Amino acid dipepetide frequency for Archaeoglobus veneficus (strain DSM 11195 / SNP6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.696AlaAla: 6.696 ± 0.157
1.121AlaCys: 1.121 ± 0.05
3.505AlaAsp: 3.505 ± 0.084
6.92AlaGlu: 6.92 ± 0.115
3.34AlaPhe: 3.34 ± 0.1
5.984AlaGly: 5.984 ± 0.125
1.094AlaHis: 1.094 ± 0.045
6.815AlaIle: 6.815 ± 0.124
5.754AlaLys: 5.754 ± 0.097
7.655AlaLeu: 7.655 ± 0.141
2.395AlaMet: 2.395 ± 0.069
2.079AlaAsn: 2.079 ± 0.057
1.873AlaPro: 1.873 ± 0.07
1.175AlaGln: 1.175 ± 0.049
4.311AlaArg: 4.311 ± 0.091
4.028AlaSer: 4.028 ± 0.085
3.308AlaThr: 3.308 ± 0.088
7.212AlaVal: 7.212 ± 0.137
0.724AlaTrp: 0.724 ± 0.038
2.552AlaTyr: 2.552 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.713CysAla: 0.713 ± 0.032
0.208CysCys: 0.208 ± 0.02
0.589CysAsp: 0.589 ± 0.033
0.874CysGlu: 0.874 ± 0.043
0.412CysPhe: 0.412 ± 0.029
1.32CysGly: 1.32 ± 0.055
0.407CysHis: 0.407 ± 0.042
0.888CysIle: 0.888 ± 0.039
0.661CysLys: 0.661 ± 0.034
0.974CysLeu: 0.974 ± 0.042
0.364CysMet: 0.364 ± 0.024
0.462CysAsn: 0.462 ± 0.033
0.844CysPro: 0.844 ± 0.046
0.213CysGln: 0.213 ± 0.019
0.797CysArg: 0.797 ± 0.037
0.876CysSer: 0.876 ± 0.048
0.559CysThr: 0.559 ± 0.036
0.989CysVal: 0.989 ± 0.041
0.131CysTrp: 0.131 ± 0.015
0.473CysTyr: 0.473 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.078AspAla: 4.078 ± 0.08
0.691AspCys: 0.691 ± 0.037
2.328AspAsp: 2.328 ± 0.064
5.07AspGlu: 5.07 ± 0.091
2.733AspPhe: 2.733 ± 0.069
3.82AspGly: 3.82 ± 0.096
0.664AspHis: 0.664 ± 0.037
4.209AspIle: 4.209 ± 0.086
2.429AspLys: 2.429 ± 0.065
3.985AspLeu: 3.985 ± 0.084
1.277AspMet: 1.277 ± 0.049
1.232AspAsn: 1.232 ± 0.078
1.855AspPro: 1.855 ± 0.074
0.498AspGln: 0.498 ± 0.03
2.72AspArg: 2.72 ± 0.073
2.434AspSer: 2.434 ± 0.074
1.945AspThr: 1.945 ± 0.058
5.95AspVal: 5.95 ± 0.11
0.618AspTrp: 0.618 ± 0.039
2.027AspTyr: 2.027 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.785GluAla: 5.785 ± 0.107
0.917GluCys: 0.917 ± 0.051
4.166GluAsp: 4.166 ± 0.093
9.111GluGlu: 9.111 ± 0.167
3.551GluPhe: 3.551 ± 0.08
5.291GluGly: 5.291 ± 0.101
1.266GluHis: 1.266 ± 0.05
7.742GluIle: 7.742 ± 0.125
7.92GluLys: 7.92 ± 0.139
8.683GluLeu: 8.683 ± 0.161
2.28GluMet: 2.28 ± 0.072
3.122GluAsn: 3.122 ± 0.093
2.375GluPro: 2.375 ± 0.066
1.436GluGln: 1.436 ± 0.055
5.337GluArg: 5.337 ± 0.11
3.426GluSer: 3.426 ± 0.082
3.005GluThr: 3.005 ± 0.083
7.782GluVal: 7.782 ± 0.131
