsp: 0.842 ± 0.013	0.801TrpGlu: 0.801 ± 0.011	0.526TrpPhe: 0.526 ± 0.01	0.789TrpGly: 0.789 ± 0.013	0.419TrpHis: 0.419 ± 0.008	0.789TrpIle: 0.789 ± 0.014	0.822TrpLys: 0.822 ± 0.012	1.403TrpLeu: 1.403 ± 0.015	0.371TrpMet: 0.371 ± 0.008	0.648TrpAsn: 0.648 ± 0.012	0.671TrpPro: 0.671 ± 0.01	0.703TrpGln: 0.703 ± 0.013	1.01TrpArg: 1.01 ± 0.015	1.114TrpSer: 1.114 ± 0.015	0.976TrpThr: 0.976 ± 0.015	0.777TrpVal: 0.777 ± 0.013	0.27TrpTrp: 0.27 ± 0.008	0.455TrpTyr: 0.455 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.301TyrAla: 2.301 ± 0.019	0.452TyrCys: 0.452 ± 0.009	1.697TyrAsp: 1.697 ± 0.02	1.594TyrGlu: 1.594 ± 0.017	1.148TyrPhe: 1.148 ± 0.016	2.201TyrGly: 2.201 ± 0.022	0.795TyrHis: 0.795 ± 0.014	1.332TyrIle: 1.332 ± 0.016	1.082TyrLys: 1.082 ± 0.014	2.48TyrLeu: 2.48 ± 0.024	0.599TyrMet: 0.599 ± 0.01	1.14TyrAsn: 1.14 ± 0.017	1.448TyrPro: 1.448 ± 0.015	1.169TyrGln: 1.169 ± 0.015	1.594TyrArg: 1.594 ± 0.016	1.991TyrSer: 1.991 ± 0.022	1.636TyrThr: 1.636 ± 0.017	1.591TyrVal: 1.591 ± 0.019	0.448TyrTrp: 0.448 ± 0.011	0.938TyrTyr: 0.938 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.024XaaXaa: 0.024 ± 0.014

Statistics based on 11956 proteins (5580759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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