Amino acid dipepetide frequency for Lawsonella clevelandensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.964AlaAla: 14.964 ± 0.295
1.087AlaCys: 1.087 ± 0.056
6.858AlaAsp: 6.858 ± 0.145
7.226AlaGlu: 7.226 ± 0.159
3.145AlaPhe: 3.145 ± 0.083
9.423AlaGly: 9.423 ± 0.166
2.739AlaHis: 2.739 ± 0.086
5.297AlaIle: 5.297 ± 0.12
3.587AlaLys: 3.587 ± 0.119
10.93AlaLeu: 10.93 ± 0.185
2.413AlaMet: 2.413 ± 0.085
2.83AlaAsn: 2.83 ± 0.093
4.726AlaPro: 4.726 ± 0.111
4.378AlaGln: 4.378 ± 0.109
6.319AlaArg: 6.319 ± 0.134
5.613AlaSer: 5.613 ± 0.112
6.76AlaThr: 6.76 ± 0.154
8.667AlaVal: 8.667 ± 0.155
1.374AlaTrp: 1.374 ± 0.057
2.376AlaTyr: 2.376 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.102CysAla: 1.102 ± 0.053
0.167CysCys: 0.167 ± 0.019
0.652CysAsp: 0.652 ± 0.038
0.578CysGlu: 0.578 ± 0.037
0.322CysPhe: 0.322 ± 0.028
0.993CysGly: 0.993 ± 0.049
0.239CysHis: 0.239 ± 0.023
0.496CysIle: 0.496 ± 0.035
0.18CysLys: 0.18 ± 0.019
0.822CysLeu: 0.822 ± 0.052
0.2CysMet: 0.2 ± 0.02
0.254CysAsn: 0.254 ± 0.024
0.598CysPro: 0.598 ± 0.041
0.383CysGln: 0.383 ± 0.028
0.611CysArg: 0.611 ± 0.038
0.615CysSer: 0.615 ± 0.038
0.663CysThr: 0.663 ± 0.038
0.739CysVal: 0.739 ± 0.044
0.154CysTrp: 0.154 ± 0.019
0.235CysTyr: 0.235 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
6.845AspAla: 6.845 ± 0.134
0.541AspCys: 0.541 ± 0.036
3.767AspAsp: 3.767 ± 0.122
3.952AspGlu: 3.952 ± 0.123
1.782AspPhe: 1.782 ± 0.058
4.969AspGly: 4.969 ± 0.113
1.291AspHis: 1.291 ± 0.056
3.243AspIle: 3.243 ± 0.089
2.022AspLys: 2.022 ± 0.081
5.695AspLeu: 5.695 ± 0.119
1.376AspMet: 1.376 ± 0.054
1.874AspAsn: 1.874 ± 0.065
3.687AspPro: 3.687 ± 0.096
1.626AspGln: 1.626 ± 0.061
3.291AspArg: 3.291 ± 0.099
2.956AspSer: 2.956 ± 0.079
3.654AspThr: 3.654 ± 0.1
4.924AspVal: 4.924 ± 0.097
0.826AspTrp: 0.826 ± 0.044
1.756AspTyr: 1.756 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.336GluAla: 6.336 ± 0.153
0.548GluCys: 0.548 ± 0.035
3.437GluAsp: 3.437 ± 0.103
4.302GluGlu: 4.302 ± 0.118
1.811GluPhe: 1.811 ± 0.065
4.206GluGly: 4.206 ± 0.105
1.406GluHis: 1.406 ± 0.065
3.163GluIle: 3.163 ± 0.083
2.658GluLys: 2.658 ± 0.087
6.186GluLeu: 6.186 ± 0.125
1.543GluMet: 1.543 ± 0.057
1.915GluAsn: 1.915 ± 0.068
2.495GluPro: 2.495 ± 0.084
2.341GluGln: 2.341 ± 0.077
3.958GluArg: 3.958 ± 0.11
2.874GluSer: 2.874 ± 0.086
2.965GluThr: 2.965 ± 0.083
4.417GluVal: 4.417 ± 0.087
0.926GluTrp: 0.926 ± 0.048
1.367GluTyr: 1.367 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.291PheAla: 3.291 ± 0.081
0.346PheCys: 0.346 ± 0.034
2.111PheAsp: 2.111 ± 0.073
1.406PheGlu: 1.406 ± 0.062
1.13PhePhe: 1.13 ± 0.059
2.954PheGly: 2.954 ± 0.084
0.802PheHis: 0.802 ± 0.043
1.472PheIle: 1.472 ± 0.063
0.759PheLys: 0.759 ± 0.039
2.852PheLeu: 2.852 ± 0.089
0.667PheMet: 0.667 ± 0.038
0.978PheAsn: 0.978 ± 0.052
1.5PhePro: 1.5 ± 0.057
0.917PheGln: 0.917 ± 0.047
1.702PheArg: 1.702 ± 0.068
2.022PheSer: 2.022 ± 0.074
2.25PheThr: 2.25 ± 0.075
2.428PheVal: 2.428 ± 0.061
0.422PheTrp: 0.422 ± 0.03
0.83PheTyr: 0.83 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
7.736GlyAla: 7.736 ± 0.164
0.926GlyCys: 0.926 ± 0.05
4.587GlyAsp: 4.587 ± 0.115
4.676GlyGlu: 4.676 ± 0.1
2.822GlyPhe: 2.822 ± 0.078
6.573GlyGly: 6.573 ± 0.156
1.926GlyHis: 1.926 ± 0.065
4.867GlyIle: 4.867 ± 0.116
3.6GlyLys: 3.6 ± 0.108
7.213GlyLeu: 7.213 ± 0.153
2.317GlyMet: 2.317 ± 0.065
2.254GlyAsn: 2.254 ± 0.074
3.237GlyPro: 3.237 ± 0.086
2.715GlyGln: 2.715 ± 0.069
4.782GlyArg: 4.782 ± 0.107
4.843GlySer: 4.843 ± 0.12
5.23GlyThr: 5.23 ± 0.124
7.006GlyVal: 7.006 ± 0.154
1.25GlyTrp: 1.25 ± 0.048
2.443GlyTyr: 2.443 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
2.204HisAla: 2.204 ± 0.07
0.32HisCys: 0.32 ± 0.028
1.435HisAsp: 1.435 ± 0.058
1.146HisGlu: 1.146 ± 0.051
0.763HisPhe: 0.763 ± 0.039
1.959HisGly: 1.959 ± 0.07
0.841HisHis: 0.841 ± 0.051
1.278HisIle: 1.278 ± 0.054
0.635HisLys: 0.635 ± 0.041
2.204HisLeu: 2.204 ± 0.077
0.554HisMet: 0.554 ± 0.033
0.804HisAsn: 0.804 ± 0.044
1.722HisPro: 1.722 ± 0.061
0.943HisGln: 0.943 ± 0.047
1.556HisArg: 1.556 ± 0.066
1.4HisSer: 1.4 ± 0.057
1.559HisThr: 1.559 ± 0.06
1.748HisVal: 1.748 ± 0.076
0.361HisTrp: 0.361 ± 0.029
0.802HisTyr: 0.802 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.937IleAla: 5.937 ± 0.122
0.537IleCys: 0.537 ± 0.035
3.458IleAsp: 3.458 ± 0.098
2.663IleGlu: 2.663 ± 0.084
1.559IlePhe: 1.559 ± 0.07
4.076IleGly: 4.076 ± 0.104
1.089IleHis: 1.089 ± 0.053
2.691IleIle: 2.691 ± 0.086
1.406IleLys: 1.406 ± 0.063
4.226IleLeu: 4.226 ± 0.112
1.03IleMet: 1.03 ± 0.051
1.687IleAsn: 1.687 ± 0.068
3.028IlePro: 3.028 ± 0.073
1.265IleGln: 1.265 ± 0.049
2.861IleArg: 2.861 ± 0.081
2.915IleSer: 2.915 ± 0.087
3.437IleThr: 3.437 ± 0.113
4.641IleVal: 4.641 ± 0.102
0.5IleTrp: 0.5 ± 0.03
1.185IleTyr: 1.185 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
3.611LysAla: 3.611 ± 0.107
0.211LysCys: 0.211 ± 0.019
2.163LysAsp: 2.163 ± 0.087
2.004LysGlu: 2.004 ± 0.082
0.826LysPhe: 0.826 ± 0.048
2.617LysGly: 2.617 ± 0.093
0.761LysHis: 0.761 ± 0.039
1.539LysIle: 1.539 ± 0.062
2.032LysLys: 2.032 ± 0.09
2.935LysLeu: 2.935 ± 0.099
0.854LysMet: 0.854 ± 0.04
1.385LysAsn: 1.385 ± 0.058
1.696LysPro: 1.696 ± 0.069
1.191LysGln: 1.191 ± 0.059
2.226LysArg: 2.226 ± 0.074
1.722LysSer: 1.722 ± 0.064
1.974LysThr: 1.974 ± 0.067
2.661LysVal: 2.661 ± 0.084
0.493LysTrp: 0.493 ± 0.035
0.856LysTyr: 0.856 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
11.299LeuAla: 11.299 ± 0.184
0.996LeuCys: 0.996 ± 0.048
5.895LeuAsp: 5.895 ± 0.139
4.728LeuGlu: 4.728 ± 0.106
2.837LeuPhe: 2.837 ± 0.084
7.789LeuGly: 7.789 ± 0.139
2.493LeuHis: 2.493 ± 0.091
4.506LeuIle: 4.506 ± 0.116
2.632LeuLys: 2.632 ± 0.091
8.893LeuLeu: 8.893 ± 0.211
1.906LeuMet: 1.906 ± 0.078
2.513LeuAsn: 2.513 ± 0.085
5.637LeuPro: 5.637 ± 0.117
3.217LeuGln: 3.217 ± 0.098
6.508LeuArg: 6.508 ± 0.115
6.015LeuSer: 6.015 ± 0.119
6.363LeuThr: 6.363 ± 0.124
7.693LeuVal: 7.693 ± 0.157
1.143LeuTrp: 1.143 ± 0.057
2.074LeuTyr: 2.074 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.7MetAla: 2.7 ± 0.083
0.224MetCys: 0.224 ± 0.023
1.165MetAsp: 1.165 ± 0.051
1.343MetGlu: 1.343 ± 0.063
0.643MetPhe: 0.643 ± 0.039
1.767MetGly: 1.767 ± 0.058
0.454MetHis: 0.454 ± 0.032
0.893MetIle: 0.893 ± 0.046
0.852MetLys: 0.852 ± 0.048
2.213MetLeu: 2.213 ± 0.071
0.606MetMet: 0.606 ± 0.037
0.717MetAsn: 0.717 ± 0.041
1.322MetPro: 1.322 ± 0.047
0.726MetGln: 0.726 ± 0.038
1.461MetArg: 1.461 ± 0.055
1.693MetSer: 1.693 ± 0.067
1.693MetThr: 1.693 ± 0.062
2.015MetVal: 2.015 ± 0.062
0.37MetTrp: 0.37 ± 0.028
0.415MetTyr: 0.415 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.011AsnAla: 3.011 ± 0.075
0.283AsnCys: 0.283 ± 0.026
1.691AsnAsp: 1.691 ± 0.055
1.439AsnGlu: 1.439 ± 0.059
0.839AsnPhe: 0.839 ± 0.042
2.569AsnGly: 2.569 ± 0.074
0.687AsnHis: 0.687 ± 0.038
1.465AsnIle: 1.465 ± 0.052
1.096AsnLys: 1.096 ± 0.055
2.595AsnLeu: 2.595 ± 0.081
0.652AsnMet: 0.652 ± 0.037
0.959AsnAsn: 0.959 ± 0.056
2.372AsnPro: 2.372 ± 0.07
0.959AsnGln: 0.959 ± 0.044
1.711AsnArg: 1.711 ± 0.068
1.693AsnSer: 1.693 ± 0.071
1.926AsnThr: 1.926 ± 0.077
2.245AsnVal: 2.245 ± 0.072
0.474AsnTrp: 0.474 ± 0.035
0.872AsnTyr: 0.872 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
6.002ProAla: 6.002 ± 0.163
0.406ProCys: 0.406 ± 0.033
3.291ProAsp: 3.291 ± 0.074
3.493ProGlu: 3.493 ± 0.094
1.682ProPhe: 1.682 ± 0.064
4.552ProGly: 4.552 ± 0.108
1.426ProHis: 1.426 ± 0.062
2.241ProIle: 2.241 ± 0.069
1.574ProLys: 1.574 ± 0.061
4.993ProLeu: 4.993 ± 0.094
0.963ProMet: 0.963 ± 0.043
1.698ProAsn: 1.698 ± 0.062
1.996ProPro: 1.996 ± 0.089
2.169ProGln: 2.169 ± 0.075
2.732ProArg: 2.732 ± 0.082
3.187ProSer: 3.187 ± 0.072
3.85ProThr: 3.85 ± 0.116
4.404ProVal: 4.404 ± 0.092
0.759ProTrp: 0.759 ± 0.046
1.396ProTyr: 1.396 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
3.765GlnAla: 3.765 ± 0.105
0.309GlnCys: 0.309 ± 0.025
1.746GlnAsp: 1.746 ± 0.064
2.228GlnGlu: 2.228 ± 0.066
0.987GlnPhe: 0.987 ± 0.047
2.356GlnGly: 2.356 ± 0.079
1.011GlnHis: 1.011 ± 0.05
1.524GlnIle: 1.524 ± 0.062
1.254GlnLys: 1.254 ± 0.059
3.906GlnLeu: 3.906 ± 0.108
0.967GlnMet: 0.967 ± 0.043
0.848GlnAsn: 0.848 ± 0.047
1.974GlnPro: 1.974 ± 0.067
2.011GlnGln: 2.011 ± 0.082
2.885GlnArg: 2.885 ± 0.094
1.641GlnSer: 1.641 ± 0.068
1.504GlnThr: 1.504 ± 0.058
2.813GlnVal: 2.813 ± 0.085
0.63GlnTrp: 0.63 ± 0.039
0.913GlnTyr: 0.913 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
5.893ArgAla: 5.893 ± 0.14
0.585ArgCys: 0.585 ± 0.039
3.563ArgAsp: 3.563 ± 0.087
3.915ArgGlu: 3.915 ± 0.092
1.985ArgPhe: 1.985 ± 0.067
4.387ArgGly: 4.387 ± 0.106
1.611ArgHis: 1.611 ± 0.058
3.369ArgIle: 3.369 ± 0.091
2.111ArgLys: 2.111 ± 0.077
5.663ArgLeu: 5.663 ± 0.12
1.802ArgMet: 1.802 ± 0.065
1.796ArgAsn: 1.796 ± 0.071
3.076ArgPro: 3.076 ± 0.086
2.265ArgGln: 2.265 ± 0.081
4.854ArgArg: 4.854 ± 0.157
3.532ArgSer: 3.532 ± 0.096
3.817ArgThr: 3.817 ± 0.102
4.508ArgVal: 4.508 ± 0.107
0.983ArgTrp: 0.983 ± 0.054
1.865ArgTyr: 1.865 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
6.31SerAla: 6.31 ± 0.124
0.604SerCys: 0.604 ± 0.041
3.13SerAsp: 3.13 ± 0.079
2.795SerGlu: 2.795 ± 0.084
1.976SerPhe: 1.976 ± 0.06
5.01SerGly: 5.01 ± 0.131
1.3SerHis: 1.3 ± 0.06
2.858SerIle: 2.858 ± 0.085
1.685SerLys: 1.685 ± 0.069
5.615SerLeu: 5.615 ± 0.127
1.411SerMet: 1.411 ± 0.063
1.398SerAsn: 1.398 ± 0.06
3.139SerPro: 3.139 ± 0.088
1.904SerGln: 1.904 ± 0.07
3.428SerArg: 3.428 ± 0.086
3.728SerSer: 3.728 ± 0.109
4.106SerThr: 4.106 ± 0.097
4.391SerVal: 4.391 ± 0.103
0.913SerTrp: 0.913 ± 0.042
1.635SerTyr: 1.635 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
7.006ThrAla: 7.006 ± 0.148
0.5ThrCys: 0.5 ± 0.036
3.591ThrAsp: 3.591 ± 0.105
3.406ThrGlu: 3.406 ± 0.096
1.928ThrPhe: 1.928 ± 0.067
5.267ThrGly: 5.267 ± 0.115
1.556ThrHis: 1.556 ± 0.058
3.458ThrIle: 3.458 ± 0.093
1.859ThrLys: 1.859 ± 0.078
6.389ThrLeu: 6.389 ± 0.129
1.409ThrMet: 1.409 ± 0.054
1.876ThrAsn: 1.876 ± 0.061
4.243ThrPro: 4.243 ± 0.121
1.972ThrGln: 1.972 ± 0.068
3.348ThrArg: 3.348 ± 0.088
3.871ThrSer: 3.871 ± 0.119
4.447ThrThr: 4.447 ± 0.13
5.745ThrVal: 5.745 ± 0.123
0.793ThrTrp: 0.793 ± 0.043
1.53ThrTyr: 1.53 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
8.897ValAla: 8.897 ± 0.157
0.913ValCys: 0.913 ± 0.045
5.228ValAsp: 5.228 ± 0.097
5.219ValGlu: 5.219 ± 0.115
2.385ValPhe: 2.385 ± 0.077
6.291ValGly: 6.291 ± 0.134
1.706ValHis: 1.706 ± 0.071
4.204ValIle: 4.204 ± 0.109
2.656ValLys: 2.656 ± 0.09
7.784ValLeu: 7.784 ± 0.149
1.726ValMet: 1.726 ± 0.064
2.363ValAsn: 2.363 ± 0.085
4.293ValPro: 4.293 ± 0.097
2.548ValGln: 2.548 ± 0.082
4.604ValArg: 4.604 ± 0.103
4.813ValSer: 4.813 ± 0.116
5.65ValThr: 5.65 ± 0.112
7.876ValVal: 7.876 ± 0.177
1.0ValTrp: 1.0 ± 0.044
1.687ValTyr: 1.687 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.413TrpAla: 1.413 ± 0.052
0.161TrpCys: 0.161 ± 0.02
0.791TrpAsp: 0.791 ± 0.041
1.017TrpGlu: 1.017 ± 0.049
0.498TrpPhe: 0.498 ± 0.038
1.024TrpGly: 1.024 ± 0.054
0.315TrpHis: 0.315 ± 0.028
0.641TrpIle: 0.641 ± 0.043
0.489TrpLys: 0.489 ± 0.033
1.422TrpLeu: 1.422 ± 0.056
0.378TrpMet: 0.378 ± 0.024
0.524TrpAsn: 0.524 ± 0.035
0.572TrpPro: 0.572 ± 0.035
0.65TrpGln: 0.65 ± 0.042
0.961TrpArg: 0.961 ± 0.047
0.77TrpSer: 0.77 ± 0.043
0.737TrpThr: 0.737 ± 0.039
1.078TrpVal: 1.078 ± 0.051
0.348TrpTrp: 0.348 ± 0.03
0.326TrpTyr: 0.326 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.389TyrAla: 2.389 ± 0.071
0.341TyrCys: 0.341 ± 0.028
1.519TyrAsp: 1.519 ± 0.061
1.319TyrGlu: 1.319 ± 0.052
0.919TyrPhe: 0.919 ± 0.044
2.219TyrGly: 2.219 ± 0.073
0.578TyrHis: 0.578 ± 0.036
0.983TyrIle: 0.983 ± 0.052
0.67TyrLys: 0.67 ± 0.044
2.602TyrLeu: 2.602 ± 0.07
0.496TyrMet: 0.496 ± 0.034
0.865TyrAsn: 0.865 ± 0.047
1.506TyrPro: 1.506 ± 0.067
1.091TyrGln: 1.091 ± 0.054
1.78TyrArg: 1.78 ± 0.075
1.435TyrSer: 1.435 ± 0.058
1.611TyrThr: 1.611 ± 0.06
1.843TyrVal: 1.843 ± 0.063
0.396TyrTrp: 0.396 ± 0.032
0.667TyrTyr: 0.667 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1376 proteins (460035 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski