Amino acid dipepetide frequency for Mycoplasma haemocanis (strain Illinois)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.325AlaAla: 3.325 ± 0.125
0.809AlaCys: 0.809 ± 0.055
2.023AlaAsp: 2.023 ± 0.078
2.509AlaGlu: 2.509 ± 0.099
2.231AlaPhe: 2.231 ± 0.09
4.081AlaGly: 4.081 ± 0.136
0.588AlaHis: 0.588 ± 0.048
3.434AlaIle: 3.434 ± 0.112
4.75AlaLys: 4.75 ± 0.127
5.545AlaLeu: 5.545 ± 0.148
0.869AlaMet: 0.869 ± 0.053
2.368AlaAsn: 2.368 ± 0.092
1.358AlaPro: 1.358 ± 0.06
1.161AlaGln: 1.161 ± 0.066
1.499AlaArg: 1.499 ± 0.074
4.768AlaSer: 4.768 ± 0.138
2.769AlaThr: 2.769 ± 0.109
2.783AlaVal: 2.783 ± 0.099
1.509AlaTrp: 1.509 ± 0.086
2.03AlaTyr: 2.03 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.651CysAla: 0.651 ± 0.052
0.144CysCys: 0.144 ± 0.029
0.651CysAsp: 0.651 ± 0.046
1.207CysGlu: 1.207 ± 0.064
0.556CysPhe: 0.556 ± 0.047
0.584CysGly: 0.584 ± 0.036
0.127CysHis: 0.127 ± 0.018
0.749CysIle: 0.749 ± 0.052
1.668CysLys: 1.668 ± 0.071
1.277CysLeu: 1.277 ± 0.071
0.099CysMet: 0.099 ± 0.019
0.574CysAsn: 0.574 ± 0.05
0.201CysPro: 0.201 ± 0.028
0.324CysGln: 0.324 ± 0.035
0.535CysArg: 0.535 ± 0.043
1.861CysSer: 1.861 ± 0.087
2.013CysThr: 2.013 ± 0.093
1.358CysVal: 1.358 ± 0.066
0.056CysTrp: 0.056 ± 0.014
0.239CysTyr: 0.239 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.015AspAla: 3.015 ± 0.105
0.348AspCys: 0.348 ± 0.037
3.424AspAsp: 3.424 ± 0.116
3.958AspGlu: 3.958 ± 0.127
3.142AspPhe: 3.142 ± 0.11
2.945AspGly: 2.945 ± 0.108
0.841AspHis: 0.841 ± 0.05
3.694AspIle: 3.694 ± 0.108
6.108AspLys: 6.108 ± 0.154
6.281AspLeu: 6.281 ± 0.148
0.728AspMet: 0.728 ± 0.05
3.248AspAsn: 3.248 ± 0.114
1.777AspPro: 1.777 ± 0.079
1.706AspGln: 1.706 ± 0.079
1.794AspArg: 1.794 ± 0.078
6.488AspSer: 6.488 ± 0.145
2.987AspThr: 2.987 ± 0.096
2.776AspVal: 2.776 ± 0.096
1.633AspTrp: 1.633 ± 0.089
2.266AspTyr: 2.266 ± 0.103
0.0AspXaa: 0.0 ± 0.0
Glu
3.92GluAla: 3.92 ± 0.121
0.697GluCys: 0.697 ± 0.05
5.228GluAsp: 5.228 ± 0.144
6.696GluGlu: 6.696 ± 0.179
3.272GluPhe: 3.272 ± 0.129
4.352GluGly: 4.352 ± 0.127
0.999GluHis: 0.999 ± 0.056
4.982GluIle: 4.982 ± 0.159
8.1GluLys: 8.1 ± 0.184
5.901GluLeu: 5.901 ± 0.148
1.049GluMet: 1.049 ± 0.064
4.595GluAsn: 4.595 ± 0.137
1.024GluPro: 1.024 ± 0.06
1.939GluGln: 1.939 ± 0.091
2.41GluArg: 2.41 ± 0.097
6.178GluSer: 6.178 ± 0.158
3.336GluThr: 3.336 ± 0.113
3.751GluVal: 3.751 ± 0.131
1.738GluTrp: 1.738 ± 0.081
2.4GluTyr: 2.4 ± 0.094
0.0GluXaa: 0.0 ± 0.0
Phe
1.587PheAla: 1.587 ± 0.075
0.992PheCys: 0.992 ± 0.056
2.157PheAsp: 2.157 ± 0.097
2.829PheGlu: 2.829 ± 0.1
2.196PhePhe: 2.196 ± 0.112
2.083PheGly: 2.083 ± 0.107
0.735PheHis: 0.735 ± 0.05
2.635PheIle: 2.635 ± 0.106
5.63PheLys: 5.63 ± 0.153
5.214PheLeu: 5.214 ± 0.161
0.88PheMet: 0.88 ± 0.06
2.336PheAsn: 2.336 ± 0.115
1.186PhePro: 1.186 ± 0.067
1.277PheGln: 1.277 ± 0.062
1.977PheArg: 1.977 ± 0.086
4.592PheSer: 4.592 ± 0.133
1.861PheThr: 1.861 ± 0.085
2.336PheVal: 2.336 ± 0.099
0.686PheTrp: 0.686 ± 0.054
1.439PheTyr: 1.439 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.955GlyAla: 3.955 ± 0.126
0.837GlyCys: 0.837 ± 0.055
3.705GlyAsp: 3.705 ± 0.122
3.61GlyGlu: 3.61 ± 0.114
2.671GlyPhe: 2.671 ± 0.105
5.918GlyGly: 5.918 ± 0.152
0.644GlyHis: 0.644 ± 0.058
4.922GlyIle: 4.922 ± 0.133
5.32GlyLys: 5.32 ± 0.143
4.785GlyLeu: 4.785 ± 0.11
0.876GlyMet: 0.876 ± 0.056
3.008GlyAsn: 3.008 ± 0.09
0.809GlyPro: 0.809 ± 0.055
1.267GlyGln: 1.267 ± 0.071
1.65GlyArg: 1.65 ± 0.077
5.316GlySer: 5.316 ± 0.138
3.891GlyThr: 3.891 ± 0.132
4.666GlyVal: 4.666 ± 0.138
1.017GlyTrp: 1.017 ± 0.064
2.157GlyTyr: 2.157 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.644HisAla: 0.644 ± 0.044
0.144HisCys: 0.144 ± 0.022
0.799HisAsp: 0.799 ± 0.059
0.89HisGlu: 0.89 ± 0.064
0.665HisPhe: 0.665 ± 0.05
0.728HisGly: 0.728 ± 0.044
0.285HisHis: 0.285 ± 0.026
0.961HisIle: 0.961 ± 0.054
1.608HisLys: 1.608 ± 0.076
1.559HisLeu: 1.559 ± 0.065
0.222HisMet: 0.222 ± 0.027
0.771HisAsn: 0.771 ± 0.055
0.637HisPro: 0.637 ± 0.047
0.45HisGln: 0.45 ± 0.041
0.556HisArg: 0.556 ± 0.045
1.369HisSer: 1.369 ± 0.067
0.644HisThr: 0.644 ± 0.046
0.584HisVal: 0.584 ± 0.041
0.419HisTrp: 0.419 ± 0.036
0.514HisTyr: 0.514 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
3.311IleAla: 3.311 ± 0.123
0.658IleCys: 0.658 ± 0.046
3.198IleAsp: 3.198 ± 0.119
3.877IleGlu: 3.877 ± 0.145
3.374IlePhe: 3.374 ± 0.134
4.124IleGly: 4.124 ± 0.104
1.094IleHis: 1.094 ± 0.065
3.237IleIle: 3.237 ± 0.147
7.016IleLys: 7.016 ± 0.154
5.506IleLeu: 5.506 ± 0.174
0.901IleMet: 0.901 ± 0.062
3.462IleAsn: 3.462 ± 0.113
2.561IlePro: 2.561 ± 0.104
1.956IleGln: 1.956 ± 0.094
2.248IleArg: 2.248 ± 0.098
7.378IleSer: 7.378 ± 0.175
3.163IleThr: 3.163 ± 0.111
2.882IleVal: 2.882 ± 0.125
0.908IleTrp: 0.908 ± 0.06
2.456IleTyr: 2.456 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.823LysAla: 5.823 ± 0.179
1.224LysCys: 1.224 ± 0.065
8.423LysAsp: 8.423 ± 0.178
9.817LysGlu: 9.817 ± 0.197
4.032LysPhe: 4.032 ± 0.134
5.651LysGly: 5.651 ± 0.14
1.692LysHis: 1.692 ± 0.08
6.062LysIle: 6.062 ± 0.16
10.098LysLys: 10.098 ± 0.211
9.12LysLeu: 9.12 ± 0.179
1.706LysMet: 1.706 ± 0.072
7.104LysAsn: 7.104 ± 0.142
2.558LysPro: 2.558 ± 0.109
2.829LysGln: 2.829 ± 0.108
3.958LysArg: 3.958 ± 0.117
8.853LysSer: 8.853 ± 0.17
6.323LysThr: 6.323 ± 0.171
5.767LysVal: 5.767 ± 0.17
2.688LysTrp: 2.688 ± 0.112
4.37LysTyr: 4.37 ± 0.129
0.0LysXaa: 0.0 ± 0.0
Leu
4.651LeuAla: 4.651 ± 0.113
0.799LeuCys: 0.799 ± 0.056
5.19LeuAsp: 5.19 ± 0.162
6.562LeuGlu: 6.562 ± 0.166
4.06LeuPhe: 4.06 ± 0.16
5.883LeuGly: 5.883 ± 0.145
1.228LeuHis: 1.228 ± 0.072
6.77LeuIle: 6.77 ± 0.171
11.196LeuLys: 11.196 ± 0.228
9.233LeuLeu: 9.233 ± 0.216
1.326LeuMet: 1.326 ± 0.077
5.352LeuAsn: 5.352 ± 0.147
2.424LeuPro: 2.424 ± 0.103
2.287LeuGln: 2.287 ± 0.09
3.427LeuArg: 3.427 ± 0.129
9.036LeuSer: 9.036 ± 0.199
4.694LeuThr: 4.694 ± 0.123
5.415LeuVal: 5.415 ± 0.142
0.992LeuTrp: 0.992 ± 0.059
2.713LeuTyr: 2.713 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
0.968MetAla: 0.968 ± 0.061
0.179MetCys: 0.179 ± 0.025
0.841MetAsp: 0.841 ± 0.051
1.027MetGlu: 1.027 ± 0.059
0.549MetPhe: 0.549 ± 0.045
1.017MetGly: 1.017 ± 0.058
0.232MetHis: 0.232 ± 0.028
0.76MetIle: 0.76 ± 0.052
1.471MetLys: 1.471 ± 0.067
0.848MetLeu: 0.848 ± 0.057
0.243MetMet: 0.243 ± 0.031
1.242MetAsn: 1.242 ± 0.06
0.559MetPro: 0.559 ± 0.047
0.38MetGln: 0.38 ± 0.041
0.496MetArg: 0.496 ± 0.044
1.833MetSer: 1.833 ± 0.074
0.778MetThr: 0.778 ± 0.047
0.841MetVal: 0.841 ± 0.059
0.179MetTrp: 0.179 ± 0.025
0.405MetTyr: 0.405 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
2.741AsnAla: 2.741 ± 0.112
0.317AsnCys: 0.317 ± 0.034
2.79AsnAsp: 2.79 ± 0.098
3.596AsnGlu: 3.596 ± 0.108
2.561AsnPhe: 2.561 ± 0.098
2.98AsnGly: 2.98 ± 0.1
0.806AsnHis: 0.806 ± 0.047
3.592AsnIle: 3.592 ± 0.125
6.84AsnLys: 6.84 ± 0.154
5.436AsnLeu: 5.436 ± 0.145
0.813AsnMet: 0.813 ± 0.056
3.473AsnAsn: 3.473 ± 0.13
2.217AsnPro: 2.217 ± 0.088
1.696AsnGln: 1.696 ± 0.067
2.002AsnArg: 2.002 ± 0.085
5.637AsnSer: 5.637 ± 0.157
3.047AsnThr: 3.047 ± 0.11
2.695AsnVal: 2.695 ± 0.096
1.274AsnTrp: 1.274 ± 0.064
2.593AsnTyr: 2.593 ± 0.093
0.0AsnXaa: 0.0 ± 0.0
Pro
1.133ProAla: 1.133 ± 0.065
0.127ProCys: 0.127 ± 0.024
1.576ProAsp: 1.576 ± 0.077
2.386ProGlu: 2.386 ± 0.097
1.4ProPhe: 1.4 ± 0.074
0.767ProGly: 0.767 ± 0.056
0.45ProHis: 0.45 ± 0.047
2.108ProIle: 2.108 ± 0.1
3.142ProLys: 3.142 ± 0.117
2.262ProLeu: 2.262 ± 0.083
0.359ProMet: 0.359 ± 0.037
1.601ProAsn: 1.601 ± 0.071
0.665ProPro: 0.665 ± 0.055
0.837ProGln: 0.837 ± 0.057
0.795ProArg: 0.795 ± 0.053
2.414ProSer: 2.414 ± 0.098
1.611ProThr: 1.611 ± 0.077
1.464ProVal: 1.464 ± 0.067
0.373ProTrp: 0.373 ± 0.038
0.827ProTyr: 0.827 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.288GlnAla: 1.288 ± 0.059
0.151GlnCys: 0.151 ± 0.023
1.977GlnAsp: 1.977 ± 0.085
2.949GlnGlu: 2.949 ± 0.113
0.894GlnPhe: 0.894 ± 0.064
1.509GlnGly: 1.509 ± 0.081
0.419GlnHis: 0.419 ± 0.04
1.671GlnIle: 1.671 ± 0.085
2.899GlnLys: 2.899 ± 0.106
2.421GlnLeu: 2.421 ± 0.095
0.64GlnMet: 0.64 ± 0.051
1.717GlnAsn: 1.717 ± 0.077
0.647GlnPro: 0.647 ± 0.048
0.936GlnGln: 0.936 ± 0.072
0.918GlnArg: 0.918 ± 0.063
2.298GlnSer: 2.298 ± 0.095
1.418GlnThr: 1.418 ± 0.072
1.291GlnVal: 1.291 ± 0.072
0.69GlnTrp: 0.69 ± 0.046
0.957GlnTyr: 0.957 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
1.509ArgAla: 1.509 ± 0.079
0.566ArgCys: 0.566 ± 0.04
2.516ArgAsp: 2.516 ± 0.091
2.998ArgGlu: 2.998 ± 0.126
1.538ArgPhe: 1.538 ± 0.069
1.492ArgGly: 1.492 ± 0.082
0.493ArgHis: 0.493 ± 0.041
2.512ArgIle: 2.512 ± 0.111
3.297ArgLys: 3.297 ± 0.113
3.1ArgLeu: 3.1 ± 0.111
0.581ArgMet: 0.581 ± 0.04
2.354ArgAsn: 2.354 ± 0.098
0.795ArgPro: 0.795 ± 0.059
0.946ArgGln: 0.946 ± 0.06
1.443ArgArg: 1.443 ± 0.078
2.34ArgSer: 2.34 ± 0.091
1.717ArgThr: 1.717 ± 0.077
1.78ArgVal: 1.78 ± 0.084
0.792ArgTrp: 0.792 ± 0.046
1.527ArgTyr: 1.527 ± 0.089
0.0ArgXaa: 0.0 ± 0.0
Ser
3.923SerAla: 3.923 ± 0.126
0.616SerCys: 0.616 ± 0.055
6.129SerAsp: 6.129 ± 0.154
7.093SerGlu: 7.093 ± 0.13
4.307SerPhe: 4.307 ± 0.154
6.228SerGly: 6.228 ± 0.167
1.735SerHis: 1.735 ± 0.075
5.763SerIle: 5.763 ± 0.142
10.809SerLys: 10.809 ± 0.236
9.31SerLeu: 9.31 ± 0.185
1.492SerMet: 1.492 ± 0.069
5.798SerAsn: 5.798 ± 0.154
2.269SerPro: 2.269 ± 0.092
3.174SerGln: 3.174 ± 0.109
2.941SerArg: 2.941 ± 0.11
11.002SerSer: 11.002 ± 0.372
4.912SerThr: 4.912 ± 0.157
4.419SerVal: 4.419 ± 0.134
1.692SerTrp: 1.692 ± 0.079
3.216SerTyr: 3.216 ± 0.101
0.0SerXaa: 0.0 ± 0.0
Thr
2.818ThrAla: 2.818 ± 0.111
0.289ThrCys: 0.289 ± 0.035
2.839ThrAsp: 2.839 ± 0.1
3.075ThrGlu: 3.075 ± 0.097
2.196ThrPhe: 2.196 ± 0.095
3.61ThrGly: 3.61 ± 0.101
0.89ThrHis: 0.89 ± 0.054
3.55ThrIle: 3.55 ± 0.114
5.313ThrLys: 5.313 ± 0.164
5.172ThrLeu: 5.172 ± 0.138
0.76ThrMet: 0.76 ± 0.046
2.692ThrAsn: 2.692 ± 0.08
1.78ThrPro: 1.78 ± 0.069
1.615ThrGln: 1.615 ± 0.084
1.819ThrArg: 1.819 ± 0.088
5.528ThrSer: 5.528 ± 0.162
3.146ThrThr: 3.146 ± 0.118
3.033ThrVal: 3.033 ± 0.103
1.056ThrTrp: 1.056 ± 0.068
1.851ThrTyr: 1.851 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
3.416ValAla: 3.416 ± 0.122
0.471ValCys: 0.471 ± 0.039
2.839ValAsp: 2.839 ± 0.116
3.416ValGlu: 3.416 ± 0.11
2.604ValPhe: 2.604 ± 0.101
4.708ValGly: 4.708 ± 0.149
0.637ValHis: 0.637 ± 0.048
3.149ValIle: 3.149 ± 0.14
5.257ValLys: 5.257 ± 0.141
5.021ValLeu: 5.021 ± 0.122
0.725ValMet: 0.725 ± 0.052
2.692ValAsn: 2.692 ± 0.113
1.661ValPro: 1.661 ± 0.073
1.136ValGln: 1.136 ± 0.059
1.58ValArg: 1.58 ± 0.078
5.506ValSer: 5.506 ± 0.153
2.544ValThr: 2.544 ± 0.092
3.48ValVal: 3.48 ± 0.134
0.788ValTrp: 0.788 ± 0.051
1.893ValTyr: 1.893 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.521TrpAla: 0.521 ± 0.047
3.842TrpCys: 3.842 ± 0.17
1.158TrpAsp: 1.158 ± 0.064
1.418TrpGlu: 1.418 ± 0.073
0.443TrpPhe: 0.443 ± 0.036
0.792TrpGly: 0.792 ± 0.053
0.113TrpHis: 0.113 ± 0.02
0.978TrpIle: 0.978 ± 0.06
3.065TrpLys: 3.065 ± 0.149
0.742TrpLeu: 0.742 ± 0.053
0.186TrpMet: 0.186 ± 0.027
1.506TrpAsn: 1.506 ± 0.078
0.176TrpPro: 0.176 ± 0.024
0.63TrpGln: 0.63 ± 0.051
0.454TrpArg: 0.454 ± 0.038
1.119TrpSer: 1.119 ± 0.063
0.999TrpThr: 0.999 ± 0.066
0.57TrpVal: 0.57 ± 0.04
0.148TrpTrp: 0.148 ± 0.021
0.38TrpTyr: 0.38 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.21TyrAla: 1.21 ± 0.069
1.661TyrCys: 1.661 ± 0.081
1.696TyrAsp: 1.696 ± 0.072
2.653TyrGlu: 2.653 ± 0.086
1.939TyrPhe: 1.939 ± 0.102
1.573TyrGly: 1.573 ± 0.072
0.44TyrHis: 0.44 ± 0.038
1.78TyrIle: 1.78 ± 0.086
4.514TyrLys: 4.514 ± 0.139
4.504TyrLeu: 4.504 ± 0.124
0.391TyrMet: 0.391 ± 0.041
1.214TyrAsn: 1.214 ± 0.069
0.992TyrPro: 0.992 ± 0.051
1.144TyrGln: 1.144 ± 0.061
1.794TyrArg: 1.794 ± 0.088
3.314TyrSer: 3.314 ± 0.123
1.179TyrThr: 1.179 ± 0.074
1.633TyrVal: 1.633 ± 0.083
0.602TyrTrp: 0.602 ± 0.041
1.154TyrTyr: 1.154 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1175 proteins (284213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski