Amino acid dipepetide frequency for SAR202 cluster bacterium AD-812-D07_MRT_10900m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.814AlaAla: 9.814 ± 0.455
0.799AlaCys: 0.799 ± 0.1
5.866AlaAsp: 5.866 ± 0.304
6.407AlaGlu: 6.407 ± 0.314
3.394AlaPhe: 3.394 ± 0.204
8.781AlaGly: 8.781 ± 0.37
1.82AlaHis: 1.82 ± 0.156
6.124AlaIle: 6.124 ± 0.332
2.939AlaLys: 2.939 ± 0.207
8.436AlaLeu: 8.436 ± 0.368
2.214AlaMet: 2.214 ± 0.21
2.755AlaAsn: 2.755 ± 0.204
4.108AlaPro: 4.108 ± 0.301
2.472AlaGln: 2.472 ± 0.179
5.805AlaArg: 5.805 ± 0.303
5.903AlaSer: 5.903 ± 0.319
6.186AlaThr: 6.186 ± 0.313
7.686AlaVal: 7.686 ± 0.335
1.045AlaTrp: 1.045 ± 0.098
2.078AlaTyr: 2.078 ± 0.2
0.0AlaXaa: 0.0 ± 0.0
Cys
0.603CysAla: 0.603 ± 0.074
0.049CysCys: 0.049 ± 0.027
0.615CysAsp: 0.615 ± 0.094
0.517CysGlu: 0.517 ± 0.083
0.307CysPhe: 0.307 ± 0.068
0.91CysGly: 0.91 ± 0.1
0.344CysHis: 0.344 ± 0.063
0.394CysIle: 0.394 ± 0.065
0.295CysLys: 0.295 ± 0.052
0.713CysLeu: 0.713 ± 0.095
0.123CysMet: 0.123 ± 0.032
0.148CysAsn: 0.148 ± 0.043
0.332CysPro: 0.332 ± 0.065
0.234CysGln: 0.234 ± 0.051
0.48CysArg: 0.48 ± 0.099
0.443CysSer: 0.443 ± 0.089
0.394CysThr: 0.394 ± 0.081
0.517CysVal: 0.517 ± 0.085
0.098CysTrp: 0.098 ± 0.038
0.16CysTyr: 0.16 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
5.128AspAla: 5.128 ± 0.283
0.43AspCys: 0.43 ± 0.075
4.329AspAsp: 4.329 ± 0.255
4.452AspGlu: 4.452 ± 0.219
2.3AspPhe: 2.3 ± 0.175
5.866AspGly: 5.866 ± 0.439
1.55AspHis: 1.55 ± 0.133
3.247AspIle: 3.247 ± 0.212
1.427AspLys: 1.427 ± 0.127
6.37AspLeu: 6.37 ± 0.301
1.476AspMet: 1.476 ± 0.145
1.808AspAsn: 1.808 ± 0.144
3.628AspPro: 3.628 ± 0.229
2.029AspGln: 2.029 ± 0.161
4.538AspArg: 4.538 ± 0.277
4.563AspSer: 4.563 ± 0.311
3.173AspThr: 3.173 ± 0.185
4.366AspVal: 4.366 ± 0.251
1.033AspTrp: 1.033 ± 0.124
1.574AspTyr: 1.574 ± 0.127
0.0AspXaa: 0.0 ± 0.0
Glu
6.321GluAla: 6.321 ± 0.364
0.418GluCys: 0.418 ± 0.068
2.853GluAsp: 2.853 ± 0.194
3.554GluGlu: 3.554 ± 0.256
2.632GluPhe: 2.632 ± 0.181
4.194GluGly: 4.194 ± 0.276
1.377GluHis: 1.377 ± 0.14
4.587GluIle: 4.587 ± 0.22
2.41GluLys: 2.41 ± 0.208
7.108GluLeu: 7.108 ± 0.286
1.55GluMet: 1.55 ± 0.155
2.164GluAsn: 2.164 ± 0.161
2.89GluPro: 2.89 ± 0.239
2.3GluGln: 2.3 ± 0.181
4.206GluArg: 4.206 ± 0.265
4.403GluSer: 4.403 ± 0.232
3.775GluThr: 3.775 ± 0.238
4.317GluVal: 4.317 ± 0.26
