Amino acid dipepetide frequency for Hallerella succinigenes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.168AlaAla: 7.168 ± 0.123	1.123AlaCys: 1.123 ± 0.036	4.754AlaAsp: 4.754 ± 0.073	6.206AlaGlu: 6.206 ± 0.1	3.97AlaPhe: 3.97 ± 0.078	5.658AlaGly: 5.658 ± 0.089	1.406AlaHis: 1.406 ± 0.041	4.844AlaIle: 4.844 ± 0.073	6.219AlaLys: 6.219 ± 0.111	8.162AlaLeu: 8.162 ± 0.112	2.122AlaMet: 2.122 ± 0.054	3.343AlaAsn: 3.343 ± 0.056	3.03AlaPro: 3.03 ± 0.071	2.624AlaGln: 2.624 ± 0.054	3.498AlaArg: 3.498 ± 0.07	5.492AlaSer: 5.492 ± 0.091	4.182AlaThr: 4.182 ± 0.078	5.604AlaVal: 5.604 ± 0.093	0.915AlaTrp: 0.915 ± 0.031	2.839AlaTyr: 2.839 ± 0.071	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.036	0.228CysCys: 0.228 ± 0.018	0.751CysAsp: 0.751 ± 0.03	0.781CysGlu: 0.781 ± 0.032	0.543CysPhe: 0.543 ± 0.025	1.165CysGly: 1.165 ± 0.035	0.277CysHis: 0.277 ± 0.02	0.736CysIle: 0.736 ± 0.03	0.81CysLys: 0.81 ± 0.035	0.965CysLeu: 0.965 ± 0.033	0.263CysMet: 0.263 ± 0.016	0.481CysAsn: 0.481 ± 0.023	0.644CysPro: 0.644 ± 0.041	0.286CysGln: 0.286 ± 0.018	0.511CysArg: 0.511 ± 0.023	0.894CysSer: 0.894 ± 0.036	0.619CysThr: 0.619 ± 0.029	0.878CysVal: 0.878 ± 0.031	0.119CysTrp: 0.119 ± 0.011	0.481CysTyr: 0.481 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.9AspAla: 4.9 ± 0.073	0.684AspCys: 0.684 ± 0.031	3.058AspAsp: 3.058 ± 0.073	3.895AspGlu: 3.895 ± 0.067	3.184AspPhe: 3.184 ± 0.066	4.255AspGly: 4.255 ± 0.078	0.89AspHis: 0.89 ± 0.03	3.464AspIle: 3.464 ± 0.069	3.203AspLys: 3.203 ± 0.062	5.153AspLeu: 5.153 ± 0.072	1.402AspMet: 1.402 ± 0.038	2.119AspAsn: 2.119 ± 0.054	2.4AspPro: 2.4 ± 0.075	1.207AspGln: 1.207 ± 0.035	2.527AspArg: 2.527 ± 0.053	5.006AspSer: 5.006 ± 0.104	2.965AspThr: 2.965 ± 0.071	3.801AspVal: 3.801 ± 0.072	0.795AspTrp: 0.795 ± 0.031	2.338AspTyr: 2.338 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.367GluAla: 5.367 ± 0.092	0.727GluCys: 0.727 ± 0.027	3.528GluAsp: 3.528 ± 0.07	4.924GluGlu: 4.924 ± 0.104	3.066GluPhe: 3.066 ± 0.06	3.961GluGly: 3.961 ± 0.066	1.233GluHis: 1.233 ± 0.042	4.566GluIle: 4.566 ± 0.083	5.774GluLys: 5.774 ± 0.097	6.11GluLeu: 6.11 ± 0.104	1.842GluMet: 1.842 ± 0.046	3.984GluAsn: 3.984 ± 0.057	1.959GluPro: 1.959 ± 0.047	2.091GluGln: 2.091 ± 0.048	3.354GluArg: 3.354 ± 0.075	4.214GluSer: 4.214 ± 0.063	3.561GluThr: 3.561 ± 0.065	3.827GluVal: 3.827 ± 0.064	0.927GluTrp: 0.927 ± 0.037	2.336GluTyr: 2.336 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	4.394PheAla: 4.394 ± 0.07	0.79PheCys: 0.79 ± 0.031	3.124PheAsp: 3.124 ± 0.058	3.192PheGlu: 3.192 ± 0.063	2.497PhePhe: 2.497 ± 0.062	3.603PheGly: 3.603 ± 0.068	0.918PheHis: 0.918 ± 0.031	2.439PheIle: 2.439 ± 0.06	2.679PheLys: 2.679 ± 0.058	4.436PheLeu: 4.436 ± 0.079	1.051PheMet: 1.051 ± 0.036	1.904PheAsn: 1.904 ± 0.05	1.987PhePro: 1.987 ± 0.042	1.347PheGln: 1.347 ± 0.036	2.333PheArg: 2.333 ± 0.053	3.533PheSer: 3.533 ± 0.066	2.5PheThr: 2.5 ± 0.059	3.349PheVal: 3.349 ± 0.066	0.658PheTrp: 0.658 ± 0.032	1.799PheTyr: 1.799 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.09GlyAla: 5.09 ± 0.083	0.943GlyCys: 0.943 ± 0.042	3.671GlyAsp: 3.671 ± 0.076	4.385GlyGlu: 4.385 ± 0.074	3.622GlyPhe: 3.622 ± 0.059	4.578GlyGly: 4.578 ± 0.093	1.241GlyHis: 1.241 ± 0.04	4.897GlyIle: 4.897 ± 0.083	5.449GlyLys: 5.449 ± 0.091	5.678GlyLeu: 5.678 ± 0.086	1.918GlyMet: 1.918 ± 0.049	3.229GlyAsn: 3.229 ± 0.067	1.57GlyPro: 1.57 ± 0.047	1.593GlyGln: 1.593 ± 0.045	3.074GlyArg: 3.074 ± 0.063	4.551GlySer: 4.551 ± 0.094	3.994GlyThr: 3.994 ± 0.08	4.955GlyVal: 4.955 ± 0.084	0.933GlyTrp: 0.933 ± 0.034	2.776GlyTyr: 2.776 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.426HisAla: 1.426 ± 0.037	0.304HisCys: 0.304 ± 0.019	0.923HisAsp: 0.923 ± 0.031	0.952HisGlu: 0.952 ± 0.031	1.157HisPhe: 1.157 ± 0.031	1.253HisGly: 1.253 ± 0.036	0.442HisHis: 0.442 ± 0.022	1.082HisIle: 1.082 ± 0.035	1.006HisLys: 1.006 ± 0.034	1.892HisLeu: 1.892 ± 0.042	0.385HisMet: 0.385 ± 0.02	0.658HisAsn: 0.658 ± 0.029	1.069HisPro: 1.069 ± 0.035	0.538HisGln: 0.538 ± 0.025	0.93HisArg: 0.93 ± 0.036	1.126HisSer: 1.126 ± 0.038	0.815HisThr: 0.815 ± 0.024	1.265HisVal: 1.265 ± 0.044	0.283HisTrp: 0.283 ± 0.016	0.828HisTyr: 0.828 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.629IleAla: 5.629 ± 0.092	0.921IleCys: 0.921 ± 0.033	3.777IleAsp: 3.777 ± 0.068	3.879IleGlu: 3.879 ± 0.074	2.819IlePhe: 2.819 ± 0.059	4.095IleGly: 4.095 ± 0.08	1.258IleHis: 1.258 ± 0.039	2.993IleIle: 2.993 ± 0.066	2.875IleLys: 2.875 ± 0.068	6.113IleLeu: 6.113 ± 0.089	1.03IleMet: 1.03 ± 0.034	1.891IleAsn: 1.891 ± 0.056	3.324IlePro: 3.324 ± 0.072	2.296IleGln: 2.296 ± 0.059	3.306IleArg: 3.306 ± 0.066	4.577IleSer: 4.577 ± 0.071	2.844IleThr: 2.844 ± 0.062	4.145IleVal: 4.145 ± 0.071	0.662IleTrp: 0.662 ± 0.025	2.002IleTyr: 2.002 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.705LysAla: 5.705 ± 0.1	0.619LysCys: 0.619 ± 0.03	4.036LysAsp: 4.036 ± 0.072	4.592LysGlu: 4.592 ± 0.085	2.762LysPhe: 2.762 ± 0.058	3.955LysGly: 3.955 ± 0.077	1.1LysHis: 1.1 ± 0.03	4.738LysIle: 4.738 ± 0.08	5.839LysLys: 5.839 ± 0.1	5.645LysLeu: 5.645 ± 0.083	2.031LysMet: 2.031 ± 0.044	3.789LysAsn: 3.789 ± 0.066	2.319LysPro: 2.319 ± 0.055	2.003LysGln: 2.003 ± 0.051	3.251LysArg: 3.251 ± 0.071	4.044LysSer: 4.044 ± 0.07	3.962LysThr: 3.962 ± 0.055	4.295LysVal: 4.295 ± 0.066	0.76LysTrp: 0.76 ± 0.028	2.262LysTyr: 2.262 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	7.778LeuAla: 7.778 ± 0.103	1.277LeuCys: 1.277 ± 0.031	5.674LeuAsp: 5.674 ± 0.093	6.021LeuGlu: 6.021 ± 0.104	4.559LeuPhe: 4.559 ± 0.081	6.209LeuGly: 6.209 ± 0.097	1.71LeuHis: 1.71 ± 0.042	4.548LeuIle: 4.548 ± 0.079	6.175LeuLys: 6.175 ± 0.083	8.435LeuLeu: 8.435 ± 0.132	2.057LeuMet: 2.057 ± 0.046	4.04LeuAsn: 4.04 ± 0.073	4.159LeuPro: 4.159 ± 0.073	3.342LeuGln: 3.342 ± 0.065	4.658LeuArg: 4.658 ± 0.072	7.294LeuSer: 7.294 ± 0.094	4.451LeuThr: 4.451 ± 0.075	5.88LeuVal: 5.88 ± 0.087	1.098LeuTrp: 1.098 ± 0.038	3.129LeuTyr: 3.129 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.113MetAla: 2.113 ± 0.048	0.194MetCys: 0.194 ± 0.015	1.476MetAsp: 1.476 ± 0.043	1.629MetGlu: 1.629 ± 0.047	0.943MetPhe: 0.943 ± 0.031	1.644MetGly: 1.644 ± 0.045	0.475MetHis: 0.475 ± 0.022	1.422MetIle: 1.422 ± 0.04	1.827MetLys: 1.827 ± 0.044	2.276MetLeu: 2.276 ± 0.049	0.667MetMet: 0.667 ± 0.027	1.248MetAsn: 1.248 ± 0.039	1.124MetPro: 1.124 ± 0.036	1.017MetGln: 1.017 ± 0.031	1.235MetArg: 1.235 ± 0.038	1.487MetSer: 1.487 ± 0.042	1.419MetThr: 1.419 ± 0.041	1.467MetVal: 1.467 ± 0.036	0.217MetTrp: 0.217 ± 0.014	0.593MetTyr: 0.593 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.961AsnAla: 3.961 ± 0.069	0.555AsnCys: 0.555 ± 0.033	2.372AsnAsp: 2.372 ± 0.054	2.643AsnGlu: 2.643 ± 0.056	2.199AsnPhe: 2.199 ± 0.05	3.686AsnGly: 3.686 ± 0.065	0.766AsnHis: 0.766 ± 0.025	2.65AsnIle: 2.65 ± 0.052	2.36AsnLys: 2.36 ± 0.067	4.154AsnLeu: 4.154 ± 0.069	1.025AsnMet: 1.025 ± 0.036	1.521AsnAsn: 1.521 ± 0.052	2.39AsnPro: 2.39 ± 0.044	1.285AsnGln: 1.285 ± 0.041	2.27AsnArg: 2.27 ± 0.058	2.855AsnSer: 2.855 ± 0.07	2.081AsnThr: 2.081 ± 0.052	3.073AsnVal: 3.073 ± 0.061	0.688AsnTrp: 0.688 ± 0.029	1.638AsnTyr: 1.638 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.095ProAla: 3.095 ± 0.067	0.464ProCys: 0.464 ± 0.024	2.488ProAsp: 2.488 ± 0.062	3.453ProGlu: 3.453 ± 0.08	1.953ProPhe: 1.953 ± 0.049	2.455ProGly: 2.455 ± 0.062	0.714ProHis: 0.714 ± 0.024	2.225ProIle: 2.225 ± 0.054	2.624ProLys: 2.624 ± 0.054	3.439ProLeu: 3.439 ± 0.064	0.984ProMet: 0.984 ± 0.033	1.812ProAsn: 1.812 ± 0.049	1.133ProPro: 1.133 ± 0.042	1.387ProGln: 1.387 ± 0.041	1.517ProArg: 1.517 ± 0.041	2.46ProSer: 2.46 ± 0.049	2.053ProThr: 2.053 ± 0.045	3.012ProVal: 3.012 ± 0.051	0.545ProTrp: 0.545 ± 0.025	1.386ProTyr: 1.386 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.407GlnAla: 2.407 ± 0.057	0.268GlnCys: 0.268 ± 0.018	1.557GlnAsp: 1.557 ± 0.044	2.133GlnGlu: 2.133 ± 0.053	1.351GlnPhe: 1.351 ± 0.043	2.071GlnGly: 2.071 ± 0.045	0.452GlnHis: 0.452 ± 0.024	2.249GlnIle: 2.249 ± 0.051	2.961GlnLys: 2.961 ± 0.059	2.502GlnLeu: 2.502 ± 0.044	0.978GlnMet: 0.978 ± 0.035	1.81GlnAsn: 1.81 ± 0.051	0.89GlnPro: 0.89 ± 0.034	0.944GlnGln: 0.944 ± 0.033	1.2GlnArg: 1.2 ± 0.038	1.876GlnSer: 1.876 ± 0.049	1.668GlnThr: 1.668 ± 0.047	2.012GlnVal: 2.012 ± 0.052	0.37GlnTrp: 0.37 ± 0.021	1.053GlnTyr: 1.053 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.363ArgAla: 3.363 ± 0.057	0.529ArgCys: 0.529 ± 0.024	2.571ArgAsp: 2.571 ± 0.054	3.455ArgGlu: 3.455 ± 0.07	2.602ArgPhe: 2.602 ± 0.055	2.775ArgGly: 2.775 ± 0.056	0.935ArgHis: 0.935 ± 0.031	3.389ArgIle: 3.389 ± 0.061	3.322ArgLys: 3.322 ± 0.064	4.546ArgLeu: 4.546 ± 0.07	1.338ArgMet: 1.338 ± 0.036	2.281ArgAsn: 2.281 ± 0.055	1.625ArgPro: 1.625 ± 0.041	1.354ArgGln: 1.354 ± 0.039	2.445ArgArg: 2.445 ± 0.062	2.769ArgSer: 2.769 ± 0.058	2.351ArgThr: 2.351 ± 0.054	3.066ArgVal: 3.066 ± 0.061	0.587ArgTrp: 0.587 ± 0.024	2.002ArgTyr: 2.002 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.919SerAla: 5.919 ± 0.108	0.771SerCys: 0.771 ± 0.034	3.819SerAsp: 3.819 ± 0.071	4.431SerGlu: 4.431 ± 0.074	3.368SerPhe: 3.368 ± 0.066	5.003SerGly: 5.003 ± 0.102	1.196SerHis: 1.196 ± 0.04	4.256SerIle: 4.256 ± 0.073	4.451SerLys: 4.451 ± 0.067	6.819SerLeu: 6.819 ± 0.091	1.544SerMet: 1.544 ± 0.036	2.682SerAsn: 2.682 ± 0.066	2.475SerPro: 2.475 ± 0.055	1.899SerGln: 1.899 ± 0.047	3.152SerArg: 3.152 ± 0.061	6.031SerSer: 6.031 ± 0.238	3.682SerThr: 3.682 ± 0.081	5.023SerVal: 5.023 ± 0.085	0.873SerTrp: 0.873 ± 0.035	2.358SerTyr: 2.358 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.443ThrAla: 4.443 ± 0.07	0.563ThrCys: 0.563 ± 0.026	2.928ThrAsp: 2.928 ± 0.063	3.193ThrGlu: 3.193 ± 0.059	2.481ThrPhe: 2.481 ± 0.057	4.039ThrGly: 4.039 ± 0.077	0.966ThrHis: 0.966 ± 0.035	3.464ThrIle: 3.464 ± 0.069	2.661ThrLys: 2.661 ± 0.053	5.539ThrLeu: 5.539 ± 0.093	1.09ThrMet: 1.09 ± 0.033	1.884ThrAsn: 1.884 ± 0.051	2.445ThrPro: 2.445 ± 0.051	1.541ThrGln: 1.541 ± 0.044	2.112ThrArg: 2.112 ± 0.05	3.437ThrSer: 3.437 ± 0.092	2.807ThrThr: 2.807 ± 0.082	4.25ThrVal: 4.25 ± 0.074	0.74ThrTrp: 0.74 ± 0.029	1.846ThrTyr: 1.846 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	5.56ValAla: 5.56 ± 0.087	0.921ValCys: 0.921 ± 0.036	3.893ValAsp: 3.893 ± 0.073	4.631ValGlu: 4.631 ± 0.086	3.1ValPhe: 3.1 ± 0.062	4.228ValGly: 4.228 ± 0.075	1.319ValHis: 1.319 ± 0.036	3.677ValIle: 3.677 ± 0.062	4.316ValLys: 4.316 ± 0.078	6.419ValLeu: 6.419 ± 0.094	1.539ValMet: 1.539 ± 0.046	3.071ValAsn: 3.071 ± 0.062	2.853ValPro: 2.853 ± 0.053	2.433ValGln: 2.433 ± 0.05	3.38ValArg: 3.38 ± 0.064	4.927ValSer: 4.927 ± 0.084	3.628ValThr: 3.628 ± 0.075	4.527ValVal: 4.527 ± 0.077	0.724ValTrp: 0.724 ± 0.026	2.332ValTyr: 2.332 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.812TrpAla: 0.812 ± 0.031	0.145TrpCys: 0.145 ± 0.012	0.73TrpAsp: 0.73 ± 0.029	0.777TrpGlu: 0.777 ± 0.031	0.546TrpPhe: 0.546 ± 0.024	0.841TrpGly: 0.841 ± 0.031	0.3TrpHis: 0.3 ± 0.019	0.948TrpIle: 0.948 ± 0.036	0.961TrpLys: 0.961 ± 0.033	1.084TrpLeu: 1.084 ± 0.037	0.419TrpMet: 0.419 ± 0.022	0.83TrpAsn: 0.83 ± 0.034	0.322TrpPro: 0.322 ± 0.022	0.428TrpGln: 0.428 ± 0.024	0.526TrpArg: 0.526 ± 0.023	0.776TrpSer: 0.776 ± 0.031	0.735TrpThr: 0.735 ± 0.028	0.735TrpVal: 0.735 ± 0.032	0.149TrpTrp: 0.149 ± 0.013	0.453TrpTyr: 0.453 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.967TyrAla: 2.967 ± 0.062	0.467TyrCys: 0.467 ± 0.026	2.114TyrAsp: 2.114 ± 0.048	2.177TyrGlu: 2.177 ± 0.055	1.813TyrPhe: 1.813 ± 0.048	2.672TyrGly: 2.672 ± 0.06	0.734TyrHis: 0.734 ± 0.027	1.851TyrIle: 1.851 ± 0.049	2.193TyrLys: 2.193 ± 0.047	3.127TyrLeu: 3.127 ± 0.052	0.789TyrMet: 0.789 ± 0.026	1.597TyrAsn: 1.597 ± 0.048	1.485TyrPro: 1.485 ± 0.041	1.138TyrGln: 1.138 ± 0.033	2.027TyrArg: 2.027 ± 0.048	2.406TyrSer: 2.406 ± 0.064	2.112TyrThr: 2.112 ± 0.059	2.311TyrVal: 2.311 ± 0.056	0.472TyrTrp: 0.472 ± 0.027	1.589TyrTyr: 1.589 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2694 proteins (925557 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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