Amino acid dipepetide frequency for Pseudoarcobacter caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.5AlaAla: 3.5 ± 0.103
0.627AlaCys: 0.627 ± 0.033
2.735AlaAsp: 2.735 ± 0.077
2.274AlaGlu: 2.274 ± 0.068
3.041AlaPhe: 3.041 ± 0.075
3.687AlaGly: 3.687 ± 0.157
0.97AlaHis: 0.97 ± 0.033
6.001AlaIle: 6.001 ± 0.094
5.358AlaLys: 5.358 ± 0.091
6.244AlaLeu: 6.244 ± 0.104
1.643AlaMet: 1.643 ± 0.053
3.653AlaAsn: 3.653 ± 0.091
1.392AlaPro: 1.392 ± 0.046
1.812AlaGln: 1.812 ± 0.047
1.726AlaArg: 1.726 ± 0.059
4.042AlaSer: 4.042 ± 0.082
3.271AlaThr: 3.271 ± 0.085
3.582AlaVal: 3.582 ± 0.086
0.395AlaTrp: 0.395 ± 0.026
2.168AlaTyr: 2.168 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.512CysAla: 0.512 ± 0.028
0.109CysCys: 0.109 ± 0.013
0.657CysAsp: 0.657 ± 0.033
0.698CysGlu: 0.698 ± 0.035
0.374CysPhe: 0.374 ± 0.022
0.724CysGly: 0.724 ± 0.03
0.244CysHis: 0.244 ± 0.023
0.704CysIle: 0.704 ± 0.035
0.763CysLys: 0.763 ± 0.036
0.63CysLeu: 0.63 ± 0.031
0.182CysMet: 0.182 ± 0.017
0.488CysAsn: 0.488 ± 0.026
0.395CysPro: 0.395 ± 0.027
0.256CysGln: 0.256 ± 0.017
0.226CysArg: 0.226 ± 0.019
0.687CysSer: 0.687 ± 0.037
0.45CysThr: 0.45 ± 0.025
0.543CysVal: 0.543 ± 0.03
0.056CysTrp: 0.056 ± 0.008
0.303CysTyr: 0.303 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.072AspAla: 3.072 ± 0.079
0.523AspCys: 0.523 ± 0.032
3.116AspAsp: 3.116 ± 0.09
5.159AspGlu: 5.159 ± 0.086
3.732AspPhe: 3.732 ± 0.072
3.34AspGly: 3.34 ± 0.121
0.527AspHis: 0.527 ± 0.03
6.211AspIle: 6.211 ± 0.091
5.269AspLys: 5.269 ± 0.094
5.559AspLeu: 5.559 ± 0.085
1.303AspMet: 1.303 ± 0.045
3.251AspAsn: 3.251 ± 0.081
1.049AspPro: 1.049 ± 0.042
0.808AspGln: 0.808 ± 0.039
1.458AspArg: 1.458 ± 0.045
3.345AspSer: 3.345 ± 0.065
2.978AspThr: 2.978 ± 0.239
3.299AspVal: 3.299 ± 0.069
0.369AspTrp: 0.369 ± 0.02
2.529AspTyr: 2.529 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
3.987GluAla: 3.987 ± 0.089
0.476GluCys: 0.476 ± 0.031
4.002GluAsp: 4.002 ± 0.081
5.607GluGlu: 5.607 ± 0.12
3.78GluPhe: 3.78 ± 0.075
2.596GluGly: 2.596 ± 0.065
1.106GluHis: 1.106 ± 0.04
7.448GluIle: 7.448 ± 0.123
7.739GluLys: 7.739 ± 0.124
7.561GluLeu: 7.561 ± 0.121
1.514GluMet: 1.514 ± 0.05
5.913GluAsn: 5.913 ± 0.103
1.425GluPro: 1.425 ± 0.043
2.231GluGln: 2.231 ± 0.061
1.701GluArg: 1.701 ± 0.048
3.378GluSer: 3.378 ± 0.066
2.992GluThr: 2.992 ± 0.056
4.249GluVal: 4.249 ± 0.082
0.421GluTrp: 0.421 ± 0.025
2.846GluTyr: 2.846 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.156PheAla: 3.156 ± 0.072
0.586PheCys: 0.586 ± 0.029
3.64PheAsp: 3.64 ± 0.075
4.145PheGlu: 4.145 ± 0.084
2.925PhePhe: 2.925 ± 0.077
3.149PheGly: 3.149 ± 0.074
0.694PheHis: 0.694 ± 0.03
5.224PheIle: 5.224 ± 0.109
4.248PheLys: 4.248 ± 0.076
5.194PheLeu: 5.194 ± 0.109
1.19PheMet: 1.19 ± 0.038
3.092PheAsn: 3.092 ± 0.067
1.272PhePro: 1.272 ± 0.044
1.186PheGln: 1.186 ± 0.038
1.343PheArg: 1.343 ± 0.04
3.855PheSer: 3.855 ± 0.08
2.665PheThr: 2.665 ± 0.061
3.057PheVal: 3.057 ± 0.076
0.441PheTrp: 0.441 ± 0.026
2.192PheTyr: 2.192 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
3.653GlyAla: 3.653 ± 0.134
0.629GlyCys: 0.629 ± 0.036
2.617GlyAsp: 2.617 ± 0.134
3.105GlyGlu: 3.105 ± 0.064
3.31GlyPhe: 3.31 ± 0.075
3.685GlyGly: 3.685 ± 0.246
0.964GlyHis: 0.964 ± 0.04
5.218GlyIle: 5.218 ± 0.1
4.365GlyLys: 4.365 ± 0.082
4.893GlyLeu: 4.893 ± 0.083
1.404GlyMet: 1.404 ± 0.039
2.966GlyAsn: 2.966 ± 0.217
0.848GlyPro: 0.848 ± 0.037
1.328GlyGln: 1.328 ± 0.049
1.648GlyArg: 1.648 ± 0.051
3.376GlySer: 3.376 ± 0.16
3.065GlyThr: 3.065 ± 0.154
3.782GlyVal: 3.782 ± 0.083
0.44GlyTrp: 0.44 ± 0.021
2.384GlyTyr: 2.384 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
0.773HisAla: 0.773 ± 0.034
0.168HisCys: 0.168 ± 0.017
0.775HisAsp: 0.775 ± 0.035
0.969HisGlu: 0.969 ± 0.034
0.83HisPhe: 0.83 ± 0.033
0.911HisGly: 0.911 ± 0.039
0.354HisHis: 0.354 ± 0.022
1.488HisIle: 1.488 ± 0.055
1.327HisLys: 1.327 ± 0.043
1.509HisLeu: 1.509 ± 0.052
0.373HisMet: 0.373 ± 0.025
0.914HisAsn: 0.914 ± 0.037
0.742HisPro: 0.742 ± 0.037
0.54HisGln: 0.54 ± 0.027
0.504HisArg: 0.504 ± 0.027
0.98HisSer: 0.98 ± 0.039
0.832HisThr: 0.832 ± 0.035
0.604HisVal: 0.604 ± 0.029
0.135HisTrp: 0.135 ± 0.015
0.586HisTyr: 0.586 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.147IleAla: 6.147 ± 0.104
0.875IleCys: 0.875 ± 0.036
6.238IleAsp: 6.238 ± 0.097
7.344IleGlu: 7.344 ± 0.103
5.283IlePhe: 5.283 ± 0.097
5.366IleGly: 5.366 ± 0.111
1.363IleHis: 1.363 ± 0.039
9.03IleIle: 9.03 ± 0.144
9.528IleLys: 9.528 ± 0.134
9.421IleLeu: 9.421 ± 0.15
1.849IleMet: 1.849 ± 0.055
6.674IleAsn: 6.674 ± 0.113
2.909IlePro: 2.909 ± 0.067
2.56IleGln: 2.56 ± 0.053
2.377IleArg: 2.377 ± 0.059
7.422IleSer: 7.422 ± 0.116
4.988IleThr: 4.988 ± 0.078
5.564IleVal: 5.564 ± 0.096
0.537IleTrp: 0.537 ± 0.03
3.518IleTyr: 3.518 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
5.108LysAla: 5.108 ± 0.095
0.557LysCys: 0.557 ± 0.029
6.344LysAsp: 6.344 ± 0.108
8.913LysGlu: 8.913 ± 0.146
3.606LysPhe: 3.606 ± 0.08
3.74LysGly: 3.74 ± 0.075
1.299LysHis: 1.299 ± 0.046
9.346LysIle: 9.346 ± 0.132
8.79LysLys: 8.79 ± 0.154
8.015LysLeu: 8.015 ± 0.114
2.253LysMet: 2.253 ± 0.059
7.608LysAsn: 7.608 ± 0.126
2.329LysPro: 2.329 ± 0.054
2.79LysGln: 2.79 ± 0.065
2.866LysArg: 2.866 ± 0.062
5.397LysSer: 5.397 ± 0.12
4.826LysThr: 4.826 ± 0.081
5.158LysVal: 5.158 ± 0.085
0.512LysTrp: 0.512 ± 0.027
4.026LysTyr: 4.026 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
5.592LeuAla: 5.592 ± 0.09
0.862LeuCys: 0.862 ± 0.04
5.669LeuAsp: 5.669 ± 0.091
7.547LeuGlu: 7.547 ± 0.13
5.226LeuPhe: 5.226 ± 0.118
5.301LeuGly: 5.301 ± 0.107
1.395LeuHis: 1.395 ± 0.051
8.514LeuIle: 8.514 ± 0.118
9.574LeuLys: 9.574 ± 0.125
8.968LeuLeu: 8.968 ± 0.151
2.084LeuMet: 2.084 ± 0.054
6.804LeuAsn: 6.804 ± 0.121
2.923LeuPro: 2.923 ± 0.065
2.743LeuGln: 2.743 ± 0.066
2.694LeuArg: 2.694 ± 0.06
6.91LeuSer: 6.91 ± 0.099
4.891LeuThr: 4.891 ± 0.082
5.348LeuVal: 5.348 ± 0.102
0.643LeuTrp: 0.643 ± 0.037
3.297LeuTyr: 3.297 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.595MetAla: 1.595 ± 0.045
0.176MetCys: 0.176 ± 0.017
1.075MetAsp: 1.075 ± 0.039
1.324MetGlu: 1.324 ± 0.043
1.155MetPhe: 1.155 ± 0.041
1.391MetGly: 1.391 ± 0.052
0.36MetHis: 0.36 ± 0.02
2.276MetIle: 2.276 ± 0.074
2.127MetLys: 2.127 ± 0.051
2.089MetLeu: 2.089 ± 0.059
0.631MetMet: 0.631 ± 0.035
1.549MetAsn: 1.549 ± 0.045
0.87MetPro: 0.87 ± 0.033
0.879MetGln: 0.879 ± 0.038
0.645MetArg: 0.645 ± 0.03
1.556MetSer: 1.556 ± 0.05
1.09MetThr: 1.09 ± 0.033
1.226MetVal: 1.226 ± 0.041
0.149MetTrp: 0.149 ± 0.015
0.714MetTyr: 0.714 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.468AsnAla: 3.468 ± 0.07
0.575AsnCys: 0.575 ± 0.03
3.754AsnAsp: 3.754 ± 0.147
5.238AsnGlu: 5.238 ± 0.109
3.329AsnPhe: 3.329 ± 0.072
3.09AsnGly: 3.09 ± 0.084
1.061AsnHis: 1.061 ± 0.039
7.832AsnIle: 7.832 ± 0.131
6.276AsnLys: 6.276 ± 0.106
6.465AsnLeu: 6.465 ± 0.108
1.43AsnMet: 1.43 ± 0.047
4.359AsnAsn: 4.359 ± 0.105
2.223AsnPro: 2.223 ± 0.061
2.095AsnGln: 2.095 ± 0.056
1.855AsnArg: 1.855 ± 0.06
4.602AsnSer: 4.602 ± 0.083
3.327AsnThr: 3.327 ± 0.114
3.009AsnVal: 3.009 ± 0.077
0.426AsnTrp: 0.426 ± 0.024
2.657AsnTyr: 2.657 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
1.362ProAla: 1.362 ± 0.048
0.224ProCys: 0.224 ± 0.018
1.291ProAsp: 1.291 ± 0.041
1.628ProGlu: 1.628 ± 0.051
1.575ProPhe: 1.575 ± 0.045
1.053ProGly: 1.053 ± 0.039
0.508ProHis: 0.508 ± 0.026
2.719ProIle: 2.719 ± 0.069
2.506ProLys: 2.506 ± 0.055
2.7ProLeu: 2.7 ± 0.061
0.599ProMet: 0.599 ± 0.028
1.844ProAsn: 1.844 ± 0.051
0.525ProPro: 0.525 ± 0.029
0.797ProGln: 0.797 ± 0.03
0.694ProArg: 0.694 ± 0.035
1.737ProSer: 1.737 ± 0.042
1.654ProThr: 1.654 ± 0.048
1.565ProVal: 1.565 ± 0.049
0.243ProTrp: 0.243 ± 0.018
1.269ProTyr: 1.269 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.493GlnAla: 1.493 ± 0.048
0.169GlnCys: 0.169 ± 0.015
1.386GlnAsp: 1.386 ± 0.043
2.202GlnGlu: 2.202 ± 0.064
1.148GlnPhe: 1.148 ± 0.044
1.313GlnGly: 1.313 ± 0.039
0.338GlnHis: 0.338 ± 0.021
2.975GlnIle: 2.975 ± 0.068
3.058GlnLys: 3.058 ± 0.073
2.446GlnLeu: 2.446 ± 0.064
0.717GlnMet: 0.717 ± 0.032
2.405GlnAsn: 2.405 ± 0.066
0.602GlnPro: 0.602 ± 0.028
0.775GlnGln: 0.775 ± 0.032
1.056GlnArg: 1.056 ± 0.038
1.647GlnSer: 1.647 ± 0.05
1.733GlnThr: 1.733 ± 0.043
1.538GlnVal: 1.538 ± 0.046
0.22GlnTrp: 0.22 ± 0.02
0.931GlnTyr: 0.931 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
1.697ArgAla: 1.697 ± 0.047
0.244ArgCys: 0.244 ± 0.021
1.62ArgAsp: 1.62 ± 0.052
1.978ArgGlu: 1.978 ± 0.06
1.631ArgPhe: 1.631 ± 0.044
1.465ArgGly: 1.465 ± 0.05
0.504ArgHis: 0.504 ± 0.025
2.672ArgIle: 2.672 ± 0.071
2.249ArgLys: 2.249 ± 0.064
2.577ArgLeu: 2.577 ± 0.072
0.706ArgMet: 0.706 ± 0.033
1.738ArgAsn: 1.738 ± 0.051
0.749ArgPro: 0.749 ± 0.031
0.682ArgGln: 0.682 ± 0.031
0.982ArgArg: 0.982 ± 0.042
1.363ArgSer: 1.363 ± 0.051
1.386ArgThr: 1.386 ± 0.045
1.999ArgVal: 1.999 ± 0.054
0.23ArgTrp: 0.23 ± 0.018
1.226ArgTyr: 1.226 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
3.463SerAla: 3.463 ± 0.078
0.687SerCys: 0.687 ± 0.037
3.203SerAsp: 3.203 ± 0.078
3.283SerGlu: 3.283 ± 0.07
4.091SerPhe: 4.091 ± 0.082
3.921SerGly: 3.921 ± 0.15
1.091SerHis: 1.091 ± 0.04
6.509SerIle: 6.509 ± 0.109
6.278SerLys: 6.278 ± 0.106
6.816SerLeu: 6.816 ± 0.109
1.613SerMet: 1.613 ± 0.056
4.417SerAsn: 4.417 ± 0.091
1.457SerPro: 1.457 ± 0.049
2.049SerGln: 2.049 ± 0.059
1.853SerArg: 1.853 ± 0.051
5.222SerSer: 5.222 ± 0.115
3.38SerThr: 3.38 ± 0.087
3.5SerVal: 3.5 ± 0.075
0.564SerTrp: 0.564 ± 0.031
2.723SerTyr: 2.723 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.25ThrAla: 3.25 ± 0.091
0.403ThrCys: 0.403 ± 0.029
2.42ThrAsp: 2.42 ± 0.07
2.034ThrGlu: 2.034 ± 0.057
2.648ThrPhe: 2.648 ± 0.065
2.983ThrGly: 2.983 ± 0.114
0.911ThrHis: 0.911 ± 0.033
5.343ThrIle: 5.343 ± 0.139
4.855ThrLys: 4.855 ± 0.094
5.528ThrLeu: 5.528 ± 0.129
1.081ThrMet: 1.081 ± 0.037
3.401ThrAsn: 3.401 ± 0.082
1.927ThrPro: 1.927 ± 0.051
1.859ThrGln: 1.859 ± 0.053
1.305ThrArg: 1.305 ± 0.044
3.479ThrSer: 3.479 ± 0.083
3.203ThrThr: 3.203 ± 0.081
2.869ThrVal: 2.869 ± 0.098
0.312ThrTrp: 0.312 ± 0.02
1.935ThrTyr: 1.935 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
3.798ValAla: 3.798 ± 0.094
0.651ValCys: 0.651 ± 0.034
3.571ValAsp: 3.571 ± 0.068
3.928ValGlu: 3.928 ± 0.08
2.742ValPhe: 2.742 ± 0.059
3.488ValGly: 3.488 ± 0.083
0.846ValHis: 0.846 ± 0.037
5.437ValIle: 5.437 ± 0.094
4.757ValLys: 4.757 ± 0.089
5.511ValLeu: 5.511 ± 0.102
1.289ValMet: 1.289 ± 0.049
3.279ValAsn: 3.279 ± 0.086
1.568ValPro: 1.568 ± 0.049
1.479ValGln: 1.479 ± 0.044
1.471ValArg: 1.471 ± 0.048
3.967ValSer: 3.967 ± 0.072
2.837ValThr: 2.837 ± 0.084
3.809ValVal: 3.809 ± 0.077
0.426ValTrp: 0.426 ± 0.025
2.117ValTyr: 2.117 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.429TrpAla: 0.429 ± 0.022
0.072TrpCys: 0.072 ± 0.01
0.355TrpAsp: 0.355 ± 0.022
0.49TrpGlu: 0.49 ± 0.027
0.399TrpPhe: 0.399 ± 0.024
0.432TrpGly: 0.432 ± 0.024
0.138TrpHis: 0.138 ± 0.014
0.687TrpIle: 0.687 ± 0.028
0.496TrpLys: 0.496 ± 0.028
0.717TrpLeu: 0.717 ± 0.035
0.225TrpMet: 0.225 ± 0.019
0.436TrpAsn: 0.436 ± 0.027
0.122TrpPro: 0.122 ± 0.013
0.277TrpGln: 0.277 ± 0.022
0.214TrpArg: 0.214 ± 0.016
0.371TrpSer: 0.371 ± 0.025
0.275TrpThr: 0.275 ± 0.02
0.425TrpVal: 0.425 ± 0.024
0.079TrpTrp: 0.079 ± 0.011
0.285TrpTyr: 0.285 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.068TyrAla: 2.068 ± 0.054
0.389TyrCys: 0.389 ± 0.023
2.431TyrAsp: 2.431 ± 0.061
3.104TyrGlu: 3.104 ± 0.074
2.428TyrPhe: 2.428 ± 0.06
2.044TyrGly: 2.044 ± 0.072
0.641TyrHis: 0.641 ± 0.029
3.36TyrIle: 3.36 ± 0.073
3.921TyrLys: 3.921 ± 0.086
4.144TyrLeu: 4.144 ± 0.085
0.787TyrMet: 0.787 ± 0.034
2.281TyrAsn: 2.281 ± 0.063
1.165TyrPro: 1.165 ± 0.043
1.005TyrGln: 1.005 ± 0.033
1.079TyrArg: 1.079 ± 0.037
2.787TyrSer: 2.787 ± 0.073
1.906TyrThr: 1.906 ± 0.064
1.844TyrVal: 1.844 ± 0.055
0.327TyrTrp: 0.327 ± 0.021
1.537TyrTyr: 1.537 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2336 proteins (746209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski