Amino acid dipepetide frequency for Lederbergia lentus (Bacillus lentus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.414AlaAla: 5.414 ± 0.086	0.602AlaCys: 0.602 ± 0.023	3.347AlaAsp: 3.347 ± 0.057	4.603AlaGlu: 4.603 ± 0.074	3.324AlaPhe: 3.324 ± 0.055	5.122AlaGly: 5.122 ± 0.079	1.233AlaHis: 1.233 ± 0.035	6.12AlaIle: 6.12 ± 0.076	4.584AlaLys: 4.584 ± 0.07	6.857AlaLeu: 6.857 ± 0.076	1.998AlaMet: 1.998 ± 0.038	2.931AlaAsn: 2.931 ± 0.048	1.952AlaPro: 1.952 ± 0.041	2.103AlaGln: 2.103 ± 0.048	2.434AlaArg: 2.434 ± 0.048	3.939AlaSer: 3.939 ± 0.066	3.602AlaThr: 3.602 ± 0.075	5.066AlaVal: 5.066 ± 0.073	0.634AlaTrp: 0.634 ± 0.026	2.272AlaTyr: 2.272 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.44CysAla: 0.44 ± 0.019	0.089CysCys: 0.089 ± 0.009	0.373CysAsp: 0.373 ± 0.018	0.454CysGlu: 0.454 ± 0.021	0.312CysPhe: 0.312 ± 0.016	0.645CysGly: 0.645 ± 0.026	0.198CysHis: 0.198 ± 0.013	0.497CysIle: 0.497 ± 0.021	0.376CysLys: 0.376 ± 0.016	0.633CysLeu: 0.633 ± 0.024	0.18CysMet: 0.18 ± 0.013	0.31CysAsn: 0.31 ± 0.016	0.307CysPro: 0.307 ± 0.018	0.216CysGln: 0.216 ± 0.013	0.256CysArg: 0.256 ± 0.016	0.484CysSer: 0.484 ± 0.021	0.375CysThr: 0.375 ± 0.018	0.381CysVal: 0.381 ± 0.016	0.067CysTrp: 0.067 ± 0.008	0.241CysTyr: 0.241 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.137AspAla: 3.137 ± 0.05	0.357AspCys: 0.357 ± 0.017	2.526AspAsp: 2.526 ± 0.052	4.367AspGlu: 4.367 ± 0.069	2.466AspPhe: 2.466 ± 0.043	3.477AspGly: 3.477 ± 0.059	1.17AspHis: 1.17 ± 0.032	4.417AspIle: 4.417 ± 0.065	3.281AspLys: 3.281 ± 0.047	4.945AspLeu: 4.945 ± 0.065	1.468AspMet: 1.468 ± 0.035	2.064AspAsn: 2.064 ± 0.047	2.026AspPro: 2.026 ± 0.047	2.002AspGln: 2.002 ± 0.036	2.208AspArg: 2.208 ± 0.043	2.676AspSer: 2.676 ± 0.047	2.412AspThr: 2.412 ± 0.047	3.61AspVal: 3.61 ± 0.056	0.745AspTrp: 0.745 ± 0.027	2.173AspTyr: 2.173 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.237GluAla: 5.237 ± 0.072	0.379GluCys: 0.379 ± 0.019	3.843GluAsp: 3.843 ± 0.059	6.702GluGlu: 6.702 ± 0.094	2.648GluPhe: 2.648 ± 0.048	4.169GluGly: 4.169 ± 0.067	1.488GluHis: 1.488 ± 0.036	5.802GluIle: 5.802 ± 0.074	6.835GluLys: 6.835 ± 0.08	7.077GluLeu: 7.077 ± 0.08	2.424GluMet: 2.424 ± 0.047	3.983GluAsn: 3.983 ± 0.057	1.92GluPro: 1.92 ± 0.038	3.336GluGln: 3.336 ± 0.051	3.225GluArg: 3.225 ± 0.05	3.602GluSer: 3.602 ± 0.055	3.843GluThr: 3.843 ± 0.056	4.784GluVal: 4.784 ± 0.058	0.884GluTrp: 0.884 ± 0.028	2.354GluTyr: 2.354 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.089PheAla: 3.089 ± 0.055	0.336PheCys: 0.336 ± 0.02	2.42PheAsp: 2.42 ± 0.045	2.794PheGlu: 2.794 ± 0.045	2.498PhePhe: 2.498 ± 0.059	3.352PheGly: 3.352 ± 0.06	1.027PheHis: 1.027 ± 0.03	4.427PheIle: 4.427 ± 0.067	2.514PheLys: 2.514 ± 0.045	4.576PheLeu: 4.576 ± 0.074	1.239PheMet: 1.239 ± 0.031	2.092PheAsn: 2.092 ± 0.037	1.665PhePro: 1.665 ± 0.04	1.667PheGln: 1.667 ± 0.039	1.554PheArg: 1.554 ± 0.036	3.373PheSer: 3.373 ± 0.061	2.854PheThr: 2.854 ± 0.047	2.962PheVal: 2.962 ± 0.053	0.553PheTrp: 0.553 ± 0.024	1.742PheTyr: 1.742 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.731GlyAla: 4.731 ± 0.102	0.594GlyCys: 0.594 ± 0.023	3.169GlyAsp: 3.169 ± 0.053	4.54GlyGlu: 4.54 ± 0.069	3.444GlyPhe: 3.444 ± 0.051	4.588GlyGly: 4.588 ± 0.074	1.28GlyHis: 1.28 ± 0.032	6.28GlyIle: 6.28 ± 0.083	5.119GlyLys: 5.119 ± 0.075	6.567GlyLeu: 6.567 ± 0.076	2.164GlyMet: 2.164 ± 0.049	2.897GlyAsn: 2.897 ± 0.052	1.723GlyPro: 1.723 ± 0.034	2.083GlyGln: 2.083 ± 0.046	2.439GlyArg: 2.439 ± 0.049	3.82GlySer: 3.82 ± 0.06	3.896GlyThr: 3.896 ± 0.06	4.818GlyVal: 4.818 ± 0.069	0.829GlyTrp: 0.829 ± 0.029	2.735GlyTyr: 2.735 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.349HisAla: 1.349 ± 0.037	0.193HisCys: 0.193 ± 0.014	1.017HisAsp: 1.017 ± 0.033	1.363HisGlu: 1.363 ± 0.037	1.171HisPhe: 1.171 ± 0.032	1.386HisGly: 1.386 ± 0.039	0.628HisHis: 0.628 ± 0.026	1.645HisIle: 1.645 ± 0.041	0.996HisLys: 0.996 ± 0.029	2.062HisLeu: 2.062 ± 0.043	0.569HisMet: 0.569 ± 0.019	0.759HisAsn: 0.759 ± 0.025	1.038HisPro: 1.038 ± 0.031	0.796HisGln: 0.796 ± 0.025	0.834HisArg: 0.834 ± 0.029	1.24HisSer: 1.24 ± 0.031	1.073HisThr: 1.073 ± 0.03	1.296HisVal: 1.296 ± 0.031	0.254HisTrp: 0.254 ± 0.016	0.862HisTyr: 0.862 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.482IleAla: 6.482 ± 0.087	0.676IleCys: 0.676 ± 0.026	4.61IleAsp: 4.61 ± 0.063	5.946IleGlu: 5.946 ± 0.074	3.83IlePhe: 3.83 ± 0.072	6.355IleGly: 6.355 ± 0.081	1.807IleHis: 1.807 ± 0.045	7.232IleIle: 7.232 ± 0.097	5.024IleLys: 5.024 ± 0.063	7.756IleLeu: 7.756 ± 0.094	2.091IleMet: 2.091 ± 0.048	3.652IleAsn: 3.652 ± 0.054	3.611IlePro: 3.611 ± 0.049	2.975IleGln: 2.975 ± 0.052	3.131IleArg: 3.131 ± 0.053	5.591IleSer: 5.591 ± 0.081	4.757IleThr: 4.757 ± 0.063	5.714IleVal: 5.714 ± 0.073	0.792IleTrp: 0.792 ± 0.021	2.718IleTyr: 2.718 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.456LysAla: 4.456 ± 0.062	0.299LysCys: 0.299 ± 0.016	3.832LysAsp: 3.832 ± 0.065	6.839LysGlu: 6.839 ± 0.085	2.034LysPhe: 2.034 ± 0.038	4.262LysGly: 4.262 ± 0.067	1.285LysHis: 1.285 ± 0.035	4.959LysIle: 4.959 ± 0.073	5.823LysLys: 5.823 ± 0.08	6.046LysLeu: 6.046 ± 0.071	2.386LysMet: 2.386 ± 0.046	3.533LysAsn: 3.533 ± 0.05	2.123LysPro: 2.123 ± 0.048	3.141LysGln: 3.141 ± 0.052	3.11LysArg: 3.11 ± 0.049	3.679LysSer: 3.679 ± 0.05	3.592LysThr: 3.592 ± 0.053	4.668LysVal: 4.668 ± 0.081	0.848LysTrp: 0.848 ± 0.029	2.4LysTyr: 2.4 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.093LeuAla: 7.093 ± 0.078	0.649LeuCys: 0.649 ± 0.024	4.962LeuAsp: 4.962 ± 0.067	6.584LeuGlu: 6.584 ± 0.082	4.995LeuPhe: 4.995 ± 0.083	6.229LeuGly: 6.229 ± 0.072	1.934LeuHis: 1.934 ± 0.042	8.091LeuIle: 8.091 ± 0.095	6.296LeuLys: 6.296 ± 0.074	10.377LeuLeu: 10.377 ± 0.115	2.624LeuMet: 2.624 ± 0.047	4.455LeuAsn: 4.455 ± 0.057	3.989LeuPro: 3.989 ± 0.062	3.589LeuGln: 3.589 ± 0.062	3.403LeuArg: 3.403 ± 0.052	6.481LeuSer: 6.481 ± 0.071	5.424LeuThr: 5.424 ± 0.071	5.874LeuVal: 5.874 ± 0.077	0.857LeuTrp: 0.857 ± 0.029	3.288LeuTyr: 3.288 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.982MetAla: 1.982 ± 0.036	0.153MetCys: 0.153 ± 0.011	1.562MetAsp: 1.562 ± 0.041	2.204MetGlu: 2.204 ± 0.041	1.123MetPhe: 1.123 ± 0.03	1.781MetGly: 1.781 ± 0.042	0.438MetHis: 0.438 ± 0.02	2.437MetIle: 2.437 ± 0.047	2.747MetLys: 2.747 ± 0.049	2.718MetLeu: 2.718 ± 0.054	0.973MetMet: 0.973 ± 0.032	1.71MetAsn: 1.71 ± 0.038	1.05MetPro: 1.05 ± 0.03	1.016MetGln: 1.016 ± 0.031	1.11MetArg: 1.11 ± 0.031	1.696MetSer: 1.696 ± 0.034	1.666MetThr: 1.666 ± 0.038	1.765MetVal: 1.765 ± 0.036	0.234MetTrp: 0.234 ± 0.014	0.814MetTyr: 0.814 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.77AsnAla: 2.77 ± 0.055	0.263AsnCys: 0.263 ± 0.015	2.405AsnAsp: 2.405 ± 0.041	3.862AsnGlu: 3.862 ± 0.057	1.797AsnPhe: 1.797 ± 0.039	3.362AsnGly: 3.362 ± 0.064	1.031AsnHis: 1.031 ± 0.032	4.058AsnIle: 4.058 ± 0.059	3.287AsnLys: 3.287 ± 0.061	3.855AsnLeu: 3.855 ± 0.055	1.363AsnMet: 1.363 ± 0.029	2.377AsnAsn: 2.377 ± 0.06	2.043AsnPro: 2.043 ± 0.039	1.894AsnGln: 1.894 ± 0.043	1.96AsnArg: 1.96 ± 0.039	2.484AsnSer: 2.484 ± 0.047	2.328AsnThr: 2.328 ± 0.046	3.121AsnVal: 3.121 ± 0.047	0.608AsnTrp: 0.608 ± 0.024	1.677AsnTyr: 1.677 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.138ProAla: 2.138 ± 0.044	0.206ProCys: 0.206 ± 0.013	1.976ProAsp: 1.976 ± 0.041	2.978ProGlu: 2.978 ± 0.048	2.008ProPhe: 2.008 ± 0.043	2.226ProGly: 2.226 ± 0.045	0.86ProHis: 0.86 ± 0.031	3.089ProIle: 3.089 ± 0.051	2.113ProLys: 2.113 ± 0.044	3.4ProLeu: 3.4 ± 0.056	0.845ProMet: 0.845 ± 0.027	1.792ProAsn: 1.792 ± 0.04	0.895ProPro: 0.895 ± 0.026	1.064ProGln: 1.064 ± 0.029	1.019ProArg: 1.019 ± 0.028	2.16ProSer: 2.16 ± 0.043	1.997ProThr: 1.997 ± 0.042	2.553ProVal: 2.553 ± 0.048	0.383ProTrp: 0.383 ± 0.018	1.422ProTyr: 1.422 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.563GlnAla: 2.563 ± 0.045	0.184GlnCys: 0.184 ± 0.012	1.634GlnAsp: 1.634 ± 0.035	2.697GlnGlu: 2.697 ± 0.051	1.729GlnPhe: 1.729 ± 0.043	2.151GlnGly: 2.151 ± 0.037	0.759GlnHis: 0.759 ± 0.026	2.756GlnIle: 2.756 ± 0.05	2.658GlnLys: 2.658 ± 0.047	4.007GlnLeu: 4.007 ± 0.063	1.192GlnMet: 1.192 ± 0.03	1.575GlnAsn: 1.575 ± 0.042	1.147GlnPro: 1.147 ± 0.032	1.692GlnGln: 1.692 ± 0.043	1.471GlnArg: 1.471 ± 0.029	2.235GlnSer: 2.235 ± 0.039	1.977GlnThr: 1.977 ± 0.041	2.282GlnVal: 2.282 ± 0.044	0.432GlnTrp: 0.432 ± 0.018	1.36GlnTyr: 1.36 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.305ArgAla: 2.305 ± 0.038	0.25ArgCys: 0.25 ± 0.014	1.973ArgAsp: 1.973 ± 0.04	2.966ArgGlu: 2.966 ± 0.056	1.824ArgPhe: 1.824 ± 0.041	2.188ArgGly: 2.188 ± 0.046	0.724ArgHis: 0.724 ± 0.028	2.983ArgIle: 2.983 ± 0.054	3.182ArgLys: 3.182 ± 0.054	3.815ArgLeu: 3.815 ± 0.058	1.326ArgMet: 1.326 ± 0.035	1.905ArgAsn: 1.905 ± 0.035	1.263ArgPro: 1.263 ± 0.035	1.422ArgGln: 1.422 ± 0.034	1.668ArgArg: 1.668 ± 0.039	2.172ArgSer: 2.172 ± 0.044	1.982ArgThr: 1.982 ± 0.041	2.346ArgVal: 2.346 ± 0.047	0.456ArgTrp: 0.456 ± 0.019	1.401ArgTyr: 1.401 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.677SerAla: 3.677 ± 0.053	0.364SerCys: 0.364 ± 0.017	2.885SerAsp: 2.885 ± 0.047	4.021SerGlu: 4.021 ± 0.062	3.271SerPhe: 3.271 ± 0.052	4.518SerGly: 4.518 ± 0.06	1.241SerHis: 1.241 ± 0.033	5.506SerIle: 5.506 ± 0.074	3.78SerLys: 3.78 ± 0.059	6.103SerLeu: 6.103 ± 0.069	1.715SerMet: 1.715 ± 0.037	2.723SerAsn: 2.723 ± 0.047	2.037SerPro: 2.037 ± 0.047	1.949SerGln: 1.949 ± 0.042	2.184SerArg: 2.184 ± 0.041	3.841SerSer: 3.841 ± 0.07	3.192SerThr: 3.192 ± 0.049	4.137SerVal: 4.137 ± 0.063	0.69SerTrp: 0.69 ± 0.026	2.171SerTyr: 2.171 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.952ThrAla: 3.952 ± 0.063	0.339ThrCys: 0.339 ± 0.018	2.836ThrAsp: 2.836 ± 0.046	3.524ThrGlu: 3.524 ± 0.054	2.704ThrPhe: 2.704 ± 0.046	4.141ThrGly: 4.141 ± 0.125	1.068ThrHis: 1.068 ± 0.029	4.872ThrIle: 4.872 ± 0.067	3.329ThrLys: 3.329 ± 0.058	5.234ThrLeu: 5.234 ± 0.065	1.421ThrMet: 1.421 ± 0.038	2.521ThrAsn: 2.521 ± 0.046	2.22ThrPro: 2.22 ± 0.046	1.451ThrGln: 1.451 ± 0.035	1.716ThrArg: 1.716 ± 0.043	3.322ThrSer: 3.322 ± 0.055	2.844ThrThr: 2.844 ± 0.048	3.934ThrVal: 3.934 ± 0.052	0.597ThrTrp: 0.597 ± 0.024	2.025ThrTyr: 2.025 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.572ValAla: 4.572 ± 0.065	0.519ValCys: 0.519 ± 0.023	3.557ValAsp: 3.557 ± 0.062	4.716ValGlu: 4.716 ± 0.074	3.085ValPhe: 3.085 ± 0.053	4.535ValGly: 4.535 ± 0.068	1.294ValHis: 1.294 ± 0.034	5.887ValIle: 5.887 ± 0.076	4.482ValLys: 4.482 ± 0.06	6.385ValLeu: 6.385 ± 0.079	1.871ValMet: 1.871 ± 0.035	3.117ValAsn: 3.117 ± 0.058	2.402ValPro: 2.402 ± 0.044	2.191ValGln: 2.191 ± 0.044	2.463ValArg: 2.463 ± 0.043	4.339ValSer: 4.339 ± 0.065	3.846ValThr: 3.846 ± 0.061	4.372ValVal: 4.372 ± 0.075	0.619ValTrp: 0.619 ± 0.027	2.18ValTyr: 2.18 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.625TrpAla: 0.625 ± 0.023	0.082TrpCys: 0.082 ± 0.008	0.629TrpAsp: 0.629 ± 0.026	0.738TrpGlu: 0.738 ± 0.024	0.547TrpPhe: 0.547 ± 0.023	0.715TrpGly: 0.715 ± 0.027	0.257TrpHis: 0.257 ± 0.014	0.911TrpIle: 0.911 ± 0.028	0.8TrpLys: 0.8 ± 0.033	1.222TrpLeu: 1.222 ± 0.031	0.389TrpMet: 0.389 ± 0.019	0.619TrpAsn: 0.619 ± 0.021	0.301TrpPro: 0.301 ± 0.018	0.405TrpGln: 0.405 ± 0.02	0.409TrpArg: 0.409 ± 0.019	0.672TrpSer: 0.672 ± 0.022	0.546TrpThr: 0.546 ± 0.024	0.644TrpVal: 0.644 ± 0.03	0.149TrpTrp: 0.149 ± 0.011	0.386TrpTyr: 0.386 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.126TyrAla: 2.126 ± 0.042	0.298TyrCys: 0.298 ± 0.018	1.972TyrAsp: 1.972 ± 0.047	2.636TyrGlu: 2.636 ± 0.05	1.922TyrPhe: 1.922 ± 0.04	2.514TyrGly: 2.514 ± 0.046	0.805TyrHis: 0.805 ± 0.025	2.784TyrIle: 2.784 ± 0.059	2.088TyrLys: 2.088 ± 0.044	3.562TyrLeu: 3.562 ± 0.055	0.943TyrMet: 0.943 ± 0.028	1.529TyrAsn: 1.529 ± 0.038	1.413TyrPro: 1.413 ± 0.041	1.51TyrGln: 1.51 ± 0.03	1.557TyrArg: 1.557 ± 0.037	2.198TyrSer: 2.198 ± 0.043	1.843TyrThr: 1.843 ± 0.045	2.106TyrVal: 2.106 ± 0.038	0.413TyrTrp: 0.413 ± 0.018	1.473TyrTyr: 1.473 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4072 proteins (1216744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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