Amino acid dipepetide frequency for Gammaproteobacteria bacterium LSUCC0057

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.608AlaAla: 18.608 ± 0.261	1.022AlaCys: 1.022 ± 0.042	6.557AlaAsp: 6.557 ± 0.125	8.325AlaGlu: 8.325 ± 0.148	3.009AlaPhe: 3.009 ± 0.064	9.529AlaGly: 9.529 ± 0.167	1.905AlaHis: 1.905 ± 0.048	6.045AlaIle: 6.045 ± 0.102	3.625AlaLys: 3.625 ± 0.087	14.853AlaLeu: 14.853 ± 0.218	2.873AlaMet: 2.873 ± 0.073	3.58AlaAsn: 3.58 ± 0.082	4.806AlaPro: 4.806 ± 0.094	5.839AlaGln: 5.839 ± 0.109	6.013AlaArg: 6.013 ± 0.113	6.477AlaSer: 6.477 ± 0.116	6.203AlaThr: 6.203 ± 0.116	9.525AlaVal: 9.525 ± 0.143	1.108AlaTrp: 1.108 ± 0.047	2.237AlaTyr: 2.237 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	1.267CysAla: 1.267 ± 0.052	0.172CysCys: 0.172 ± 0.016	0.724CysAsp: 0.724 ± 0.037	0.623CysGlu: 0.623 ± 0.036	0.343CysPhe: 0.343 ± 0.023	1.169CysGly: 1.169 ± 0.045	0.402CysHis: 0.402 ± 0.044	0.393CysIle: 0.393 ± 0.026	0.271CysLys: 0.271 ± 0.021	0.81CysLeu: 0.81 ± 0.04	0.169CysMet: 0.169 ± 0.015	0.337CysAsn: 0.337 ± 0.024	0.512CysPro: 0.512 ± 0.032	0.631CysGln: 0.631 ± 0.033	0.733CysArg: 0.733 ± 0.038	0.73CysSer: 0.73 ± 0.038	0.443CysThr: 0.443 ± 0.03	0.584CysVal: 0.584 ± 0.03	0.159CysTrp: 0.159 ± 0.013	0.312CysTyr: 0.312 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.228AspAla: 5.228 ± 0.117	0.664AspCys: 0.664 ± 0.039	3.07AspAsp: 3.07 ± 0.094	3.203AspGlu: 3.203 ± 0.077	2.033AspPhe: 2.033 ± 0.055	4.576AspGly: 4.576 ± 0.121	1.363AspHis: 1.363 ± 0.05	3.14AspIle: 3.14 ± 0.076	1.788AspLys: 1.788 ± 0.054	5.053AspLeu: 5.053 ± 0.097	1.178AspMet: 1.178 ± 0.039	2.083AspAsn: 2.083 ± 0.061	2.482AspPro: 2.482 ± 0.068	2.488AspGln: 2.488 ± 0.065	3.285AspArg: 3.285 ± 0.071	4.042AspSer: 4.042 ± 0.09	2.231AspThr: 2.231 ± 0.068	3.106AspVal: 3.106 ± 0.114	0.882AspTrp: 0.882 ± 0.042	2.171AspTyr: 2.171 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	5.417GluAla: 5.417 ± 0.11	0.455GluCys: 0.455 ± 0.023	1.731GluAsp: 1.731 ± 0.054	2.61GluGlu: 2.61 ± 0.092	1.894GluPhe: 1.894 ± 0.056	3.313GluGly: 3.313 ± 0.069	1.189GluHis: 1.189 ± 0.044	3.032GluIle: 3.032 ± 0.075	1.821GluLys: 1.821 ± 0.059	7.819GluLeu: 7.819 ± 0.138	1.332GluMet: 1.332 ± 0.052	1.332GluAsn: 1.332 ± 0.05	2.514GluPro: 2.514 ± 0.07	5.557GluGln: 5.557 ± 0.111	4.651GluArg: 4.651 ± 0.095	3.0GluSer: 3.0 ± 0.07	2.174GluThr: 2.174 ± 0.061	4.026GluVal: 4.026 ± 0.098	0.721GluTrp: 0.721 ± 0.039	1.288GluTyr: 1.288 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	4.283PheAla: 4.283 ± 0.074	0.421PheCys: 0.421 ± 0.029	2.491PheAsp: 2.491 ± 0.063	1.874PheGlu: 1.874 ± 0.058	1.326PhePhe: 1.326 ± 0.044	2.97PheGly: 2.97 ± 0.069	0.68PheHis: 0.68 ± 0.031	1.908PheIle: 1.908 ± 0.06	1.052PheLys: 1.052 ± 0.042	2.735PheLeu: 2.735 ± 0.08	0.76PheMet: 0.76 ± 0.038	1.553PheAsn: 1.553 ± 0.048	1.147PhePro: 1.147 ± 0.046	0.98PheGln: 0.98 ± 0.041	1.403PheArg: 1.403 ± 0.045	2.457PheSer: 2.457 ± 0.07	1.947PheThr: 1.947 ± 0.05	2.438PheVal: 2.438 ± 0.061	0.386PheTrp: 0.386 ± 0.027	1.182PheTyr: 1.182 ± 0.041	0.007PheXaa: 0.007 ± 0.003
Gly	8.04GlyAla: 8.04 ± 0.128	1.027GlyCys: 1.027 ± 0.039	4.791GlyAsp: 4.791 ± 0.11	5.102GlyGlu: 5.102 ± 0.095	3.026GlyPhe: 3.026 ± 0.074	6.769GlyGly: 6.769 ± 0.132	1.715GlyHis: 1.715 ± 0.05	4.129GlyIle: 4.129 ± 0.088	2.645GlyLys: 2.645 ± 0.072	7.667GlyLeu: 7.667 ± 0.13	1.861GlyMet: 1.861 ± 0.063	2.396GlyAsn: 2.396 ± 0.086	2.237GlyPro: 2.237 ± 0.062	3.281GlyGln: 3.281 ± 0.076	4.913GlyArg: 4.913 ± 0.104	5.199GlySer: 5.199 ± 0.156	3.288GlyThr: 3.288 ± 0.092	5.939GlyVal: 5.939 ± 0.1	1.32GlyTrp: 1.32 ± 0.047	2.569GlyTyr: 2.569 ± 0.062	0.004GlyXaa: 0.004 ± 0.002
His	1.824HisAla: 1.824 ± 0.058	0.471HisCys: 0.471 ± 0.031	0.948HisAsp: 0.948 ± 0.037	0.736HisGlu: 0.736 ± 0.028	0.977HisPhe: 0.977 ± 0.039	1.846HisGly: 1.846 ± 0.057	0.709HisHis: 0.709 ± 0.031	1.014HisIle: 1.014 ± 0.047	0.531HisLys: 0.531 ± 0.029	2.046HisLeu: 2.046 ± 0.058	0.383HisMet: 0.383 ± 0.024	0.76HisAsn: 0.76 ± 0.039	1.322HisPro: 1.322 ± 0.047	1.133HisGln: 1.133 ± 0.042	1.565HisArg: 1.565 ± 0.056	1.634HisSer: 1.634 ± 0.048	0.951HisThr: 0.951 ± 0.037	0.995HisVal: 0.995 ± 0.036	0.487HisTrp: 0.487 ± 0.031	1.001HisTyr: 1.001 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	7.201IleAla: 7.201 ± 0.096	0.564IleCys: 0.564 ± 0.032	3.986IleAsp: 3.986 ± 0.1	3.7IleGlu: 3.7 ± 0.082	1.462IlePhe: 1.462 ± 0.053	4.379IleGly: 4.379 ± 0.094	0.966IleHis: 0.966 ± 0.042	2.41IleIle: 2.41 ± 0.071	1.687IleLys: 1.687 ± 0.055	3.36IleLeu: 3.36 ± 0.077	0.832IleMet: 0.832 ± 0.035	2.072IleAsn: 2.072 ± 0.066	1.93IlePro: 1.93 ± 0.058	1.261IleGln: 1.261 ± 0.049	2.279IleArg: 2.279 ± 0.069	3.106IleSer: 3.106 ± 0.086	3.056IleThr: 3.056 ± 0.103	3.58IleVal: 3.58 ± 0.067	0.486IleTrp: 0.486 ± 0.025	1.357IleTyr: 1.357 ± 0.046	0.001IleXaa: 0.001 ± 0.001
Lys	2.959LysAla: 2.959 ± 0.086	0.168LysCys: 0.168 ± 0.015	1.072LysAsp: 1.072 ± 0.047	1.331LysGlu: 1.331 ± 0.051	0.944LysPhe: 0.944 ± 0.035	1.847LysGly: 1.847 ± 0.056	0.558LysHis: 0.558 ± 0.03	1.73LysIle: 1.73 ± 0.062	1.267LysLys: 1.267 ± 0.057	3.408LysLeu: 3.408 ± 0.084	0.777LysMet: 0.777 ± 0.036	0.923LysAsn: 0.923 ± 0.041	1.615LysPro: 1.615 ± 0.057	1.576LysGln: 1.576 ± 0.049	2.006LysArg: 2.006 ± 0.066	1.646LysSer: 1.646 ± 0.057	1.619LysThr: 1.619 ± 0.056	2.234LysVal: 2.234 ± 0.066	0.278LysTrp: 0.278 ± 0.021	0.656LysTyr: 0.656 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	15.283LeuAla: 15.283 ± 0.217	1.375LeuCys: 1.375 ± 0.045	5.908LeuAsp: 5.908 ± 0.105	5.695LeuGlu: 5.695 ± 0.103	3.93LeuPhe: 3.93 ± 0.092	7.84LeuGly: 7.84 ± 0.129	2.242LeuHis: 2.242 ± 0.059	4.852LeuIle: 4.852 ± 0.107	2.847LeuLys: 2.847 ± 0.067	14.306LeuLeu: 14.306 ± 0.263	2.143LeuMet: 2.143 ± 0.059	3.469LeuAsn: 3.469 ± 0.071	5.955LeuPro: 5.955 ± 0.115	6.035LeuGln: 6.035 ± 0.136	6.965LeuArg: 6.965 ± 0.118	7.031LeuSer: 7.031 ± 0.112	5.582LeuThr: 5.582 ± 0.098	7.246LeuVal: 7.246 ± 0.114	1.437LeuTrp: 1.437 ± 0.049	2.658LeuTyr: 2.658 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	3.017MetAla: 3.017 ± 0.075	0.149MetCys: 0.149 ± 0.016	0.895MetAsp: 0.895 ± 0.044	0.88MetGlu: 0.88 ± 0.037	0.631MetPhe: 0.631 ± 0.032	1.519MetGly: 1.519 ± 0.052	0.406MetHis: 0.406 ± 0.022	0.992MetIle: 0.992 ± 0.044	0.664MetLys: 0.664 ± 0.039	2.186MetLeu: 2.186 ± 0.068	0.48MetMet: 0.48 ± 0.028	0.674MetAsn: 0.674 ± 0.037	1.135MetPro: 1.135 ± 0.052	1.004MetGln: 1.004 ± 0.039	1.248MetArg: 1.248 ± 0.048	1.632MetSer: 1.632 ± 0.047	1.253MetThr: 1.253 ± 0.047	1.818MetVal: 1.818 ± 0.055	0.16MetTrp: 0.16 ± 0.015	0.356MetTyr: 0.356 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.119AsnAla: 3.119 ± 0.082	0.403AsnCys: 0.403 ± 0.027	1.569AsnAsp: 1.569 ± 0.056	1.334AsnGlu: 1.334 ± 0.048	1.238AsnPhe: 1.238 ± 0.047	2.661AsnGly: 2.661 ± 0.086	0.671AsnHis: 0.671 ± 0.031	1.888AsnIle: 1.888 ± 0.072	0.879AsnLys: 0.879 ± 0.037	2.935AsnLeu: 2.935 ± 0.061	0.596AsnMet: 0.596 ± 0.03	1.154AsnAsn: 1.154 ± 0.061	1.881AsnPro: 1.881 ± 0.058	1.388AsnGln: 1.388 ± 0.052	2.164AsnArg: 2.164 ± 0.06	2.279AsnSer: 2.279 ± 0.066	1.459AsnThr: 1.459 ± 0.061	1.837AsnVal: 1.837 ± 0.057	0.492AsnTrp: 0.492 ± 0.026	1.038AsnTyr: 1.038 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	5.695ProAla: 5.695 ± 0.108	0.392ProCys: 0.392 ± 0.025	2.29ProAsp: 2.29 ± 0.066	2.86ProGlu: 2.86 ± 0.062	1.599ProPhe: 1.599 ± 0.049	3.403ProGly: 3.403 ± 0.072	1.035ProHis: 1.035 ± 0.039	2.021ProIle: 2.021 ± 0.054	1.15ProLys: 1.15 ± 0.042	5.966ProLeu: 5.966 ± 0.122	0.974ProMet: 0.974 ± 0.04	1.257ProAsn: 1.257 ± 0.046	1.944ProPro: 1.944 ± 0.068	2.323ProGln: 2.323 ± 0.063	2.274ProArg: 2.274 ± 0.063	2.861ProSer: 2.861 ± 0.073	2.231ProThr: 2.231 ± 0.053	3.209ProVal: 3.209 ± 0.074	0.559ProTrp: 0.559 ± 0.035	1.083ProTyr: 1.083 ± 0.046	0.001ProXaa: 0.001 ± 0.001
Gln	4.983GlnAla: 4.983 ± 0.096	0.446GlnCys: 0.446 ± 0.033	1.231GlnAsp: 1.231 ± 0.049	1.59GlnGlu: 1.59 ± 0.048	2.006GlnPhe: 2.006 ± 0.06	2.879GlnGly: 2.879 ± 0.064	1.266GlnHis: 1.266 ± 0.045	2.383GlnIle: 2.383 ± 0.062	1.01GlnLys: 1.01 ± 0.039	9.119GlnLeu: 9.119 ± 0.181	1.052GlnMet: 1.052 ± 0.037	0.882GlnAsn: 0.882 ± 0.039	3.328GlnPro: 3.328 ± 0.083	4.912GlnGln: 4.912 ± 0.146	5.178GlnArg: 5.178 ± 0.106	2.798GlnSer: 2.798 ± 0.067	1.997GlnThr: 1.997 ± 0.059	2.975GlnVal: 2.975 ± 0.067	1.013GlnTrp: 1.013 ± 0.047	0.979GlnTyr: 0.979 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	6.643ArgAla: 6.643 ± 0.108	0.779ArgCys: 0.779 ± 0.037	3.765ArgAsp: 3.765 ± 0.088	3.689ArgGlu: 3.689 ± 0.083	2.386ArgPhe: 2.386 ± 0.065	4.681ArgGly: 4.681 ± 0.089	1.69ArgHis: 1.69 ± 0.055	2.904ArgIle: 2.904 ± 0.065	1.597ArgLys: 1.597 ± 0.06	6.652ArgLeu: 6.652 ± 0.113	1.18ArgMet: 1.18 ± 0.042	1.861ArgAsn: 1.861 ± 0.051	2.577ArgPro: 2.577 ± 0.082	3.777ArgGln: 3.777 ± 0.098	4.503ArgArg: 4.503 ± 0.103	3.936ArgSer: 3.936 ± 0.081	2.256ArgThr: 2.256 ± 0.058	4.024ArgVal: 4.024 ± 0.085	1.157ArgTrp: 1.157 ± 0.047	2.202ArgTyr: 2.202 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	8.159SerAla: 8.159 ± 0.142	0.734SerCys: 0.734 ± 0.042	4.079SerAsp: 4.079 ± 0.107	3.809SerGlu: 3.809 ± 0.082	2.12SerPhe: 2.12 ± 0.055	6.426SerGly: 6.426 ± 0.135	1.432SerHis: 1.432 ± 0.047	2.511SerIle: 2.511 ± 0.076	1.616SerLys: 1.616 ± 0.052	5.979SerLeu: 5.979 ± 0.114	1.197SerMet: 1.197 ± 0.042	1.785SerAsn: 1.785 ± 0.062	2.343SerPro: 2.343 ± 0.051	2.72SerGln: 2.72 ± 0.064	3.649SerArg: 3.649 ± 0.08	4.211SerSer: 4.211 ± 0.134	2.598SerThr: 2.598 ± 0.094	4.013SerVal: 4.013 ± 0.081	1.033SerTrp: 1.033 ± 0.045	1.98SerTyr: 1.98 ± 0.061	0.001SerXaa: 0.001 ± 0.002
Thr	6.778ThrAla: 6.778 ± 0.149	0.362ThrCys: 0.362 ± 0.027	2.405ThrAsp: 2.405 ± 0.073	2.315ThrGlu: 2.315 ± 0.058	1.484ThrPhe: 1.484 ± 0.049	3.799ThrGly: 3.799 ± 0.109	0.836ThrHis: 0.836 ± 0.038	2.813ThrIle: 2.813 ± 0.074	1.064ThrLys: 1.064 ± 0.043	6.362ThrLeu: 6.362 ± 0.124	0.898ThrMet: 0.898 ± 0.038	1.25ThrAsn: 1.25 ± 0.047	2.649ThrPro: 2.649 ± 0.064	1.66ThrGln: 1.66 ± 0.057	2.181ThrArg: 2.181 ± 0.062	2.521ThrSer: 2.521 ± 0.079	2.895ThrThr: 2.895 ± 0.103	4.406ThrVal: 4.406 ± 0.1	0.396ThrTrp: 0.396 ± 0.021	0.885ThrTyr: 0.885 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.958ValAla: 9.958 ± 0.16	0.682ValCys: 0.682 ± 0.03	4.69ValAsp: 4.69 ± 0.117	4.775ValGlu: 4.775 ± 0.096	2.062ValPhe: 2.062 ± 0.06	5.305ValGly: 5.305 ± 0.116	1.206ValHis: 1.206 ± 0.044	3.873ValIle: 3.873 ± 0.084	2.209ValLys: 2.209 ± 0.063	6.287ValLeu: 6.287 ± 0.123	1.659ValMet: 1.659 ± 0.054	2.429ValAsn: 2.429 ± 0.075	2.757ValPro: 2.757 ± 0.073	2.168ValGln: 2.168 ± 0.055	3.609ValArg: 3.609 ± 0.081	4.194ValSer: 4.194 ± 0.087	4.057ValThr: 4.057 ± 0.114	6.708ValVal: 6.708 ± 0.112	0.779ValTrp: 0.779 ± 0.038	1.451ValTyr: 1.451 ± 0.047	0.001ValXaa: 0.001 ± 0.002
Trp	1.042TrpAla: 1.042 ± 0.042	0.147TrpCys: 0.147 ± 0.013	0.514TrpAsp: 0.514 ± 0.027	0.442TrpGlu: 0.442 ± 0.025	0.468TrpPhe: 0.468 ± 0.026	0.891TrpGly: 0.891 ± 0.038	0.362TrpHis: 0.362 ± 0.022	0.514TrpIle: 0.514 ± 0.027	0.244TrpLys: 0.244 ± 0.019	2.152TrpLeu: 2.152 ± 0.081	0.291TrpMet: 0.291 ± 0.021	0.312TrpAsn: 0.312 ± 0.023	0.662TrpPro: 0.662 ± 0.035	1.456TrpGln: 1.456 ± 0.058	1.25TrpArg: 1.25 ± 0.049	0.866TrpSer: 0.866 ± 0.038	0.411TrpThr: 0.411 ± 0.029	0.877TrpVal: 0.877 ± 0.04	0.236TrpTrp: 0.236 ± 0.022	0.344TrpTyr: 0.344 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.635TyrAla: 2.635 ± 0.07	0.353TyrCys: 0.353 ± 0.023	1.35TyrAsp: 1.35 ± 0.049	0.985TyrGlu: 0.985 ± 0.038	1.061TyrPhe: 1.061 ± 0.043	2.117TyrGly: 2.117 ± 0.061	0.701TyrHis: 0.701 ± 0.036	1.122TyrIle: 1.122 ± 0.042	0.643TyrLys: 0.643 ± 0.033	3.104TyrLeu: 3.104 ± 0.074	0.462TyrMet: 0.462 ± 0.028	0.876TyrAsn: 0.876 ± 0.036	1.329TyrPro: 1.329 ± 0.044	1.834TyrGln: 1.834 ± 0.055	2.389TyrArg: 2.389 ± 0.063	1.777TyrSer: 1.777 ± 0.045	1.307TyrThr: 1.307 ± 0.046	1.316TyrVal: 1.316 ± 0.051	0.392TyrTrp: 0.392 ± 0.023	0.836TyrTyr: 0.836 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.002	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.002	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1957 proteins (679377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---