Amino acid dipepetide frequency for Tenacibaculum adriaticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.406AlaAla: 3.406 ± 0.081	0.521AlaCys: 0.521 ± 0.024	3.086AlaAsp: 3.086 ± 0.065	3.687AlaGlu: 3.687 ± 0.078	3.086AlaPhe: 3.086 ± 0.063	3.852AlaGly: 3.852 ± 0.077	1.009AlaHis: 1.009 ± 0.036	5.392AlaIle: 5.392 ± 0.095	4.992AlaLys: 4.992 ± 0.092	5.481AlaLeu: 5.481 ± 0.071	1.333AlaMet: 1.333 ± 0.043	3.439AlaAsn: 3.439 ± 0.066	1.641AlaPro: 1.641 ± 0.043	2.084AlaGln: 2.084 ± 0.044	1.847AlaArg: 1.847 ± 0.05	4.009AlaSer: 4.009 ± 0.072	3.54AlaThr: 3.54 ± 0.074	3.806AlaVal: 3.806 ± 0.077	0.545AlaTrp: 0.545 ± 0.026	2.209AlaTyr: 2.209 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.41CysAla: 0.41 ± 0.02	0.092CysCys: 0.092 ± 0.01	0.427CysAsp: 0.427 ± 0.025	0.438CysGlu: 0.438 ± 0.022	0.378CysPhe: 0.378 ± 0.021	0.581CysGly: 0.581 ± 0.027	0.183CysHis: 0.183 ± 0.015	0.522CysIle: 0.522 ± 0.022	0.544CysLys: 0.544 ± 0.027	0.574CysLeu: 0.574 ± 0.025	0.143CysMet: 0.143 ± 0.014	0.422CysAsn: 0.422 ± 0.023	0.286CysPro: 0.286 ± 0.021	0.167CysGln: 0.167 ± 0.014	0.188CysArg: 0.188 ± 0.014	0.495CysSer: 0.495 ± 0.024	0.358CysThr: 0.358 ± 0.022	0.428CysVal: 0.428 ± 0.025	0.055CysTrp: 0.055 ± 0.008	0.272CysTyr: 0.272 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.396AspAla: 3.396 ± 0.07	0.397AspCys: 0.397 ± 0.023	2.867AspAsp: 2.867 ± 0.063	3.927AspGlu: 3.927 ± 0.076	3.697AspPhe: 3.697 ± 0.061	3.413AspGly: 3.413 ± 0.093	0.71AspHis: 0.71 ± 0.029	4.475AspIle: 4.475 ± 0.073	4.448AspLys: 4.448 ± 0.081	5.131AspLeu: 5.131 ± 0.078	1.049AspMet: 1.049 ± 0.038	3.218AspAsn: 3.218 ± 0.058	1.393AspPro: 1.393 ± 0.051	1.19AspGln: 1.19 ± 0.036	1.707AspArg: 1.707 ± 0.043	3.001AspSer: 3.001 ± 0.063	2.795AspThr: 2.795 ± 0.063	3.763AspVal: 3.763 ± 0.068	0.675AspTrp: 0.675 ± 0.027	2.769AspTyr: 2.769 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.178GluAla: 4.178 ± 0.084	0.344GluCys: 0.344 ± 0.021	3.581GluAsp: 3.581 ± 0.063	5.422GluGlu: 5.422 ± 0.099	3.138GluPhe: 3.138 ± 0.057	3.695GluGly: 3.695 ± 0.062	1.135GluHis: 1.135 ± 0.036	5.955GluIle: 5.955 ± 0.095	6.65GluLys: 6.65 ± 0.119	6.354GluLeu: 6.354 ± 0.099	1.469GluMet: 1.469 ± 0.043	5.109GluAsn: 5.109 ± 0.072	1.403GluPro: 1.403 ± 0.04	2.205GluGln: 2.205 ± 0.051	2.354GluArg: 2.354 ± 0.063	3.045GluSer: 3.045 ± 0.055	3.692GluThr: 3.692 ± 0.068	4.578GluVal: 4.578 ± 0.08	0.603GluTrp: 0.603 ± 0.025	2.525GluTyr: 2.525 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.796PheAla: 2.796 ± 0.057	0.404PheCys: 0.404 ± 0.02	3.222PheAsp: 3.222 ± 0.064	3.312PheGlu: 3.312 ± 0.059	3.044PhePhe: 3.044 ± 0.078	3.693PheGly: 3.693 ± 0.065	0.802PheHis: 0.802 ± 0.024	4.387PheIle: 4.387 ± 0.085	4.238PheLys: 4.238 ± 0.072	5.068PheLeu: 5.068 ± 0.094	1.123PheMet: 1.123 ± 0.035	3.7PheAsn: 3.7 ± 0.062	1.683PhePro: 1.683 ± 0.037	1.525PheGln: 1.525 ± 0.04	1.477PheArg: 1.477 ± 0.037	4.242PheSer: 4.242 ± 0.071	3.214PheThr: 3.214 ± 0.061	3.03PheVal: 3.03 ± 0.06	0.563PheTrp: 0.563 ± 0.023	2.237PheTyr: 2.237 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.921GlyAla: 3.921 ± 0.076	0.524GlyCys: 0.524 ± 0.025	3.177GlyAsp: 3.177 ± 0.082	3.53GlyGlu: 3.53 ± 0.065	3.772GlyPhe: 3.772 ± 0.067	4.535GlyGly: 4.535 ± 0.124	1.007GlyHis: 1.007 ± 0.035	5.402GlyIle: 5.402 ± 0.084	5.269GlyLys: 5.269 ± 0.077	5.671GlyLeu: 5.671 ± 0.086	1.494GlyMet: 1.494 ± 0.042	3.703GlyAsn: 3.703 ± 0.074	1.13GlyPro: 1.13 ± 0.04	1.607GlyGln: 1.607 ± 0.047	1.93GlyArg: 1.93 ± 0.049	3.8GlySer: 3.8 ± 0.086	3.882GlyThr: 3.882 ± 0.08	4.277GlyVal: 4.277 ± 0.075	0.704GlyTrp: 0.704 ± 0.033	2.697GlyTyr: 2.697 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.861HisAla: 0.861 ± 0.03	0.178HisCys: 0.178 ± 0.014	0.774HisAsp: 0.774 ± 0.029	0.917HisGlu: 0.917 ± 0.031	1.125HisPhe: 1.125 ± 0.034	0.903HisGly: 0.903 ± 0.033	0.464HisHis: 0.464 ± 0.026	1.376HisIle: 1.376 ± 0.042	1.349HisLys: 1.349 ± 0.041	1.707HisLeu: 1.707 ± 0.042	0.291HisMet: 0.291 ± 0.018	1.033HisAsn: 1.033 ± 0.035	0.881HisPro: 0.881 ± 0.032	0.769HisGln: 0.769 ± 0.03	0.623HisArg: 0.623 ± 0.028	0.994HisSer: 0.994 ± 0.029	0.953HisThr: 0.953 ± 0.034	0.879HisVal: 0.879 ± 0.024	0.182HisTrp: 0.182 ± 0.014	0.733HisTyr: 0.733 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.454IleAla: 5.454 ± 0.086	0.611IleCys: 0.611 ± 0.024	5.345IleAsp: 5.345 ± 0.076	5.961IleGlu: 5.961 ± 0.09	3.813IlePhe: 3.813 ± 0.081	5.199IleGly: 5.199 ± 0.082	1.402IleHis: 1.402 ± 0.042	6.826IleIle: 6.826 ± 0.109	6.839IleLys: 6.839 ± 0.098	7.341IleLeu: 7.341 ± 0.116	1.34IleMet: 1.34 ± 0.039	5.529IleAsn: 5.529 ± 0.079	3.24IlePro: 3.24 ± 0.053	2.755IleGln: 2.755 ± 0.056	2.457IleArg: 2.457 ± 0.058	6.084IleSer: 6.084 ± 0.088	5.181IleThr: 5.181 ± 0.083	4.92IleVal: 4.92 ± 0.075	0.658IleTrp: 0.658 ± 0.027	2.893IleTyr: 2.893 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.989LysAla: 4.989 ± 0.102	0.369LysCys: 0.369 ± 0.022	4.608LysAsp: 4.608 ± 0.076	7.318LysGlu: 7.318 ± 0.115	3.237LysPhe: 3.237 ± 0.062	4.909LysGly: 4.909 ± 0.083	1.512LysHis: 1.512 ± 0.04	7.255LysIle: 7.255 ± 0.101	8.481LysLys: 8.481 ± 0.124	7.207LysLeu: 7.207 ± 0.085	2.125LysMet: 2.125 ± 0.049	6.274LysAsn: 6.274 ± 0.084	2.461LysPro: 2.461 ± 0.056	3.053LysGln: 3.053 ± 0.068	2.977LysArg: 2.977 ± 0.067	4.849LysSer: 4.849 ± 0.072	5.229LysThr: 5.229 ± 0.087	5.125LysVal: 5.125 ± 0.076	0.786LysTrp: 0.786 ± 0.03	3.363LysTyr: 3.363 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.532LeuAla: 5.532 ± 0.09	0.566LeuCys: 0.566 ± 0.026	4.731LeuAsp: 4.731 ± 0.085	6.005LeuGlu: 6.005 ± 0.084	5.076LeuPhe: 5.076 ± 0.087	5.846LeuGly: 5.846 ± 0.088	1.629LeuHis: 1.629 ± 0.044	7.455LeuIle: 7.455 ± 0.109	8.174LeuLys: 8.174 ± 0.113	8.823LeuLeu: 8.823 ± 0.136	1.979LeuMet: 1.979 ± 0.051	5.936LeuAsn: 5.936 ± 0.08	3.406LeuPro: 3.406 ± 0.067	3.417LeuGln: 3.417 ± 0.072	2.941LeuArg: 2.941 ± 0.063	6.756LeuSer: 6.756 ± 0.098	4.999LeuThr: 4.999 ± 0.079	5.2LeuVal: 5.2 ± 0.074	0.731LeuTrp: 0.731 ± 0.031	3.083LeuTyr: 3.083 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.425MetAla: 1.425 ± 0.041	0.141MetCys: 0.141 ± 0.014	0.982MetAsp: 0.982 ± 0.031	1.216MetGlu: 1.216 ± 0.037	0.914MetPhe: 0.914 ± 0.033	1.198MetGly: 1.198 ± 0.039	0.364MetHis: 0.364 ± 0.02	1.57MetIle: 1.57 ± 0.043	2.281MetLys: 2.281 ± 0.049	1.928MetLeu: 1.928 ± 0.043	0.58MetMet: 0.58 ± 0.026	1.283MetAsn: 1.283 ± 0.036	0.738MetPro: 0.738 ± 0.027	0.783MetGln: 0.783 ± 0.034	0.807MetArg: 0.807 ± 0.032	1.401MetSer: 1.401 ± 0.04	1.04MetThr: 1.04 ± 0.034	1.261MetVal: 1.261 ± 0.034	0.147MetTrp: 0.147 ± 0.012	0.677MetTyr: 0.677 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.643AsnAla: 3.643 ± 0.066	0.441AsnCys: 0.441 ± 0.023	3.389AsnAsp: 3.389 ± 0.068	4.007AsnGlu: 4.007 ± 0.066	3.389AsnPhe: 3.389 ± 0.067	3.984AsnGly: 3.984 ± 0.087	1.118AsnHis: 1.118 ± 0.031	5.529AsnIle: 5.529 ± 0.09	5.328AsnLys: 5.328 ± 0.086	5.806AsnLeu: 5.806 ± 0.084	1.289AsnMet: 1.289 ± 0.037	4.46AsnAsn: 4.46 ± 0.082	2.816AsnPro: 2.816 ± 0.055	2.334AsnGln: 2.334 ± 0.052	2.078AsnArg: 2.078 ± 0.044	4.193AsnSer: 4.193 ± 0.074	3.924AsnThr: 3.924 ± 0.075	3.704AsnVal: 3.704 ± 0.062	0.832AsnTrp: 0.832 ± 0.031	3.135AsnTyr: 3.135 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.703ProAla: 1.703 ± 0.049	0.203ProCys: 0.203 ± 0.013	1.699ProAsp: 1.699 ± 0.04	2.526ProGlu: 2.526 ± 0.051	1.804ProPhe: 1.804 ± 0.045	1.593ProGly: 1.593 ± 0.04	0.562ProHis: 0.562 ± 0.027	2.735ProIle: 2.735 ± 0.055	2.741ProLys: 2.741 ± 0.051	2.774ProLeu: 2.774 ± 0.06	0.639ProMet: 0.639 ± 0.026	2.2ProAsn: 2.2 ± 0.051	0.75ProPro: 0.75 ± 0.032	1.062ProGln: 1.062 ± 0.034	0.846ProArg: 0.846 ± 0.027	2.083ProSer: 2.083 ± 0.048	2.08ProThr: 2.08 ± 0.06	2.111ProVal: 2.111 ± 0.051	0.324ProTrp: 0.324 ± 0.019	1.266ProTyr: 1.266 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.723GlnAla: 1.723 ± 0.044	0.184GlnCys: 0.184 ± 0.016	1.515GlnAsp: 1.515 ± 0.044	2.447GlnGlu: 2.447 ± 0.059	1.861GlnPhe: 1.861 ± 0.042	1.584GlnGly: 1.584 ± 0.042	0.629GlnHis: 0.629 ± 0.027	2.758GlnIle: 2.758 ± 0.052	3.078GlnLys: 3.078 ± 0.061	3.456GlnLeu: 3.456 ± 0.069	0.728GlnMet: 0.728 ± 0.026	2.202GlnAsn: 2.202 ± 0.058	1.03GlnPro: 1.03 ± 0.033	1.614GlnGln: 1.614 ± 0.046	1.177GlnArg: 1.177 ± 0.036	1.893GlnSer: 1.893 ± 0.046	1.848GlnThr: 1.848 ± 0.038	1.832GlnVal: 1.832 ± 0.049	0.261GlnTrp: 0.261 ± 0.017	1.293GlnTyr: 1.293 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.853ArgAla: 1.853 ± 0.051	0.193ArgCys: 0.193 ± 0.015	1.609ArgAsp: 1.609 ± 0.04	2.175ArgGlu: 2.175 ± 0.051	1.794ArgPhe: 1.794 ± 0.041	1.829ArgGly: 1.829 ± 0.05	0.516ArgHis: 0.516 ± 0.022	2.797ArgIle: 2.797 ± 0.058	2.942ArgLys: 2.942 ± 0.06	3.036ArgLeu: 3.036 ± 0.063	0.819ArgMet: 0.819 ± 0.029	2.051ArgAsn: 2.051 ± 0.047	0.957ArgPro: 0.957 ± 0.03	0.994ArgGln: 0.994 ± 0.033	1.165ArgArg: 1.165 ± 0.039	1.678ArgSer: 1.678 ± 0.046	1.668ArgThr: 1.668 ± 0.039	2.026ArgVal: 2.026 ± 0.05	0.326ArgTrp: 0.326 ± 0.018	1.383ArgTyr: 1.383 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.545SerAla: 3.545 ± 0.067	0.592SerCys: 0.592 ± 0.025	3.399SerAsp: 3.399 ± 0.063	4.228SerGlu: 4.228 ± 0.07	4.049SerPhe: 4.049 ± 0.077	4.333SerGly: 4.333 ± 0.089	1.021SerHis: 1.021 ± 0.033	5.63SerIle: 5.63 ± 0.078	5.29SerLys: 5.29 ± 0.073	6.081SerLeu: 6.081 ± 0.094	1.211SerMet: 1.211 ± 0.04	3.949SerAsn: 3.949 ± 0.081	1.885SerPro: 1.885 ± 0.048	2.033SerGln: 2.033 ± 0.054	1.916SerArg: 1.916 ± 0.047	4.536SerSer: 4.536 ± 0.087	3.67SerThr: 3.67 ± 0.076	4.205SerVal: 4.205 ± 0.063	0.693SerTrp: 0.693 ± 0.027	2.728SerTyr: 2.728 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.429ThrAla: 3.429 ± 0.08	0.355ThrCys: 0.355 ± 0.02	3.262ThrAsp: 3.262 ± 0.066	3.544ThrGlu: 3.544 ± 0.062	3.07ThrPhe: 3.07 ± 0.061	3.957ThrGly: 3.957 ± 0.084	1.003ThrHis: 1.003 ± 0.032	5.337ThrIle: 5.337 ± 0.084	4.462ThrLys: 4.462 ± 0.068	5.123ThrLeu: 5.123 ± 0.071	0.932ThrMet: 0.932 ± 0.037	3.623ThrAsn: 3.623 ± 0.075	2.385ThrPro: 2.385 ± 0.059	1.924ThrGln: 1.924 ± 0.045	1.623ThrArg: 1.623 ± 0.038	4.082ThrSer: 4.082 ± 0.084	3.647ThrThr: 3.647 ± 0.08	3.693ThrVal: 3.693 ± 0.074	0.537ThrTrp: 0.537 ± 0.023	2.225ThrTyr: 2.225 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.939ValAla: 3.939 ± 0.073	0.464ValCys: 0.464 ± 0.024	3.578ValAsp: 3.578 ± 0.066	3.94ValGlu: 3.94 ± 0.073	3.546ValPhe: 3.546 ± 0.062	3.808ValGly: 3.808 ± 0.076	0.955ValHis: 0.955 ± 0.038	4.793ValIle: 4.793 ± 0.07	4.742ValLys: 4.742 ± 0.074	6.063ValLeu: 6.063 ± 0.103	1.218ValMet: 1.218 ± 0.037	3.784ValAsn: 3.784 ± 0.069	2.006ValPro: 2.006 ± 0.047	1.702ValGln: 1.702 ± 0.047	1.919ValArg: 1.919 ± 0.053	4.587ValSer: 4.587 ± 0.07	3.609ValThr: 3.609 ± 0.072	4.235ValVal: 4.235 ± 0.077	0.593ValTrp: 0.593 ± 0.023	2.344ValTyr: 2.344 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.528TrpAla: 0.528 ± 0.029	0.086TrpCys: 0.086 ± 0.011	0.538TrpAsp: 0.538 ± 0.029	0.587TrpGlu: 0.587 ± 0.026	0.552TrpPhe: 0.552 ± 0.026	0.609TrpGly: 0.609 ± 0.025	0.182TrpHis: 0.182 ± 0.013	0.731TrpIle: 0.731 ± 0.028	0.841TrpLys: 0.841 ± 0.032	0.958TrpLeu: 0.958 ± 0.036	0.293TrpMet: 0.293 ± 0.018	0.675TrpAsn: 0.675 ± 0.029	0.191TrpPro: 0.191 ± 0.016	0.392TrpGln: 0.392 ± 0.022	0.366TrpArg: 0.366 ± 0.02	0.597TrpSer: 0.597 ± 0.03	0.498TrpThr: 0.498 ± 0.026	0.572TrpVal: 0.572 ± 0.024	0.149TrpTrp: 0.149 ± 0.013	0.443TrpTyr: 0.443 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.234TyrAla: 2.234 ± 0.05	0.298TyrCys: 0.298 ± 0.018	2.23TyrAsp: 2.23 ± 0.047	2.249TyrGlu: 2.249 ± 0.045	2.415TyrPhe: 2.415 ± 0.048	2.512TyrGly: 2.512 ± 0.051	0.789TyrHis: 0.789 ± 0.028	2.921TyrIle: 2.921 ± 0.06	3.44TyrLys: 3.44 ± 0.074	3.703TyrLeu: 3.703 ± 0.072	0.681TyrMet: 0.681 ± 0.026	2.809TyrAsn: 2.809 ± 0.058	1.416TyrPro: 1.416 ± 0.041	1.505TyrGln: 1.505 ± 0.044	1.411TyrArg: 1.411 ± 0.042	2.669TyrSer: 2.669 ± 0.055	2.384TyrThr: 2.384 ± 0.065	2.18TyrVal: 2.18 ± 0.045	0.426TyrTrp: 0.426 ± 0.022	1.719TyrTyr: 1.719 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2925 proteins (971420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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