Amino acid dipepetide frequency for Raphidiopsis brookii D9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.961AlaAla: 5.961 ± 0.112
0.774AlaCys: 0.774 ± 0.031
3.31AlaAsp: 3.31 ± 0.064
4.071AlaGlu: 4.071 ± 0.065
2.463AlaPhe: 2.463 ± 0.057
5.04AlaGly: 5.04 ± 0.084
1.243AlaHis: 1.243 ± 0.042
6.334AlaIle: 6.334 ± 0.094
3.951AlaLys: 3.951 ± 0.074
7.329AlaLeu: 7.329 ± 0.112
1.508AlaMet: 1.508 ± 0.044
3.15AlaAsn: 3.15 ± 0.064
2.431AlaPro: 2.431 ± 0.049
3.727AlaGln: 3.727 ± 0.067
3.366AlaArg: 3.366 ± 0.066
3.961AlaSer: 3.961 ± 0.065
3.878AlaThr: 3.878 ± 0.069
4.911AlaVal: 4.911 ± 0.085
0.835AlaTrp: 0.835 ± 0.03
2.116AlaTyr: 2.116 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.627CysAla: 0.627 ± 0.026
0.154CysCys: 0.154 ± 0.013
0.623CysAsp: 0.623 ± 0.028
0.555CysGlu: 0.555 ± 0.028
0.426CysPhe: 0.426 ± 0.023
0.884CysGly: 0.884 ± 0.035
0.291CysHis: 0.291 ± 0.02
0.561CysIle: 0.561 ± 0.021
0.347CysLys: 0.347 ± 0.021
1.217CysLeu: 1.217 ± 0.042
0.181CysMet: 0.181 ± 0.015
0.395CysAsn: 0.395 ± 0.024
0.57CysPro: 0.57 ± 0.028
0.677CysGln: 0.677 ± 0.031
0.47CysArg: 0.47 ± 0.025
0.599CysSer: 0.599 ± 0.028
0.458CysThr: 0.458 ± 0.024
0.628CysVal: 0.628 ± 0.026
0.147CysTrp: 0.147 ± 0.013
0.359CysTyr: 0.359 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.022AspAla: 3.022 ± 0.06
0.523AspCys: 0.523 ± 0.024
1.964AspAsp: 1.964 ± 0.055
2.565AspGlu: 2.565 ± 0.055
2.267AspPhe: 2.267 ± 0.053
3.161AspGly: 3.161 ± 0.067
1.032AspHis: 1.032 ± 0.033
3.607AspIle: 3.607 ± 0.065
2.369AspLys: 2.369 ± 0.056
6.112AspLeu: 6.112 ± 0.089
0.959AspMet: 0.959 ± 0.033
2.013AspAsn: 2.013 ± 0.049
2.498AspPro: 2.498 ± 0.058
2.15AspGln: 2.15 ± 0.047
2.816AspArg: 2.816 ± 0.06
2.817AspSer: 2.817 ± 0.049
2.199AspThr: 2.199 ± 0.06
2.838AspVal: 2.838 ± 0.057
0.826AspTrp: 0.826 ± 0.029
1.881AspTyr: 1.881 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
4.003GluAla: 4.003 ± 0.078
0.488GluCys: 0.488 ± 0.026
2.719GluAsp: 2.719 ± 0.058
4.287GluGlu: 4.287 ± 0.09
2.487GluPhe: 2.487 ± 0.058
3.166GluGly: 3.166 ± 0.067
0.97GluHis: 0.97 ± 0.032
5.432GluIle: 5.432 ± 0.088
4.003GluLys: 4.003 ± 0.074
6.979GluLeu: 6.979 ± 0.106
1.38GluMet: 1.38 ± 0.045
3.29GluAsn: 3.29 ± 0.067
2.129GluPro: 2.129 ± 0.057
3.072GluGln: 3.072 ± 0.07
3.184GluArg: 3.184 ± 0.064
3.484GluSer: 3.484 ± 0.065
3.484GluThr: 3.484 ± 0.061
4.211GluVal: 4.211 ± 0.066
0.808GluTrp: 0.808 ± 0.03
2.037GluTyr: 2.037 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
2.732PheAla: 2.732 ± 0.059
0.55PheCys: 0.55 ± 0.025
2.155PheAsp: 2.155 ± 0.05
1.836PheGlu: 1.836 ± 0.042
1.601PhePhe: 1.601 ± 0.046
2.92PheGly: 2.92 ± 0.067
0.856PheHis: 0.856 ± 0.034
2.515PheIle: 2.515 ± 0.058
1.595PheLys: 1.595 ± 0.045
4.343PheLeu: 4.343 ± 0.088
0.777PheMet: 0.777 ± 0.028
1.862PheAsn: 1.862 ± 0.048
1.939PhePro: 1.939 ± 0.047
1.719PheGln: 1.719 ± 0.046
1.793PheArg: 1.793 ± 0.044
2.972PheSer: 2.972 ± 0.069
2.371PheThr: 2.371 ± 0.053
2.354PheVal: 2.354 ± 0.052
0.719PheTrp: 0.719 ± 0.03
1.378PheTyr: 1.378 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.607GlyAla: 4.607 ± 0.085
0.818GlyCys: 0.818 ± 0.033
3.458GlyAsp: 3.458 ± 0.061
4.41GlyGlu: 4.41 ± 0.071
3.031GlyPhe: 3.031 ± 0.057
5.05GlyGly: 5.05 ± 0.092
1.232GlyHis: 1.232 ± 0.043
5.51GlyIle: 5.51 ± 0.088
4.736GlyLys: 4.736 ± 0.083
7.109GlyLeu: 7.109 ± 0.094
1.698GlyMet: 1.698 ± 0.048
3.084GlyAsn: 3.084 ± 0.072
1.529GlyPro: 1.529 ± 0.041
2.705GlyGln: 2.705 ± 0.055
3.296GlyArg: 3.296 ± 0.063
4.218GlySer: 4.218 ± 0.073
3.84GlyThr: 3.84 ± 0.081
5.117GlyVal: 5.117 ± 0.091
1.161GlyTrp: 1.161 ± 0.043
2.437GlyTyr: 2.437 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.05HisAla: 1.05 ± 0.037
0.255HisCys: 0.255 ± 0.018
0.791HisAsp: 0.791 ± 0.03
0.91HisGlu: 0.91 ± 0.034
0.838HisPhe: 0.838 ± 0.032
1.347HisGly: 1.347 ± 0.048
0.732HisHis: 0.732 ± 0.031
1.42HisIle: 1.42 ± 0.044
0.917HisLys: 0.917 ± 0.032
2.364HisLeu: 2.364 ± 0.057
0.175HisMet: 0.175 ± 0.014
0.925HisAsn: 0.925 ± 0.034
1.43HisPro: 1.43 ± 0.04
1.349HisGln: 1.349 ± 0.042
1.131HisArg: 1.131 ± 0.041
1.306HisSer: 1.306 ± 0.036
1.007HisThr: 1.007 ± 0.038
0.928HisVal: 0.928 ± 0.032
0.353HisTrp: 0.353 ± 0.022
0.672HisTyr: 0.672 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.611IleAla: 6.611 ± 0.098
0.848IleCys: 0.848 ± 0.032
3.893IleAsp: 3.893 ± 0.063
4.215IleGlu: 4.215 ± 0.081
2.798IlePhe: 2.798 ± 0.055
4.87IleGly: 4.87 ± 0.081
1.471IleHis: 1.471 ± 0.043
4.901IleIle: 4.901 ± 0.074
3.602IleLys: 3.602 ± 0.067
7.675IleLeu: 7.675 ± 0.108
1.226IleMet: 1.226 ± 0.041
3.637IleAsn: 3.637 ± 0.078
4.03IlePro: 4.03 ± 0.068
3.155IleGln: 3.155 ± 0.053
3.404IleArg: 3.404 ± 0.069
5.259IleSer: 5.259 ± 0.079
4.258IleThr: 4.258 ± 0.076
4.56IleVal: 4.56 ± 0.058
0.974IleTrp: 0.974 ± 0.034
2.234IleTyr: 2.234 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
3.424LysAla: 3.424 ± 0.068
0.362LysCys: 0.362 ± 0.02
2.265LysAsp: 2.265 ± 0.052
3.09LysGlu: 3.09 ± 0.067
2.004LysPhe: 2.004 ± 0.05
2.703LysGly: 2.703 ± 0.06
0.856LysHis: 0.856 ± 0.034
4.334LysIle: 4.334 ± 0.079
2.737LysLys: 2.737 ± 0.073
5.969LysLeu: 5.969 ± 0.085
1.099LysMet: 1.099 ± 0.036
2.661LysAsn: 2.661 ± 0.057
2.43LysPro: 2.43 ± 0.054
2.749LysGln: 2.749 ± 0.057
2.372LysArg: 2.372 ± 0.046
3.502LysSer: 3.502 ± 0.061
3.325LysThr: 3.325 ± 0.066
3.319LysVal: 3.319 ± 0.061
0.603LysTrp: 0.603 ± 0.032
1.818LysTyr: 1.818 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
8.845LeuAla: 8.845 ± 0.111
1.033LeuCys: 1.033 ± 0.032
5.378LeuAsp: 5.378 ± 0.072
7.625LeuGlu: 7.625 ± 0.104
3.802LeuPhe: 3.802 ± 0.065
8.321LeuGly: 8.321 ± 0.121
1.957LeuHis: 1.957 ± 0.049
7.452LeuIle: 7.452 ± 0.103
5.724LeuLys: 5.724 ± 0.083
11.247LeuLeu: 11.247 ± 0.141
2.255LeuMet: 2.255 ± 0.05
4.655LeuAsn: 4.655 ± 0.076
5.876LeuPro: 5.876 ± 0.089
5.346LeuGln: 5.346 ± 0.079
5.211LeuArg: 5.211 ± 0.076
7.345LeuSer: 7.345 ± 0.118
6.584LeuThr: 6.584 ± 0.095
7.707LeuVal: 7.707 ± 0.103
1.346LeuTrp: 1.346 ± 0.046
2.711LeuTyr: 2.711 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
1.73MetAla: 1.73 ± 0.047
0.135MetCys: 0.135 ± 0.012
0.847MetAsp: 0.847 ± 0.032
1.341MetGlu: 1.341 ± 0.045
0.628MetPhe: 0.628 ± 0.029
1.714MetGly: 1.714 ± 0.046
0.265MetHis: 0.265 ± 0.019
1.362MetIle: 1.362 ± 0.038
1.029MetLys: 1.029 ± 0.034
1.997MetLeu: 1.997 ± 0.048
0.436MetMet: 0.436 ± 0.021
0.902MetAsn: 0.902 ± 0.031
0.813MetPro: 0.813 ± 0.034
0.835MetGln: 0.835 ± 0.032
1.006MetArg: 1.006 ± 0.034
1.432MetSer: 1.432 ± 0.044
1.361MetThr: 1.361 ± 0.035
1.552MetVal: 1.552 ± 0.045
0.147MetTrp: 0.147 ± 0.013
0.434MetTyr: 0.434 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.562AsnAla: 2.562 ± 0.053
0.54AsnCys: 0.54 ± 0.025
1.588AsnAsp: 1.588 ± 0.045
1.763AsnGlu: 1.763 ± 0.044
2.034AsnPhe: 2.034 ± 0.048
2.653AsnGly: 2.653 ± 0.065
1.139AsnHis: 1.139 ± 0.037
3.282AsnIle: 3.282 ± 0.066
2.002AsnLys: 2.002 ± 0.049
6.079AsnLeu: 6.079 ± 0.101
0.753AsnMet: 0.753 ± 0.031
2.316AsnAsn: 2.316 ± 0.071
2.858AsnPro: 2.858 ± 0.068
2.924AsnGln: 2.924 ± 0.053
2.613AsnArg: 2.613 ± 0.064
3.387AsnSer: 3.387 ± 0.069
2.305AsnThr: 2.305 ± 0.052
2.286AsnVal: 2.286 ± 0.055
0.859AsnTrp: 0.859 ± 0.039
1.844AsnTyr: 1.844 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.723ProAla: 2.723 ± 0.057
0.387ProCys: 0.387 ± 0.022
2.834ProAsp: 2.834 ± 0.063
3.7ProGlu: 3.7 ± 0.068
1.59ProPhe: 1.59 ± 0.041
3.37ProGly: 3.37 ± 0.066
1.105ProHis: 1.105 ± 0.039
3.359ProIle: 3.359 ± 0.071
2.193ProLys: 2.193 ± 0.052
4.755ProLeu: 4.755 ± 0.074
0.822ProMet: 0.822 ± 0.028
2.161ProAsn: 2.161 ± 0.055
2.237ProPro: 2.237 ± 0.063
2.687ProGln: 2.687 ± 0.058
1.873ProArg: 1.873 ± 0.044
2.932ProSer: 2.932 ± 0.061
2.784ProThr: 2.784 ± 0.068
3.26ProVal: 3.26 ± 0.061
0.669ProTrp: 0.669 ± 0.027
1.44ProTyr: 1.44 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.839GlnAla: 3.839 ± 0.07
0.348GlnCys: 0.348 ± 0.02
2.131GlnAsp: 2.131 ± 0.041
3.899GlnGlu: 3.899 ± 0.076
1.675GlnPhe: 1.675 ± 0.042
3.314GlnGly: 3.314 ± 0.067
0.879GlnHis: 0.879 ± 0.03
3.919GlnIle: 3.919 ± 0.071
3.026GlnLys: 3.026 ± 0.057
5.707GlnLeu: 5.707 ± 0.09
1.087GlnMet: 1.087 ± 0.038
2.238GlnAsn: 2.238 ± 0.05
2.437GlnPro: 2.437 ± 0.05
3.056GlnGln: 3.056 ± 0.071
2.667GlnArg: 2.667 ± 0.061
2.925GlnSer: 2.925 ± 0.061
2.76GlnThr: 2.76 ± 0.059
4.026GlnVal: 4.026 ± 0.077
0.657GlnTrp: 0.657 ± 0.028
1.2GlnTyr: 1.2 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.916ArgAla: 2.916 ± 0.065
0.494ArgCys: 0.494 ± 0.024
2.443ArgAsp: 2.443 ± 0.051
3.7ArgGlu: 3.7 ± 0.071
2.123ArgPhe: 2.123 ± 0.048
3.182ArgGly: 3.182 ± 0.068
0.961ArgHis: 0.961 ± 0.033
3.458ArgIle: 3.458 ± 0.058
2.369ArgLys: 2.369 ± 0.058
5.57ArgLeu: 5.57 ± 0.088
1.002ArgMet: 1.002 ± 0.035
2.131ArgAsn: 2.131 ± 0.043
1.966ArgPro: 1.966 ± 0.045
2.962ArgGln: 2.962 ± 0.059
2.788ArgArg: 2.788 ± 0.062
3.142ArgSer: 3.142 ± 0.058
2.374ArgThr: 2.374 ± 0.054
3.481ArgVal: 3.481 ± 0.073
0.697ArgTrp: 0.697 ± 0.026
1.752ArgTyr: 1.752 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.938SerAla: 3.938 ± 0.069
0.675SerCys: 0.675 ± 0.027
2.955SerAsp: 2.955 ± 0.061
3.308SerGlu: 3.308 ± 0.062
2.505SerPhe: 2.505 ± 0.06
4.753SerGly: 4.753 ± 0.072
1.553SerHis: 1.553 ± 0.046
4.215SerIle: 4.215 ± 0.07
2.821SerLys: 2.821 ± 0.06
7.751SerLeu: 7.751 ± 0.11
1.386SerMet: 1.386 ± 0.041
2.761SerAsn: 2.761 ± 0.063
3.567SerPro: 3.567 ± 0.071
3.996SerGln: 3.996 ± 0.077
3.23SerArg: 3.23 ± 0.061
4.541SerSer: 4.541 ± 0.096
3.568SerThr: 3.568 ± 0.07
4.022SerVal: 4.022 ± 0.069
1.054SerTrp: 1.054 ± 0.037
2.015SerTyr: 2.015 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.205ThrAla: 4.205 ± 0.06
0.536ThrCys: 0.536 ± 0.023
2.591ThrAsp: 2.591 ± 0.057
3.151ThrGlu: 3.151 ± 0.055
1.988ThrPhe: 1.988 ± 0.051
4.385ThrGly: 4.385 ± 0.071
1.061ThrHis: 1.061 ± 0.036
4.188ThrIle: 4.188 ± 0.075
2.593ThrLys: 2.593 ± 0.055
5.892ThrLeu: 5.892 ± 0.08
0.98ThrMet: 0.98 ± 0.036
2.471ThrAsn: 2.471 ± 0.058
3.226ThrPro: 3.226 ± 0.069
2.707ThrGln: 2.707 ± 0.063
2.544ThrArg: 2.544 ± 0.061
3.64ThrSer: 3.64 ± 0.065
3.443ThrThr: 3.443 ± 0.068
3.85ThrVal: 3.85 ± 0.068
0.768ThrTrp: 0.768 ± 0.029
1.638ThrTyr: 1.638 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
4.894ValAla: 4.894 ± 0.079
0.695ValCys: 0.695 ± 0.032
3.548ValAsp: 3.548 ± 0.073
4.425ValGlu: 4.425 ± 0.066
2.729ValPhe: 2.729 ± 0.051
4.869ValGly: 4.869 ± 0.082
1.138ValHis: 1.138 ± 0.034
4.973ValIle: 4.973 ± 0.075
3.668ValLys: 3.668 ± 0.063
6.652ValLeu: 6.652 ± 0.09
1.408ValMet: 1.408 ± 0.042
3.114ValAsn: 3.114 ± 0.062
2.839ValPro: 2.839 ± 0.056
2.599ValGln: 2.599 ± 0.056
3.173ValArg: 3.173 ± 0.057
4.261ValSer: 4.261 ± 0.071
3.791ValThr: 3.791 ± 0.077
4.87ValVal: 4.87 ± 0.089
0.806ValTrp: 0.806 ± 0.033
1.983ValTyr: 1.983 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.731TrpAla: 0.731 ± 0.032
0.146TrpCys: 0.146 ± 0.013
0.672TrpAsp: 0.672 ± 0.033
1.074TrpGlu: 1.074 ± 0.034
0.651TrpPhe: 0.651 ± 0.024
1.083TrpGly: 1.083 ± 0.041
0.378TrpHis: 0.378 ± 0.019
0.847TrpIle: 0.847 ± 0.032
0.627TrpLys: 0.627 ± 0.028
1.86TrpLeu: 1.86 ± 0.054
0.299TrpMet: 0.299 ± 0.017
0.614TrpAsn: 0.614 ± 0.031
0.321TrpPro: 0.321 ± 0.021
1.271TrpGln: 1.271 ± 0.042
0.769TrpArg: 0.769 ± 0.027
0.825TrpSer: 0.825 ± 0.026
0.513TrpThr: 0.513 ± 0.022
0.878TrpVal: 0.878 ± 0.03
0.242TrpTrp: 0.242 ± 0.017
0.426TrpTyr: 0.426 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.94TyrAla: 1.94 ± 0.045
0.407TyrCys: 0.407 ± 0.022
1.452TyrAsp: 1.452 ± 0.043
1.69TyrGlu: 1.69 ± 0.047
1.343TyrPhe: 1.343 ± 0.041
2.263TyrGly: 2.263 ± 0.058
0.782TyrHis: 0.782 ± 0.029
1.952TyrIle: 1.952 ± 0.048
1.313TyrLys: 1.313 ± 0.039
3.811TyrLeu: 3.811 ± 0.067
0.535TyrMet: 0.535 ± 0.024
1.407TyrAsn: 1.407 ± 0.044
1.757TyrPro: 1.757 ± 0.045
2.107TyrGln: 2.107 ± 0.053
1.806TyrArg: 1.806 ± 0.051
2.065TyrSer: 2.065 ± 0.045
1.553TyrThr: 1.553 ± 0.043
1.638TyrVal: 1.638 ± 0.044
0.555TyrTrp: 0.555 ± 0.028
1.195TyrTyr: 1.195 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3007 proteins (904229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski