Amino acid dipepetide frequency for Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.54AlaAla: 5.54 ± 0.125	0.471AlaCys: 0.471 ± 0.032	2.338AlaAsp: 2.338 ± 0.061	3.539AlaGlu: 3.539 ± 0.092	2.498AlaPhe: 2.498 ± 0.064	4.671AlaGly: 4.671 ± 0.101	0.992AlaHis: 0.992 ± 0.041	5.33AlaIle: 5.33 ± 0.11	3.926AlaLys: 3.926 ± 0.098	9.953AlaLeu: 9.953 ± 0.174	1.935AlaMet: 1.935 ± 0.054	2.22AlaAsn: 2.22 ± 0.059	2.559AlaPro: 2.559 ± 0.065	1.493AlaGln: 1.493 ± 0.049	3.834AlaArg: 3.834 ± 0.078	5.32AlaSer: 5.32 ± 0.108	3.415AlaThr: 3.415 ± 0.084	7.062AlaVal: 7.062 ± 0.114	1.02AlaTrp: 1.02 ± 0.047	3.508AlaTyr: 3.508 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	0.29CysAla: 0.29 ± 0.022	0.103CysCys: 0.103 ± 0.014	0.261CysAsp: 0.261 ± 0.022	0.29CysGlu: 0.29 ± 0.024	0.143CysPhe: 0.143 ± 0.016	0.775CysGly: 0.775 ± 0.043	0.107CysHis: 0.107 ± 0.014	0.516CysIle: 0.516 ± 0.029	0.195CysLys: 0.195 ± 0.02	0.559CysLeu: 0.559 ± 0.032	0.171CysMet: 0.171 ± 0.016	0.24CysAsn: 0.24 ± 0.02	0.577CysPro: 0.577 ± 0.039	0.103CysGln: 0.103 ± 0.013	0.458CysArg: 0.458 ± 0.028	0.606CysSer: 0.606 ± 0.031	0.346CysThr: 0.346 ± 0.025	0.491CysVal: 0.491 ± 0.033	0.082CysTrp: 0.082 ± 0.013	0.208CysTyr: 0.208 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.613AspAla: 3.613 ± 0.1	0.291AspCys: 0.291 ± 0.021	2.238AspAsp: 2.238 ± 0.075	3.854AspGlu: 3.854 ± 0.089	1.516AspPhe: 1.516 ± 0.044	2.914AspGly: 2.914 ± 0.077	0.577AspHis: 0.577 ± 0.028	2.841AspIle: 2.841 ± 0.068	2.618AspLys: 2.618 ± 0.068	4.841AspLeu: 4.841 ± 0.1	0.839AspMet: 0.839 ± 0.037	1.622AspAsn: 1.622 ± 0.056	2.34AspPro: 2.34 ± 0.065	0.707AspGln: 0.707 ± 0.034	1.762AspArg: 1.762 ± 0.057	2.716AspSer: 2.716 ± 0.073	1.802AspThr: 1.802 ± 0.057	4.601AspVal: 4.601 ± 0.093	0.746AspTrp: 0.746 ± 0.036	2.551AspTyr: 2.551 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	5.615GluAla: 5.615 ± 0.115	0.428GluCys: 0.428 ± 0.028	2.894GluAsp: 2.894 ± 0.072	4.503GluGlu: 4.503 ± 0.129	2.145GluPhe: 2.145 ± 0.059	3.899GluGly: 3.899 ± 0.091	0.852GluHis: 0.852 ± 0.036	3.09GluIle: 3.09 ± 0.087	2.441GluLys: 2.441 ± 0.073	8.216GluLeu: 8.216 ± 0.164	1.068GluMet: 1.068 ± 0.045	1.811GluAsn: 1.811 ± 0.064	2.468GluPro: 2.468 ± 0.061	1.03GluGln: 1.03 ± 0.043	2.962GluArg: 2.962 ± 0.089	3.285GluSer: 3.285 ± 0.072	2.396GluThr: 2.396 ± 0.07	5.961GluVal: 5.961 ± 0.125	0.789GluTrp: 0.789 ± 0.036	2.786GluTyr: 2.786 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	1.974PheAla: 1.974 ± 0.063	0.148PheCys: 0.148 ± 0.016	1.406PheAsp: 1.406 ± 0.057	1.586PheGlu: 1.586 ± 0.05	1.097PhePhe: 1.097 ± 0.044	2.187PheGly: 2.187 ± 0.073	0.554PheHis: 0.554 ± 0.032	3.516PheIle: 3.516 ± 0.088	2.308PheLys: 2.308 ± 0.063	2.881PheLeu: 2.881 ± 0.081	1.067PheMet: 1.067 ± 0.042	2.506PheAsn: 2.506 ± 0.071	1.167PhePro: 1.167 ± 0.044	0.574PheGln: 0.574 ± 0.033	1.82PheArg: 1.82 ± 0.061	2.275PheSer: 2.275 ± 0.063	2.576PheThr: 2.576 ± 0.072	1.664PheVal: 1.664 ± 0.062	0.344PheTrp: 0.344 ± 0.025	1.246PheTyr: 1.246 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.541GlyAla: 4.541 ± 0.099	0.489GlyCys: 0.489 ± 0.033	3.594GlyAsp: 3.594 ± 0.083	4.604GlyGlu: 4.604 ± 0.103	3.569GlyPhe: 3.569 ± 0.084	5.615GlyGly: 5.615 ± 0.108	1.135GlyHis: 1.135 ± 0.044	5.937GlyIle: 5.937 ± 0.111	4.317GlyLys: 4.317 ± 0.092	8.798GlyLeu: 8.798 ± 0.139	1.647GlyMet: 1.647 ± 0.053	3.035GlyAsn: 3.035 ± 0.075	2.373GlyPro: 2.373 ± 0.06	1.373GlyGln: 1.373 ± 0.054	4.044GlyArg: 4.044 ± 0.087	5.155GlySer: 5.155 ± 0.101	3.06GlyThr: 3.06 ± 0.089	7.648GlyVal: 7.648 ± 0.106	1.097GlyTrp: 1.097 ± 0.039	3.564GlyTyr: 3.564 ± 0.079	0.0GlyXaa: 0.0 ± 0.0
His	0.965HisAla: 0.965 ± 0.043	0.158HisCys: 0.158 ± 0.015	0.719HisAsp: 0.719 ± 0.035	0.967HisGlu: 0.967 ± 0.04	0.413HisPhe: 0.413 ± 0.028	1.443HisGly: 1.443 ± 0.049	0.31HisHis: 0.31 ± 0.024	0.937HisIle: 0.937 ± 0.041	0.514HisLys: 0.514 ± 0.029	1.331HisLeu: 1.331 ± 0.047	0.458HisMet: 0.458 ± 0.028	0.506HisAsn: 0.506 ± 0.031	0.842HisPro: 0.842 ± 0.036	0.27HisGln: 0.27 ± 0.021	0.899HisArg: 0.899 ± 0.042	0.81HisSer: 0.81 ± 0.042	0.582HisThr: 0.582 ± 0.03	1.469HisVal: 1.469 ± 0.054	0.295HisTrp: 0.295 ± 0.024	0.676HisTyr: 0.676 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.751IleAla: 5.751 ± 0.115	0.379IleCys: 0.379 ± 0.029	4.403IleAsp: 4.403 ± 0.092	5.017IleGlu: 5.017 ± 0.117	1.757IlePhe: 1.757 ± 0.052	5.991IleGly: 5.991 ± 0.13	1.338IleHis: 1.338 ± 0.048	7.27IleIle: 7.27 ± 0.145	5.257IleLys: 5.257 ± 0.081	6.928IleLeu: 6.928 ± 0.124	2.295IleMet: 2.295 ± 0.066	5.741IleAsn: 5.741 ± 0.115	4.105IlePro: 4.105 ± 0.09	1.335IleGln: 1.335 ± 0.042	4.756IleArg: 4.756 ± 0.103	4.696IleSer: 4.696 ± 0.098	4.114IleThr: 4.114 ± 0.091	6.052IleVal: 6.052 ± 0.103	0.679IleTrp: 0.679 ± 0.038	2.862IleTyr: 2.862 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.927LysAla: 4.927 ± 0.092	0.479LysCys: 0.479 ± 0.031	2.479LysAsp: 2.479 ± 0.072	3.125LysGlu: 3.125 ± 0.09	1.235LysPhe: 1.235 ± 0.051	3.999LysGly: 3.999 ± 0.082	0.78LysHis: 0.78 ± 0.034	2.846LysIle: 2.846 ± 0.093	1.3LysLys: 1.3 ± 0.06	5.683LysLeu: 5.683 ± 0.11	1.053LysMet: 1.053 ± 0.042	1.338LysAsn: 1.338 ± 0.052	3.566LysPro: 3.566 ± 0.076	0.872LysGln: 0.872 ± 0.037	2.531LysArg: 2.531 ± 0.08	2.626LysSer: 2.626 ± 0.068	1.849LysThr: 1.849 ± 0.06	5.465LysVal: 5.465 ± 0.098	0.747LysTrp: 0.747 ± 0.035	2.747LysTyr: 2.747 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	8.269LeuAla: 8.269 ± 0.139	0.546LeuCys: 0.546 ± 0.03	3.962LeuAsp: 3.962 ± 0.094	4.916LeuGlu: 4.916 ± 0.103	3.113LeuPhe: 3.113 ± 0.088	8.295LeuGly: 8.295 ± 0.128	1.261LeuHis: 1.261 ± 0.046	10.354LeuIle: 10.354 ± 0.18	5.528LeuLys: 5.528 ± 0.104	9.86LeuLeu: 9.86 ± 0.172	3.534LeuMet: 3.534 ± 0.092	5.688LeuAsn: 5.688 ± 0.108	4.315LeuPro: 4.315 ± 0.086	1.551LeuGln: 1.551 ± 0.055	6.967LeuArg: 6.967 ± 0.128	8.746LeuSer: 8.746 ± 0.135	6.999LeuThr: 6.999 ± 0.127	7.928LeuVal: 7.928 ± 0.133	1.122LeuTrp: 1.122 ± 0.044	3.802LeuTyr: 3.802 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	2.01MetAla: 2.01 ± 0.067	0.107MetCys: 0.107 ± 0.013	1.245MetAsp: 1.245 ± 0.046	1.391MetGlu: 1.391 ± 0.054	0.722MetPhe: 0.722 ± 0.035	2.498MetGly: 2.498 ± 0.074	0.519MetHis: 0.519 ± 0.031	2.1MetIle: 2.1 ± 0.065	0.884MetLys: 0.884 ± 0.038	2.674MetLeu: 2.674 ± 0.077	0.641MetMet: 0.641 ± 0.037	1.336MetAsn: 1.336 ± 0.048	1.383MetPro: 1.383 ± 0.049	0.547MetGln: 0.547 ± 0.03	1.583MetArg: 1.583 ± 0.054	2.062MetSer: 2.062 ± 0.06	1.01MetThr: 1.01 ± 0.046	2.521MetVal: 2.521 ± 0.062	0.293MetTrp: 0.293 ± 0.021	0.978MetTyr: 0.978 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	3.678AsnAla: 3.678 ± 0.084	0.384AsnCys: 0.384 ± 0.025	2.453AsnAsp: 2.453 ± 0.064	3.36AsnGlu: 3.36 ± 0.082	1.067AsnPhe: 1.067 ± 0.043	4.18AsnGly: 4.18 ± 0.107	0.649AsnHis: 0.649 ± 0.034	3.315AsnIle: 3.315 ± 0.08	1.882AsnLys: 1.882 ± 0.055	4.267AsnLeu: 4.267 ± 0.086	1.193AsnMet: 1.193 ± 0.041	2.132AsnAsn: 2.132 ± 0.076	3.01AsnPro: 3.01 ± 0.078	1.015AsnGln: 1.015 ± 0.04	1.892AsnArg: 1.892 ± 0.07	2.524AsnSer: 2.524 ± 0.083	2.233AsnThr: 2.233 ± 0.069	4.283AsnVal: 4.283 ± 0.093	0.711AsnTrp: 0.711 ± 0.039	2.157AsnTyr: 2.157 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	2.232ProAla: 2.232 ± 0.062	0.333ProCys: 0.333 ± 0.022	1.96ProAsp: 1.96 ± 0.063	2.681ProGlu: 2.681 ± 0.078	1.631ProPhe: 1.631 ± 0.057	3.39ProGly: 3.39 ± 0.082	0.737ProHis: 0.737 ± 0.037	3.767ProIle: 3.767 ± 0.069	1.832ProLys: 1.832 ± 0.057	4.643ProLeu: 4.643 ± 0.093	1.2ProMet: 1.2 ± 0.042	1.995ProAsn: 1.995 ± 0.063	2.406ProPro: 2.406 ± 0.079	1.273ProGln: 1.273 ± 0.056	2.526ProArg: 2.526 ± 0.069	3.431ProSer: 3.431 ± 0.085	2.311ProThr: 2.311 ± 0.072	3.886ProVal: 3.886 ± 0.082	0.827ProTrp: 0.827 ± 0.045	2.213ProTyr: 2.213 ± 0.071	0.0ProXaa: 0.0 ± 0.0
Gln	1.418GlnAla: 1.418 ± 0.047	0.216GlnCys: 0.216 ± 0.02	0.759GlnAsp: 0.759 ± 0.035	0.99GlnGlu: 0.99 ± 0.046	0.731GlnPhe: 0.731 ± 0.034	1.463GlnGly: 1.463 ± 0.049	0.286GlnHis: 0.286 ± 0.021	1.018GlnIle: 1.018 ± 0.044	0.411GlnLys: 0.411 ± 0.025	2.406GlnLeu: 2.406 ± 0.061	0.547GlnMet: 0.547 ± 0.025	0.559GlnAsn: 0.559 ± 0.036	0.924GlnPro: 0.924 ± 0.044	0.567GlnGln: 0.567 ± 0.042	1.03GlnArg: 1.03 ± 0.043	1.115GlnSer: 1.115 ± 0.049	0.629GlnThr: 0.629 ± 0.034	2.068GlnVal: 2.068 ± 0.067	0.369GlnTrp: 0.369 ± 0.027	1.205GlnTyr: 1.205 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	3.02ArgAla: 3.02 ± 0.076	0.368ArgCys: 0.368 ± 0.031	2.869ArgAsp: 2.869 ± 0.073	3.982ArgGlu: 3.982 ± 0.1	2.243ArgPhe: 2.243 ± 0.073	4.689ArgGly: 4.689 ± 0.094	0.882ArgHis: 0.882 ± 0.042	4.976ArgIle: 4.976 ± 0.099	2.073ArgLys: 2.073 ± 0.057	6.586ArgLeu: 6.586 ± 0.14	1.38ArgMet: 1.38 ± 0.048	2.202ArgAsn: 2.202 ± 0.059	1.89ArgPro: 1.89 ± 0.069	1.163ArgGln: 1.163 ± 0.045	4.994ArgArg: 4.994 ± 0.105	3.069ArgSer: 3.069 ± 0.074	1.827ArgThr: 1.827 ± 0.063	5.561ArgVal: 5.561 ± 0.106	0.657ArgTrp: 0.657 ± 0.034	2.205ArgTyr: 2.205 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	3.491SerAla: 3.491 ± 0.084	0.391SerCys: 0.391 ± 0.027	2.776SerAsp: 2.776 ± 0.066	3.864SerGlu: 3.864 ± 0.09	2.217SerPhe: 2.217 ± 0.058	5.122SerGly: 5.122 ± 0.112	0.82SerHis: 0.82 ± 0.04	6.573SerIle: 6.573 ± 0.111	3.265SerLys: 3.265 ± 0.078	7.19SerLeu: 7.19 ± 0.135	2.32SerMet: 2.32 ± 0.069	3.258SerAsn: 3.258 ± 0.088	2.441SerPro: 2.441 ± 0.071	1.308SerGln: 1.308 ± 0.049	4.43SerArg: 4.43 ± 0.101	5.119SerSer: 5.119 ± 0.139	3.949SerThr: 3.949 ± 0.12	5.032SerVal: 5.032 ± 0.093	0.789SerTrp: 0.789 ± 0.041	2.496SerTyr: 2.496 ± 0.076	0.0SerXaa: 0.0 ± 0.0
Thr	3.784ThrAla: 3.784 ± 0.099	0.354ThrCys: 0.354 ± 0.027	1.704ThrAsp: 1.704 ± 0.055	2.273ThrGlu: 2.273 ± 0.059	1.403ThrPhe: 1.403 ± 0.058	4.332ThrGly: 4.332 ± 0.096	0.857ThrHis: 0.857 ± 0.04	4.205ThrIle: 4.205 ± 0.091	1.827ThrLys: 1.827 ± 0.056	5.621ThrLeu: 5.621 ± 0.105	1.468ThrMet: 1.468 ± 0.05	1.789ThrAsn: 1.789 ± 0.066	2.767ThrPro: 2.767 ± 0.079	1.305ThrGln: 1.305 ± 0.051	2.381ThrArg: 2.381 ± 0.075	3.24ThrSer: 3.24 ± 0.096	3.21ThrThr: 3.21 ± 0.166	4.991ThrVal: 4.991 ± 0.115	0.819ThrTrp: 0.819 ± 0.039	2.393ThrTyr: 2.393 ± 0.075	0.0ThrXaa: 0.0 ± 0.0
Val	6.35ValAla: 6.35 ± 0.119	0.431ValCys: 0.431 ± 0.028	4.282ValAsp: 4.282 ± 0.105	4.916ValGlu: 4.916 ± 0.099	3.172ValPhe: 3.172 ± 0.084	5.28ValGly: 5.28 ± 0.098	1.138ValHis: 1.138 ± 0.046	8.061ValIle: 8.061 ± 0.127	7.38ValLys: 7.38 ± 0.125	8.179ValLeu: 8.179 ± 0.137	2.26ValMet: 2.26 ± 0.06	6.134ValAsn: 6.134 ± 0.121	3.4ValPro: 3.4 ± 0.086	1.251ValGln: 1.251 ± 0.05	4.411ValArg: 4.411 ± 0.095	5.904ValSer: 5.904 ± 0.1	5.556ValThr: 5.556 ± 0.124	7.397ValVal: 7.397 ± 0.137	0.752ValTrp: 0.752 ± 0.035	3.561ValTyr: 3.561 ± 0.074	0.0ValXaa: 0.0 ± 0.0
Trp	0.889TrpAla: 0.889 ± 0.045	0.111TrpCys: 0.111 ± 0.014	0.689TrpAsp: 0.689 ± 0.036	0.544TrpGlu: 0.544 ± 0.033	0.684TrpPhe: 0.684 ± 0.031	1.185TrpGly: 1.185 ± 0.048	0.186TrpHis: 0.186 ± 0.019	0.882TrpIle: 0.882 ± 0.043	0.318TrpLys: 0.318 ± 0.024	1.556TrpLeu: 1.556 ± 0.051	0.266TrpMet: 0.266 ± 0.019	0.493TrpAsn: 0.493 ± 0.028	0.567TrpPro: 0.567 ± 0.039	0.251TrpGln: 0.251 ± 0.023	0.957TrpArg: 0.957 ± 0.042	0.99TrpSer: 0.99 ± 0.05	0.526TrpThr: 0.526 ± 0.034	1.298TrpVal: 1.298 ± 0.047	0.25TrpTrp: 0.25 ± 0.02	0.561TrpTyr: 0.561 ± 0.037	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.268TyrAla: 3.268 ± 0.078	0.331TyrCys: 0.331 ± 0.027	1.957TyrAsp: 1.957 ± 0.058	2.235TyrGlu: 2.235 ± 0.059	1.541TyrPhe: 1.541 ± 0.047	3.673TyrGly: 3.673 ± 0.079	0.581TyrHis: 0.581 ± 0.033	3.192TyrIle: 3.192 ± 0.076	1.373TyrLys: 1.373 ± 0.046	4.586TyrLeu: 4.586 ± 0.09	1.16TyrMet: 1.16 ± 0.046	1.781TyrAsn: 1.781 ± 0.075	2.173TyrPro: 2.173 ± 0.063	0.724TyrGln: 0.724 ± 0.037	2.4TyrArg: 2.4 ± 0.073	3.162TyrSer: 3.162 ± 0.073	2.331TyrThr: 2.331 ± 0.064	4.436TyrVal: 4.436 ± 0.086	0.817TyrTrp: 0.817 ± 0.037	2.227TyrTyr: 2.227 ± 0.078	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1962 proteins (600938 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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