Amino acid dipepetide frequency for Amaricoccus sp. HAR-UPW-R2A-40

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.46AlaAla: 17.46 ± 0.183	1.125AlaCys: 1.125 ± 0.042	6.656AlaAsp: 6.656 ± 0.092	8.521AlaGlu: 8.521 ± 0.123	4.879AlaPhe: 4.879 ± 0.08	10.791AlaGly: 10.791 ± 0.121	2.356AlaHis: 2.356 ± 0.053	6.227AlaIle: 6.227 ± 0.099	3.46AlaLys: 3.46 ± 0.076	13.096AlaLeu: 13.096 ± 0.141	3.777AlaMet: 3.777 ± 0.074	2.552AlaAsn: 2.552 ± 0.064	6.17AlaPro: 6.17 ± 0.091	4.004AlaGln: 4.004 ± 0.07	9.873AlaArg: 9.873 ± 0.129	6.113AlaSer: 6.113 ± 0.092	6.09AlaThr: 6.09 ± 0.083	8.655AlaVal: 8.655 ± 0.105	1.877AlaTrp: 1.877 ± 0.054	2.67AlaTyr: 2.67 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.04	0.131CysCys: 0.131 ± 0.012	0.539CysAsp: 0.539 ± 0.026	0.469CysGlu: 0.469 ± 0.025	0.336CysPhe: 0.336 ± 0.021	0.961CysGly: 0.961 ± 0.037	0.225CysHis: 0.225 ± 0.02	0.329CysIle: 0.329 ± 0.024	0.189CysLys: 0.189 ± 0.016	0.839CysLeu: 0.839 ± 0.033	0.139CysMet: 0.139 ± 0.015	0.185CysAsn: 0.185 ± 0.015	0.579CysPro: 0.579 ± 0.029	0.2CysGln: 0.2 ± 0.015	0.762CysArg: 0.762 ± 0.037	0.494CysSer: 0.494 ± 0.026	0.385CysThr: 0.385 ± 0.023	0.652CysVal: 0.652 ± 0.029	0.145CysTrp: 0.145 ± 0.013	0.202CysTyr: 0.202 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.866AspAla: 6.866 ± 0.091	0.472AspCys: 0.472 ± 0.023	3.031AspAsp: 3.031 ± 0.087	3.234AspGlu: 3.234 ± 0.067	2.462AspPhe: 2.462 ± 0.054	5.206AspGly: 5.206 ± 0.077	1.297AspHis: 1.297 ± 0.052	2.346AspIle: 2.346 ± 0.054	1.457AspLys: 1.457 ± 0.043	6.288AspLeu: 6.288 ± 0.086	1.377AspMet: 1.377 ± 0.037	1.171AspAsn: 1.171 ± 0.039	4.204AspPro: 4.204 ± 0.078	1.701AspGln: 1.701 ± 0.048	4.911AspArg: 4.911 ± 0.086	1.99AspSer: 1.99 ± 0.049	2.337AspThr: 2.337 ± 0.057	4.116AspVal: 4.116 ± 0.082	1.242AspTrp: 1.242 ± 0.037	1.572AspTyr: 1.572 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.476GluAla: 8.476 ± 0.122	0.332GluCys: 0.332 ± 0.024	3.166GluAsp: 3.166 ± 0.068	3.22GluGlu: 3.22 ± 0.079	1.902GluPhe: 1.902 ± 0.047	5.099GluGly: 5.099 ± 0.081	1.127GluHis: 1.127 ± 0.038	3.714GluIle: 3.714 ± 0.072	1.94GluLys: 1.94 ± 0.052	5.005GluLeu: 5.005 ± 0.093	1.691GluMet: 1.691 ± 0.045	1.517GluAsn: 1.517 ± 0.045	2.742GluPro: 2.742 ± 0.053	1.765GluGln: 1.765 ± 0.047	4.927GluArg: 4.927 ± 0.085	2.235GluSer: 2.235 ± 0.059	3.774GluThr: 3.774 ± 0.079	4.309GluVal: 4.309 ± 0.086	0.706GluTrp: 0.706 ± 0.03	0.992GluTyr: 0.992 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.77PheAla: 4.77 ± 0.086	0.474PheCys: 0.474 ± 0.026	2.601PheAsp: 2.601 ± 0.064	2.256PheGlu: 2.256 ± 0.051	1.604PhePhe: 1.604 ± 0.052	3.821PheGly: 3.821 ± 0.079	0.752PheHis: 0.752 ± 0.027	1.589PheIle: 1.589 ± 0.054	0.917PheLys: 0.917 ± 0.036	3.769PheLeu: 3.769 ± 0.077	0.782PheMet: 0.782 ± 0.036	1.021PheAsn: 1.021 ± 0.037	1.711PhePro: 1.711 ± 0.048	1.174PheGln: 1.174 ± 0.039	2.482PheArg: 2.482 ± 0.06	2.229PheSer: 2.229 ± 0.057	1.934PheThr: 1.934 ± 0.048	2.924PheVal: 2.924 ± 0.071	0.616PheTrp: 0.616 ± 0.028	0.985PheTyr: 0.985 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	10.273GlyAla: 10.273 ± 0.116	0.842GlyCys: 0.842 ± 0.031	4.68GlyAsp: 4.68 ± 0.081	5.007GlyGlu: 5.007 ± 0.082	3.812GlyPhe: 3.812 ± 0.072	7.932GlyGly: 7.932 ± 0.139	1.857GlyHis: 1.857 ± 0.054	3.872GlyIle: 3.872 ± 0.077	2.951GlyLys: 2.951 ± 0.069	9.216GlyLeu: 9.216 ± 0.116	2.526GlyMet: 2.526 ± 0.064	1.9GlyAsn: 1.9 ± 0.068	3.969GlyPro: 3.969 ± 0.069	2.639GlyGln: 2.639 ± 0.059	6.84GlyArg: 6.84 ± 0.102	4.491GlySer: 4.491 ± 0.083	4.182GlyThr: 4.182 ± 0.073	7.28GlyVal: 7.28 ± 0.092	1.586GlyTrp: 1.586 ± 0.041	2.367GlyTyr: 2.367 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.327HisAla: 2.327 ± 0.056	0.23HisCys: 0.23 ± 0.015	1.282HisAsp: 1.282 ± 0.042	0.959HisGlu: 0.959 ± 0.035	0.804HisPhe: 0.804 ± 0.035	1.961HisGly: 1.961 ± 0.051	0.537HisHis: 0.537 ± 0.03	0.776HisIle: 0.776 ± 0.035	0.446HisLys: 0.446 ± 0.023	2.081HisLeu: 2.081 ± 0.054	0.481HisMet: 0.481 ± 0.026	0.481HisAsn: 0.481 ± 0.026	1.414HisPro: 1.414 ± 0.046	0.559HisGln: 0.559 ± 0.026	1.57HisArg: 1.57 ± 0.052	0.866HisSer: 0.866 ± 0.028	0.665HisThr: 0.665 ± 0.029	1.712HisVal: 1.712 ± 0.045	0.317HisTrp: 0.317 ± 0.019	0.537HisTyr: 0.537 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.551IleAla: 6.551 ± 0.083	0.477IleCys: 0.477 ± 0.026	3.38IleAsp: 3.38 ± 0.064	3.467IleGlu: 3.467 ± 0.064	1.769IlePhe: 1.769 ± 0.053	4.715IleGly: 4.715 ± 0.088	0.914IleHis: 0.914 ± 0.033	1.781IleIle: 1.781 ± 0.057	1.094IleLys: 1.094 ± 0.038	4.574IleLeu: 4.574 ± 0.076	0.932IleMet: 0.932 ± 0.037	1.186IleAsn: 1.186 ± 0.039	2.316IlePro: 2.316 ± 0.047	1.197IleGln: 1.197 ± 0.039	3.629IleArg: 3.629 ± 0.064	2.554IleSer: 2.554 ± 0.062	2.366IleThr: 2.366 ± 0.054	3.93IleVal: 3.93 ± 0.077	0.696IleTrp: 0.696 ± 0.031	1.121IleTyr: 1.121 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.884LysAla: 3.884 ± 0.081	0.167LysCys: 0.167 ± 0.015	1.557LysAsp: 1.557 ± 0.049	1.334LysGlu: 1.334 ± 0.047	0.849LysPhe: 0.849 ± 0.036	2.525LysGly: 2.525 ± 0.065	0.519LysHis: 0.519 ± 0.027	1.512LysIle: 1.512 ± 0.048	0.994LysLys: 0.994 ± 0.043	2.847LysLeu: 2.847 ± 0.066	0.699LysMet: 0.699 ± 0.03	0.686LysAsn: 0.686 ± 0.029	1.717LysPro: 1.717 ± 0.053	0.75LysGln: 0.75 ± 0.032	2.0LysArg: 2.0 ± 0.051	1.489LysSer: 1.489 ± 0.047	1.705LysThr: 1.705 ± 0.042	2.142LysVal: 2.142 ± 0.055	0.351LysTrp: 0.351 ± 0.022	0.514LysTyr: 0.514 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.542LeuAla: 13.542 ± 0.136	0.914LeuCys: 0.914 ± 0.037	6.133LeuAsp: 6.133 ± 0.09	5.107LeuGlu: 5.107 ± 0.08	3.429LeuPhe: 3.429 ± 0.068	8.866LeuGly: 8.866 ± 0.13	1.985LeuHis: 1.985 ± 0.058	4.741LeuIle: 4.741 ± 0.086	2.892LeuLys: 2.892 ± 0.071	8.937LeuLeu: 8.937 ± 0.147	2.446LeuMet: 2.446 ± 0.059	2.429LeuAsn: 2.429 ± 0.055	5.389LeuPro: 5.389 ± 0.085	2.554LeuGln: 2.554 ± 0.051	7.688LeuArg: 7.688 ± 0.105	5.562LeuSer: 5.562 ± 0.085	5.835LeuThr: 5.835 ± 0.086	7.223LeuVal: 7.223 ± 0.115	1.336LeuTrp: 1.336 ± 0.048	2.094LeuTyr: 2.094 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.374MetAla: 3.374 ± 0.072	0.16MetCys: 0.16 ± 0.013	1.274MetAsp: 1.274 ± 0.043	1.241MetGlu: 1.241 ± 0.04	0.737MetPhe: 0.737 ± 0.032	2.016MetGly: 2.016 ± 0.052	0.411MetHis: 0.411 ± 0.019	1.452MetIle: 1.452 ± 0.041	0.902MetLys: 0.902 ± 0.037	2.541MetLeu: 2.541 ± 0.051	0.609MetMet: 0.609 ± 0.03	0.81MetAsn: 0.81 ± 0.033	1.471MetPro: 1.471 ± 0.045	0.777MetGln: 0.777 ± 0.031	2.074MetArg: 2.074 ± 0.057	1.49MetSer: 1.49 ± 0.04	2.016MetThr: 2.016 ± 0.047	1.671MetVal: 1.671 ± 0.049	0.255MetTrp: 0.255 ± 0.018	0.365MetTyr: 0.365 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.889AsnAla: 2.889 ± 0.062	0.227AsnCys: 0.227 ± 0.016	1.306AsnAsp: 1.306 ± 0.041	1.121AsnGlu: 1.121 ± 0.037	0.922AsnPhe: 0.922 ± 0.038	2.115AsnGly: 2.115 ± 0.059	0.487AsnHis: 0.487 ± 0.025	1.165AsnIle: 1.165 ± 0.043	0.516AsnLys: 0.516 ± 0.03	2.41AsnLeu: 2.41 ± 0.054	0.551AsnMet: 0.551 ± 0.027	0.612AsnAsn: 0.612 ± 0.033	1.862AsnPro: 1.862 ± 0.053	0.76AsnGln: 0.76 ± 0.029	1.815AsnArg: 1.815 ± 0.049	1.134AsnSer: 1.134 ± 0.039	1.185AsnThr: 1.185 ± 0.047	1.812AsnVal: 1.812 ± 0.057	0.406AsnTrp: 0.406 ± 0.024	0.685AsnTyr: 0.685 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.638ProAla: 6.638 ± 0.095	0.421ProCys: 0.421 ± 0.025	3.78ProAsp: 3.78 ± 0.072	4.279ProGlu: 4.279 ± 0.074	2.144ProPhe: 2.144 ± 0.053	5.07ProGly: 5.07 ± 0.084	1.121ProHis: 1.121 ± 0.041	2.327ProIle: 2.327 ± 0.052	1.625ProLys: 1.625 ± 0.053	4.646ProLeu: 4.646 ± 0.077	1.362ProMet: 1.362 ± 0.043	1.287ProAsn: 1.287 ± 0.041	2.915ProPro: 2.915 ± 0.068	1.644ProGln: 1.644 ± 0.049	3.601ProArg: 3.601 ± 0.088	2.832ProSer: 2.832 ± 0.067	2.637ProThr: 2.637 ± 0.061	4.064ProVal: 4.064 ± 0.062	0.849ProTrp: 0.849 ± 0.036	1.207ProTyr: 1.207 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.032GlnAla: 4.032 ± 0.076	0.19GlnCys: 0.19 ± 0.016	1.537GlnAsp: 1.537 ± 0.041	1.491GlnGlu: 1.491 ± 0.046	0.979GlnPhe: 0.979 ± 0.039	2.471GlnGly: 2.471 ± 0.055	0.602GlnHis: 0.602 ± 0.027	1.79GlnIle: 1.79 ± 0.05	0.926GlnLys: 0.926 ± 0.037	2.491GlnLeu: 2.491 ± 0.057	0.822GlnMet: 0.822 ± 0.033	0.785GlnAsn: 0.785 ± 0.032	1.602GlnPro: 1.602 ± 0.044	0.889GlnGln: 0.889 ± 0.035	2.336GlnArg: 2.336 ± 0.057	1.562GlnSer: 1.562 ± 0.05	1.726GlnThr: 1.726 ± 0.043	2.197GlnVal: 2.197 ± 0.054	0.389GlnTrp: 0.389 ± 0.021	0.604GlnTyr: 0.604 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.866ArgAla: 8.866 ± 0.12	0.61ArgCys: 0.61 ± 0.029	4.421ArgAsp: 4.421 ± 0.08	4.385ArgGlu: 4.385 ± 0.081	2.959ArgPhe: 2.959 ± 0.058	5.672ArgGly: 5.672 ± 0.091	1.876ArgHis: 1.876 ± 0.056	4.234ArgIle: 4.234 ± 0.071	2.277ArgLys: 2.277 ± 0.059	8.318ArgLeu: 8.318 ± 0.114	2.13ArgMet: 2.13 ± 0.048	1.911ArgAsn: 1.911 ± 0.045	4.316ArgPro: 4.316 ± 0.088	2.575ArgGln: 2.575 ± 0.059	7.542ArgArg: 7.542 ± 0.144	4.071ArgSer: 4.071 ± 0.065	3.591ArgThr: 3.591 ± 0.074	5.01ArgVal: 5.01 ± 0.091	1.16ArgTrp: 1.16 ± 0.039	1.669ArgTyr: 1.669 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.758SerAla: 5.758 ± 0.091	0.519SerCys: 0.519 ± 0.03	2.87SerAsp: 2.87 ± 0.055	2.707SerGlu: 2.707 ± 0.063	2.119SerPhe: 2.119 ± 0.054	5.051SerGly: 5.051 ± 0.073	0.939SerHis: 0.939 ± 0.036	2.422SerIle: 2.422 ± 0.053	1.301SerLys: 1.301 ± 0.043	4.84SerLeu: 4.84 ± 0.083	1.279SerMet: 1.279 ± 0.037	1.294SerAsn: 1.294 ± 0.038	3.005SerPro: 3.005 ± 0.06	1.637SerGln: 1.637 ± 0.04	3.812SerArg: 3.812 ± 0.065	2.851SerSer: 2.851 ± 0.07	2.661SerThr: 2.661 ± 0.062	3.586SerVal: 3.586 ± 0.072	0.881SerTrp: 0.881 ± 0.036	1.266SerTyr: 1.266 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.148ThrAla: 6.148 ± 0.083	0.475ThrCys: 0.475 ± 0.03	2.727ThrAsp: 2.727 ± 0.062	2.805ThrGlu: 2.805 ± 0.062	2.087ThrPhe: 2.087 ± 0.054	5.09ThrGly: 5.09 ± 0.081	0.954ThrHis: 0.954 ± 0.029	2.819ThrIle: 2.819 ± 0.063	1.241ThrLys: 1.241 ± 0.046	5.872ThrLeu: 5.872 ± 0.088	1.195ThrMet: 1.195 ± 0.038	1.205ThrAsn: 1.205 ± 0.037	3.572ThrPro: 3.572 ± 0.071	1.407ThrGln: 1.407 ± 0.042	3.579ThrArg: 3.579 ± 0.068	2.677ThrSer: 2.677 ± 0.058	2.801ThrThr: 2.801 ± 0.067	4.006ThrVal: 4.006 ± 0.076	0.729ThrTrp: 0.729 ± 0.027	1.156ThrTyr: 1.156 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.26ValAla: 9.26 ± 0.123	0.66ValCys: 0.66 ± 0.029	3.976ValAsp: 3.976 ± 0.071	4.985ValGlu: 4.985 ± 0.077	3.109ValPhe: 3.109 ± 0.07	5.608ValGly: 5.608 ± 0.092	1.289ValHis: 1.289 ± 0.042	3.962ValIle: 3.962 ± 0.078	2.032ValLys: 2.032 ± 0.065	7.217ValLeu: 7.217 ± 0.109	1.901ValMet: 1.901 ± 0.051	1.946ValAsn: 1.946 ± 0.054	3.484ValPro: 3.484 ± 0.069	2.051ValGln: 2.051 ± 0.049	4.876ValArg: 4.876 ± 0.08	4.175ValSer: 4.175 ± 0.074	4.65ValThr: 4.65 ± 0.083	5.895ValVal: 5.895 ± 0.103	1.131ValTrp: 1.131 ± 0.039	1.711ValTyr: 1.711 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.461TrpAla: 1.461 ± 0.048	0.149TrpCys: 0.149 ± 0.014	0.784TrpAsp: 0.784 ± 0.032	0.74TrpGlu: 0.74 ± 0.032	0.602TrpPhe: 0.602 ± 0.034	1.064TrpGly: 1.064 ± 0.035	0.295TrpHis: 0.295 ± 0.02	0.761TrpIle: 0.761 ± 0.028	0.489TrpLys: 0.489 ± 0.025	1.789TrpLeu: 1.789 ± 0.05	0.427TrpMet: 0.427 ± 0.025	0.456TrpAsn: 0.456 ± 0.026	0.867TrpPro: 0.867 ± 0.033	0.51TrpGln: 0.51 ± 0.024	1.487TrpArg: 1.487 ± 0.043	0.96TrpSer: 0.96 ± 0.035	1.0TrpThr: 1.0 ± 0.037	0.924TrpVal: 0.924 ± 0.036	0.275TrpTrp: 0.275 ± 0.019	0.275TrpTyr: 0.275 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.714TyrAla: 2.714 ± 0.056	0.245TyrCys: 0.245 ± 0.017	1.582TyrAsp: 1.582 ± 0.046	1.312TyrGlu: 1.312 ± 0.037	0.907TyrPhe: 0.907 ± 0.032	2.19TyrGly: 2.19 ± 0.051	0.462TyrHis: 0.462 ± 0.028	0.829TyrIle: 0.829 ± 0.034	0.59TyrLys: 0.59 ± 0.026	2.327TyrLeu: 2.327 ± 0.054	0.519TyrMet: 0.519 ± 0.024	0.546TyrAsn: 0.546 ± 0.025	1.145TyrPro: 1.145 ± 0.039	0.631TyrGln: 0.631 ± 0.027	1.787TyrArg: 1.787 ± 0.044	1.024TyrSer: 1.024 ± 0.033	1.006TyrThr: 1.006 ± 0.038	1.81TyrVal: 1.81 ± 0.05	0.366TyrTrp: 0.366 ± 0.023	0.6TyrTyr: 0.6 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4378 proteins (800038 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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