0.89GluTrp: 0.89 ± 0.049
2.876GluTyr: 2.876 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
3.482PheAla: 3.482 ± 0.091
0.57PheCys: 0.57 ± 0.035
2.411PheAsp: 2.411 ± 0.066
3.449PheGlu: 3.449 ± 0.089
1.947PhePhe: 1.947 ± 0.068
3.399PheGly: 3.399 ± 0.088
0.686PheHis: 0.686 ± 0.04
3.048PheIle: 3.048 ± 0.071
2.149PheLys: 2.149 ± 0.07
3.829PheLeu: 3.829 ± 0.095
1.001PheMet: 1.001 ± 0.046
1.325PheAsn: 1.325 ± 0.048
1.562PhePro: 1.562 ± 0.062
0.747PheGln: 0.747 ± 0.035
2.486PheArg: 2.486 ± 0.066
2.738PheSer: 2.738 ± 0.08
1.829PheThr: 1.829 ± 0.062
3.714PheVal: 3.714 ± 0.096
0.41PheTrp: 0.41 ± 0.03
1.524PheTyr: 1.524 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.366GlyAla: 4.366 ± 0.109
1.125GlyCys: 1.125 ± 0.051
3.571GlyAsp: 3.571 ± 0.077
5.842GlyGlu: 5.842 ± 0.106
3.331GlyPhe: 3.331 ± 0.069
4.888GlyGly: 4.888 ± 0.117
1.066GlyHis: 1.066 ± 0.047
6.397GlyIle: 6.397 ± 0.127
5.917GlyLys: 5.917 ± 0.106
6.272GlyLeu: 6.272 ± 0.127
2.24GlyMet: 2.24 ± 0.062
2.264GlyAsn: 2.264 ± 0.075
1.367GlyPro: 1.367 ± 0.057
1.032GlyGln: 1.032 ± 0.047
4.232GlyArg: 4.232 ± 0.103
3.806GlySer: 3.806 ± 0.118
2.898GlyThr: 2.898 ± 0.089
6.406GlyVal: 6.406 ± 0.114
0.845GlyTrp: 0.845 ± 0.046
3.02GlyTyr: 3.02 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.261HisAla: 1.261 ± 0.048
0.279HisCys: 0.279 ± 0.021
0.752HisAsp: 0.752 ± 0.032
1.109HisGlu: 1.109 ± 0.048
0.713HisPhe: 0.713 ± 0.033
1.27HisGly: 1.27 ± 0.045
0.383HisHis: 0.383 ± 0.029
1.178HisIle: 1.178 ± 0.044
0.734HisLys: 0.734 ± 0.04
1.458HisLeu: 1.458 ± 0.053
0.405HisMet: 0.405 ± 0.024
0.48HisAsn: 0.48 ± 0.031
1.119HisPro: 1.119 ± 0.044
0.261HisGln: 0.261 ± 0.021
1.007HisArg: 1.007 ± 0.046
0.915HisSer: 0.915 ± 0.041
0.718HisThr: 0.718 ± 0.041
1.361HisVal: 1.361 ± 0.048
0.193HisTrp: 0.193 ± 0.016
0.643HisTyr: 0.643 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
7.545IleAla: 7.545 ± 0.136
0.818IleCys: 0.818 ± 0.04
4.558IleAsp: 4.558 ± 0.103
6.994IleGlu: 6.994 ± 0.126
2.828IlePhe: 2.828 ± 0.076
5.181IleGly: 5.181 ± 0.12
1.289IleHis: 1.289 ± 0.053
4.995IleIle: 4.995 ± 0.114
4.929IleLys: 4.929 ± 0.097
6.967IleLeu: 6.967 ± 0.099
1.641IleMet: 1.641 ± 0.054
2.368IleAsn: 2.368 ± 0.074
3.596IlePro: 3.596 ± 0.088
1.359IleGln: 1.359 ± 0.052
3.983IleArg: 3.983 ± 0.078
4.716IleSer: 4.716 ± 0.092
3.772IleThr: 3.772 ± 0.112
6.716IleVal: 6.716 ± 0.127
0.577IleTrp: 0.577 ± 0.032
2.733IleTyr: 2.733 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
6.148LysAla: 6.148 ± 0.113
0.849LysCys: 0.849 ± 0.04
3.544LysAsp: 3.544 ± 0.085
6.564LysGlu: 6.564 ± 0.13
2.316LysPhe: 2.316 ± 0.066
4.682LysGly: 4.682 ± 0.098
1.22LysHis: 1.22 ± 0.051
5.403LysIle: 5.403 ± 0.109
5.615LysLys: 5.615 ± 0.132
6.786LysLeu: 6.786 ± 0.126
1.517LysMet: 1.517 ± 0.055
2.266LysAsn: 2.266 ± 0.065
3.057LysPro: 3.057 ± 0.077
1.399LysGln: 1.399 ± 0.05
3.992LysArg: 3.992 ± 0.095
3.057LysSer: 3.057 ± 0.082
3.02LysThr: 3.02 ± 0.083
5.557LysVal: 5.557 ± 0.119
0.668LysTrp: 0.668 ± 0.036
2.421LysTyr: 2.421 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
7.873LeuAla: 7.873 ± 0.129
1.044LeuCys: 1.044 ± 0.047
4.587LeuAsp: 4.587 ± 0.098
7.61LeuGlu: 7.61 ± 0.134
3.602LeuPhe: 3.602 ± 0.092
6.319LeuGly: 6.319 ± 0.112
1.401LeuHis: 1.401 ± 0.059
6.661LeuIle: 6.661 ± 0.119
7.45LeuLys: 7.45 ± 0.119
9.168LeuLeu: 9.168 ± 0.177
2.484LeuMet: 2.484 ± 0.07
3.34LeuAsn: 3.34 ± 0.073
3.913LeuPro: 3.913 ± 0.09
1.796LeuGln: 1.796 ± 0.064
5.77LeuArg: 5.77 ± 0.11
6.152LeuSer: 6.152 ± 0.119
4.232LeuThr: 4.232 ± 0.104
6.718LeuVal: 6.718 ± 0.114
0.802LeuTrp: 0.802 ± 0.034
2.9LeuTyr: 2.9 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.011MetAla: 2.011 ± 0.061
0.294MetCys: 0.294 ± 0.023
1.485MetAsp: 1.485 ± 0.053
2.122MetGlu: 2.122 ± 0.057
0.858MetPhe: 0.858 ± 0.039
1.82MetGly: 1.82 ± 0.062
0.544MetHis: 0.544 ± 0.038
1.467MetIle: 1.467 ± 0.059
2.036MetLys: 2.036 ± 0.061
2.826MetLeu: 2.826 ± 0.072
0.507MetMet: 0.507 ± 0.03
0.878MetAsn: 0.878 ± 0.045
1.168MetPro: 1.168 ± 0.048
0.602MetGln: 0.602 ± 0.032
1.676MetArg: 1.676 ± 0.051
1.343MetSer: 1.343 ± 0.053
0.912MetThr: 0.912 ± 0.038
1.714MetVal: 1.714 ± 0.069
0.184MetTrp: 0.184 ± 0.018
0.75MetTyr: 0.75 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.968AsnAla: 2.968 ± 0.071
0.43AsnCys: 0.43 ± 0.03
1.37AsnAsp: 1.37 ± 0.055
2.271AsnGlu: 2.271 ± 0.064
1.415AsnPhe: 1.415 ± 0.058
2.423AsnGly: 2.423 ± 0.088
0.419AsnHis: 0.419 ± 0.029
2.357AsnIle: 2.357 ± 0.088
1.424AsnLys: 1.424 ± 0.056
3.227AsnLeu: 3.227 ± 0.078
0.715AsnMet: 0.715 ± 0.037
0.917AsnAsn: 0.917 ± 0.096
2.16AsnPro: 2.16 ± 0.068
0.496AsnGln: 0.496 ± 0.031
1.655AsnArg: 1.655 ± 0.057
1.705AsnSer: 1.705 ± 0.088
1.438AsnThr: 1.438 ± 0.066
3.202AsnVal: 3.202 ± 0.082
0.39AsnTrp: 0.39 ± 0.027
1.238AsnTyr: 1.238 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.706ProAla: 2.706 ± 0.076
0.458ProCys: 0.458 ± 0.032
2.303ProAsp: 2.303 ± 0.06
4.014ProGlu: 4.014 ± 0.086
1.804ProPhe: 1.804 ± 0.053
2.525ProGly: 2.525 ± 0.069
0.872ProHis: 0.872 ± 0.04
2.341ProIle: 2.341 ± 0.07
2.461ProLys: 2.461 ± 0.066
3.381ProLeu: 3.381 ± 0.083
0.788ProMet: 0.788 ± 0.039
1.248ProAsn: 1.248 ± 0.05
1.83ProPro: 1.83 ± 0.064
0.827ProGln: 0.827 ± 0.039
1.603ProArg: 1.603 ± 0.055
2.292ProSer: 2.292 ± 0.065
1.762ProThr: 1.762 ± 0.068
3.512ProVal: 3.512 ± 0.082
0.401ProTrp: 0.401 ± 0.026
1.587ProTyr: 1.587 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.388GlnAla: 1.388 ± 0.053
0.215GlnCys: 0.215 ± 0.021
0.768GlnAsp: 0.768 ± 0.036
1.248GlnGlu: 1.248 ± 0.052
0.657GlnPhe: 0.657 ± 0.032
0.917GlnGly: 0.917 ± 0.042
0.342GlnHis: 0.342 ± 0.025
1.546GlnIle: 1.546 ± 0.06
1.368GlnLys: 1.368 ± 0.054
1.707GlnLeu: 1.707 ± 0.058
0.516GlnMet: 0.516 ± 0.029
0.729GlnAsn: 0.729 ± 0.042
0.749GlnPro: 0.749 ± 0.034
0.552GlnGln: 0.552 ± 0.035
1.119GlnArg: 1.119 ± 0.049
0.833GlnSer: 0.833 ± 0.043
0.84GlnThr: 0.84 ± 0.038
1.148GlnVal: 1.148 ± 0.041
0.199GlnTrp: 0.199 ± 0.018
0.639GlnTyr: 0.639 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.836ArgAla: 3.836 ± 0.087
0.79ArgCys: 0.79 ± 0.042
2.896ArgAsp: 2.896 ± 0.075
4.927ArgGlu: 4.927 ± 0.126
2.509ArgPhe: 2.509 ± 0.073
3.84ArgGly: 3.84 ± 0.087
0.887ArgHis: 0.887 ± 0.041
5.217ArgIle: 5.217 ± 0.105
4.956ArgLys: 4.956 ± 0.088
5.511ArgLeu: 5.511 ± 0.103
1.501ArgMet: 1.501 ± 0.044
2.065ArgAsn: 2.065 ± 0.066
1.623ArgPro: 1.623 ± 0.056
1.209ArgGln: 1.209 ± 0.051
4.062ArgArg: 4.062 ± 0.104
2.412ArgSer: 2.412 ± 0.068
2.214ArgThr: 2.214 ± 0.057
4.529ArgVal: 4.529 ± 0.102
0.53ArgTrp: 0.53 ± 0.036
2.011ArgTyr: 2.011 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.756SerAla: 3.756 ± 0.098
0.616SerCys: 0.616 ± 0.037
2.706SerAsp: 2.706 ± 0.07
4.237SerGlu: 4.237 ± 0.083
2.486SerPhe: 2.486 ± 0.065
4.574SerGly: 4.574 ± 0.109
0.822SerHis: 0.822 ± 0.039
4.22SerIle: 4.22 ± 0.103
3.483SerLys: 3.483 ± 0.081
4.984SerLeu: 4.984 ± 0.103
1.411SerMet: 1.411 ± 0.052
1.739SerAsn: 1.739 ± 0.115
2.266SerPro: 2.266 ± 0.07
0.955SerGln: 0.955 ± 0.044
3.097SerArg: 3.097 ± 0.084
3.322SerSer: 3.322 ± 0.125
2.566SerThr: 2.566 ± 0.087
4.25SerVal: 4.25 ± 0.094
0.476SerTrp: 0.476 ± 0.03
2.063SerTyr: 2.063 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
3.729ThrAla: 3.729 ± 0.082
0.514ThrCys: 0.514 ± 0.031
1.934ThrAsp: 1.934 ± 0.064
2.64ThrGlu: 2.64 ± 0.07
2.052ThrPhe: 2.052 ± 0.065
3.657ThrGly: 3.657 ± 0.083
0.835ThrHis: 0.835 ± 0.03
3.496ThrIle: 3.496 ± 0.091
2.316ThrLys: 2.316 ± 0.071
4.336ThrLeu: 4.336 ± 0.091
0.892ThrMet: 0.892 ± 0.042
1.413ThrAsn: 1.413 ± 0.08
2.55ThrPro: 2.55 ± 0.074
0.763ThrGln: 0.763 ± 0.038
1.956ThrArg: 1.956 ± 0.058
2.491ThrSer: 2.491 ± 0.068
2.509ThrThr: 2.509 ± 0.094
3.501ThrVal: 3.501 ± 0.115
0.374ThrTrp: 0.374 ± 0.029
1.538ThrTyr: 1.538 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
6.7ValAla: 6.7 ± 0.124
1.15ValCys: 1.15 ± 0.042
4.649ValAsp: 4.649 ± 0.098
8.579ValGlu: 8.579 ± 0.135
3.636ValPhe: 3.636 ± 0.09
5.489ValGly: 5.489 ± 0.116
1.257ValHis: 1.257 ± 0.049
6.503ValIle: 6.503 ± 0.108
6.048ValLys: 6.048 ± 0.134
7.681ValLeu: 7.681 ± 0.143
2.149ValMet: 2.149 ± 0.073
2.661ValAsn: 2.661 ± 0.065
3.009ValPro: 3.009 ± 0.069
1.288ValGln: 1.288 ± 0.043
4.952ValArg: 4.952 ± 0.101
4.893ValSer: 4.893 ± 0.117
3.854ValThr: 3.854 ± 0.098
8.115ValVal: 8.115 ± 0.138
0.759ValTrp: 0.759 ± 0.034
2.803ValTyr: 2.803 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.647TrpAla: 0.647 ± 0.036
0.113TrpCys: 0.113 ± 0.014
0.53TrpAsp: 0.53 ± 0.035
0.738TrpGlu: 0.738 ± 0.04
0.45TrpPhe: 0.45 ± 0.033
0.63TrpGly: 0.63 ± 0.036
0.156TrpHis: 0.156 ± 0.018
0.734TrpIle: 0.734 ± 0.038
0.831TrpLys: 0.831 ± 0.042
1.11TrpLeu: 1.11 ± 0.048
0.31TrpMet: 0.31 ± 0.026
0.405TrpAsn: 0.405 ± 0.028
0.202TrpPro: 0.202 ± 0.02
0.244TrpGln: 0.244 ± 0.023
0.596TrpArg: 0.596 ± 0.033
0.471TrpSer: 0.471 ± 0.028
0.362TrpThr: 0.362 ± 0.025
0.761TrpVal: 0.761 ± 0.031
0.184TrpTrp: 0.184 ± 0.02
0.333TrpTyr: 0.333 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.853TyrAla: 2.853 ± 0.085
0.55TyrCys: 0.55 ± 0.032
1.913TyrAsp: 1.913 ± 0.058
2.642TyrGlu: 2.642 ± 0.072
1.667TyrPhe: 1.667 ± 0.057
2.857TyrGly: 2.857 ± 0.071
0.63TyrHis: 0.63 ± 0.03
2.348TyrIle: 2.348 ± 0.063
1.599TyrLys: 1.599 ± 0.06
3.281TyrLeu: 3.281 ± 0.08
0.804TyrMet: 0.804 ± 0.041
1.227TyrAsn: 1.227 ± 0.058
1.599TyrPro: 1.599 ± 0.049
0.629TyrGln: 0.629 ± 0.031
2.172TyrArg: 2.172 ± 0.061
2.119TyrSer: 2.119 ± 0.059
1.755TyrThr: 1.755 ± 0.054
3.037TyrVal: 3.037 ± 0.072
0.45TyrTrp: 0.45 ± 0.029
1.504TyrTyr: 1.504 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2065 proteins (558359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski