Amino acid dipepetide frequency for Anaerotruncus sp. AF02-27

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.805AlaAla: 11.805 ± 0.155	1.671AlaCys: 1.671 ± 0.043	5.489AlaAsp: 5.489 ± 0.08	5.967AlaGlu: 5.967 ± 0.087	3.723AlaPhe: 3.723 ± 0.057	7.689AlaGly: 7.689 ± 0.095	1.53AlaHis: 1.53 ± 0.035	5.374AlaIle: 5.374 ± 0.091	5.097AlaLys: 5.097 ± 0.067	9.13AlaLeu: 9.13 ± 0.102	2.719AlaMet: 2.719 ± 0.046	2.793AlaAsn: 2.793 ± 0.057	3.536AlaPro: 3.536 ± 0.072	3.845AlaGln: 3.845 ± 0.066	4.631AlaArg: 4.631 ± 0.071	4.762AlaSer: 4.762 ± 0.066	3.599AlaThr: 3.599 ± 0.07	7.968AlaVal: 7.968 ± 0.102	0.774AlaTrp: 0.774 ± 0.029	2.863AlaTyr: 2.863 ± 0.047	0.001AlaXaa: 0.001 ± 0.001
Cys	1.649CysAla: 1.649 ± 0.044	0.357CysCys: 0.357 ± 0.018	0.97CysAsp: 0.97 ± 0.033	1.098CysGlu: 1.098 ± 0.032	0.677CysPhe: 0.677 ± 0.024	1.984CysGly: 1.984 ± 0.042	0.298CysHis: 0.298 ± 0.015	1.005CysIle: 1.005 ± 0.035	0.819CysLys: 0.819 ± 0.026	1.218CysLeu: 1.218 ± 0.033	0.439CysMet: 0.439 ± 0.023	0.495CysAsn: 0.495 ± 0.022	0.853CysPro: 0.853 ± 0.029	0.379CysGln: 0.379 ± 0.019	0.967CysArg: 0.967 ± 0.032	0.845CysSer: 0.845 ± 0.03	0.822CysThr: 0.822 ± 0.025	1.068CysVal: 1.068 ± 0.034	0.136CysTrp: 0.136 ± 0.012	0.527CysTyr: 0.527 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.187AspAla: 5.187 ± 0.077	0.904AspCys: 0.904 ± 0.031	2.954AspAsp: 2.954 ± 0.099	4.146AspGlu: 4.146 ± 0.082	2.539AspPhe: 2.539 ± 0.06	4.86AspGly: 4.86 ± 0.073	0.881AspHis: 0.881 ± 0.03	3.675AspIle: 3.675 ± 0.055	2.69AspLys: 2.69 ± 0.061	5.138AspLeu: 5.138 ± 0.068	1.569AspMet: 1.569 ± 0.036	1.689AspAsn: 1.689 ± 0.043	2.648AspPro: 2.648 ± 0.052	1.404AspGln: 1.404 ± 0.039	3.0AspArg: 3.0 ± 0.054	2.81AspSer: 2.81 ± 0.05	2.863AspThr: 2.863 ± 0.052	3.551AspVal: 3.551 ± 0.062	0.546AspTrp: 0.546 ± 0.024	2.347AspTyr: 2.347 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.878GluAla: 5.878 ± 0.089	0.791GluCys: 0.791 ± 0.025	3.354GluAsp: 3.354 ± 0.07	4.921GluGlu: 4.921 ± 0.093	2.05GluPhe: 2.05 ± 0.046	4.078GluGly: 4.078 ± 0.069	1.222GluHis: 1.222 ± 0.034	4.976GluIle: 4.976 ± 0.071	5.001GluLys: 5.001 ± 0.083	6.582GluLeu: 6.582 ± 0.091	2.129GluMet: 2.129 ± 0.047	3.239GluAsn: 3.239 ± 0.057	2.266GluPro: 2.266 ± 0.054	2.988GluGln: 2.988 ± 0.068	4.062GluArg: 4.062 ± 0.065	3.22GluSer: 3.22 ± 0.062	3.615GluThr: 3.615 ± 0.065	3.944GluVal: 3.944 ± 0.066	0.59GluTrp: 0.59 ± 0.023	2.26GluTyr: 2.26 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.96PheAla: 3.96 ± 0.064	0.876PheCys: 0.876 ± 0.029	2.578PheAsp: 2.578 ± 0.055	2.415PheGlu: 2.415 ± 0.051	1.845PhePhe: 1.845 ± 0.049	3.34PheGly: 3.34 ± 0.062	0.729PheHis: 0.729 ± 0.023	2.392PheIle: 2.392 ± 0.056	1.586PheLys: 1.586 ± 0.044	4.025PheLeu: 4.025 ± 0.084	1.029PheMet: 1.029 ± 0.034	1.286PheAsn: 1.286 ± 0.033	1.61PhePro: 1.61 ± 0.035	1.131PheGln: 1.131 ± 0.033	1.671PheArg: 1.671 ± 0.04	3.013PheSer: 3.013 ± 0.058	2.474PheThr: 2.474 ± 0.055	2.71PheVal: 2.71 ± 0.053	0.41PheTrp: 0.41 ± 0.02	1.484PheTyr: 1.484 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.59GlyAla: 6.59 ± 0.087	1.516GlyCys: 1.516 ± 0.042	3.693GlyAsp: 3.693 ± 0.061	4.915GlyGlu: 4.915 ± 0.073	3.219GlyPhe: 3.219 ± 0.054	6.278GlyGly: 6.278 ± 0.108	1.358GlyHis: 1.358 ± 0.039	5.76GlyIle: 5.76 ± 0.096	4.864GlyLys: 4.864 ± 0.07	6.897GlyLeu: 6.897 ± 0.086	2.702GlyMet: 2.702 ± 0.056	2.623GlyAsn: 2.623 ± 0.051	1.786GlyPro: 1.786 ± 0.041	2.392GlyGln: 2.392 ± 0.048	4.234GlyArg: 4.234 ± 0.062	4.28GlySer: 4.28 ± 0.066	4.021GlyThr: 4.021 ± 0.065	6.006GlyVal: 6.006 ± 0.075	0.887GlyTrp: 0.887 ± 0.031	3.015GlyTyr: 3.015 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.436HisAla: 1.436 ± 0.037	0.366HisCys: 0.366 ± 0.018	0.884HisAsp: 0.884 ± 0.032	1.017HisGlu: 1.017 ± 0.033	0.8HisPhe: 0.8 ± 0.029	1.357HisGly: 1.357 ± 0.037	0.368HisHis: 0.368 ± 0.017	1.217HisIle: 1.217 ± 0.037	0.803HisLys: 0.803 ± 0.033	1.599HisLeu: 1.599 ± 0.037	0.487HisMet: 0.487 ± 0.022	0.684HisAsn: 0.684 ± 0.029	1.095HisPro: 1.095 ± 0.028	0.501HisGln: 0.501 ± 0.021	0.922HisArg: 0.922 ± 0.027	0.952HisSer: 0.952 ± 0.028	0.982HisThr: 0.982 ± 0.032	1.027HisVal: 1.027 ± 0.029	0.181HisTrp: 0.181 ± 0.012	0.633HisTyr: 0.633 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.185IleAla: 6.185 ± 0.077	1.201IleCys: 1.201 ± 0.032	3.932IleAsp: 3.932 ± 0.066	4.039IleGlu: 4.039 ± 0.073	2.558IlePhe: 2.558 ± 0.054	5.095IleGly: 5.095 ± 0.074	1.129IleHis: 1.129 ± 0.034	3.685IleIle: 3.685 ± 0.077	2.852IleLys: 2.852 ± 0.063	6.096IleLeu: 6.096 ± 0.092	1.586IleMet: 1.586 ± 0.043	2.143IleAsn: 2.143 ± 0.051	3.402IlePro: 3.402 ± 0.063	1.746IleGln: 1.746 ± 0.041	3.474IleArg: 3.474 ± 0.063	4.22IleSer: 4.22 ± 0.058	3.669IleThr: 3.669 ± 0.055	4.368IleVal: 4.368 ± 0.088	0.541IleTrp: 0.541 ± 0.022	2.095IleTyr: 2.095 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.878LysAla: 4.878 ± 0.086	0.601LysCys: 0.601 ± 0.023	2.647LysAsp: 2.647 ± 0.058	3.847LysGlu: 3.847 ± 0.073	1.604LysPhe: 1.604 ± 0.036	3.514LysGly: 3.514 ± 0.056	0.852LysHis: 0.852 ± 0.031	3.638LysIle: 3.638 ± 0.068	3.863LysLys: 3.863 ± 0.072	5.181LysLeu: 5.181 ± 0.078	1.702LysMet: 1.702 ± 0.04	2.32LysAsn: 2.32 ± 0.054	2.182LysPro: 2.182 ± 0.049	2.006LysGln: 2.006 ± 0.045	2.959LysArg: 2.959 ± 0.052	2.752LysSer: 2.752 ± 0.048	3.149LysThr: 3.149 ± 0.055	3.414LysVal: 3.414 ± 0.075	0.486LysTrp: 0.486 ± 0.02	1.892LysTyr: 1.892 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	9.131LeuAla: 9.131 ± 0.119	1.918LeuCys: 1.918 ± 0.046	5.183LeuAsp: 5.183 ± 0.067	5.987LeuGlu: 5.987 ± 0.085	4.143LeuPhe: 4.143 ± 0.078	6.894LeuGly: 6.894 ± 0.087	1.676LeuHis: 1.676 ± 0.041	5.655LeuIle: 5.655 ± 0.078	4.544LeuLys: 4.544 ± 0.066	9.889LeuLeu: 9.889 ± 0.159	2.806LeuMet: 2.806 ± 0.06	2.987LeuAsn: 2.987 ± 0.053	4.521LeuPro: 4.521 ± 0.069	2.881LeuGln: 2.881 ± 0.051	5.362LeuArg: 5.362 ± 0.084	6.877LeuSer: 6.877 ± 0.081	5.392LeuThr: 5.392 ± 0.071	5.955LeuVal: 5.955 ± 0.079	0.798LeuTrp: 0.798 ± 0.027	3.068LeuTyr: 3.068 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.701MetAla: 2.701 ± 0.057	0.356MetCys: 0.356 ± 0.019	1.705MetAsp: 1.705 ± 0.038	2.005MetGlu: 2.005 ± 0.043	0.965MetPhe: 0.965 ± 0.035	2.189MetGly: 2.189 ± 0.048	0.394MetHis: 0.394 ± 0.021	1.825MetIle: 1.825 ± 0.05	1.906MetLys: 1.906 ± 0.047	2.968MetLeu: 2.968 ± 0.06	0.865MetMet: 0.865 ± 0.031	1.238MetAsn: 1.238 ± 0.038	1.388MetPro: 1.388 ± 0.036	1.066MetGln: 1.066 ± 0.033	1.617MetArg: 1.617 ± 0.046	1.637MetSer: 1.637 ± 0.039	1.585MetThr: 1.585 ± 0.045	1.982MetVal: 1.982 ± 0.049	0.208MetTrp: 0.208 ± 0.015	0.687MetTyr: 0.687 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.252AsnAla: 3.252 ± 0.055	0.583AsnCys: 0.583 ± 0.025	1.69AsnAsp: 1.69 ± 0.046	2.04AsnGlu: 2.04 ± 0.05	1.391AsnPhe: 1.391 ± 0.037	2.94AsnGly: 2.94 ± 0.05	0.655AsnHis: 0.655 ± 0.024	2.392AsnIle: 2.392 ± 0.046	1.585AsnLys: 1.585 ± 0.042	3.514AsnLeu: 3.514 ± 0.063	0.966AsnMet: 0.966 ± 0.032	1.174AsnAsn: 1.174 ± 0.039	2.197AsnPro: 2.197 ± 0.047	1.105AsnGln: 1.105 ± 0.031	1.98AsnArg: 1.98 ± 0.046	1.738AsnSer: 1.738 ± 0.044	1.88AsnThr: 1.88 ± 0.044	2.305AsnVal: 2.305 ± 0.043	0.381AsnTrp: 0.381 ± 0.021	1.313AsnTyr: 1.313 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.348ProAla: 4.348 ± 0.071	0.563ProCys: 0.563 ± 0.025	3.032ProAsp: 3.032 ± 0.056	3.725ProGlu: 3.725 ± 0.065	1.83ProPhe: 1.83 ± 0.047	3.087ProGly: 3.087 ± 0.058	0.771ProHis: 0.771 ± 0.024	2.234ProIle: 2.234 ± 0.046	1.982ProLys: 1.982 ± 0.044	3.547ProLeu: 3.547 ± 0.057	1.13ProMet: 1.13 ± 0.036	1.378ProAsn: 1.378 ± 0.034	1.646ProPro: 1.646 ± 0.054	1.729ProGln: 1.729 ± 0.041	1.756ProArg: 1.756 ± 0.047	2.266ProSer: 2.266 ± 0.048	1.817ProThr: 1.817 ± 0.04	3.817ProVal: 3.817 ± 0.06	0.337ProTrp: 0.337 ± 0.017	1.457ProTyr: 1.457 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.242GlnAla: 3.242 ± 0.061	0.361GlnCys: 0.361 ± 0.018	1.513GlnAsp: 1.513 ± 0.041	2.386GlnGlu: 2.386 ± 0.059	1.242GlnPhe: 1.242 ± 0.034	1.986GlnGly: 1.986 ± 0.043	0.493GlnHis: 0.493 ± 0.021	2.316GlnIle: 2.316 ± 0.052	2.537GlnLys: 2.537 ± 0.057	3.098GlnLeu: 3.098 ± 0.064	1.227GlnMet: 1.227 ± 0.036	1.697GlnAsn: 1.697 ± 0.042	1.268GlnPro: 1.268 ± 0.036	1.377GlnGln: 1.377 ± 0.048	1.769GlnArg: 1.769 ± 0.047	1.755GlnSer: 1.755 ± 0.043	1.8GlnThr: 1.8 ± 0.038	2.193GlnVal: 2.193 ± 0.053	0.323GlnTrp: 0.323 ± 0.019	1.226GlnTyr: 1.226 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.471ArgAla: 4.471 ± 0.074	0.867ArgCys: 0.867 ± 0.028	2.866ArgAsp: 2.866 ± 0.053	4.636ArgGlu: 4.636 ± 0.072	2.362ArgPhe: 2.362 ± 0.049	3.465ArgGly: 3.465 ± 0.056	0.956ArgHis: 0.956 ± 0.033	3.678ArgIle: 3.678 ± 0.06	2.87ArgLys: 2.87 ± 0.063	5.224ArgLeu: 5.224 ± 0.076	1.895ArgMet: 1.895 ± 0.041	1.744ArgAsn: 1.744 ± 0.049	2.09ArgPro: 2.09 ± 0.046	2.221ArgGln: 2.221 ± 0.045	3.506ArgArg: 3.506 ± 0.071	2.593ArgSer: 2.593 ± 0.05	2.625ArgThr: 2.625 ± 0.05	3.454ArgVal: 3.454 ± 0.059	0.498ArgTrp: 0.498 ± 0.023	2.03ArgTyr: 2.03 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.266SerAla: 5.266 ± 0.079	0.95SerCys: 0.95 ± 0.03	3.254SerAsp: 3.254 ± 0.062	3.526SerGlu: 3.526 ± 0.066	2.602SerPhe: 2.602 ± 0.05	5.269SerGly: 5.269 ± 0.071	1.024SerHis: 1.024 ± 0.03	3.515SerIle: 3.515 ± 0.068	2.519SerLys: 2.519 ± 0.056	5.234SerLeu: 5.234 ± 0.085	1.584SerMet: 1.584 ± 0.04	1.76SerAsn: 1.76 ± 0.041	2.403SerPro: 2.403 ± 0.049	1.828SerGln: 1.828 ± 0.04	3.117SerArg: 3.117 ± 0.062	3.468SerSer: 3.468 ± 0.095	2.707SerThr: 2.707 ± 0.051	4.19SerVal: 4.19 ± 0.064	0.56SerTrp: 0.56 ± 0.027	2.016SerTyr: 2.016 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.43ThrAla: 5.43 ± 0.065	0.658ThrCys: 0.658 ± 0.023	2.943ThrAsp: 2.943 ± 0.054	3.154ThrGlu: 3.154 ± 0.059	2.08ThrPhe: 2.08 ± 0.048	4.835ThrGly: 4.835 ± 0.069	0.944ThrHis: 0.944 ± 0.035	3.372ThrIle: 3.372 ± 0.061	2.125ThrLys: 2.125 ± 0.052	5.152ThrLeu: 5.152 ± 0.072	1.376ThrMet: 1.376 ± 0.035	1.58ThrAsn: 1.58 ± 0.049	2.756ThrPro: 2.756 ± 0.049	1.472ThrGln: 1.472 ± 0.038	2.485ThrArg: 2.485 ± 0.048	2.565ThrSer: 2.565 ± 0.057	2.577ThrThr: 2.577 ± 0.054	4.668ThrVal: 4.668 ± 0.073	0.422ThrTrp: 0.422 ± 0.02	1.584ThrTyr: 1.584 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.909ValAla: 5.909 ± 0.079	1.327ValCys: 1.327 ± 0.035	3.906ValAsp: 3.906 ± 0.063	4.308ValGlu: 4.308 ± 0.069	2.995ValPhe: 2.995 ± 0.059	4.787ValGly: 4.787 ± 0.088	1.117ValHis: 1.117 ± 0.035	4.603ValIle: 4.603 ± 0.076	3.774ValLys: 3.774 ± 0.062	6.865ValLeu: 6.865 ± 0.084	2.028ValMet: 2.028 ± 0.047	2.52ValAsn: 2.52 ± 0.056	3.098ValPro: 3.098 ± 0.05	2.113ValGln: 2.113 ± 0.043	3.941ValArg: 3.941 ± 0.071	4.656ValSer: 4.656 ± 0.075	4.166ValThr: 4.166 ± 0.069	5.17ValVal: 5.17 ± 0.08	0.657ValTrp: 0.657 ± 0.027	2.428ValTyr: 2.428 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.676TrpAla: 0.676 ± 0.028	0.172TrpCys: 0.172 ± 0.012	0.547TrpAsp: 0.547 ± 0.022	0.661TrpGlu: 0.661 ± 0.025	0.413TrpPhe: 0.413 ± 0.019	0.649TrpGly: 0.649 ± 0.023	0.182TrpHis: 0.182 ± 0.013	0.593TrpIle: 0.593 ± 0.026	0.556TrpLys: 0.556 ± 0.023	0.927TrpLeu: 0.927 ± 0.033	0.296TrpMet: 0.296 ± 0.018	0.403TrpAsn: 0.403 ± 0.02	0.238TrpPro: 0.238 ± 0.016	0.406TrpGln: 0.406 ± 0.022	0.494TrpArg: 0.494 ± 0.023	0.45TrpSer: 0.45 ± 0.024	0.438TrpThr: 0.438 ± 0.02	0.577TrpVal: 0.577 ± 0.022	0.126TrpTrp: 0.126 ± 0.011	0.353TrpTyr: 0.353 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.971TyrAla: 2.971 ± 0.057	0.567TyrCys: 0.567 ± 0.023	2.26TyrAsp: 2.26 ± 0.048	2.378TyrGlu: 2.378 ± 0.052	1.529TyrPhe: 1.529 ± 0.034	2.741TyrGly: 2.741 ± 0.059	0.734TyrHis: 0.734 ± 0.026	2.111TyrIle: 2.111 ± 0.045	1.514TyrLys: 1.514 ± 0.044	3.38TyrLeu: 3.38 ± 0.057	0.752TyrMet: 0.752 ± 0.027	1.327TyrAsn: 1.327 ± 0.037	1.467TyrPro: 1.467 ± 0.039	1.217TyrGln: 1.217 ± 0.037	2.105TyrArg: 2.105 ± 0.053	1.934TyrSer: 1.934 ± 0.044	1.998TyrThr: 1.998 ± 0.047	2.003TyrVal: 2.003 ± 0.043	0.293TyrTrp: 0.293 ± 0.016	1.327TyrTyr: 1.327 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3622 proteins (1085505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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