Amino acid dipepetide frequency for Ornithinimicrobium humiphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.275AlaAla: 19.275 ± 0.24	0.884AlaCys: 0.884 ± 0.031	8.186AlaAsp: 8.186 ± 0.103	8.578AlaGlu: 8.578 ± 0.105	3.08AlaPhe: 3.08 ± 0.061	12.51AlaGly: 12.51 ± 0.121	2.413AlaHis: 2.413 ± 0.052	3.728AlaIle: 3.728 ± 0.068	1.93AlaLys: 1.93 ± 0.047	14.304AlaLeu: 14.304 ± 0.149	2.662AlaMet: 2.662 ± 0.05	1.703AlaAsn: 1.703 ± 0.048	6.742AlaPro: 6.742 ± 0.107	3.526AlaGln: 3.526 ± 0.057	10.566AlaArg: 10.566 ± 0.12	6.009AlaSer: 6.009 ± 0.075	7.531AlaThr: 7.531 ± 0.092	12.314AlaVal: 12.314 ± 0.145	2.066AlaTrp: 2.066 ± 0.046	2.428AlaTyr: 2.428 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.726CysAla: 0.726 ± 0.028	0.069CysCys: 0.069 ± 0.008	0.413CysAsp: 0.413 ± 0.02	0.343CysGlu: 0.343 ± 0.019	0.184CysPhe: 0.184 ± 0.012	0.783CysGly: 0.783 ± 0.028	0.17CysHis: 0.17 ± 0.013	0.167CysIle: 0.167 ± 0.012	0.078CysLys: 0.078 ± 0.01	0.593CysLeu: 0.593 ± 0.025	0.089CysMet: 0.089 ± 0.008	0.114CysAsn: 0.114 ± 0.012	0.44CysPro: 0.44 ± 0.02	0.16CysGln: 0.16 ± 0.012	0.469CysArg: 0.469 ± 0.023	0.374CysSer: 0.374 ± 0.021	0.435CysThr: 0.435 ± 0.022	0.541CysVal: 0.541 ± 0.021	0.098CysTrp: 0.098 ± 0.01	0.117CysTyr: 0.117 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.769AspAla: 7.769 ± 0.096	0.295AspCys: 0.295 ± 0.018	4.397AspAsp: 4.397 ± 0.087	4.677AspGlu: 4.677 ± 0.076	1.396AspPhe: 1.396 ± 0.038	6.413AspGly: 6.413 ± 0.09	1.473AspHis: 1.473 ± 0.038	1.634AspIle: 1.634 ± 0.043	0.889AspLys: 0.889 ± 0.027	7.486AspLeu: 7.486 ± 0.098	0.86AspMet: 0.86 ± 0.03	0.811AspAsn: 0.811 ± 0.031	5.135AspPro: 5.135 ± 0.08	1.698AspGln: 1.698 ± 0.043	5.057AspArg: 5.057 ± 0.088	2.094AspSer: 2.094 ± 0.05	2.851AspThr: 2.851 ± 0.052	6.133AspVal: 6.133 ± 0.079	0.948AspTrp: 0.948 ± 0.026	1.291AspTyr: 1.291 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.142GluAla: 8.142 ± 0.122	0.285GluCys: 0.285 ± 0.017	3.865GluAsp: 3.865 ± 0.071	4.465GluGlu: 4.465 ± 0.08	1.213GluPhe: 1.213 ± 0.041	5.463GluGly: 5.463 ± 0.088	1.869GluHis: 1.869 ± 0.043	2.369GluIle: 2.369 ± 0.05	1.083GluLys: 1.083 ± 0.038	7.112GluLeu: 7.112 ± 0.082	1.01GluMet: 1.01 ± 0.034	0.804GluAsn: 0.804 ± 0.028	3.527GluPro: 3.527 ± 0.064	2.675GluGln: 2.675 ± 0.049	5.729GluArg: 5.729 ± 0.093	2.313GluSer: 2.313 ± 0.052	3.047GluThr: 3.047 ± 0.061	6.162GluVal: 6.162 ± 0.086	0.796GluTrp: 0.796 ± 0.028	0.718GluTyr: 0.718 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.098PheAla: 3.098 ± 0.059	0.198PheCys: 0.198 ± 0.014	1.82PheAsp: 1.82 ± 0.043	1.368PheGlu: 1.368 ± 0.041	0.817PhePhe: 0.817 ± 0.034	2.739PheGly: 2.739 ± 0.059	0.475PheHis: 0.475 ± 0.02	0.627PheIle: 0.627 ± 0.024	0.33PheLys: 0.33 ± 0.02	2.458PheLeu: 2.458 ± 0.058	0.357PheMet: 0.357 ± 0.019	0.461PheAsn: 0.461 ± 0.025	1.201PhePro: 1.201 ± 0.033	0.541PheGln: 0.541 ± 0.028	1.519PheArg: 1.519 ± 0.036	1.345PheSer: 1.345 ± 0.038	1.668PheThr: 1.668 ± 0.042	2.576PheVal: 2.576 ± 0.063	0.443PheTrp: 0.443 ± 0.024	0.54PheTyr: 0.54 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.012GlyAla: 11.012 ± 0.128	0.721GlyCys: 0.721 ± 0.03	5.379GlyAsp: 5.379 ± 0.095	5.66GlyGlu: 5.66 ± 0.08	2.582GlyPhe: 2.582 ± 0.05	8.521GlyGly: 8.521 ± 0.116	2.129GlyHis: 2.129 ± 0.048	3.354GlyIle: 3.354 ± 0.057	1.729GlyLys: 1.729 ± 0.048	10.019GlyLeu: 10.019 ± 0.12	2.277GlyMet: 2.277 ± 0.045	1.453GlyAsn: 1.453 ± 0.046	5.158GlyPro: 5.158 ± 0.085	2.778GlyGln: 2.778 ± 0.055	7.845GlyArg: 7.845 ± 0.09	5.529GlySer: 5.529 ± 0.075	6.246GlyThr: 6.246 ± 0.089	8.383GlyVal: 8.383 ± 0.095	1.866GlyTrp: 1.866 ± 0.043	2.12GlyTyr: 2.12 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.605HisAla: 2.605 ± 0.048	0.145HisCys: 0.145 ± 0.011	1.527HisAsp: 1.527 ± 0.042	1.348HisGlu: 1.348 ± 0.038	0.482HisPhe: 0.482 ± 0.021	2.251HisGly: 2.251 ± 0.043	0.654HisHis: 0.654 ± 0.028	0.5HisIle: 0.5 ± 0.021	0.267HisLys: 0.267 ± 0.016	2.512HisLeu: 2.512 ± 0.052	0.283HisMet: 0.283 ± 0.016	0.358HisAsn: 0.358 ± 0.019	1.733HisPro: 1.733 ± 0.037	0.604HisGln: 0.604 ± 0.024	1.886HisArg: 1.886 ± 0.048	0.8HisSer: 0.8 ± 0.027	1.125HisThr: 1.125 ± 0.032	2.184HisVal: 2.184 ± 0.044	0.314HisTrp: 0.314 ± 0.017	0.394HisTyr: 0.394 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.133IleAla: 4.133 ± 0.073	0.264IleCys: 0.264 ± 0.014	2.143IleAsp: 2.143 ± 0.052	1.941IleGlu: 1.941 ± 0.047	0.836IlePhe: 0.836 ± 0.034	3.129IleGly: 3.129 ± 0.06	0.53IleHis: 0.53 ± 0.022	1.021IleIle: 1.021 ± 0.039	0.531IleLys: 0.531 ± 0.027	2.595IleLeu: 2.595 ± 0.056	0.464IleMet: 0.464 ± 0.02	0.657IleAsn: 0.657 ± 0.029	1.736IlePro: 1.736 ± 0.037	0.611IleGln: 0.611 ± 0.025	1.916IleArg: 1.916 ± 0.037	1.686IleSer: 1.686 ± 0.045	2.123IleThr: 2.123 ± 0.05	3.046IleVal: 3.046 ± 0.065	0.337IleTrp: 0.337 ± 0.017	0.597IleTyr: 0.597 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	1.983LysAla: 1.983 ± 0.048	0.061LysCys: 0.061 ± 0.008	1.026LysAsp: 1.026 ± 0.038	0.909LysGlu: 0.909 ± 0.027	0.351LysPhe: 0.351 ± 0.021	1.353LysGly: 1.353 ± 0.037	0.361LysHis: 0.361 ± 0.02	0.667LysIle: 0.667 ± 0.032	0.553LysLys: 0.553 ± 0.032	1.24LysLeu: 1.24 ± 0.037	0.325LysMet: 0.325 ± 0.019	0.361LysAsn: 0.361 ± 0.02	0.776LysPro: 0.776 ± 0.029	0.478LysGln: 0.478 ± 0.023	1.044LysArg: 1.044 ± 0.036	0.748LysSer: 0.748 ± 0.027	0.87LysThr: 0.87 ± 0.034	1.584LysVal: 1.584 ± 0.049	0.159LysTrp: 0.159 ± 0.013	0.3LysTyr: 0.3 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.618LeuAla: 15.618 ± 0.148	0.613LeuCys: 0.613 ± 0.024	7.109LeuAsp: 7.109 ± 0.098	6.172LeuGlu: 6.172 ± 0.085	2.218LeuPhe: 2.218 ± 0.061	10.386LeuGly: 10.386 ± 0.114	2.248LeuHis: 2.248 ± 0.049	2.427LeuIle: 2.427 ± 0.063	1.404LeuLys: 1.404 ± 0.04	11.794LeuLeu: 11.794 ± 0.187	1.72LeuMet: 1.72 ± 0.044	1.305LeuAsn: 1.305 ± 0.039	6.381LeuPro: 6.381 ± 0.077	2.53LeuGln: 2.53 ± 0.05	8.676LeuArg: 8.676 ± 0.101	5.121LeuSer: 5.121 ± 0.066	6.561LeuThr: 6.561 ± 0.078	11.413LeuVal: 11.413 ± 0.138	1.333LeuTrp: 1.333 ± 0.034	1.407LeuTyr: 1.407 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.394MetAla: 2.394 ± 0.045	0.122MetCys: 0.122 ± 0.01	0.933MetAsp: 0.933 ± 0.028	0.792MetGlu: 0.792 ± 0.026	0.451MetPhe: 0.451 ± 0.021	1.467MetGly: 1.467 ± 0.038	0.367MetHis: 0.367 ± 0.019	0.675MetIle: 0.675 ± 0.024	0.335MetLys: 0.335 ± 0.019	1.823MetLeu: 1.823 ± 0.048	0.314MetMet: 0.314 ± 0.018	0.37MetAsn: 0.37 ± 0.021	1.103MetPro: 1.103 ± 0.032	0.501MetGln: 0.501 ± 0.023	1.471MetArg: 1.471 ± 0.039	1.45MetSer: 1.45 ± 0.037	1.803MetThr: 1.803 ± 0.042	1.603MetVal: 1.603 ± 0.044	0.195MetTrp: 0.195 ± 0.013	0.272MetTyr: 0.272 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.877AsnAla: 1.877 ± 0.052	0.123AsnCys: 0.123 ± 0.011	0.859AsnAsp: 0.859 ± 0.03	0.699AsnGlu: 0.699 ± 0.03	0.456AsnPhe: 0.456 ± 0.024	1.435AsnGly: 1.435 ± 0.043	0.314AsnHis: 0.314 ± 0.018	0.557AsnIle: 0.557 ± 0.024	0.268AsnLys: 0.268 ± 0.018	1.622AsnLeu: 1.622 ± 0.04	0.252AsnMet: 0.252 ± 0.018	0.347AsnAsn: 0.347 ± 0.022	1.293AsnPro: 1.293 ± 0.042	0.419AsnGln: 0.419 ± 0.023	0.952AsnArg: 0.952 ± 0.035	0.616AsnSer: 0.616 ± 0.028	0.784AsnThr: 0.784 ± 0.031	1.379AsnVal: 1.379 ± 0.038	0.196AsnTrp: 0.196 ± 0.014	0.331AsnTyr: 0.331 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.783ProAla: 7.783 ± 0.111	0.257ProCys: 0.257 ± 0.017	4.67ProAsp: 4.67 ± 0.077	4.756ProGlu: 4.756 ± 0.081	1.42ProPhe: 1.42 ± 0.035	6.531ProGly: 6.531 ± 0.102	1.289ProHis: 1.289 ± 0.038	1.334ProIle: 1.334 ± 0.038	0.749ProLys: 0.749 ± 0.026	5.111ProLeu: 5.111 ± 0.064	1.07ProMet: 1.07 ± 0.033	0.713ProAsn: 0.713 ± 0.03	3.145ProPro: 3.145 ± 0.084	1.664ProGln: 1.664 ± 0.043	4.15ProArg: 4.15 ± 0.08	3.078ProSer: 3.078 ± 0.055	3.706ProThr: 3.706 ± 0.059	6.25ProVal: 6.25 ± 0.082	1.049ProTrp: 1.049 ± 0.032	1.056ProTyr: 1.056 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.545GlnAla: 3.545 ± 0.066	0.126GlnCys: 0.126 ± 0.01	1.474GlnAsp: 1.474 ± 0.036	1.77GlnGlu: 1.77 ± 0.04	0.624GlnPhe: 0.624 ± 0.023	2.38GlnGly: 2.38 ± 0.054	0.671GlnHis: 0.671 ± 0.024	1.075GlnIle: 1.075 ± 0.032	0.406GlnLys: 0.406 ± 0.02	3.182GlnLeu: 3.182 ± 0.054	0.522GlnMet: 0.522 ± 0.026	0.421GlnAsn: 0.421 ± 0.023	1.614GlnPro: 1.614 ± 0.043	1.218GlnGln: 1.218 ± 0.04	2.459GlnArg: 2.459 ± 0.048	1.033GlnSer: 1.033 ± 0.033	1.415GlnThr: 1.415 ± 0.036	3.138GlnVal: 3.138 ± 0.058	0.383GlnTrp: 0.383 ± 0.02	0.391GlnTyr: 0.391 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.995ArgAla: 9.995 ± 0.118	0.471ArgCys: 0.471 ± 0.023	4.513ArgAsp: 4.513 ± 0.071	5.233ArgGlu: 5.233 ± 0.075	1.952ArgPhe: 1.952 ± 0.046	6.082ArgGly: 6.082 ± 0.087	2.048ArgHis: 2.048 ± 0.046	2.774ArgIle: 2.774 ± 0.053	1.121ArgLys: 1.121 ± 0.036	8.408ArgLeu: 8.408 ± 0.114	1.844ArgMet: 1.844 ± 0.037	1.081ArgAsn: 1.081 ± 0.031	4.916ArgPro: 4.916 ± 0.082	2.302ArgGln: 2.302 ± 0.044	7.904ArgArg: 7.904 ± 0.109	4.359ArgSer: 4.359 ± 0.064	5.085ArgThr: 5.085 ± 0.076	6.758ArgVal: 6.758 ± 0.088	1.563ArgTrp: 1.563 ± 0.037	1.607ArgTyr: 1.607 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.936SerAla: 5.936 ± 0.079	0.341SerCys: 0.341 ± 0.018	2.66SerAsp: 2.66 ± 0.05	2.525SerGlu: 2.525 ± 0.048	1.467SerPhe: 1.467 ± 0.043	5.506SerGly: 5.506 ± 0.081	0.902SerHis: 0.902 ± 0.028	1.545SerIle: 1.545 ± 0.044	0.735SerLys: 0.735 ± 0.027	4.797SerLeu: 4.797 ± 0.073	1.148SerMet: 1.148 ± 0.031	0.781SerAsn: 0.781 ± 0.033	2.993SerPro: 2.993 ± 0.052	1.259SerGln: 1.259 ± 0.035	3.742SerArg: 3.742 ± 0.059	2.879SerSer: 2.879 ± 0.06	3.475SerThr: 3.475 ± 0.059	4.474SerVal: 4.474 ± 0.073	0.945SerTrp: 0.945 ± 0.03	1.057SerTyr: 1.057 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.602ThrAla: 7.602 ± 0.088	0.428ThrCys: 0.428 ± 0.023	3.768ThrAsp: 3.768 ± 0.059	3.241ThrGlu: 3.241 ± 0.061	1.811ThrPhe: 1.811 ± 0.046	6.297ThrGly: 6.297 ± 0.086	1.14ThrHis: 1.14 ± 0.036	1.989ThrIle: 1.989 ± 0.046	0.869ThrLys: 0.869 ± 0.031	5.976ThrLeu: 5.976 ± 0.078	1.024ThrMet: 1.024 ± 0.032	0.974ThrAsn: 0.974 ± 0.031	4.061ThrPro: 4.061 ± 0.065	1.35ThrGln: 1.35 ± 0.038	4.071ThrArg: 4.071 ± 0.062	3.406ThrSer: 3.406 ± 0.058	4.277ThrThr: 4.277 ± 0.075	6.34ThrVal: 6.34 ± 0.084	1.067ThrTrp: 1.067 ± 0.032	1.286ThrTyr: 1.286 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	12.722ValAla: 12.722 ± 0.138	0.676ValCys: 0.676 ± 0.024	6.425ValAsp: 6.425 ± 0.078	6.339ValGlu: 6.339 ± 0.07	2.197ValPhe: 2.197 ± 0.051	8.503ValGly: 8.503 ± 0.107	2.191ValHis: 2.191 ± 0.047	2.901ValIle: 2.901 ± 0.064	1.333ValLys: 1.333 ± 0.037	11.475ValLeu: 11.475 ± 0.137	1.691ValMet: 1.691 ± 0.045	1.504ValAsn: 1.504 ± 0.039	6.006ValPro: 6.006 ± 0.085	2.411ValGln: 2.411 ± 0.048	7.694ValArg: 7.694 ± 0.082	4.594ValSer: 4.594 ± 0.072	6.018ValThr: 6.018 ± 0.073	11.763ValVal: 11.763 ± 0.128	1.29ValTrp: 1.29 ± 0.034	1.469ValTyr: 1.469 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.844TrpAla: 1.844 ± 0.041	0.155TrpCys: 0.155 ± 0.014	0.854TrpAsp: 0.854 ± 0.029	0.807TrpGlu: 0.807 ± 0.027	0.502TrpPhe: 0.502 ± 0.022	1.203TrpGly: 1.203 ± 0.038	0.373TrpHis: 0.373 ± 0.015	0.543TrpIle: 0.543 ± 0.023	0.256TrpLys: 0.256 ± 0.017	1.818TrpLeu: 1.818 ± 0.037	0.32TrpMet: 0.32 ± 0.018	0.273TrpAsn: 0.273 ± 0.016	0.803TrpPro: 0.803 ± 0.029	0.57TrpGln: 0.57 ± 0.024	1.396TrpArg: 1.396 ± 0.035	0.917TrpSer: 0.917 ± 0.032	0.993TrpThr: 0.993 ± 0.033	1.415TrpVal: 1.415 ± 0.041	0.446TrpTrp: 0.446 ± 0.022	0.297TrpTyr: 0.297 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.375TyrAla: 2.375 ± 0.05	0.127TyrCys: 0.127 ± 0.011	1.287TyrAsp: 1.287 ± 0.037	1.021TyrGlu: 1.021 ± 0.033	0.546TyrPhe: 0.546 ± 0.025	1.809TyrGly: 1.809 ± 0.046	0.353TyrHis: 0.353 ± 0.018	0.411TyrIle: 0.411 ± 0.022	0.285TyrLys: 0.285 ± 0.018	2.115TyrLeu: 2.115 ± 0.048	0.207TyrMet: 0.207 ± 0.015	0.289TyrAsn: 0.289 ± 0.019	1.018TyrPro: 1.018 ± 0.032	0.553TyrGln: 0.553 ± 0.026	1.467TyrArg: 1.467 ± 0.04	0.816TyrSer: 0.816 ± 0.031	0.965TyrThr: 0.965 ± 0.029	1.747TyrVal: 1.747 ± 0.04	0.287TyrTrp: 0.287 ± 0.015	0.39TyrTyr: 0.39 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3155 proteins (1044644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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