Amino acid dipepetide frequency for Desemzia incerta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.163AlaAla: 6.163 ± 0.131
0.398AlaCys: 0.398 ± 0.021
3.909AlaAsp: 3.909 ± 0.08
5.369AlaGlu: 5.369 ± 0.107
3.231AlaPhe: 3.231 ± 0.071
5.259AlaGly: 5.259 ± 0.107
1.185AlaHis: 1.185 ± 0.044
5.535AlaIle: 5.535 ± 0.105
4.458AlaLys: 4.458 ± 0.082
7.168AlaLeu: 7.168 ± 0.11
1.927AlaMet: 1.927 ± 0.053
2.859AlaAsn: 2.859 ± 0.067
1.994AlaPro: 1.994 ± 0.062
2.535AlaGln: 2.535 ± 0.063
2.399AlaArg: 2.399 ± 0.06
4.017AlaSer: 4.017 ± 0.089
3.874AlaThr: 3.874 ± 0.088
5.738AlaVal: 5.738 ± 0.103
0.513AlaTrp: 0.513 ± 0.032
2.504AlaTyr: 2.504 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.024
0.062CysCys: 0.062 ± 0.01
0.253CysAsp: 0.253 ± 0.017
0.287CysGlu: 0.287 ± 0.021
0.262CysPhe: 0.262 ± 0.019
0.504CysGly: 0.504 ± 0.027
0.163CysHis: 0.163 ± 0.017
0.357CysIle: 0.357 ± 0.021
0.213CysLys: 0.213 ± 0.018
0.48CysLeu: 0.48 ± 0.031
0.113CysMet: 0.113 ± 0.014
0.204CysAsn: 0.204 ± 0.017
0.221CysPro: 0.221 ± 0.018
0.171CysGln: 0.171 ± 0.017
0.204CysArg: 0.204 ± 0.02
0.33CysSer: 0.33 ± 0.024
0.253CysThr: 0.253 ± 0.02
0.292CysVal: 0.292 ± 0.024
0.03CysTrp: 0.03 ± 0.008
0.206CysTyr: 0.206 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.56AspAla: 3.56 ± 0.075
0.251AspCys: 0.251 ± 0.018
2.51AspAsp: 2.51 ± 0.068
4.613AspGlu: 4.613 ± 0.095
2.678AspPhe: 2.678 ± 0.063
3.425AspGly: 3.425 ± 0.069
1.11AspHis: 1.11 ± 0.037
4.301AspIle: 4.301 ± 0.086
3.21AspLys: 3.21 ± 0.076
5.079AspLeu: 5.079 ± 0.085
1.522AspMet: 1.522 ± 0.056
2.145AspAsn: 2.145 ± 0.058
2.198AspPro: 2.198 ± 0.071
2.063AspGln: 2.063 ± 0.058
2.136AspArg: 2.136 ± 0.057
3.03AspSer: 3.03 ± 0.083
3.069AspThr: 3.069 ± 0.073
3.956AspVal: 3.956 ± 0.076
0.607AspTrp: 0.607 ± 0.03
2.535AspTyr: 2.535 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
5.83GluAla: 5.83 ± 0.1
0.262GluCys: 0.262 ± 0.024
4.437GluAsp: 4.437 ± 0.088
8.174GluGlu: 8.174 ± 0.139
2.64GluPhe: 2.64 ± 0.066
4.366GluGly: 4.366 ± 0.094
1.222GluHis: 1.222 ± 0.047
5.708GluIle: 5.708 ± 0.095
6.609GluLys: 6.609 ± 0.127
7.561GluLeu: 7.561 ± 0.12
2.667GluMet: 2.667 ± 0.065
4.384GluAsn: 4.384 ± 0.086
2.1GluPro: 2.1 ± 0.058
3.404GluGln: 3.404 ± 0.082
3.169GluArg: 3.169 ± 0.064
4.24GluSer: 4.24 ± 0.094
4.714GluThr: 4.714 ± 0.095
5.679GluVal: 5.679 ± 0.086
0.767GluTrp: 0.767 ± 0.037
2.529GluTyr: 2.529 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.812PheAla: 2.812 ± 0.065
0.256PheCys: 0.256 ± 0.019
2.62PheAsp: 2.62 ± 0.057
3.009PheGlu: 3.009 ± 0.068
2.206PhePhe: 2.206 ± 0.074
3.219PheGly: 3.219 ± 0.079
0.762PheHis: 0.762 ± 0.038
3.455PheIle: 3.455 ± 0.08
2.433PheLys: 2.433 ± 0.06
4.165PheLeu: 4.165 ± 0.102
1.101PheMet: 1.101 ± 0.04
2.009PheAsn: 2.009 ± 0.053
1.529PhePro: 1.529 ± 0.055
1.499PheGln: 1.499 ± 0.046
1.366PheArg: 1.366 ± 0.051
3.398PheSer: 3.398 ± 0.079
2.585PheThr: 2.585 ± 0.063
3.218PheVal: 3.218 ± 0.074
0.451PheTrp: 0.451 ± 0.028
1.808PheTyr: 1.808 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.569GlyAla: 4.569 ± 0.097
0.395GlyCys: 0.395 ± 0.028
3.216GlyAsp: 3.216 ± 0.087
4.667GlyGlu: 4.667 ± 0.089
3.224GlyPhe: 3.224 ± 0.081
4.463GlyGly: 4.463 ± 0.112
1.277GlyHis: 1.277 ± 0.045
5.891GlyIle: 5.891 ± 0.112
4.8GlyLys: 4.8 ± 0.093
6.584GlyLeu: 6.584 ± 0.109
2.088GlyMet: 2.088 ± 0.058
2.846GlyAsn: 2.846 ± 0.06
1.51GlyPro: 1.51 ± 0.054
2.2GlyGln: 2.2 ± 0.062
2.396GlyArg: 2.396 ± 0.07
4.021GlySer: 4.021 ± 0.08
4.298GlyThr: 4.298 ± 0.074
5.053GlyVal: 5.053 ± 0.096
0.688GlyTrp: 0.688 ± 0.039
2.776GlyTyr: 2.776 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.085HisAla: 1.085 ± 0.044
0.113HisCys: 0.113 ± 0.013
0.947HisAsp: 0.947 ± 0.042
1.244HisGlu: 1.244 ± 0.049
1.012HisPhe: 1.012 ± 0.04
1.16HisGly: 1.16 ± 0.042
0.587HisHis: 0.587 ± 0.04
1.268HisIle: 1.268 ± 0.043
0.933HisLys: 0.933 ± 0.041
1.979HisLeu: 1.979 ± 0.06
0.478HisMet: 0.478 ± 0.025
0.637HisAsn: 0.637 ± 0.028
1.015HisPro: 1.015 ± 0.034
0.887HisGln: 0.887 ± 0.039
0.765HisArg: 0.765 ± 0.032
1.11HisSer: 1.11 ± 0.04
1.038HisThr: 1.038 ± 0.043
1.08HisVal: 1.08 ± 0.041
0.175HisTrp: 0.175 ± 0.015
0.893HisTyr: 0.893 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.01IleAla: 6.01 ± 0.091
0.545IleCys: 0.545 ± 0.03
4.485IleAsp: 4.485 ± 0.092
6.103IleGlu: 6.103 ± 0.093
3.007IlePhe: 3.007 ± 0.081
5.743IleGly: 5.743 ± 0.118
1.396IleHis: 1.396 ± 0.042
5.42IleIle: 5.42 ± 0.117
4.194IleLys: 4.194 ± 0.085
7.101IleLeu: 7.101 ± 0.111
1.759IleMet: 1.759 ± 0.05
3.045IleAsn: 3.045 ± 0.078
3.348IlePro: 3.348 ± 0.073
3.248IleGln: 3.248 ± 0.08
2.796IleArg: 2.796 ± 0.07
4.973IleSer: 4.973 ± 0.094
4.337IleThr: 4.337 ± 0.076
5.65IleVal: 5.65 ± 0.104
0.592IleTrp: 0.592 ± 0.031
2.469IleTyr: 2.469 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.482LysAla: 4.482 ± 0.096
0.195LysCys: 0.195 ± 0.019
3.846LysAsp: 3.846 ± 0.074
7.319LysGlu: 7.319 ± 0.112
1.817LysPhe: 1.817 ± 0.059
4.062LysGly: 4.062 ± 0.079
1.009LysHis: 1.009 ± 0.036
4.36LysIle: 4.36 ± 0.076
5.827LysLys: 5.827 ± 0.108
5.051LysLeu: 5.051 ± 0.088
2.127LysMet: 2.127 ± 0.054
3.638LysAsn: 3.638 ± 0.076
2.009LysPro: 2.009 ± 0.055
2.906LysGln: 2.906 ± 0.074
2.967LysArg: 2.967 ± 0.065
3.479LysSer: 3.479 ± 0.089
3.709LysThr: 3.709 ± 0.071
4.458LysVal: 4.458 ± 0.081
0.598LysTrp: 0.598 ± 0.031
2.073LysTyr: 2.073 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.216LeuAla: 7.216 ± 0.103
0.467LeuCys: 0.467 ± 0.027
5.192LeuAsp: 5.192 ± 0.096
6.879LeuGlu: 6.879 ± 0.107
4.715LeuPhe: 4.715 ± 0.109
6.333LeuGly: 6.333 ± 0.114
1.622LeuHis: 1.622 ± 0.05
7.041LeuIle: 7.041 ± 0.119
6.289LeuLys: 6.289 ± 0.102
9.576LeuLeu: 9.576 ± 0.17
2.738LeuMet: 2.738 ± 0.063
4.681LeuAsn: 4.681 ± 0.089
3.585LeuPro: 3.585 ± 0.077
3.197LeuGln: 3.197 ± 0.069
3.187LeuArg: 3.187 ± 0.084
6.98LeuSer: 6.98 ± 0.104
6.249LeuThr: 6.249 ± 0.112
6.591LeuVal: 6.591 ± 0.114
0.737LeuTrp: 0.737 ± 0.039
3.082LeuTyr: 3.082 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
1.998MetAla: 1.998 ± 0.06
0.1MetCys: 0.1 ± 0.011
1.732MetAsp: 1.732 ± 0.049
2.118MetGlu: 2.118 ± 0.062
0.887MetPhe: 0.887 ± 0.04
1.773MetGly: 1.773 ± 0.05
0.44MetHis: 0.44 ± 0.028
2.2MetIle: 2.2 ± 0.059
2.281MetLys: 2.281 ± 0.063
2.374MetLeu: 2.374 ± 0.062
0.888MetMet: 0.888 ± 0.037
1.531MetAsn: 1.531 ± 0.054
1.0MetPro: 1.0 ± 0.031
0.994MetGln: 0.994 ± 0.04
1.033MetArg: 1.033 ± 0.041
1.823MetSer: 1.823 ± 0.05
1.759MetThr: 1.759 ± 0.054
1.865MetVal: 1.865 ± 0.056
0.172MetTrp: 0.172 ± 0.018
0.743MetTyr: 0.743 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.927AsnAla: 2.927 ± 0.073
0.238AsnCys: 0.238 ± 0.021
2.484AsnAsp: 2.484 ± 0.064
3.803AsnGlu: 3.803 ± 0.084
1.722AsnPhe: 1.722 ± 0.051
3.548AsnGly: 3.548 ± 0.08
1.021AsnHis: 1.021 ± 0.04
3.339AsnIle: 3.339 ± 0.079
2.88AsnLys: 2.88 ± 0.065
4.0AsnLeu: 4.0 ± 0.07
1.18AsnMet: 1.18 ± 0.045
1.997AsnAsn: 1.997 ± 0.065
2.086AsnPro: 2.086 ± 0.066
2.319AsnGln: 2.319 ± 0.064
2.053AsnArg: 2.053 ± 0.06
2.321AsnSer: 2.321 ± 0.061
2.362AsnThr: 2.362 ± 0.064
2.945AsnVal: 2.945 ± 0.073
0.528AsnTrp: 0.528 ± 0.032
1.759AsnTyr: 1.759 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.33ProAla: 2.33 ± 0.07
0.13ProCys: 0.13 ± 0.015
2.006ProAsp: 2.006 ± 0.052
3.398ProGlu: 3.398 ± 0.071
1.803ProPhe: 1.803 ± 0.06
2.142ProGly: 2.142 ± 0.065
0.655ProHis: 0.655 ± 0.038
2.8ProIle: 2.8 ± 0.073
2.112ProLys: 2.112 ± 0.055
3.358ProLeu: 3.358 ± 0.072
0.815ProMet: 0.815 ± 0.034
1.641ProAsn: 1.641 ± 0.054
0.682ProPro: 0.682 ± 0.032
1.148ProGln: 1.148 ± 0.044
0.998ProArg: 0.998 ± 0.043
2.178ProSer: 2.178 ± 0.057
2.059ProThr: 2.059 ± 0.048
2.699ProVal: 2.699 ± 0.063
0.277ProTrp: 0.277 ± 0.026
1.399ProTyr: 1.399 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.716GlnAla: 2.716 ± 0.061
0.133GlnCys: 0.133 ± 0.014
1.738GlnAsp: 1.738 ± 0.044
3.231GlnGlu: 3.231 ± 0.086
1.649GlnPhe: 1.649 ± 0.055
1.974GlnGly: 1.974 ± 0.058
0.767GlnHis: 0.767 ± 0.04
2.699GlnIle: 2.699 ± 0.07
2.885GlnLys: 2.885 ± 0.071
4.446GlnLeu: 4.446 ± 0.102
1.151GlnMet: 1.151 ± 0.035
1.729GlnAsn: 1.729 ± 0.049
1.219GlnPro: 1.219 ± 0.051
2.186GlnGln: 2.186 ± 0.069
1.557GlnArg: 1.557 ± 0.051
2.209GlnSer: 2.209 ± 0.06
2.355GlnThr: 2.355 ± 0.064
2.554GlnVal: 2.554 ± 0.07
0.39GlnTrp: 0.39 ± 0.021
1.528GlnTyr: 1.528 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.271ArgAla: 2.271 ± 0.066
0.156ArgCys: 0.156 ± 0.017
1.899ArgAsp: 1.899 ± 0.045
2.938ArgGlu: 2.938 ± 0.069
1.772ArgPhe: 1.772 ± 0.048
2.15ArgGly: 2.15 ± 0.062
0.682ArgHis: 0.682 ± 0.029
3.079ArgIle: 3.079 ± 0.07
2.873ArgLys: 2.873 ± 0.07
3.694ArgLeu: 3.694 ± 0.066
1.166ArgMet: 1.166 ± 0.041
1.772ArgAsn: 1.772 ± 0.054
1.225ArgPro: 1.225 ± 0.043
1.443ArgGln: 1.443 ± 0.051
1.595ArgArg: 1.595 ± 0.061
2.06ArgSer: 2.06 ± 0.061
2.045ArgThr: 2.045 ± 0.056
2.626ArgVal: 2.626 ± 0.068
0.28ArgTrp: 0.28 ± 0.021
1.557ArgTyr: 1.557 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.172SerAla: 4.172 ± 0.095
0.295SerCys: 0.295 ± 0.023
3.094SerAsp: 3.094 ± 0.069
4.249SerGlu: 4.249 ± 0.097
3.234SerPhe: 3.234 ± 0.071
4.646SerGly: 4.646 ± 0.093
1.091SerHis: 1.091 ± 0.044
5.107SerIle: 5.107 ± 0.086
3.752SerLys: 3.752 ± 0.077
6.162SerLeu: 6.162 ± 0.109
1.588SerMet: 1.588 ± 0.044
2.743SerAsn: 2.743 ± 0.07
2.02SerPro: 2.02 ± 0.052
2.322SerGln: 2.322 ± 0.06
2.292SerArg: 2.292 ± 0.057
4.321SerSer: 4.321 ± 0.115
3.461SerThr: 3.461 ± 0.066
4.287SerVal: 4.287 ± 0.073
0.545SerTrp: 0.545 ± 0.028
2.316SerTyr: 2.316 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.426ThrAla: 4.426 ± 0.081
0.23ThrCys: 0.23 ± 0.022
3.24ThrAsp: 3.24 ± 0.075
4.305ThrGlu: 4.305 ± 0.1
2.569ThrPhe: 2.569 ± 0.063
4.296ThrGly: 4.296 ± 0.076
1.139ThrHis: 1.139 ± 0.042
5.124ThrIle: 5.124 ± 0.097
3.519ThrLys: 3.519 ± 0.074
5.551ThrLeu: 5.551 ± 0.096
1.407ThrMet: 1.407 ± 0.05
2.504ThrAsn: 2.504 ± 0.059
2.362ThrPro: 2.362 ± 0.061
1.93ThrGln: 1.93 ± 0.06
1.908ThrArg: 1.908 ± 0.053
3.578ThrSer: 3.578 ± 0.077
3.64ThrThr: 3.64 ± 0.093
4.613ThrVal: 4.613 ± 0.1
0.493ThrTrp: 0.493 ± 0.028
2.074ThrTyr: 2.074 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.159ValAla: 5.159 ± 0.096
0.439ValCys: 0.439 ± 0.025
3.897ValAsp: 3.897 ± 0.086
5.522ValGlu: 5.522 ± 0.1
3.153ValPhe: 3.153 ± 0.08
4.777ValGly: 4.777 ± 0.097
1.306ValHis: 1.306 ± 0.046
5.422ValIle: 5.422 ± 0.103
4.181ValLys: 4.181 ± 0.102
7.293ValLeu: 7.293 ± 0.114
1.893ValMet: 1.893 ± 0.057
3.044ValAsn: 3.044 ± 0.069
2.778ValPro: 2.778 ± 0.072
2.505ValGln: 2.505 ± 0.065
2.551ValArg: 2.551 ± 0.057
4.805ValSer: 4.805 ± 0.09
4.358ValThr: 4.358 ± 0.077
5.505ValVal: 5.505 ± 0.113
0.522ValTrp: 0.522 ± 0.027
2.454ValTyr: 2.454 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.466TrpAla: 0.466 ± 0.03
0.038TrpCys: 0.038 ± 0.008
0.469TrpAsp: 0.469 ± 0.029
0.658TrpGlu: 0.658 ± 0.032
0.415TrpPhe: 0.415 ± 0.028
0.576TrpGly: 0.576 ± 0.031
0.159TrpHis: 0.159 ± 0.016
0.738TrpIle: 0.738 ± 0.038
0.61TrpLys: 0.61 ± 0.027
0.939TrpLeu: 0.939 ± 0.042
0.292TrpMet: 0.292 ± 0.021
0.525TrpAsn: 0.525 ± 0.028
0.231TrpPro: 0.231 ± 0.023
0.337TrpGln: 0.337 ± 0.027
0.327TrpArg: 0.327 ± 0.025
0.546TrpSer: 0.546 ± 0.031
0.511TrpThr: 0.511 ± 0.031
0.52TrpVal: 0.52 ± 0.029
0.103TrpTrp: 0.103 ± 0.012
0.351TrpTyr: 0.351 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.52TyrAla: 2.52 ± 0.074
0.225TyrCys: 0.225 ± 0.017
2.024TyrAsp: 2.024 ± 0.061
2.578TyrGlu: 2.578 ± 0.06
1.908TyrPhe: 1.908 ± 0.055
2.545TyrGly: 2.545 ± 0.059
0.812TyrHis: 0.812 ± 0.036
2.378TyrIle: 2.378 ± 0.066
1.873TyrLys: 1.873 ± 0.057
3.797TyrLeu: 3.797 ± 0.089
0.808TyrMet: 0.808 ± 0.033
1.578TyrAsn: 1.578 ± 0.05
1.52TyrPro: 1.52 ± 0.05
1.823TyrGln: 1.823 ± 0.062
1.582TyrArg: 1.582 ± 0.051
2.278TyrSer: 2.278 ± 0.056
2.228TyrThr: 2.228 ± 0.053
2.231TyrVal: 2.231 ± 0.061
0.345TyrTrp: 0.345 ± 0.02
1.507TyrTyr: 1.507 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2143 proteins (661021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski