Amino acid dipepetide frequency for Ophiocordyceps unilateralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.975AlaAla: 11.975 ± 0.084	1.245AlaCys: 1.245 ± 0.021	5.412AlaAsp: 5.412 ± 0.036	5.586AlaGlu: 5.586 ± 0.051	3.057AlaPhe: 3.057 ± 0.033	6.607AlaGly: 6.607 ± 0.047	2.018AlaHis: 2.018 ± 0.023	3.759AlaIle: 3.759 ± 0.033	4.059AlaLys: 4.059 ± 0.042	8.439AlaLeu: 8.439 ± 0.053	2.297AlaMet: 2.297 ± 0.028	2.727AlaAsn: 2.727 ± 0.029	5.377AlaPro: 5.377 ± 0.057	3.555AlaGln: 3.555 ± 0.039	6.36AlaArg: 6.36 ± 0.047	8.494AlaSer: 8.494 ± 0.071	5.497AlaThr: 5.497 ± 0.037	6.547AlaVal: 6.547 ± 0.047	1.254AlaTrp: 1.254 ± 0.019	2.028AlaTyr: 2.028 ± 0.025	0.001AlaXaa: 0.001 ± 0.001
Cys	1.074CysAla: 1.074 ± 0.019	0.294CysCys: 0.294 ± 0.009	0.705CysAsp: 0.705 ± 0.014	0.639CysGlu: 0.639 ± 0.012	0.571CysPhe: 0.571 ± 0.012	1.03CysGly: 1.03 ± 0.02	0.415CysHis: 0.415 ± 0.013	0.613CysIle: 0.613 ± 0.014	0.493CysLys: 0.493 ± 0.013	1.442CysLeu: 1.442 ± 0.022	0.271CysMet: 0.271 ± 0.008	0.416CysAsn: 0.416 ± 0.012	0.802CysPro: 0.802 ± 0.016	0.497CysGln: 0.497 ± 0.012	1.04CysArg: 1.04 ± 0.017	1.02CysSer: 1.02 ± 0.018	0.614CysThr: 0.614 ± 0.013	0.916CysVal: 0.916 ± 0.019	0.214CysTrp: 0.214 ± 0.008	0.35CysTyr: 0.35 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.872AspAla: 5.872 ± 0.043	0.754AspCys: 0.754 ± 0.015	6.253AspAsp: 6.253 ± 0.086	5.067AspGlu: 5.067 ± 0.046	2.132AspPhe: 2.132 ± 0.026	5.162AspGly: 5.162 ± 0.043	1.244AspHis: 1.244 ± 0.021	2.373AspIle: 2.373 ± 0.025	2.553AspLys: 2.553 ± 0.028	4.84AspLeu: 4.84 ± 0.045	1.487AspMet: 1.487 ± 0.021	1.682AspAsn: 1.682 ± 0.023	2.958AspPro: 2.958 ± 0.032	1.911AspGln: 1.911 ± 0.025	3.546AspArg: 3.546 ± 0.035	4.261AspSer: 4.261 ± 0.036	2.563AspThr: 2.563 ± 0.028	4.256AspVal: 4.256 ± 0.033	0.894AspTrp: 0.894 ± 0.014	1.451AspTyr: 1.451 ± 0.021	0.001AspXaa: 0.001 ± 0.001
Glu	6.461GluAla: 6.461 ± 0.056	0.642GluCys: 0.642 ± 0.016	3.783GluAsp: 3.783 ± 0.042	4.783GluGlu: 4.783 ± 0.055	1.66GluPhe: 1.66 ± 0.019	3.432GluGly: 3.432 ± 0.036	1.275GluHis: 1.275 ± 0.018	2.144GluIle: 2.144 ± 0.026	3.051GluLys: 3.051 ± 0.034	5.163GluLeu: 5.163 ± 0.04	1.486GluMet: 1.486 ± 0.019	1.691GluAsn: 1.691 ± 0.024	3.098GluPro: 3.098 ± 0.033	2.296GluGln: 2.296 ± 0.03	4.166GluArg: 4.166 ± 0.042	4.111GluSer: 4.111 ± 0.038	3.325GluThr: 3.325 ± 0.031	3.193GluVal: 3.193 ± 0.03	0.79GluTrp: 0.79 ± 0.015	1.338GluTyr: 1.338 ± 0.018	0.001GluXaa: 0.001 ± 0.0
Phe	3.034PheAla: 3.034 ± 0.034	0.576PheCys: 0.576 ± 0.013	2.198PheAsp: 2.198 ± 0.022	1.822PheGlu: 1.822 ± 0.024	1.53PhePhe: 1.53 ± 0.026	2.586PheGly: 2.586 ± 0.034	0.894PheHis: 0.894 ± 0.016	1.451PheIle: 1.451 ± 0.021	1.258PheLys: 1.258 ± 0.02	3.238PheLeu: 3.238 ± 0.033	0.679PheMet: 0.679 ± 0.013	1.177PheAsn: 1.177 ± 0.019	1.85PhePro: 1.85 ± 0.022	1.211PheGln: 1.211 ± 0.017	2.186PheArg: 2.186 ± 0.023	2.727PheSer: 2.727 ± 0.025	1.745PheThr: 1.745 ± 0.022	2.375PheVal: 2.375 ± 0.026	0.557PheTrp: 0.557 ± 0.011	0.936PheTyr: 0.936 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.768GlyAla: 5.768 ± 0.047	0.973GlyCys: 0.973 ± 0.017	4.049GlyAsp: 4.049 ± 0.029	3.668GlyGlu: 3.668 ± 0.032	2.646GlyPhe: 2.646 ± 0.032	6.749GlyGly: 6.749 ± 0.071	1.912GlyHis: 1.912 ± 0.023	2.965GlyIle: 2.965 ± 0.029	3.192GlyLys: 3.192 ± 0.036	6.376GlyLeu: 6.376 ± 0.046	1.511GlyMet: 1.511 ± 0.019	2.315GlyAsn: 2.315 ± 0.029	4.038GlyPro: 4.038 ± 0.055	2.801GlyGln: 2.801 ± 0.036	5.342GlyArg: 5.342 ± 0.049	6.112GlySer: 6.112 ± 0.058	3.573GlyThr: 3.573 ± 0.036	4.216GlyVal: 4.216 ± 0.038	1.137GlyTrp: 1.137 ± 0.021	1.898GlyTyr: 1.898 ± 0.032	0.002GlyXaa: 0.002 ± 0.001
His	1.998HisAla: 1.998 ± 0.024	0.365HisCys: 0.365 ± 0.01	1.587HisAsp: 1.587 ± 0.022	1.28HisGlu: 1.28 ± 0.018	0.847HisPhe: 0.847 ± 0.013	1.994HisGly: 1.994 ± 0.025	1.195HisHis: 1.195 ± 0.025	0.985HisIle: 0.985 ± 0.016	0.834HisLys: 0.834 ± 0.015	2.369HisLeu: 2.369 ± 0.028	0.512HisMet: 0.512 ± 0.012	0.701HisAsn: 0.701 ± 0.013	1.651HisPro: 1.651 ± 0.023	1.128HisGln: 1.128 ± 0.017	1.859HisArg: 1.859 ± 0.025	1.704HisSer: 1.704 ± 0.023	1.057HisThr: 1.057 ± 0.019	1.727HisVal: 1.727 ± 0.02	0.315HisTrp: 0.315 ± 0.009	0.633HisTyr: 0.633 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.362IleAla: 3.362 ± 0.029	0.644IleCys: 0.644 ± 0.015	2.447IleAsp: 2.447 ± 0.024	2.171IleGlu: 2.171 ± 0.024	1.562IlePhe: 1.562 ± 0.021	2.61IleGly: 2.61 ± 0.031	1.007IleHis: 1.007 ± 0.017	1.809IleIle: 1.809 ± 0.025	1.819IleLys: 1.819 ± 0.026	3.621IleLeu: 3.621 ± 0.035	0.892IleMet: 0.892 ± 0.016	1.393IleAsn: 1.393 ± 0.019	2.291IlePro: 2.291 ± 0.022	1.456IleGln: 1.456 ± 0.02	2.726IleArg: 2.726 ± 0.027	2.966IleSer: 2.966 ± 0.03	1.943IleThr: 1.943 ± 0.02	2.755IleVal: 2.755 ± 0.028	0.548IleTrp: 0.548 ± 0.013	1.043IleTyr: 1.043 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.325LysAla: 4.325 ± 0.038	0.49LysCys: 0.49 ± 0.013	2.444LysAsp: 2.444 ± 0.029	2.697LysGlu: 2.697 ± 0.035	1.195LysPhe: 1.195 ± 0.02	2.673LysGly: 2.673 ± 0.032	0.996LysHis: 0.996 ± 0.017	1.622LysIle: 1.622 ± 0.025	2.944LysLys: 2.944 ± 0.052	3.813LysLeu: 3.813 ± 0.036	1.044LysMet: 1.044 ± 0.018	1.305LysAsn: 1.305 ± 0.022	2.75LysPro: 2.75 ± 0.035	1.752LysGln: 1.752 ± 0.025	3.45LysArg: 3.45 ± 0.034	3.03LysSer: 3.03 ± 0.036	2.676LysThr: 2.676 ± 0.029	2.432LysVal: 2.432 ± 0.031	0.529LysTrp: 0.529 ± 0.011	1.005LysTyr: 1.005 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.965LeuAla: 8.965 ± 0.072	1.351LeuCys: 1.351 ± 0.02	5.6LeuAsp: 5.6 ± 0.042	5.167LeuGlu: 5.167 ± 0.048	3.224LeuPhe: 3.224 ± 0.037	6.165LeuGly: 6.165 ± 0.045	2.229LeuHis: 2.229 ± 0.026	3.264LeuIle: 3.264 ± 0.027	3.549LeuLys: 3.549 ± 0.033	8.885LeuLeu: 8.885 ± 0.07	1.838LeuMet: 1.838 ± 0.023	2.626LeuAsn: 2.626 ± 0.03	5.784LeuPro: 5.784 ± 0.051	3.645LeuGln: 3.645 ± 0.029	6.806LeuArg: 6.806 ± 0.045	7.461LeuSer: 7.461 ± 0.054	4.593LeuThr: 4.593 ± 0.037	6.18LeuVal: 6.18 ± 0.047	1.204LeuTrp: 1.204 ± 0.02	2.19LeuTyr: 2.19 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.701MetAla: 2.701 ± 0.026	0.246MetCys: 0.246 ± 0.009	1.337MetAsp: 1.337 ± 0.019	1.284MetGlu: 1.284 ± 0.019	0.632MetPhe: 0.632 ± 0.014	1.475MetGly: 1.475 ± 0.02	0.476MetHis: 0.476 ± 0.014	0.784MetIle: 0.784 ± 0.013	0.89MetLys: 0.89 ± 0.016	1.963MetLeu: 1.963 ± 0.023	0.631MetMet: 0.631 ± 0.015	0.659MetAsn: 0.659 ± 0.014	1.489MetPro: 1.489 ± 0.019	0.871MetGln: 0.871 ± 0.016	1.485MetArg: 1.485 ± 0.019	1.851MetSer: 1.851 ± 0.023	1.476MetThr: 1.476 ± 0.021	1.38MetVal: 1.38 ± 0.02	0.238MetTrp: 0.238 ± 0.007	0.461MetTyr: 0.461 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.63AsnAla: 2.63 ± 0.029	0.404AsnCys: 0.404 ± 0.011	1.737AsnAsp: 1.737 ± 0.022	1.592AsnGlu: 1.592 ± 0.018	1.113AsnPhe: 1.113 ± 0.017	2.535AsnGly: 2.535 ± 0.034	0.748AsnHis: 0.748 ± 0.014	1.352AsnIle: 1.352 ± 0.02	1.422AsnLys: 1.422 ± 0.019	2.787AsnLeu: 2.787 ± 0.028	0.761AsnMet: 0.761 ± 0.011	1.216AsnAsn: 1.216 ± 0.028	1.968AsnPro: 1.968 ± 0.028	1.122AsnGln: 1.122 ± 0.018	1.934AsnArg: 1.934 ± 0.024	2.289AsnSer: 2.289 ± 0.027	1.492AsnThr: 1.492 ± 0.02	1.996AsnVal: 1.996 ± 0.022	0.455AsnTrp: 0.455 ± 0.011	0.835AsnTyr: 0.835 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.083ProAla: 6.083 ± 0.06	0.699ProCys: 0.699 ± 0.015	3.653ProAsp: 3.653 ± 0.032	3.539ProGlu: 3.539 ± 0.032	1.985ProPhe: 1.985 ± 0.024	4.344ProGly: 4.344 ± 0.058	1.393ProHis: 1.393 ± 0.022	2.044ProIle: 2.044 ± 0.025	2.329ProLys: 2.329 ± 0.03	5.207ProLeu: 5.207 ± 0.04	1.178ProMet: 1.178 ± 0.02	1.762ProAsn: 1.762 ± 0.022	6.585ProPro: 6.585 ± 0.094	2.483ProGln: 2.483 ± 0.032	4.358ProArg: 4.358 ± 0.048	6.575ProSer: 6.575 ± 0.068	3.786ProThr: 3.786 ± 0.034	3.904ProVal: 3.904 ± 0.038	0.802ProTrp: 0.802 ± 0.016	1.375ProTyr: 1.375 ± 0.021	0.002ProXaa: 0.002 ± 0.001
Gln	3.827GlnAla: 3.827 ± 0.04	0.436GlnCys: 0.436 ± 0.011	2.074GlnAsp: 2.074 ± 0.026	2.083GlnGlu: 2.083 ± 0.027	1.107GlnPhe: 1.107 ± 0.017	2.541GlnGly: 2.541 ± 0.03	1.169GlnHis: 1.169 ± 0.022	1.412GlnIle: 1.412 ± 0.021	1.667GlnLys: 1.667 ± 0.024	3.646GlnLeu: 3.646 ± 0.037	0.946GlnMet: 0.946 ± 0.016	1.173GlnAsn: 1.173 ± 0.02	2.883GlnPro: 2.883 ± 0.039	3.141GlnGln: 3.141 ± 0.081	3.043GlnArg: 3.043 ± 0.032	2.898GlnSer: 2.898 ± 0.03	2.185GlnThr: 2.185 ± 0.027	2.211GlnVal: 2.211 ± 0.027	0.504GlnTrp: 0.504 ± 0.012	0.92GlnTyr: 0.92 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.975ArgAla: 5.975 ± 0.046	0.992ArgCys: 0.992 ± 0.017	4.141ArgAsp: 4.141 ± 0.037	4.041ArgGlu: 4.041 ± 0.038	2.373ArgPhe: 2.373 ± 0.028	4.652ArgGly: 4.652 ± 0.048	2.174ArgHis: 2.174 ± 0.024	2.83ArgIle: 2.83 ± 0.028	3.375ArgLys: 3.375 ± 0.033	7.091ArgLeu: 7.091 ± 0.054	1.461ArgMet: 1.461 ± 0.019	2.215ArgAsn: 2.215 ± 0.025	4.788ArgPro: 4.788 ± 0.048	3.252ArgGln: 3.252 ± 0.034	7.519ArgArg: 7.519 ± 0.078	5.402ArgSer: 5.402 ± 0.045	3.465ArgThr: 3.465 ± 0.032	3.928ArgVal: 3.928 ± 0.032	1.052ArgTrp: 1.052 ± 0.015	1.652ArgTyr: 1.652 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	7.344SerAla: 7.344 ± 0.058	1.002SerCys: 1.002 ± 0.018	4.377SerAsp: 4.377 ± 0.041	3.764SerGlu: 3.764 ± 0.039	2.85SerPhe: 2.85 ± 0.025	5.782SerGly: 5.782 ± 0.062	1.975SerHis: 1.975 ± 0.023	3.242SerIle: 3.242 ± 0.032	3.238SerLys: 3.238 ± 0.036	7.535SerLeu: 7.535 ± 0.056	1.748SerMet: 1.748 ± 0.021	2.399SerAsn: 2.399 ± 0.024	6.132SerPro: 6.132 ± 0.069	3.147SerGln: 3.147 ± 0.036	6.097SerArg: 6.097 ± 0.048	9.68SerSer: 9.68 ± 0.126	4.97SerThr: 4.97 ± 0.051	4.756SerVal: 4.756 ± 0.044	1.114SerTrp: 1.114 ± 0.017	1.756SerTyr: 1.756 ± 0.028	0.001SerXaa: 0.001 ± 0.001
Thr	5.554ThrAla: 5.554 ± 0.047	0.746ThrCys: 0.746 ± 0.016	2.758ThrAsp: 2.758 ± 0.027	2.746ThrGlu: 2.746 ± 0.032	1.771ThrPhe: 1.771 ± 0.02	3.895ThrGly: 3.895 ± 0.043	1.136ThrHis: 1.136 ± 0.018	2.341ThrIle: 2.341 ± 0.026	2.211ThrLys: 2.211 ± 0.026	4.885ThrLeu: 4.885 ± 0.037	1.27ThrMet: 1.27 ± 0.016	1.594ThrAsn: 1.594 ± 0.021	3.93ThrPro: 3.93 ± 0.046	1.817ThrGln: 1.817 ± 0.022	3.445ThrArg: 3.445 ± 0.029	4.771ThrSer: 4.771 ± 0.043	4.148ThrThr: 4.148 ± 0.058	3.573ThrVal: 3.573 ± 0.031	0.759ThrTrp: 0.759 ± 0.014	1.25ThrTyr: 1.25 ± 0.018	0.001ThrXaa: 0.001 ± 0.001
Val	6.255ValAla: 6.255 ± 0.043	0.959ValCys: 0.959 ± 0.016	4.278ValAsp: 4.278 ± 0.032	3.906ValGlu: 3.906 ± 0.033	2.369ValPhe: 2.369 ± 0.028	4.273ValGly: 4.273 ± 0.04	1.392ValHis: 1.392 ± 0.02	2.501ValIle: 2.501 ± 0.028	2.732ValLys: 2.732 ± 0.029	5.708ValLeu: 5.708 ± 0.05	1.419ValMet: 1.419 ± 0.017	1.978ValAsn: 1.978 ± 0.023	3.731ValPro: 3.731 ± 0.03	2.327ValGln: 2.327 ± 0.025	4.173ValArg: 4.173 ± 0.037	4.822ValSer: 4.822 ± 0.037	3.421ValThr: 3.421 ± 0.031	5.02ValVal: 5.02 ± 0.048	0.839ValTrp: 0.839 ± 0.015	1.552ValTyr: 1.552 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.158TrpAla: 1.158 ± 0.018	0.201TrpCys: 0.201 ± 0.007	0.859TrpAsp: 0.859 ± 0.017	0.768TrpGlu: 0.768 ± 0.015	0.479TrpPhe: 0.479 ± 0.012	0.797TrpGly: 0.797 ± 0.015	0.398TrpHis: 0.398 ± 0.01	0.616TrpIle: 0.616 ± 0.015	0.679TrpLys: 0.679 ± 0.014	1.368TrpLeu: 1.368 ± 0.021	0.342TrpMet: 0.342 ± 0.009	0.549TrpAsn: 0.549 ± 0.011	0.692TrpPro: 0.692 ± 0.013	0.543TrpGln: 0.543 ± 0.012	1.128TrpArg: 1.128 ± 0.016	1.012TrpSer: 1.012 ± 0.017	0.893TrpThr: 0.893 ± 0.015	0.761TrpVal: 0.761 ± 0.015	0.271TrpTrp: 0.271 ± 0.009	0.338TrpTyr: 0.338 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.93TyrAla: 1.93 ± 0.026	0.398TyrCys: 0.398 ± 0.011	1.566TyrAsp: 1.566 ± 0.019	1.288TyrGlu: 1.288 ± 0.022	0.926TyrPhe: 0.926 ± 0.018	1.939TyrGly: 1.939 ± 0.036	0.695TyrHis: 0.695 ± 0.014	0.958TyrIle: 0.958 ± 0.019	0.876TyrLys: 0.876 ± 0.016	2.35TyrLeu: 2.35 ± 0.026	0.556TyrMet: 0.556 ± 0.013	0.81TyrAsn: 0.81 ± 0.016	1.285TyrPro: 1.285 ± 0.024	0.91TyrGln: 0.91 ± 0.015	1.718TyrArg: 1.718 ± 0.021	1.725TyrSer: 1.725 ± 0.023	1.178TyrThr: 1.178 ± 0.018	1.529TyrVal: 1.529 ± 0.021	0.375TyrTrp: 0.375 ± 0.01	0.725TyrTyr: 0.725 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.34XaaXaa: 0.34 ± 0.071

Statistics based on 8572 proteins (4052776 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---