1.107GluTrp: 1.107 ± 0.112
1.673GluTyr: 1.673 ± 0.168
0.0GluXaa: 0.0 ± 0.0
Phe
3.837PheAla: 3.837 ± 0.218
0.344PheCys: 0.344 ± 0.066
2.841PheAsp: 2.841 ± 0.19
2.706PheGlu: 2.706 ± 0.212
1.254PhePhe: 1.254 ± 0.122
3.8PheGly: 3.8 ± 0.25
0.738PheHis: 0.738 ± 0.091
1.636PheIle: 1.636 ± 0.147
1.082PheLys: 1.082 ± 0.113
2.558PheLeu: 2.558 ± 0.21
0.775PheMet: 0.775 ± 0.096
1.267PheAsn: 1.267 ± 0.138
1.365PhePro: 1.365 ± 0.12
1.021PheGln: 1.021 ± 0.107
2.386PheArg: 2.386 ± 0.201
2.287PheSer: 2.287 ± 0.202
2.066PheThr: 2.066 ± 0.182
2.829PheVal: 2.829 ± 0.199
0.541PheTrp: 0.541 ± 0.088
0.996PheTyr: 0.996 ± 0.112
0.0PheXaa: 0.0 ± 0.0
Gly
7.834GlyAla: 7.834 ± 0.417
0.738GlyCys: 0.738 ± 0.104
5.264GlyAsp: 5.264 ± 0.297
5.128GlyGlu: 5.128 ± 0.277
3.345GlyPhe: 3.345 ± 0.187
7.391GlyGly: 7.391 ± 0.445
1.673GlyHis: 1.673 ± 0.165
5.153GlyIle: 5.153 ± 0.294
3.271GlyLys: 3.271 ± 0.216
8.031GlyLeu: 8.031 ± 0.389
2.201GlyMet: 2.201 ± 0.178
2.816GlyAsn: 2.816 ± 0.241
3.739GlyPro: 3.739 ± 0.232
2.607GlyGln: 2.607 ± 0.18
5.079GlyArg: 5.079 ± 0.28
5.989GlySer: 5.989 ± 0.349
5.042GlyThr: 5.042 ± 0.34
7.391GlyVal: 7.391 ± 0.346
1.439GlyTrp: 1.439 ± 0.124
2.41GlyTyr: 2.41 ± 0.192
0.0GlyXaa: 0.0 ± 0.0
His
1.771HisAla: 1.771 ± 0.175
0.271HisCys: 0.271 ± 0.061
1.39HisAsp: 1.39 ± 0.148
1.058HisGlu: 1.058 ± 0.116
0.701HisPhe: 0.701 ± 0.087
1.463HisGly: 1.463 ± 0.144
0.492HisHis: 0.492 ± 0.089
1.07HisIle: 1.07 ± 0.113
0.48HisLys: 0.48 ± 0.081
2.078HisLeu: 2.078 ± 0.167
0.418HisMet: 0.418 ± 0.071
0.775HisAsn: 0.775 ± 0.102
1.463HisPro: 1.463 ± 0.14
0.676HisGln: 0.676 ± 0.095
1.55HisArg: 1.55 ± 0.192
1.168HisSer: 1.168 ± 0.134
1.082HisThr: 1.082 ± 0.126
1.39HisVal: 1.39 ± 0.146
0.418HisTrp: 0.418 ± 0.072
0.48HisTyr: 0.48 ± 0.08
0.0HisXaa: 0.0 ± 0.0
Ile
6.137IleAla: 6.137 ± 0.291
0.492IleCys: 0.492 ± 0.075
5.03IleAsp: 5.03 ± 0.253
4.144IleGlu: 4.144 ± 0.247
1.869IlePhe: 1.869 ± 0.154
5.792IleGly: 5.792 ± 0.33
0.849IleHis: 0.849 ± 0.093
2.496IleIle: 2.496 ± 0.211
1.636IleLys: 1.636 ± 0.132
3.431IleLeu: 3.431 ± 0.217
0.885IleMet: 0.885 ± 0.106
1.759IleAsn: 1.759 ± 0.137
2.804IlePro: 2.804 ± 0.192
1.476IleGln: 1.476 ± 0.129
3.665IleArg: 3.665 ± 0.19
4.415IleSer: 4.415 ± 0.227
3.517IleThr: 3.517 ± 0.22
4.526IleVal: 4.526 ± 0.268
0.762IleTrp: 0.762 ± 0.1
1.267IleTyr: 1.267 ± 0.141
0.0IleXaa: 0.0 ± 0.0
Lys
2.423LysAla: 2.423 ± 0.2
0.234LysCys: 0.234 ± 0.054
1.611LysAsp: 1.611 ± 0.152
1.796LysGlu: 1.796 ± 0.195
1.193LysPhe: 1.193 ± 0.113
2.189LysGly: 2.189 ± 0.18
0.652LysHis: 0.652 ± 0.099
2.238LysIle: 2.238 ± 0.189
1.193LysLys: 1.193 ± 0.12
3.05LysLeu: 3.05 ± 0.238
0.885LysMet: 0.885 ± 0.108
1.107LysAsn: 1.107 ± 0.11
1.709LysPro: 1.709 ± 0.181
1.095LysGln: 1.095 ± 0.126
2.152LysArg: 2.152 ± 0.202
2.435LysSer: 2.435 ± 0.156
2.275LysThr: 2.275 ± 0.153
2.669LysVal: 2.669 ± 0.21
0.603LysTrp: 0.603 ± 0.108
1.008LysTyr: 1.008 ± 0.131
0.0LysXaa: 0.0 ± 0.0
Leu
9.322LeuAla: 9.322 ± 0.332
0.553LeuCys: 0.553 ± 0.085
6.038LeuAsp: 6.038 ± 0.316
5.755LeuGlu: 5.755 ± 0.266
3.075LeuPhe: 3.075 ± 0.239
7.477LeuGly: 7.477 ± 0.348
1.734LeuHis: 1.734 ± 0.18
4.784LeuIle: 4.784 ± 0.232
3.542LeuLys: 3.542 ± 0.216
8.387LeuLeu: 8.387 ± 0.398
1.808LeuMet: 1.808 ± 0.156
3.087LeuAsn: 3.087 ± 0.203
4.304LeuPro: 4.304 ± 0.267
2.656LeuGln: 2.656 ± 0.173
5.977LeuArg: 5.977 ± 0.322
6.616LeuSer: 6.616 ± 0.292
5.534LeuThr: 5.534 ± 0.26
7.244LeuVal: 7.244 ± 0.355
1.267LeuTrp: 1.267 ± 0.142
1.5LeuTyr: 1.5 ± 0.131
0.0LeuXaa: 0.0 ± 0.0
Met
2.583MetAla: 2.583 ± 0.168
0.184MetCys: 0.184 ± 0.054
0.984MetAsp: 0.984 ± 0.126
0.984MetGlu: 0.984 ± 0.114
0.812MetPhe: 0.812 ± 0.097
1.869MetGly: 1.869 ± 0.171
0.578MetHis: 0.578 ± 0.089
1.254MetIle: 1.254 ± 0.121
1.033MetLys: 1.033 ± 0.116
2.029MetLeu: 2.029 ± 0.163
0.43MetMet: 0.43 ± 0.071
0.726MetAsn: 0.726 ± 0.093
1.23MetPro: 1.23 ± 0.127
0.627MetGln: 0.627 ± 0.084
1.414MetArg: 1.414 ± 0.147
1.808MetSer: 1.808 ± 0.137
1.845MetThr: 1.845 ± 0.154
1.267MetVal: 1.267 ± 0.117
0.283MetTrp: 0.283 ± 0.058
0.418MetTyr: 0.418 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
2.89AsnAla: 2.89 ± 0.19
0.283AsnCys: 0.283 ± 0.062
1.882AsnAsp: 1.882 ± 0.167
1.697AsnGlu: 1.697 ± 0.157
1.279AsnPhe: 1.279 ± 0.117
2.853AsnGly: 2.853 ± 0.21
0.627AsnHis: 0.627 ± 0.075
1.611AsnIle: 1.611 ± 0.135
0.91AsnLys: 0.91 ± 0.11
2.976AsnLeu: 2.976 ± 0.168
0.738AsnMet: 0.738 ± 0.102
1.218AsnAsn: 1.218 ± 0.137
2.054AsnPro: 2.054 ± 0.153
1.39AsnGln: 1.39 ± 0.148
2.238AsnArg: 2.238 ± 0.165
2.275AsnSer: 2.275 ± 0.184
1.636AsnThr: 1.636 ± 0.156
2.607AsnVal: 2.607 ± 0.239
0.578AsnTrp: 0.578 ± 0.105
0.898AsnTyr: 0.898 ± 0.107
0.0AsnXaa: 0.0 ± 0.0
Pro
3.972ProAla: 3.972 ± 0.291
0.209ProCys: 0.209 ± 0.049
4.489ProAsp: 4.489 ± 0.278
4.206ProGlu: 4.206 ± 0.283
1.636ProPhe: 1.636 ± 0.15
4.575ProGly: 4.575 ± 0.311
1.144ProHis: 1.144 ± 0.117
2.927ProIle: 2.927 ± 0.215
1.402ProLys: 1.402 ± 0.133
3.898ProLeu: 3.898 ± 0.275
1.033ProMet: 1.033 ± 0.107
1.648ProAsn: 1.648 ± 0.157
2.509ProPro: 2.509 ± 0.201
1.205ProGln: 1.205 ± 0.104
2.853ProArg: 2.853 ± 0.231
3.419ProSer: 3.419 ± 0.205
3.763ProThr: 3.763 ± 0.524
4.353ProVal: 4.353 ± 0.272
0.627ProTrp: 0.627 ± 0.085
1.279ProTyr: 1.279 ± 0.128
0.0ProXaa: 0.0 ± 0.0
Gln
2.779GlnAla: 2.779 ± 0.175
0.221GlnCys: 0.221 ± 0.053
1.451GlnAsp: 1.451 ± 0.139
1.599GlnGlu: 1.599 ± 0.124
1.304GlnPhe: 1.304 ± 0.135
2.091GlnGly: 2.091 ± 0.148
0.652GlnHis: 0.652 ± 0.088
1.648GlnIle: 1.648 ± 0.119
1.008GlnLys: 1.008 ± 0.128
3.185GlnLeu: 3.185 ± 0.242
0.738GlnMet: 0.738 ± 0.091
1.021GlnAsn: 1.021 ± 0.127
1.562GlnPro: 1.562 ± 0.144
1.07GlnGln: 1.07 ± 0.113
1.869GlnArg: 1.869 ± 0.19
1.808GlnSer: 1.808 ± 0.148
2.029GlnThr: 2.029 ± 0.159
2.496GlnVal: 2.496 ± 0.208
0.492GlnTrp: 0.492 ± 0.077
0.701GlnTyr: 0.701 ± 0.1
0.0GlnXaa: 0.0 ± 0.0
Arg
5.46ArgAla: 5.46 ± 0.305
0.529ArgCys: 0.529 ± 0.074
3.308ArgAsp: 3.308 ± 0.224
4.095ArgGlu: 4.095 ± 0.264
2.57ArgPhe: 2.57 ± 0.178
4.759ArgGly: 4.759 ± 0.253
1.316ArgHis: 1.316 ± 0.159
4.083ArgIle: 4.083 ± 0.254
2.398ArgLys: 2.398 ± 0.209
6.297ArgLeu: 6.297 ± 0.344
1.562ArgMet: 1.562 ± 0.153
2.226ArgAsn: 2.226 ± 0.159
3.419ArgPro: 3.419 ± 0.246
1.955ArgGln: 1.955 ± 0.16
4.698ArgArg: 4.698 ± 0.339
4.39ArgSer: 4.39 ± 0.303
3.566ArgThr: 3.566 ± 0.207
4.882ArgVal: 4.882 ± 0.238
0.984ArgTrp: 0.984 ± 0.133
1.906ArgTyr: 1.906 ± 0.168
0.0ArgXaa: 0.0 ± 0.0
Ser
6.493SerAla: 6.493 ± 0.345
0.467SerCys: 0.467 ± 0.081
4.181SerAsp: 4.181 ± 0.281
4.39SerGlu: 4.39 ± 0.274
2.46SerPhe: 2.46 ± 0.217
7.367SerGly: 7.367 ± 0.357
1.144SerHis: 1.144 ± 0.128
3.935SerIle: 3.935 ± 0.232
2.263SerLys: 2.263 ± 0.171
6.001SerLeu: 6.001 ± 0.255
1.476SerMet: 1.476 ± 0.129
2.386SerAsn: 2.386 ± 0.179
3.653SerPro: 3.653 ± 0.226
1.955SerGln: 1.955 ± 0.153
4.132SerArg: 4.132 ± 0.223
4.907SerSer: 4.907 ± 0.282
4.304SerThr: 4.304 ± 0.273
5.436SerVal: 5.436 ± 0.281
0.762SerTrp: 0.762 ± 0.102
1.5SerTyr: 1.5 ± 0.151
0.0SerXaa: 0.0 ± 0.0
Thr
6.198ThrAla: 6.198 ± 0.299
0.394ThrCys: 0.394 ± 0.067
3.665ThrAsp: 3.665 ± 0.188
3.21ThrGlu: 3.21 ± 0.191
1.894ThrPhe: 1.894 ± 0.165
6.014ThrGly: 6.014 ± 0.306
1.291ThrHis: 1.291 ± 0.116
3.148ThrIle: 3.148 ± 0.189
1.648ThrLys: 1.648 ± 0.132
5.399ThrLeu: 5.399 ± 0.289
1.218ThrMet: 1.218 ± 0.132
1.832ThrAsn: 1.832 ± 0.174
4.304ThrPro: 4.304 ± 0.445
1.488ThrGln: 1.488 ± 0.149
3.21ThrArg: 3.21 ± 0.251
4.12ThrSer: 4.12 ± 0.307
3.197ThrThr: 3.197 ± 0.227
5.214ThrVal: 5.214 ± 0.38
0.75ThrTrp: 0.75 ± 0.107
1.66ThrTyr: 1.66 ± 0.123
0.0ThrXaa: 0.0 ± 0.0
Val
8.006ValAla: 8.006 ± 0.309
0.713ValCys: 0.713 ± 0.091
5.018ValAsp: 5.018 ± 0.273
5.755ValGlu: 5.755 ± 0.269
2.952ValPhe: 2.952 ± 0.183
6.001ValGly: 6.001 ± 0.261
1.144ValHis: 1.144 ± 0.122
4.673ValIle: 4.673 ± 0.28
2.263ValLys: 2.263 ± 0.188
6.715ValLeu: 6.715 ± 0.326
1.82ValMet: 1.82 ± 0.177
2.533ValAsn: 2.533 ± 0.19
4.169ValPro: 4.169 ± 0.276
2.164ValGln: 2.164 ± 0.178
5.19ValArg: 5.19 ± 0.259
5.485ValSer: 5.485 ± 0.307
4.673ValThr: 4.673 ± 0.27
7.219ValVal: 7.219 ± 0.429
1.033ValTrp: 1.033 ± 0.117
1.734ValTyr: 1.734 ± 0.165
0.0ValXaa: 0.0 ± 0.0
Trp
1.193TrpAla: 1.193 ± 0.116
0.098TrpCys: 0.098 ± 0.036
0.935TrpAsp: 0.935 ± 0.116
0.799TrpGlu: 0.799 ± 0.09
0.541TrpPhe: 0.541 ± 0.089
1.058TrpGly: 1.058 ± 0.129
0.295TrpHis: 0.295 ± 0.059
0.935TrpIle: 0.935 ± 0.106
0.627TrpLys: 0.627 ± 0.117
1.451TrpLeu: 1.451 ± 0.169
0.492TrpMet: 0.492 ± 0.088
0.639TrpAsn: 0.639 ± 0.095
0.578TrpPro: 0.578 ± 0.084
0.578TrpGln: 0.578 ± 0.079
1.021TrpArg: 1.021 ± 0.119
0.972TrpSer: 0.972 ± 0.114
0.627TrpThr: 0.627 ± 0.083
0.935TrpVal: 0.935 ± 0.107
0.209TrpTrp: 0.209 ± 0.056
0.406TrpTyr: 0.406 ± 0.059
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.869TyrAla: 1.869 ± 0.146
0.246TyrCys: 0.246 ± 0.062
1.537TyrAsp: 1.537 ± 0.155
1.586TyrGlu: 1.586 ± 0.137
0.812TyrPhe: 0.812 ± 0.094
2.091TyrGly: 2.091 ± 0.207
0.775TyrHis: 0.775 ± 0.117
1.008TyrIle: 1.008 ± 0.125
0.689TyrLys: 0.689 ± 0.094
2.546TyrLeu: 2.546 ± 0.165
0.504TyrMet: 0.504 ± 0.072
0.726TyrAsn: 0.726 ± 0.103
1.328TyrPro: 1.328 ± 0.139
0.726TyrGln: 0.726 ± 0.09
1.943TyrArg: 1.943 ± 0.174
1.808TyrSer: 1.808 ± 0.134
1.181TyrThr: 1.181 ± 0.117
1.918TyrVal: 1.918 ± 0.176
0.357TyrTrp: 0.357 ± 0.07
0.738TyrTyr: 0.738 ± 0.122
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 274 proteins (81315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski