Amino acid dipepetide frequency for Pseudorhodoplanes sinuspersici

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.097AlaAla: 16.097 ± 0.122	1.045AlaCys: 1.045 ± 0.023	6.487AlaAsp: 6.487 ± 0.065	6.601AlaGlu: 6.601 ± 0.067	4.479AlaPhe: 4.479 ± 0.056	9.815AlaGly: 9.815 ± 0.082	2.234AlaHis: 2.234 ± 0.036	6.971AlaIle: 6.971 ± 0.069	4.825AlaLys: 4.825 ± 0.059	12.443AlaLeu: 12.443 ± 0.105	3.492AlaMet: 3.492 ± 0.051	3.041AlaAsn: 3.041 ± 0.043	5.509AlaPro: 5.509 ± 0.068	4.097AlaGln: 4.097 ± 0.053	8.009AlaArg: 8.009 ± 0.081	6.293AlaSer: 6.293 ± 0.067	6.024AlaThr: 6.024 ± 0.063	8.458AlaVal: 8.458 ± 0.074	1.388AlaTrp: 1.388 ± 0.029	2.537AlaTyr: 2.537 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.027	0.124CysCys: 0.124 ± 0.009	0.498CysAsp: 0.498 ± 0.016	0.425CysGlu: 0.425 ± 0.016	0.328CysPhe: 0.328 ± 0.015	0.907CysGly: 0.907 ± 0.026	0.24CysHis: 0.24 ± 0.012	0.46CysIle: 0.46 ± 0.017	0.245CysLys: 0.245 ± 0.012	0.748CysLeu: 0.748 ± 0.02	0.188CysMet: 0.188 ± 0.01	0.208CysAsn: 0.208 ± 0.012	0.43CysPro: 0.43 ± 0.018	0.209CysGln: 0.209 ± 0.011	0.6CysArg: 0.6 ± 0.02	0.441CysSer: 0.441 ± 0.016	0.436CysThr: 0.436 ± 0.017	0.66CysVal: 0.66 ± 0.019	0.115CysTrp: 0.115 ± 0.008	0.195CysTyr: 0.195 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.504AspAla: 6.504 ± 0.067	0.462AspCys: 0.462 ± 0.016	3.199AspAsp: 3.199 ± 0.047	3.302AspGlu: 3.302 ± 0.048	2.234AspPhe: 2.234 ± 0.037	4.735AspGly: 4.735 ± 0.055	1.233AspHis: 1.233 ± 0.026	3.444AspIle: 3.444 ± 0.052	2.103AspLys: 2.103 ± 0.041	5.599AspLeu: 5.599 ± 0.061	1.364AspMet: 1.364 ± 0.027	1.476AspAsn: 1.476 ± 0.03	3.272AspPro: 3.272 ± 0.047	1.717AspGln: 1.717 ± 0.028	4.075AspArg: 4.075 ± 0.047	2.131AspSer: 2.131 ± 0.034	2.626AspThr: 2.626 ± 0.041	4.4AspVal: 4.4 ± 0.057	0.887AspTrp: 0.887 ± 0.023	1.51AspTyr: 1.51 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.49GluAla: 6.49 ± 0.074	0.361GluCys: 0.361 ± 0.016	2.43GluAsp: 2.43 ± 0.04	2.66GluGlu: 2.66 ± 0.048	1.839GluPhe: 1.839 ± 0.035	3.645GluGly: 3.645 ± 0.054	1.19GluHis: 1.19 ± 0.026	3.404GluIle: 3.404 ± 0.041	2.509GluLys: 2.509 ± 0.044	4.794GluLeu: 4.794 ± 0.051	1.509GluMet: 1.509 ± 0.032	1.623GluAsn: 1.623 ± 0.033	2.645GluPro: 2.645 ± 0.049	2.173GluGln: 2.173 ± 0.035	4.739GluArg: 4.739 ± 0.061	2.331GluSer: 2.331 ± 0.038	3.243GluThr: 3.243 ± 0.047	3.489GluVal: 3.489 ± 0.053	0.702GluTrp: 0.702 ± 0.021	1.046GluTyr: 1.046 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.73PheAla: 4.73 ± 0.056	0.411PheCys: 0.411 ± 0.015	2.635PheAsp: 2.635 ± 0.044	2.161PheGlu: 2.161 ± 0.032	1.585PhePhe: 1.585 ± 0.037	3.872PheGly: 3.872 ± 0.052	0.769PheHis: 0.769 ± 0.022	1.939PheIle: 1.939 ± 0.032	1.227PheLys: 1.227 ± 0.03	3.452PheLeu: 3.452 ± 0.062	0.838PheMet: 0.838 ± 0.021	1.147PheAsn: 1.147 ± 0.029	1.747PhePro: 1.747 ± 0.029	1.003PheGln: 1.003 ± 0.023	2.306PheArg: 2.306 ± 0.034	2.282PheSer: 2.282 ± 0.041	2.057PheThr: 2.057 ± 0.035	3.051PheVal: 3.051 ± 0.044	0.571PheTrp: 0.571 ± 0.021	0.956PheTyr: 0.956 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.616GlyAla: 8.616 ± 0.074	0.813GlyCys: 0.813 ± 0.023	4.058GlyAsp: 4.058 ± 0.055	4.285GlyGlu: 4.285 ± 0.049	3.678GlyPhe: 3.678 ± 0.051	7.011GlyGly: 7.011 ± 0.094	1.85GlyHis: 1.85 ± 0.031	4.851GlyIle: 4.851 ± 0.057	3.504GlyLys: 3.504 ± 0.051	8.36GlyLeu: 8.36 ± 0.084	2.235GlyMet: 2.235 ± 0.04	2.248GlyAsn: 2.248 ± 0.045	3.456GlyPro: 3.456 ± 0.047	2.802GlyGln: 2.802 ± 0.046	5.707GlyArg: 5.707 ± 0.063	4.495GlySer: 4.495 ± 0.058	4.481GlyThr: 4.481 ± 0.056	5.903GlyVal: 5.903 ± 0.058	1.306GlyTrp: 1.306 ± 0.031	2.482GlyTyr: 2.482 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.298HisAla: 2.298 ± 0.037	0.226HisCys: 0.226 ± 0.011	1.246HisAsp: 1.246 ± 0.028	1.023HisGlu: 1.023 ± 0.026	0.855HisPhe: 0.855 ± 0.02	1.854HisGly: 1.854 ± 0.031	0.605HisHis: 0.605 ± 0.024	1.053HisIle: 1.053 ± 0.025	0.596HisLys: 0.596 ± 0.021	1.97HisLeu: 1.97 ± 0.036	0.503HisMet: 0.503 ± 0.018	0.511HisAsn: 0.511 ± 0.017	1.342HisPro: 1.342 ± 0.027	0.56HisGln: 0.56 ± 0.018	1.415HisArg: 1.415 ± 0.029	0.97HisSer: 0.97 ± 0.021	0.837HisThr: 0.837 ± 0.022	1.644HisVal: 1.644 ± 0.032	0.35HisTrp: 0.35 ± 0.015	0.58HisTyr: 0.58 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.087IleAla: 8.087 ± 0.078	0.56IleCys: 0.56 ± 0.019	3.907IleAsp: 3.907 ± 0.054	3.744IleGlu: 3.744 ± 0.047	1.902IlePhe: 1.902 ± 0.035	5.436IleGly: 5.436 ± 0.063	0.942IleHis: 0.942 ± 0.023	2.652IleIle: 2.652 ± 0.052	1.871IleLys: 1.871 ± 0.036	4.709IleLeu: 4.709 ± 0.056	1.134IleMet: 1.134 ± 0.026	1.616IleAsn: 1.616 ± 0.032	2.665IlePro: 2.665 ± 0.038	1.291IleGln: 1.291 ± 0.028	3.373IleArg: 3.373 ± 0.044	3.04IleSer: 3.04 ± 0.042	2.854IleThr: 2.854 ± 0.044	5.066IleVal: 5.066 ± 0.067	0.643IleTrp: 0.643 ± 0.019	1.283IleTyr: 1.283 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.749LysAla: 4.749 ± 0.057	0.198LysCys: 0.198 ± 0.012	2.239LysAsp: 2.239 ± 0.039	1.836LysGlu: 1.836 ± 0.034	1.124LysPhe: 1.124 ± 0.027	2.779LysGly: 2.779 ± 0.042	0.735LysHis: 0.735 ± 0.018	2.209LysIle: 2.209 ± 0.04	1.79LysLys: 1.79 ± 0.039	3.982LysLeu: 3.982 ± 0.054	0.933LysMet: 0.933 ± 0.025	1.135LysAsn: 1.135 ± 0.025	2.555LysPro: 2.555 ± 0.042	1.267LysGln: 1.267 ± 0.03	2.803LysArg: 2.803 ± 0.044	2.282LysSer: 2.282 ± 0.038	2.464LysThr: 2.464 ± 0.039	2.697LysVal: 2.697 ± 0.042	0.419LysTrp: 0.419 ± 0.016	0.743LysTyr: 0.743 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.482LeuAla: 12.482 ± 0.091	0.852LeuCys: 0.852 ± 0.022	5.572LeuAsp: 5.572 ± 0.062	4.619LeuGlu: 4.619 ± 0.054	3.721LeuPhe: 3.721 ± 0.057	7.731LeuGly: 7.731 ± 0.078	1.777LeuHis: 1.777 ± 0.033	5.391LeuIle: 5.391 ± 0.07	4.096LeuLys: 4.096 ± 0.049	9.16LeuLeu: 9.16 ± 0.093	2.342LeuMet: 2.342 ± 0.039	2.735LeuAsn: 2.735 ± 0.046	5.483LeuPro: 5.483 ± 0.058	2.798LeuGln: 2.798 ± 0.041	6.503LeuArg: 6.503 ± 0.064	6.28LeuSer: 6.28 ± 0.064	5.539LeuThr: 5.539 ± 0.056	7.273LeuVal: 7.273 ± 0.073	1.099LeuTrp: 1.099 ± 0.025	2.009LeuTyr: 2.009 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.926MetAla: 2.926 ± 0.043	0.156MetCys: 0.156 ± 0.009	1.069MetAsp: 1.069 ± 0.028	1.022MetGlu: 1.022 ± 0.021	0.782MetPhe: 0.782 ± 0.021	1.708MetGly: 1.708 ± 0.033	0.492MetHis: 0.492 ± 0.016	1.523MetIle: 1.523 ± 0.031	1.172MetLys: 1.172 ± 0.03	2.661MetLeu: 2.661 ± 0.042	0.786MetMet: 0.786 ± 0.022	0.829MetAsn: 0.829 ± 0.022	1.684MetPro: 1.684 ± 0.031	0.925MetGln: 0.925 ± 0.022	1.996MetArg: 1.996 ± 0.029	1.71MetSer: 1.71 ± 0.034	1.911MetThr: 1.911 ± 0.038	1.691MetVal: 1.691 ± 0.036	0.249MetTrp: 0.249 ± 0.012	0.353MetTyr: 0.353 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.484AsnAla: 3.484 ± 0.045	0.235AsnCys: 0.235 ± 0.011	1.617AsnAsp: 1.617 ± 0.038	1.461AsnGlu: 1.461 ± 0.029	1.104AsnPhe: 1.104 ± 0.024	2.567AsnGly: 2.567 ± 0.047	0.495AsnHis: 0.495 ± 0.016	1.623AsnIle: 1.623 ± 0.035	0.946AsnLys: 0.946 ± 0.024	2.646AsnLeu: 2.646 ± 0.038	0.654AsnMet: 0.654 ± 0.022	0.842AsnAsn: 0.842 ± 0.027	1.901AsnPro: 1.901 ± 0.032	0.77AsnGln: 0.77 ± 0.023	1.893AsnArg: 1.893 ± 0.033	1.309AsnSer: 1.309 ± 0.031	1.359AsnThr: 1.359 ± 0.029	2.3AsnVal: 2.3 ± 0.039	0.464AsnTrp: 0.464 ± 0.016	0.761AsnTyr: 0.761 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.149ProAla: 6.149 ± 0.068	0.328ProCys: 0.328 ± 0.014	3.812ProAsp: 3.812 ± 0.049	3.24ProGlu: 3.24 ± 0.048	2.127ProPhe: 2.127 ± 0.035	4.395ProGly: 4.395 ± 0.056	1.138ProHis: 1.138 ± 0.027	2.664ProIle: 2.664 ± 0.038	2.12ProLys: 2.12 ± 0.036	4.701ProLeu: 4.701 ± 0.056	1.252ProMet: 1.252 ± 0.03	1.659ProAsn: 1.659 ± 0.032	2.64ProPro: 2.64 ± 0.055	1.858ProGln: 1.858 ± 0.033	3.025ProArg: 3.025 ± 0.043	3.05ProSer: 3.05 ± 0.046	2.577ProThr: 2.577 ± 0.037	4.243ProVal: 4.243 ± 0.05	0.7ProTrp: 0.7 ± 0.019	1.373ProTyr: 1.373 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.826GlnAla: 3.826 ± 0.051	0.234GlnCys: 0.234 ± 0.012	1.498GlnAsp: 1.498 ± 0.029	1.336GlnGlu: 1.336 ± 0.029	1.171GlnPhe: 1.171 ± 0.026	2.219GlnGly: 2.219 ± 0.039	0.725GlnHis: 0.725 ± 0.017	1.938GlnIle: 1.938 ± 0.039	1.312GlnLys: 1.312 ± 0.028	2.87GlnLeu: 2.87 ± 0.041	0.921GlnMet: 0.921 ± 0.022	0.99GlnAsn: 0.99 ± 0.022	1.839GlnPro: 1.839 ± 0.036	1.337GlnGln: 1.337 ± 0.035	2.521GlnArg: 2.521 ± 0.044	1.981GlnSer: 1.981 ± 0.03	1.809GlnThr: 1.809 ± 0.03	2.206GlnVal: 2.206 ± 0.044	0.416GlnTrp: 0.416 ± 0.015	0.662GlnTyr: 0.662 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.457ArgAla: 7.457 ± 0.074	0.56ArgCys: 0.56 ± 0.02	4.021ArgAsp: 4.021 ± 0.053	3.974ArgGlu: 3.974 ± 0.054	2.85ArgPhe: 2.85 ± 0.038	4.801ArgGly: 4.801 ± 0.052	1.632ArgHis: 1.632 ± 0.029	4.131ArgIle: 4.131 ± 0.057	2.747ArgLys: 2.747 ± 0.042	7.089ArgLeu: 7.089 ± 0.073	1.884ArgMet: 1.884 ± 0.035	2.165ArgAsn: 2.165 ± 0.04	3.503ArgPro: 3.503 ± 0.051	2.315ArgGln: 2.315 ± 0.037	5.272ArgArg: 5.272 ± 0.068	3.829ArgSer: 3.829 ± 0.049	3.46ArgThr: 3.46 ± 0.049	4.72ArgVal: 4.72 ± 0.06	0.979ArgTrp: 0.979 ± 0.024	1.825ArgTyr: 1.825 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.151SerAla: 6.151 ± 0.057	0.433SerCys: 0.433 ± 0.018	3.095SerAsp: 3.095 ± 0.045	2.845SerGlu: 2.845 ± 0.042	2.354SerPhe: 2.354 ± 0.042	5.435SerGly: 5.435 ± 0.06	1.12SerHis: 1.12 ± 0.026	3.07SerIle: 3.07 ± 0.042	1.954SerLys: 1.954 ± 0.032	5.384SerLeu: 5.384 ± 0.056	1.412SerMet: 1.412 ± 0.028	1.522SerAsn: 1.522 ± 0.031	2.959SerPro: 2.959 ± 0.04	1.675SerGln: 1.675 ± 0.031	3.674SerArg: 3.674 ± 0.049	3.066SerSer: 3.066 ± 0.046	2.702SerThr: 2.702 ± 0.036	4.06SerVal: 4.06 ± 0.054	0.743SerTrp: 0.743 ± 0.022	1.303SerTyr: 1.303 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.067ThrAla: 6.067 ± 0.064	0.441ThrCys: 0.441 ± 0.017	2.762ThrAsp: 2.762 ± 0.04	2.485ThrGlu: 2.485 ± 0.041	2.246ThrPhe: 2.246 ± 0.032	4.784ThrGly: 4.784 ± 0.061	1.077ThrHis: 1.077 ± 0.025	3.364ThrIle: 3.364 ± 0.051	1.864ThrLys: 1.864 ± 0.034	5.768ThrLeu: 5.768 ± 0.069	1.334ThrMet: 1.334 ± 0.028	1.459ThrAsn: 1.459 ± 0.034	3.465ThrPro: 3.465 ± 0.052	1.606ThrGln: 1.606 ± 0.035	3.342ThrArg: 3.342 ± 0.04	2.897ThrSer: 2.897 ± 0.043	2.941ThrThr: 2.941 ± 0.039	4.144ThrVal: 4.144 ± 0.05	0.685ThrTrp: 0.685 ± 0.023	1.217ThrTyr: 1.217 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.091ValAla: 9.091 ± 0.083	0.598ValCys: 0.598 ± 0.02	4.003ValAsp: 4.003 ± 0.052	4.102ValGlu: 4.102 ± 0.049	2.836ValPhe: 2.836 ± 0.041	5.446ValGly: 5.446 ± 0.059	1.364ValHis: 1.364 ± 0.027	4.359ValIle: 4.359 ± 0.053	2.799ValLys: 2.799 ± 0.047	7.169ValLeu: 7.169 ± 0.073	1.999ValMet: 1.999 ± 0.032	2.148ValAsn: 2.148 ± 0.035	3.974ValPro: 3.974 ± 0.051	2.118ValGln: 2.118 ± 0.039	4.911ValArg: 4.911 ± 0.058	4.458ValSer: 4.458 ± 0.056	4.672ValThr: 4.672 ± 0.058	6.043ValVal: 6.043 ± 0.071	0.875ValTrp: 0.875 ± 0.024	1.562ValTyr: 1.562 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.136TrpAla: 1.136 ± 0.028	0.136TrpCys: 0.136 ± 0.009	0.623TrpAsp: 0.623 ± 0.018	0.489TrpGlu: 0.489 ± 0.016	0.51TrpPhe: 0.51 ± 0.016	0.857TrpGly: 0.857 ± 0.022	0.351TrpHis: 0.351 ± 0.015	0.713TrpIle: 0.713 ± 0.021	0.496TrpLys: 0.496 ± 0.019	1.626TrpLeu: 1.626 ± 0.031	0.376TrpMet: 0.376 ± 0.015	0.446TrpAsn: 0.446 ± 0.016	0.743TrpPro: 0.743 ± 0.024	0.582TrpGln: 0.582 ± 0.017	1.168TrpArg: 1.168 ± 0.025	0.891TrpSer: 0.891 ± 0.025	0.792TrpThr: 0.792 ± 0.022	0.772TrpVal: 0.772 ± 0.022	0.22TrpTrp: 0.22 ± 0.012	0.282TrpTyr: 0.282 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.541TyrAla: 2.541 ± 0.04	0.247TyrCys: 0.247 ± 0.012	1.503TyrAsp: 1.503 ± 0.027	1.215TyrGlu: 1.215 ± 0.027	1.015TyrPhe: 1.015 ± 0.022	2.145TyrGly: 2.145 ± 0.038	0.468TyrHis: 0.468 ± 0.015	1.016TyrIle: 1.016 ± 0.025	0.761TyrLys: 0.761 ± 0.022	2.328TyrLeu: 2.328 ± 0.04	0.488TyrMet: 0.488 ± 0.017	0.629TyrAsn: 0.629 ± 0.021	1.24TyrPro: 1.24 ± 0.026	0.707TyrGln: 0.707 ± 0.02	1.883TyrArg: 1.883 ± 0.033	1.22TyrSer: 1.22 ± 0.027	1.167TyrThr: 1.167 ± 0.025	1.708TyrVal: 1.708 ± 0.033	0.398TyrTrp: 0.398 ± 0.017	0.673TyrTyr: 0.673 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5631 proteins (1729092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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