Amino acid dipepetide frequency for Rotavirus D chicken/05V0049/DEU/2005

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.399AlaAla: 2.399 ± 0.687
0.343AlaCys: 0.343 ± 0.255
3.427AlaAsp: 3.427 ± 0.43
2.742AlaGlu: 2.742 ± 0.839
1.371AlaPhe: 1.371 ± 0.398
2.056AlaGly: 2.056 ± 0.71
0.343AlaHis: 0.343 ± 0.18
4.455AlaIle: 4.455 ± 0.685
2.228AlaLys: 2.228 ± 0.691
4.455AlaLeu: 4.455 ± 0.7
1.542AlaMet: 1.542 ± 0.435
4.112AlaAsn: 4.112 ± 0.711
0.514AlaPro: 0.514 ± 0.25
1.199AlaGln: 1.199 ± 0.393
2.913AlaArg: 2.913 ± 0.619
5.826AlaSer: 5.826 ± 1.429
2.913AlaThr: 2.913 ± 0.805
4.455AlaVal: 4.455 ± 0.985
0.0AlaTrp: 0.0 ± 0.0
2.57AlaTyr: 2.57 ± 0.747
0.0AlaXaa: 0.0 ± 0.0
Cys
0.343CysAla: 0.343 ± 0.249
0.514CysCys: 0.514 ± 0.27
0.685CysAsp: 0.685 ± 0.312
0.857CysGlu: 0.857 ± 0.297
1.028CysPhe: 1.028 ± 0.445
0.857CysGly: 0.857 ± 0.535
0.0CysHis: 0.0 ± 0.0
0.514CysIle: 0.514 ± 0.379
1.199CysLys: 1.199 ± 0.49
1.028CysLeu: 1.028 ± 0.532
0.171CysMet: 0.171 ± 0.204
1.199CysAsn: 1.199 ± 0.327
0.685CysPro: 0.685 ± 0.405
0.514CysGln: 0.514 ± 0.243
0.857CysArg: 0.857 ± 0.462
1.028CysSer: 1.028 ± 0.492
0.343CysThr: 0.343 ± 0.233
0.685CysVal: 0.685 ± 0.274
0.0CysTrp: 0.0 ± 0.0
0.343CysTyr: 0.343 ± 0.23
0.0CysXaa: 0.0 ± 0.0
Asp
2.742AspAla: 2.742 ± 0.842
1.199AspCys: 1.199 ± 0.754
5.997AspAsp: 5.997 ± 0.92
4.798AspGlu: 4.798 ± 1.028
2.399AspPhe: 2.399 ± 0.54
1.714AspGly: 1.714 ± 0.572
0.514AspHis: 0.514 ± 0.228
6.34AspIle: 6.34 ± 0.982
5.997AspLys: 5.997 ± 0.791
5.997AspLeu: 5.997 ± 0.677
2.056AspMet: 2.056 ± 0.399
2.742AspAsn: 2.742 ± 0.734
1.028AspPro: 1.028 ± 0.376
3.084AspGln: 3.084 ± 0.631
2.57AspArg: 2.57 ± 0.583
3.598AspSer: 3.598 ± 0.909
4.284AspThr: 4.284 ± 0.791
4.112AspVal: 4.112 ± 0.714
0.343AspTrp: 0.343 ± 0.277
3.256AspTyr: 3.256 ± 0.413
0.0AspXaa: 0.0 ± 0.0
Glu
1.542GluAla: 1.542 ± 0.577
0.514GluCys: 0.514 ± 0.3
3.084GluAsp: 3.084 ± 0.963
3.598GluGlu: 3.598 ± 0.86
2.228GluPhe: 2.228 ± 0.793
1.371GluGly: 1.371 ± 0.432
0.685GluHis: 0.685 ± 0.248
5.312GluIle: 5.312 ± 0.859
4.455GluLys: 4.455 ± 0.918
6.511GluLeu: 6.511 ± 0.827
1.714GluMet: 1.714 ± 0.618
3.77GluAsn: 3.77 ± 0.799
0.343GluPro: 0.343 ± 0.311
1.371GluGln: 1.371 ± 0.389
2.913GluArg: 2.913 ± 0.652
5.312GluSer: 5.312 ± 0.877
2.742GluThr: 2.742 ± 0.763
2.228GluVal: 2.228 ± 0.563
0.857GluTrp: 0.857 ± 0.351
3.084GluTyr: 3.084 ± 0.597
0.0GluXaa: 0.0 ± 0.0
Phe
2.399PheAla: 2.399 ± 0.607
0.171PheCys: 0.171 ± 0.155
4.284PheAsp: 4.284 ± 0.668
3.256PheGlu: 3.256 ± 0.53
1.028PhePhe: 1.028 ± 0.409
2.228PheGly: 2.228 ± 0.529
1.028PheHis: 1.028 ± 0.327
2.399PheIle: 2.399 ± 0.753
2.913PheLys: 2.913 ± 0.9
2.399PheLeu: 2.399 ± 0.465
0.685PheMet: 0.685 ± 0.363
2.913PheAsn: 2.913 ± 0.563
1.542PhePro: 1.542 ± 0.535
1.371PheGln: 1.371 ± 0.417
2.056PheArg: 2.056 ± 0.67
2.913PheSer: 2.913 ± 0.391
2.57PheThr: 2.57 ± 0.764
3.084PheVal: 3.084 ± 0.498
0.0PheTrp: 0.0 ± 0.0
1.714PheTyr: 1.714 ± 0.643
0.0PheXaa: 0.0 ± 0.0
Gly
1.542GlyAla: 1.542 ± 0.273
0.685GlyCys: 0.685 ± 0.356
1.199GlyAsp: 1.199 ± 0.356
0.685GlyGlu: 0.685 ± 0.404
0.685GlyPhe: 0.685 ± 0.432
0.685GlyGly: 0.685 ± 0.323
0.685GlyHis: 0.685 ± 0.294
3.77GlyIle: 3.77 ± 0.709
2.399GlyLys: 2.399 ± 0.684
3.084GlyLeu: 3.084 ± 0.493
0.857GlyMet: 0.857 ± 0.376
2.913GlyAsn: 2.913 ± 0.712
1.714GlyPro: 1.714 ± 0.865
0.857GlyGln: 0.857 ± 0.42
1.542GlyArg: 1.542 ± 0.684
2.056GlySer: 2.056 ± 0.485
2.228GlyThr: 2.228 ± 0.928
2.399GlyVal: 2.399 ± 0.558
0.0GlyTrp: 0.0 ± 0.0
1.371GlyTyr: 1.371 ± 0.45
0.0GlyXaa: 0.0 ± 0.0
His
0.514HisAla: 0.514 ± 0.262
0.0HisCys: 0.0 ± 0.0
0.514HisAsp: 0.514 ± 0.339
1.199HisGlu: 1.199 ± 0.241
0.857HisPhe: 0.857 ± 0.41
0.514HisGly: 0.514 ± 0.272
0.0HisHis: 0.0 ± 0.0
1.371HisIle: 1.371 ± 0.509
0.0HisLys: 0.0 ± 0.0
1.371HisLeu: 1.371 ± 0.386
0.343HisMet: 0.343 ± 0.262
1.542HisAsn: 1.542 ± 0.52
0.514HisPro: 0.514 ± 0.288
0.685HisGln: 0.685 ± 0.37
0.343HisArg: 0.343 ± 0.217
0.685HisSer: 0.685 ± 0.259
1.371HisThr: 1.371 ± 0.412
2.228HisVal: 2.228 ± 0.494
0.0HisTrp: 0.0 ± 0.0
1.542HisTyr: 1.542 ± 0.605
0.0HisXaa: 0.0 ± 0.0
Ile
6.169IleAla: 6.169 ± 1.024
1.028IleCys: 1.028 ± 0.493
5.826IleAsp: 5.826 ± 0.727
4.455IleGlu: 4.455 ± 0.874
3.941IlePhe: 3.941 ± 0.615
2.228IleGly: 2.228 ± 0.692
1.885IleHis: 1.885 ± 0.604
6.511IleIle: 6.511 ± 1.02
4.455IleLys: 4.455 ± 0.714
7.711IleLeu: 7.711 ± 0.982
1.885IleMet: 1.885 ± 0.505
5.997IleAsn: 5.997 ± 1.253
3.427IlePro: 3.427 ± 0.83
2.228IleGln: 2.228 ± 0.626
3.256IleArg: 3.256 ± 0.7
5.655IleSer: 5.655 ± 0.7
6.169IleThr: 6.169 ± 1.266
5.141IleVal: 5.141 ± 0.788
0.343IleTrp: 0.343 ± 0.24
2.742IleTyr: 2.742 ± 0.634
0.0IleXaa: 0.0 ± 0.0
Lys
2.056LysAla: 2.056 ± 0.669
0.685LysCys: 0.685 ± 0.281
4.112LysAsp: 4.112 ± 1.151
2.913LysGlu: 2.913 ± 1.021
2.57LysPhe: 2.57 ± 0.822
1.199LysGly: 1.199 ± 0.346
1.542LysHis: 1.542 ± 0.443
5.826LysIle: 5.826 ± 1.113
5.141LysLys: 5.141 ± 0.896
7.882LysLeu: 7.882 ± 1.278
2.228LysMet: 2.228 ± 0.876
4.284LysAsn: 4.284 ± 1.211
1.714LysPro: 1.714 ± 0.454
2.056LysGln: 2.056 ± 0.78
1.885LysArg: 1.885 ± 0.523
5.141LysSer: 5.141 ± 1.099
3.598LysThr: 3.598 ± 1.029
3.941LysVal: 3.941 ± 0.662
0.857LysTrp: 0.857 ± 0.356
4.284LysTyr: 4.284 ± 0.971
0.0LysXaa: 0.0 ± 0.0
Leu
4.626LeuAla: 4.626 ± 0.504
1.542LeuCys: 1.542 ± 0.558
5.141LeuAsp: 5.141 ± 0.692
4.626LeuGlu: 4.626 ± 1.223
4.798LeuPhe: 4.798 ± 1.159
2.399LeuGly: 2.399 ± 0.82
0.857LeuHis: 0.857 ± 0.257
7.025LeuIle: 7.025 ± 0.693
5.655LeuLys: 5.655 ± 1.003
6.854LeuLeu: 6.854 ± 0.92
2.228LeuMet: 2.228 ± 0.695
8.396LeuAsn: 8.396 ± 1.192
3.427LeuPro: 3.427 ± 0.75
3.77LeuGln: 3.77 ± 0.485
6.34LeuArg: 6.34 ± 0.922
7.539LeuSer: 7.539 ± 0.949
7.197LeuThr: 7.197 ± 1.154
4.798LeuVal: 4.798 ± 1.135
1.542LeuTrp: 1.542 ± 0.551
6.854LeuTyr: 6.854 ± 0.865
0.0LeuXaa: 0.0 ± 0.0
Met
1.885MetAla: 1.885 ± 0.433
0.171MetCys: 0.171 ± 0.175
1.885MetAsp: 1.885 ± 0.499
1.028MetGlu: 1.028 ± 0.323
1.371MetPhe: 1.371 ± 0.329
0.514MetGly: 0.514 ± 0.286
0.857MetHis: 0.857 ± 0.407
1.542MetIle: 1.542 ± 0.575
1.199MetLys: 1.199 ± 0.508
4.969MetLeu: 4.969 ± 0.797
1.714MetMet: 1.714 ± 0.57
2.056MetAsn: 2.056 ± 0.579
0.514MetPro: 0.514 ± 0.258
0.685MetGln: 0.685 ± 0.208
1.714MetArg: 1.714 ± 0.312
2.57MetSer: 2.57 ± 0.85
2.056MetThr: 2.056 ± 0.619
1.371MetVal: 1.371 ± 0.512
0.0MetTrp: 0.0 ± 0.0
1.542MetTyr: 1.542 ± 0.535
0.0MetXaa: 0.0 ± 0.0
Asn
4.284AsnAla: 4.284 ± 1.036
1.199AsnCys: 1.199 ± 0.485
4.626AsnAsp: 4.626 ± 1.071
4.969AsnGlu: 4.969 ± 1.151
2.399AsnPhe: 2.399 ± 0.59
2.913AsnGly: 2.913 ± 0.572
1.714AsnHis: 1.714 ± 0.504
5.997AsnIle: 5.997 ± 0.893
3.598AsnLys: 3.598 ± 1.006
5.826AsnLeu: 5.826 ± 0.656
2.742AsnMet: 2.742 ± 0.329
4.969AsnAsn: 4.969 ± 0.754
2.399AsnPro: 2.399 ± 0.518
3.427AsnGln: 3.427 ± 0.35
3.598AsnArg: 3.598 ± 0.845
7.197AsnSer: 7.197 ± 1.036
3.256AsnThr: 3.256 ± 0.747
4.112AsnVal: 4.112 ± 0.697
0.857AsnTrp: 0.857 ± 0.497
4.798AsnTyr: 4.798 ± 0.838
0.0AsnXaa: 0.0 ± 0.0
Pro
2.228ProAla: 2.228 ± 0.581
0.343ProCys: 0.343 ± 0.225
1.885ProAsp: 1.885 ± 0.737
0.514ProGlu: 0.514 ± 0.245
1.371ProPhe: 1.371 ± 0.629
0.514ProGly: 0.514 ± 0.234
0.514ProHis: 0.514 ± 0.347
2.57ProIle: 2.57 ± 0.572
0.685ProLys: 0.685 ± 0.269
3.427ProLeu: 3.427 ± 0.526
0.685ProMet: 0.685 ± 0.321
1.199ProAsn: 1.199 ± 0.506
0.514ProPro: 0.514 ± 0.256
1.371ProGln: 1.371 ± 0.629
1.028ProArg: 1.028 ± 0.433
2.913ProSer: 2.913 ± 0.57
2.399ProThr: 2.399 ± 0.613
2.399ProVal: 2.399 ± 0.584
0.171ProTrp: 0.171 ± 0.135
1.885ProTyr: 1.885 ± 0.893
0.0ProXaa: 0.0 ± 0.0
Gln
1.028GlnAla: 1.028 ± 0.509
0.514GlnCys: 0.514 ± 0.35
2.056GlnAsp: 2.056 ± 0.602
1.028GlnGlu: 1.028 ± 0.427
2.228GlnPhe: 2.228 ± 0.47
0.685GlnGly: 0.685 ± 0.266
0.343GlnHis: 0.343 ± 0.17
3.427GlnIle: 3.427 ± 0.701
2.399GlnLys: 2.399 ± 0.764
5.483GlnLeu: 5.483 ± 0.973
1.714GlnMet: 1.714 ± 0.502
1.885GlnAsn: 1.885 ± 0.418
1.199GlnPro: 1.199 ± 0.282
2.913GlnGln: 2.913 ± 0.749
1.028GlnArg: 1.028 ± 0.445
3.77GlnSer: 3.77 ± 0.473
2.399GlnThr: 2.399 ± 0.454
1.371GlnVal: 1.371 ± 0.451
0.171GlnTrp: 0.171 ± 0.135
1.371GlnTyr: 1.371 ± 0.309
0.0GlnXaa: 0.0 ± 0.0
Arg
2.056ArgAla: 2.056 ± 0.553
0.685ArgCys: 0.685 ± 0.447
2.399ArgAsp: 2.399 ± 0.522
3.084ArgGlu: 3.084 ± 0.649
2.056ArgPhe: 2.056 ± 0.703
1.885ArgGly: 1.885 ± 0.375
1.028ArgHis: 1.028 ± 0.418
2.399ArgIle: 2.399 ± 0.456
3.084ArgLys: 3.084 ± 0.625
4.626ArgLeu: 4.626 ± 0.916
1.885ArgMet: 1.885 ± 0.462
3.941ArgAsn: 3.941 ± 0.924
0.514ArgPro: 0.514 ± 0.304
2.57ArgGln: 2.57 ± 0.789
3.256ArgArg: 3.256 ± 0.687
2.57ArgSer: 2.57 ± 0.748
3.77ArgThr: 3.77 ± 0.926
3.77ArgVal: 3.77 ± 0.774
0.685ArgTrp: 0.685 ± 0.219
3.084ArgTyr: 3.084 ± 0.517
0.0ArgXaa: 0.0 ± 0.0
Ser
4.455SerAla: 4.455 ± 1.048
1.371SerCys: 1.371 ± 0.55
4.798SerAsp: 4.798 ± 0.787
4.626SerGlu: 4.626 ± 0.961
3.084SerPhe: 3.084 ± 0.635
4.626SerGly: 4.626 ± 1.055
1.028SerHis: 1.028 ± 0.497
5.997SerIle: 5.997 ± 0.677
4.455SerLys: 4.455 ± 0.635
7.882SerLeu: 7.882 ± 1.54
2.399SerMet: 2.399 ± 0.484
6.34SerAsn: 6.34 ± 0.881
1.714SerPro: 1.714 ± 0.49
3.598SerGln: 3.598 ± 0.717
2.228SerArg: 2.228 ± 0.55
6.511SerSer: 6.511 ± 1.26
4.112SerThr: 4.112 ± 0.691
5.655SerVal: 5.655 ± 0.613
0.171SerTrp: 0.171 ± 0.155
4.455SerTyr: 4.455 ± 0.773
0.0SerXaa: 0.0 ± 0.0
Thr
3.941ThrAla: 3.941 ± 0.874
0.514ThrCys: 0.514 ± 0.466
3.427ThrAsp: 3.427 ± 0.729
3.941ThrGlu: 3.941 ± 0.498
3.427ThrPhe: 3.427 ± 0.668
1.542ThrGly: 1.542 ± 0.413
1.028ThrHis: 1.028 ± 0.401
5.312ThrIle: 5.312 ± 0.861
3.427ThrLys: 3.427 ± 0.727
6.511ThrLeu: 6.511 ± 1.101
1.714ThrMet: 1.714 ± 0.631
3.77ThrAsn: 3.77 ± 0.958
2.228ThrPro: 2.228 ± 0.463
1.714ThrGln: 1.714 ± 0.602
3.77ThrArg: 3.77 ± 0.499
4.798ThrSer: 4.798 ± 0.941
6.683ThrThr: 6.683 ± 1.135
4.798ThrVal: 4.798 ± 0.93
0.0ThrTrp: 0.0 ± 0.0
4.112ThrTyr: 4.112 ± 0.84
0.0ThrXaa: 0.0 ± 0.0
Val
2.399ValAla: 2.399 ± 0.593
0.857ValCys: 0.857 ± 0.353
4.798ValAsp: 4.798 ± 0.976
2.742ValGlu: 2.742 ± 0.608
2.742ValPhe: 2.742 ± 0.527
1.028ValGly: 1.028 ± 0.503
1.028ValHis: 1.028 ± 0.342
7.025ValIle: 7.025 ± 0.837
5.312ValLys: 5.312 ± 0.836
3.77ValLeu: 3.77 ± 0.841
1.542ValMet: 1.542 ± 0.411
6.511ValAsn: 6.511 ± 0.849
2.57ValPro: 2.57 ± 0.547
1.028ValGln: 1.028 ± 0.255
4.284ValArg: 4.284 ± 0.804
5.141ValSer: 5.141 ± 0.812
4.112ValThr: 4.112 ± 0.776
3.084ValVal: 3.084 ± 0.804
0.343ValTrp: 0.343 ± 0.18
3.084ValTyr: 3.084 ± 0.733
0.0ValXaa: 0.0 ± 0.0
Trp
0.343TrpAla: 0.343 ± 0.23
0.171TrpCys: 0.171 ± 0.175
0.514TrpAsp: 0.514 ± 0.207
0.685TrpGlu: 0.685 ± 0.294
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.171TrpHis: 0.171 ± 0.167
0.0TrpIle: 0.0 ± 0.0
0.857TrpLys: 0.857 ± 0.31
1.199TrpLeu: 1.199 ± 0.463
0.171TrpMet: 0.171 ± 0.175
0.343TrpAsn: 0.343 ± 0.249
0.343TrpPro: 0.343 ± 0.217
0.514TrpGln: 0.514 ± 0.304
0.343TrpArg: 0.343 ± 0.194
0.171TrpSer: 0.171 ± 0.147
0.514TrpThr: 0.514 ± 0.285
0.171TrpVal: 0.171 ± 0.142
0.171TrpTrp: 0.171 ± 0.204
0.171TrpTyr: 0.171 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.913TyrAla: 2.913 ± 0.424
0.343TyrCys: 0.343 ± 0.23
4.112TyrAsp: 4.112 ± 0.64
1.885TyrGlu: 1.885 ± 0.435
1.371TyrPhe: 1.371 ± 0.299
2.399TyrGly: 2.399 ± 0.691
0.343TyrHis: 0.343 ± 0.282
3.256TyrIle: 3.256 ± 0.885
4.455TyrLys: 4.455 ± 1.091
4.626TyrLeu: 4.626 ± 0.848
1.199TyrMet: 1.199 ± 0.402
5.997TyrAsn: 5.997 ± 0.86
1.714TyrPro: 1.714 ± 0.299
2.056TyrGln: 2.056 ± 0.387
3.427TyrArg: 3.427 ± 0.924
4.112TyrSer: 4.112 ± 0.765
3.941TyrThr: 3.941 ± 0.784
3.598TyrVal: 3.598 ± 0.749
0.343TyrTrp: 0.343 ± 0.241
2.399TyrTyr: 2.399 ± 0.82
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (5837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski