Amino acid dipepetide frequency for Arcobacter butzleri (strain RM4018)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.214AlaAla: 3.214 ± 0.096	0.62AlaCys: 0.62 ± 0.033	2.519AlaAsp: 2.519 ± 0.061	2.314AlaGlu: 2.314 ± 0.07	2.989AlaPhe: 2.989 ± 0.073	3.471AlaGly: 3.471 ± 0.09	0.891AlaHis: 0.891 ± 0.038	6.096AlaIle: 6.096 ± 0.115	5.676AlaLys: 5.676 ± 0.094	6.162AlaLeu: 6.162 ± 0.121	1.66AlaMet: 1.66 ± 0.056	3.617AlaAsn: 3.617 ± 0.082	1.419AlaPro: 1.419 ± 0.048	1.884AlaGln: 1.884 ± 0.056	1.812AlaArg: 1.812 ± 0.05	3.998AlaSer: 3.998 ± 0.088	3.435AlaThr: 3.435 ± 0.082	3.561AlaVal: 3.561 ± 0.083	0.376AlaTrp: 0.376 ± 0.024	2.125AlaTyr: 2.125 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.522CysAla: 0.522 ± 0.032	0.12CysCys: 0.12 ± 0.013	0.581CysAsp: 0.581 ± 0.032	0.693CysGlu: 0.693 ± 0.033	0.394CysPhe: 0.394 ± 0.024	0.649CysGly: 0.649 ± 0.033	0.22CysHis: 0.22 ± 0.021	0.617CysIle: 0.617 ± 0.033	0.723CysLys: 0.723 ± 0.036	0.58CysLeu: 0.58 ± 0.032	0.163CysMet: 0.163 ± 0.015	0.427CysAsn: 0.427 ± 0.027	0.333CysPro: 0.333 ± 0.026	0.224CysGln: 0.224 ± 0.016	0.223CysArg: 0.223 ± 0.02	0.688CysSer: 0.688 ± 0.035	0.43CysThr: 0.43 ± 0.025	0.491CysVal: 0.491 ± 0.031	0.055CysTrp: 0.055 ± 0.008	0.303CysTyr: 0.303 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.926AspAla: 2.926 ± 0.065	0.495AspCys: 0.495 ± 0.027	3.019AspAsp: 3.019 ± 0.069	5.406AspGlu: 5.406 ± 0.102	3.739AspPhe: 3.739 ± 0.077	3.243AspGly: 3.243 ± 0.104	0.472AspHis: 0.472 ± 0.029	6.373AspIle: 6.373 ± 0.103	5.387AspLys: 5.387 ± 0.091	5.431AspLeu: 5.431 ± 0.088	1.302AspMet: 1.302 ± 0.039	3.251AspAsn: 3.251 ± 0.07	1.085AspPro: 1.085 ± 0.045	0.701AspGln: 0.701 ± 0.032	1.522AspArg: 1.522 ± 0.051	3.38AspSer: 3.38 ± 0.079	2.667AspThr: 2.667 ± 0.069	3.232AspVal: 3.232 ± 0.072	0.376AspTrp: 0.376 ± 0.023	2.486AspTyr: 2.486 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.259GluAla: 4.259 ± 0.088	0.459GluCys: 0.459 ± 0.03	4.1GluAsp: 4.1 ± 0.069	5.715GluGlu: 5.715 ± 0.11	3.832GluPhe: 3.832 ± 0.081	2.738GluGly: 2.738 ± 0.061	1.091GluHis: 1.091 ± 0.035	7.321GluIle: 7.321 ± 0.111	7.831GluLys: 7.831 ± 0.121	7.347GluLeu: 7.347 ± 0.106	1.4GluMet: 1.4 ± 0.055	6.043GluAsn: 6.043 ± 0.093	1.419GluPro: 1.419 ± 0.046	2.28GluGln: 2.28 ± 0.058	1.677GluArg: 1.677 ± 0.048	3.27GluSer: 3.27 ± 0.069	3.175GluThr: 3.175 ± 0.069	4.371GluVal: 4.371 ± 0.096	0.416GluTrp: 0.416 ± 0.026	2.763GluTyr: 2.763 ± 0.074	0.0GluXaa: 0.0 ± 0.0
Phe	3.183PheAla: 3.183 ± 0.084	0.564PheCys: 0.564 ± 0.031	3.692PheAsp: 3.692 ± 0.067	4.118PheGlu: 4.118 ± 0.082	3.233PhePhe: 3.233 ± 0.095	3.345PheGly: 3.345 ± 0.078	0.667PheHis: 0.667 ± 0.028	5.338PheIle: 5.338 ± 0.119	4.391PheLys: 4.391 ± 0.085	5.471PheLeu: 5.471 ± 0.133	1.226PheMet: 1.226 ± 0.046	2.908PheAsn: 2.908 ± 0.072	1.267PhePro: 1.267 ± 0.042	1.199PheGln: 1.199 ± 0.039	1.338PheArg: 1.338 ± 0.044	4.017PheSer: 4.017 ± 0.083	2.675PheThr: 2.675 ± 0.068	3.164PheVal: 3.164 ± 0.071	0.44PheTrp: 0.44 ± 0.025	2.191PheTyr: 2.191 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	3.511GlyAla: 3.511 ± 0.089	0.602GlyCys: 0.602 ± 0.036	2.646GlyAsp: 2.646 ± 0.082	3.262GlyGlu: 3.262 ± 0.078	3.305GlyPhe: 3.305 ± 0.077	3.517GlyGly: 3.517 ± 0.098	0.975GlyHis: 0.975 ± 0.039	5.092GlyIle: 5.092 ± 0.1	4.489GlyLys: 4.489 ± 0.087	4.849GlyLeu: 4.849 ± 0.1	1.331GlyMet: 1.331 ± 0.049	2.674GlyAsn: 2.674 ± 0.098	0.858GlyPro: 0.858 ± 0.04	1.429GlyGln: 1.429 ± 0.043	1.624GlyArg: 1.624 ± 0.045	3.23GlySer: 3.23 ± 0.078	3.049GlyThr: 3.049 ± 0.086	3.861GlyVal: 3.861 ± 0.089	0.462GlyTrp: 0.462 ± 0.031	2.428GlyTyr: 2.428 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.645HisAla: 0.645 ± 0.033	0.145HisCys: 0.145 ± 0.014	0.653HisAsp: 0.653 ± 0.029	0.829HisGlu: 0.829 ± 0.037	0.854HisPhe: 0.854 ± 0.034	0.86HisGly: 0.86 ± 0.038	0.324HisHis: 0.324 ± 0.023	1.455HisIle: 1.455 ± 0.041	1.223HisLys: 1.223 ± 0.04	1.403HisLeu: 1.403 ± 0.047	0.288HisMet: 0.288 ± 0.02	0.884HisAsn: 0.884 ± 0.041	0.671HisPro: 0.671 ± 0.039	0.497HisGln: 0.497 ± 0.031	0.498HisArg: 0.498 ± 0.028	0.985HisSer: 0.985 ± 0.033	0.83HisThr: 0.83 ± 0.036	0.537HisVal: 0.537 ± 0.024	0.131HisTrp: 0.131 ± 0.014	0.585HisTyr: 0.585 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.993IleAla: 5.993 ± 0.107	0.877IleCys: 0.877 ± 0.039	6.049IleAsp: 6.049 ± 0.092	7.379IleGlu: 7.379 ± 0.132	5.463IlePhe: 5.463 ± 0.123	5.168IleGly: 5.168 ± 0.107	1.259IleHis: 1.259 ± 0.041	8.335IleIle: 8.335 ± 0.145	9.412IleLys: 9.412 ± 0.125	9.552IleLeu: 9.552 ± 0.145	1.724IleMet: 1.724 ± 0.051	6.366IleAsn: 6.366 ± 0.113	2.895IlePro: 2.895 ± 0.063	2.252IleGln: 2.252 ± 0.057	2.314IleArg: 2.314 ± 0.068	7.303IleSer: 7.303 ± 0.101	4.932IleThr: 4.932 ± 0.094	5.841IleVal: 5.841 ± 0.103	0.506IleTrp: 0.506 ± 0.03	3.667IleTyr: 3.667 ± 0.09	0.0IleXaa: 0.0 ± 0.0
Lys	5.329LysAla: 5.329 ± 0.083	0.499LysCys: 0.499 ± 0.027	6.743LysAsp: 6.743 ± 0.116	9.108LysGlu: 9.108 ± 0.126	3.739LysPhe: 3.739 ± 0.076	3.837LysGly: 3.837 ± 0.066	1.195LysHis: 1.195 ± 0.039	9.356LysIle: 9.356 ± 0.141	9.025LysLys: 9.025 ± 0.133	8.187LysLeu: 8.187 ± 0.123	2.229LysMet: 2.229 ± 0.053	7.983LysAsn: 7.983 ± 0.133	2.273LysPro: 2.273 ± 0.061	2.775LysGln: 2.775 ± 0.071	2.829LysArg: 2.829 ± 0.073	5.431LysSer: 5.431 ± 0.095	4.856LysThr: 4.856 ± 0.081	5.309LysVal: 5.309 ± 0.1	0.491LysTrp: 0.491 ± 0.027	4.089LysTyr: 4.089 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	5.679LeuAla: 5.679 ± 0.103	0.746LeuCys: 0.746 ± 0.035	5.818LeuAsp: 5.818 ± 0.11	7.687LeuGlu: 7.687 ± 0.109	5.258LeuPhe: 5.258 ± 0.117	5.406LeuGly: 5.406 ± 0.09	1.321LeuHis: 1.321 ± 0.044	8.257LeuIle: 8.257 ± 0.14	9.967LeuLys: 9.967 ± 0.13	8.837LeuLeu: 8.837 ± 0.149	2.061LeuMet: 2.061 ± 0.059	6.957LeuAsn: 6.957 ± 0.126	2.941LeuPro: 2.941 ± 0.069	2.664LeuGln: 2.664 ± 0.063	2.514LeuArg: 2.514 ± 0.063	7.0LeuSer: 7.0 ± 0.119	4.868LeuThr: 4.868 ± 0.085	5.272LeuVal: 5.272 ± 0.112	0.613LeuTrp: 0.613 ± 0.036	3.457LeuTyr: 3.457 ± 0.085	0.0LeuXaa: 0.0 ± 0.0
Met	1.558MetAla: 1.558 ± 0.052	0.162MetCys: 0.162 ± 0.014	1.057MetAsp: 1.057 ± 0.041	1.194MetGlu: 1.194 ± 0.04	1.103MetPhe: 1.103 ± 0.041	1.287MetGly: 1.287 ± 0.047	0.307MetHis: 0.307 ± 0.019	2.251MetIle: 2.251 ± 0.062	2.226MetLys: 2.226 ± 0.05	2.045MetLeu: 2.045 ± 0.063	0.57MetMet: 0.57 ± 0.027	1.49MetAsn: 1.49 ± 0.049	0.822MetPro: 0.822 ± 0.036	0.83MetGln: 0.83 ± 0.037	0.585MetArg: 0.585 ± 0.026	1.572MetSer: 1.572 ± 0.047	1.024MetThr: 1.024 ± 0.042	1.188MetVal: 1.188 ± 0.045	0.136MetTrp: 0.136 ± 0.016	0.692MetTyr: 0.692 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.468AsnAla: 3.468 ± 0.082	0.522AsnCys: 0.522 ± 0.031	3.525AsnAsp: 3.525 ± 0.083	5.038AsnGlu: 5.038 ± 0.103	3.609AsnPhe: 3.609 ± 0.083	3.244AsnGly: 3.244 ± 0.089	0.964AsnHis: 0.964 ± 0.037	7.626AsnIle: 7.626 ± 0.14	6.055AsnLys: 6.055 ± 0.109	6.897AsnLeu: 6.897 ± 0.117	1.4AsnMet: 1.4 ± 0.045	4.151AsnAsn: 4.151 ± 0.108	2.258AsnPro: 2.258 ± 0.058	2.211AsnGln: 2.211 ± 0.062	1.84AsnArg: 1.84 ± 0.054	4.969AsnSer: 4.969 ± 0.107	2.883AsnThr: 2.883 ± 0.084	3.283AsnVal: 3.283 ± 0.078	0.437AsnTrp: 0.437 ± 0.027	2.747AsnTyr: 2.747 ± 0.073	0.0AsnXaa: 0.0 ± 0.0
Pro	1.354ProAla: 1.354 ± 0.05	0.228ProCys: 0.228 ± 0.019	1.292ProAsp: 1.292 ± 0.048	1.613ProGlu: 1.613 ± 0.054	1.601ProPhe: 1.601 ± 0.052	1.054ProGly: 1.054 ± 0.045	0.461ProHis: 0.461 ± 0.025	2.695ProIle: 2.695 ± 0.069	2.551ProLys: 2.551 ± 0.063	2.627ProLeu: 2.627 ± 0.066	0.598ProMet: 0.598 ± 0.03	1.833ProAsn: 1.833 ± 0.046	0.523ProPro: 0.523 ± 0.025	0.813ProGln: 0.813 ± 0.034	0.697ProArg: 0.697 ± 0.033	1.713ProSer: 1.713 ± 0.05	1.838ProThr: 1.838 ± 0.051	1.562ProVal: 1.562 ± 0.048	0.243ProTrp: 0.243 ± 0.021	1.219ProTyr: 1.219 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.602GlnAla: 1.602 ± 0.05	0.131GlnCys: 0.131 ± 0.013	1.469GlnAsp: 1.469 ± 0.05	2.159GlnGlu: 2.159 ± 0.06	1.085GlnPhe: 1.085 ± 0.033	1.329GlnGly: 1.329 ± 0.041	0.34GlnHis: 0.34 ± 0.021	2.823GlnIle: 2.823 ± 0.06	3.243GlnLys: 3.243 ± 0.077	2.259GlnLeu: 2.259 ± 0.054	0.739GlnMet: 0.739 ± 0.033	2.568GlnAsn: 2.568 ± 0.063	0.585GlnPro: 0.585 ± 0.031	0.809GlnGln: 0.809 ± 0.036	1.057GlnArg: 1.057 ± 0.038	1.567GlnSer: 1.567 ± 0.047	1.798GlnThr: 1.798 ± 0.065	1.515GlnVal: 1.515 ± 0.046	0.205GlnTrp: 0.205 ± 0.015	0.909GlnTyr: 0.909 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.764ArgAla: 1.764 ± 0.054	0.227ArgCys: 0.227 ± 0.019	1.541ArgAsp: 1.541 ± 0.052	1.973ArgGlu: 1.973 ± 0.053	1.585ArgPhe: 1.585 ± 0.05	1.408ArgGly: 1.408 ± 0.051	0.439ArgHis: 0.439 ± 0.025	2.404ArgIle: 2.404 ± 0.066	2.22ArgLys: 2.22 ± 0.064	2.58ArgLeu: 2.58 ± 0.072	0.73ArgMet: 0.73 ± 0.036	1.677ArgAsn: 1.677 ± 0.051	0.754ArgPro: 0.754 ± 0.036	0.697ArgGln: 0.697 ± 0.031	0.975ArgArg: 0.975 ± 0.041	1.329ArgSer: 1.329 ± 0.05	1.417ArgThr: 1.417 ± 0.049	2.18ArgVal: 2.18 ± 0.049	0.219ArgTrp: 0.219 ± 0.019	1.285ArgTyr: 1.285 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.471SerAla: 3.471 ± 0.081	0.631SerCys: 0.631 ± 0.035	3.02SerAsp: 3.02 ± 0.074	3.255SerGlu: 3.255 ± 0.07	4.257SerPhe: 4.257 ± 0.086	3.77SerGly: 3.77 ± 0.089	1.029SerHis: 1.029 ± 0.034	6.261SerIle: 6.261 ± 0.105	6.654SerLys: 6.654 ± 0.11	7.07SerLeu: 7.07 ± 0.109	1.529SerMet: 1.529 ± 0.049	4.584SerAsn: 4.584 ± 0.106	1.428SerPro: 1.428 ± 0.049	2.126SerGln: 2.126 ± 0.061	1.796SerArg: 1.796 ± 0.052	5.236SerSer: 5.236 ± 0.117	3.427SerThr: 3.427 ± 0.082	3.396SerVal: 3.396 ± 0.068	0.606SerTrp: 0.606 ± 0.027	2.865SerTyr: 2.865 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	3.072ThrAla: 3.072 ± 0.077	0.362ThrCys: 0.362 ± 0.026	2.285ThrAsp: 2.285 ± 0.074	2.15ThrGlu: 2.15 ± 0.061	2.706ThrPhe: 2.706 ± 0.069	2.859ThrGly: 2.859 ± 0.068	0.866ThrHis: 0.866 ± 0.036	5.51ThrIle: 5.51 ± 0.113	4.882ThrLys: 4.882 ± 0.088	5.399ThrLeu: 5.399 ± 0.088	0.993ThrMet: 0.993 ± 0.035	3.499ThrAsn: 3.499 ± 0.105	1.966ThrPro: 1.966 ± 0.055	1.897ThrGln: 1.897 ± 0.063	1.334ThrArg: 1.334 ± 0.045	3.514ThrSer: 3.514 ± 0.081	3.238ThrThr: 3.238 ± 0.1	2.861ThrVal: 2.861 ± 0.084	0.353ThrTrp: 0.353 ± 0.024	1.973ThrTyr: 1.973 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	3.884ValAla: 3.884 ± 0.09	0.629ValCys: 0.629 ± 0.029	3.666ValAsp: 3.666 ± 0.089	4.142ValGlu: 4.142 ± 0.083	2.769ValPhe: 2.769 ± 0.069	3.482ValGly: 3.482 ± 0.082	0.764ValHis: 0.764 ± 0.033	5.397ValIle: 5.397 ± 0.102	4.774ValLys: 4.774 ± 0.094	5.663ValLeu: 5.663 ± 0.097	1.166ValMet: 1.166 ± 0.04	3.404ValAsn: 3.404 ± 0.087	1.652ValPro: 1.652 ± 0.054	1.477ValGln: 1.477 ± 0.046	1.538ValArg: 1.538 ± 0.047	4.035ValSer: 4.035 ± 0.083	2.963ValThr: 2.963 ± 0.096	4.046ValVal: 4.046 ± 0.082	0.405ValTrp: 0.405 ± 0.023	2.02ValTyr: 2.02 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.445TrpAla: 0.445 ± 0.026	0.071TrpCys: 0.071 ± 0.01	0.379TrpAsp: 0.379 ± 0.024	0.429TrpGlu: 0.429 ± 0.027	0.391TrpPhe: 0.391 ± 0.029	0.432TrpGly: 0.432 ± 0.025	0.14TrpHis: 0.14 ± 0.014	0.632TrpIle: 0.632 ± 0.035	0.497TrpLys: 0.497 ± 0.026	0.746TrpLeu: 0.746 ± 0.038	0.217TrpMet: 0.217 ± 0.016	0.414TrpAsn: 0.414 ± 0.023	0.145TrpPro: 0.145 ± 0.017	0.282TrpGln: 0.282 ± 0.022	0.21TrpArg: 0.21 ± 0.018	0.38TrpSer: 0.38 ± 0.025	0.297TrpThr: 0.297 ± 0.019	0.394TrpVal: 0.394 ± 0.024	0.079TrpTrp: 0.079 ± 0.013	0.3TrpTyr: 0.3 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.962TyrAla: 1.962 ± 0.056	0.346TyrCys: 0.346 ± 0.022	2.436TyrAsp: 2.436 ± 0.054	3.043TyrGlu: 3.043 ± 0.069	2.516TyrPhe: 2.516 ± 0.073	2.094TyrGly: 2.094 ± 0.054	0.571TyrHis: 0.571 ± 0.03	3.447TyrIle: 3.447 ± 0.072	4.059TyrLys: 4.059 ± 0.076	4.219TyrLeu: 4.219 ± 0.087	0.769TyrMet: 0.769 ± 0.035	2.397TyrAsn: 2.397 ± 0.061	1.222TyrPro: 1.222 ± 0.041	1.144TyrGln: 1.144 ± 0.041	1.022TyrArg: 1.022 ± 0.045	2.793TyrSer: 2.793 ± 0.064	1.916TyrThr: 1.916 ± 0.06	1.815TyrVal: 1.815 ± 0.046	0.331TyrTrp: 0.331 ± 0.021	1.585TyrTyr: 1.585 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2254 proteins (722876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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