Amino acid dipepetide frequency for Comamonas serinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.97AlaAla: 18.97 ± 0.213
1.513AlaCys: 1.513 ± 0.038
7.242AlaAsp: 7.242 ± 0.087
6.769AlaGlu: 6.769 ± 0.105
4.064AlaPhe: 4.064 ± 0.059
11.142AlaGly: 11.142 ± 0.115
3.227AlaHis: 3.227 ± 0.05
4.826AlaIle: 4.826 ± 0.063
3.978AlaLys: 3.978 ± 0.075
15.947AlaLeu: 15.947 ± 0.156
3.73AlaMet: 3.73 ± 0.055
3.026AlaAsn: 3.026 ± 0.055
7.491AlaPro: 7.491 ± 0.113
7.658AlaGln: 7.658 ± 0.118
9.531AlaArg: 9.531 ± 0.109
7.347AlaSer: 7.347 ± 0.111
6.632AlaThr: 6.632 ± 0.088
9.756AlaVal: 9.756 ± 0.097
2.369AlaTrp: 2.369 ± 0.056
2.523AlaTyr: 2.523 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.257CysAla: 1.257 ± 0.034
0.124CysCys: 0.124 ± 0.01
0.496CysAsp: 0.496 ± 0.019
0.49CysGlu: 0.49 ± 0.02
0.299CysPhe: 0.299 ± 0.017
0.94CysGly: 0.94 ± 0.028
0.239CysHis: 0.239 ± 0.016
0.366CysIle: 0.366 ± 0.017
0.192CysLys: 0.192 ± 0.013
0.952CysLeu: 0.952 ± 0.034
0.233CysMet: 0.233 ± 0.015
0.241CysAsn: 0.241 ± 0.013
0.487CysPro: 0.487 ± 0.019
0.32CysGln: 0.32 ± 0.016
0.553CysArg: 0.553 ± 0.023
0.467CysSer: 0.467 ± 0.019
0.57CysThr: 0.57 ± 0.024
0.716CysVal: 0.716 ± 0.026
0.152CysTrp: 0.152 ± 0.011
0.166CysTyr: 0.166 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.656AspAla: 7.656 ± 0.094
0.448AspCys: 0.448 ± 0.021
2.867AspAsp: 2.867 ± 0.06
3.17AspGlu: 3.17 ± 0.061
1.866AspPhe: 1.866 ± 0.041
4.645AspGly: 4.645 ± 0.081
1.2AspHis: 1.2 ± 0.037
2.083AspIle: 2.083 ± 0.046
1.617AspLys: 1.617 ± 0.044
5.489AspLeu: 5.489 ± 0.072
1.216AspMet: 1.216 ± 0.032
1.139AspAsn: 1.139 ± 0.03
2.82AspPro: 2.82 ± 0.052
1.851AspGln: 1.851 ± 0.038
3.141AspArg: 3.141 ± 0.056
2.018AspSer: 2.018 ± 0.044
2.718AspThr: 2.718 ± 0.05
4.082AspVal: 4.082 ± 0.06
1.108AspTrp: 1.108 ± 0.036
1.222AspTyr: 1.222 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.204GluAla: 7.204 ± 0.097
0.33GluCys: 0.33 ± 0.018
2.015GluAsp: 2.015 ± 0.052
1.742GluGlu: 1.742 ± 0.047
1.552GluPhe: 1.552 ± 0.036
3.431GluGly: 3.431 ± 0.061
1.271GluHis: 1.271 ± 0.032
1.928GluIle: 1.928 ± 0.042
1.252GluLys: 1.252 ± 0.045
5.686GluLeu: 5.686 ± 0.086
1.076GluMet: 1.076 ± 0.031
0.982GluAsn: 0.982 ± 0.03
2.481GluPro: 2.481 ± 0.048
2.543GluGln: 2.543 ± 0.05
4.234GluArg: 4.234 ± 0.07
2.102GluSer: 2.102 ± 0.043
2.107GluThr: 2.107 ± 0.044
3.981GluVal: 3.981 ± 0.061
0.655GluTrp: 0.655 ± 0.024
0.875GluTyr: 0.875 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.121PheAla: 4.121 ± 0.065
0.375PheCys: 0.375 ± 0.019
2.266PheAsp: 2.266 ± 0.049
1.86PheGlu: 1.86 ± 0.037
1.144PhePhe: 1.144 ± 0.036
3.082PheGly: 3.082 ± 0.057
0.656PheHis: 0.656 ± 0.024
1.357PheIle: 1.357 ± 0.039
1.051PheLys: 1.051 ± 0.033
2.572PheLeu: 2.572 ± 0.05
0.771PheMet: 0.771 ± 0.027
1.017PheAsn: 1.017 ± 0.031
1.367PhePro: 1.367 ± 0.037
1.061PheGln: 1.061 ± 0.032
1.603PheArg: 1.603 ± 0.038
1.883PheSer: 1.883 ± 0.045
1.874PheThr: 1.874 ± 0.045
2.646PheVal: 2.646 ± 0.049
0.516PheTrp: 0.516 ± 0.019
0.746PheTyr: 0.746 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.694GlyAla: 9.694 ± 0.101
0.865GlyCys: 0.865 ± 0.028
4.169GlyAsp: 4.169 ± 0.059
4.453GlyGlu: 4.453 ± 0.064
3.001GlyPhe: 3.001 ± 0.052
6.975GlyGly: 6.975 ± 0.124
2.028GlyHis: 2.028 ± 0.056
3.309GlyIle: 3.309 ± 0.061
3.024GlyLys: 3.024 ± 0.072
9.599GlyLeu: 9.599 ± 0.148
2.328GlyMet: 2.328 ± 0.048
2.102GlyAsn: 2.102 ± 0.045
3.467GlyPro: 3.467 ± 0.058
4.281GlyGln: 4.281 ± 0.057
5.276GlyArg: 5.276 ± 0.078
4.45GlySer: 4.45 ± 0.067
4.47GlyThr: 4.47 ± 0.07
6.87GlyVal: 6.87 ± 0.093
1.635GlyTrp: 1.635 ± 0.043
2.091GlyTyr: 2.091 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
3.425HisAla: 3.425 ± 0.068
0.28HisCys: 0.28 ± 0.013
1.293HisAsp: 1.293 ± 0.034
1.154HisGlu: 1.154 ± 0.03
0.777HisPhe: 0.777 ± 0.025
2.314HisGly: 2.314 ± 0.051
0.696HisHis: 0.696 ± 0.025
0.969HisIle: 0.969 ± 0.027
0.522HisLys: 0.522 ± 0.019
2.493HisLeu: 2.493 ± 0.049
0.543HisMet: 0.543 ± 0.02
0.504HisAsn: 0.504 ± 0.021
1.607HisPro: 1.607 ± 0.036
0.879HisGln: 0.879 ± 0.028
1.558HisArg: 1.558 ± 0.037
0.982HisSer: 0.982 ± 0.027
1.329HisThr: 1.329 ± 0.036
1.764HisVal: 1.764 ± 0.035
0.498HisTrp: 0.498 ± 0.022
0.546HisTyr: 0.546 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.47IleAla: 5.47 ± 0.065
0.387IleCys: 0.387 ± 0.02
2.615IleAsp: 2.615 ± 0.043
2.575IleGlu: 2.575 ± 0.052
0.986IlePhe: 0.986 ± 0.03
3.679IleGly: 3.679 ± 0.065
0.871IleHis: 0.871 ± 0.027
1.195IleIle: 1.195 ± 0.035
1.21IleLys: 1.21 ± 0.04
2.702IleLeu: 2.702 ± 0.049
0.613IleMet: 0.613 ± 0.022
1.17IleAsn: 1.17 ± 0.033
1.653IlePro: 1.653 ± 0.041
1.328IleGln: 1.328 ± 0.035
2.28IleArg: 2.28 ± 0.043
1.953IleSer: 1.953 ± 0.045
2.369IleThr: 2.369 ± 0.051
3.161IleVal: 3.161 ± 0.063
0.489IleTrp: 0.489 ± 0.021
0.816IleTyr: 0.816 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.001LysAla: 4.001 ± 0.084
0.133LysCys: 0.133 ± 0.01
1.515LysAsp: 1.515 ± 0.053
1.137LysGlu: 1.137 ± 0.039
0.72LysPhe: 0.72 ± 0.023
2.222LysGly: 2.222 ± 0.055
0.595LysHis: 0.595 ± 0.022
1.061LysIle: 1.061 ± 0.036
1.074LysLys: 1.074 ± 0.044
3.126LysLeu: 3.126 ± 0.065
0.584LysMet: 0.584 ± 0.025
0.705LysAsn: 0.705 ± 0.03
2.058LysPro: 2.058 ± 0.05
1.184LysGln: 1.184 ± 0.033
2.117LysArg: 2.117 ± 0.047
1.459LysSer: 1.459 ± 0.045
1.657LysThr: 1.657 ± 0.042
2.219LysVal: 2.219 ± 0.056
0.303LysTrp: 0.303 ± 0.018
0.509LysTyr: 0.509 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.449LeuAla: 16.449 ± 0.165
1.057LeuCys: 1.057 ± 0.03
5.823LeuAsp: 5.823 ± 0.09
4.065LeuGlu: 4.065 ± 0.076
3.156LeuPhe: 3.156 ± 0.052
9.198LeuGly: 9.198 ± 0.123
2.539LeuHis: 2.539 ± 0.048
4.031LeuIle: 4.031 ± 0.068
3.087LeuLys: 3.087 ± 0.059
11.102LeuLeu: 11.102 ± 0.165
2.519LeuMet: 2.519 ± 0.051
2.863LeuAsn: 2.863 ± 0.045
6.655LeuPro: 6.655 ± 0.077
5.11LeuGln: 5.11 ± 0.075
7.61LeuArg: 7.61 ± 0.096
6.14LeuSer: 6.14 ± 0.077
5.871LeuThr: 5.871 ± 0.073
7.994LeuVal: 7.994 ± 0.101
1.435LeuTrp: 1.435 ± 0.042
1.91LeuTyr: 1.91 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.368MetAla: 3.368 ± 0.051
0.164MetCys: 0.164 ± 0.011
1.033MetAsp: 1.033 ± 0.027
0.827MetGlu: 0.827 ± 0.025
0.663MetPhe: 0.663 ± 0.026
1.969MetGly: 1.969 ± 0.045
0.517MetHis: 0.517 ± 0.022
0.75MetIle: 0.75 ± 0.022
0.771MetLys: 0.771 ± 0.027
2.57MetLeu: 2.57 ± 0.049
0.464MetMet: 0.464 ± 0.022
0.809MetAsn: 0.809 ± 0.029
1.556MetPro: 1.556 ± 0.038
1.202MetGln: 1.202 ± 0.028
1.713MetArg: 1.713 ± 0.037
1.506MetSer: 1.506 ± 0.036
1.586MetThr: 1.586 ± 0.036
1.614MetVal: 1.614 ± 0.037
0.213MetTrp: 0.213 ± 0.014
0.343MetTyr: 0.343 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.347AsnAla: 3.347 ± 0.055
0.214AsnCys: 0.214 ± 0.013
1.226AsnAsp: 1.226 ± 0.033
0.991AsnGlu: 0.991 ± 0.027
0.794AsnPhe: 0.794 ± 0.025
2.164AsnGly: 2.164 ± 0.054
0.56AsnHis: 0.56 ± 0.022
0.954AsnIle: 0.954 ± 0.033
0.764AsnLys: 0.764 ± 0.031
2.475AsnLeu: 2.475 ± 0.049
0.536AsnMet: 0.536 ± 0.023
0.675AsnAsn: 0.675 ± 0.026
1.867AsnPro: 1.867 ± 0.039
0.967AsnGln: 0.967 ± 0.027
1.586AsnArg: 1.586 ± 0.038
1.046AsnSer: 1.046 ± 0.037
1.361AsnThr: 1.361 ± 0.038
1.858AsnVal: 1.858 ± 0.046
0.416AsnTrp: 0.416 ± 0.017
0.576AsnTyr: 0.576 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
8.4ProAla: 8.4 ± 0.112
0.382ProCys: 0.382 ± 0.02
3.438ProAsp: 3.438 ± 0.059
3.389ProGlu: 3.389 ± 0.053
1.722ProPhe: 1.722 ± 0.036
5.134ProGly: 5.134 ± 0.073
1.392ProHis: 1.392 ± 0.039
1.889ProIle: 1.889 ± 0.033
1.446ProLys: 1.446 ± 0.041
5.517ProLeu: 5.517 ± 0.076
1.358ProMet: 1.358 ± 0.034
1.236ProAsn: 1.236 ± 0.033
3.149ProPro: 3.149 ± 0.081
2.641ProGln: 2.641 ± 0.054
3.367ProArg: 3.367 ± 0.064
3.134ProSer: 3.134 ± 0.062
3.064ProThr: 3.064 ± 0.055
4.533ProVal: 4.533 ± 0.061
0.909ProTrp: 0.909 ± 0.033
1.077ProTyr: 1.077 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
8.54GlnAla: 8.54 ± 0.144
0.314GlnCys: 0.314 ± 0.017
1.975GlnAsp: 1.975 ± 0.038
1.471GlnGlu: 1.471 ± 0.036
1.23GlnPhe: 1.23 ± 0.032
3.974GlnGly: 3.974 ± 0.065
1.16GlnHis: 1.16 ± 0.031
1.708GlnIle: 1.708 ± 0.04
0.894GlnLys: 0.894 ± 0.034
5.048GlnLeu: 5.048 ± 0.078
0.911GlnMet: 0.911 ± 0.026
0.797GlnAsn: 0.797 ± 0.023
3.002GlnPro: 3.002 ± 0.053
2.292GlnGln: 2.292 ± 0.057
3.757GlnArg: 3.757 ± 0.065
1.939GlnSer: 1.939 ± 0.041
2.233GlnThr: 2.233 ± 0.044
3.812GlnVal: 3.812 ± 0.061
0.747GlnTrp: 0.747 ± 0.026
0.794GlnTyr: 0.794 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.058ArgAla: 8.058 ± 0.101
0.593ArgCys: 0.593 ± 0.025
3.564ArgAsp: 3.564 ± 0.069
3.981ArgGlu: 3.981 ± 0.069
2.663ArgPhe: 2.663 ± 0.047
4.542ArgGly: 4.542 ± 0.067
2.085ArgHis: 2.085 ± 0.044
2.926ArgIle: 2.926 ± 0.049
1.822ArgLys: 1.822 ± 0.049
8.057ArgLeu: 8.057 ± 0.111
1.891ArgMet: 1.891 ± 0.034
1.608ArgAsn: 1.608 ± 0.041
3.518ArgPro: 3.518 ± 0.063
3.39ArgGln: 3.39 ± 0.063
4.871ArgArg: 4.871 ± 0.08
3.309ArgSer: 3.309 ± 0.049
3.167ArgThr: 3.167 ± 0.054
5.274ArgVal: 5.274 ± 0.072
1.359ArgTrp: 1.359 ± 0.04
1.558ArgTyr: 1.558 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.779SerAla: 6.779 ± 0.092
0.452SerCys: 0.452 ± 0.02
2.462SerAsp: 2.462 ± 0.049
2.258SerGlu: 2.258 ± 0.044
1.822SerPhe: 1.822 ± 0.039
4.994SerGly: 4.994 ± 0.071
1.22SerHis: 1.22 ± 0.033
1.898SerIle: 1.898 ± 0.04
1.329SerLys: 1.329 ± 0.038
5.635SerLeu: 5.635 ± 0.068
1.163SerMet: 1.163 ± 0.037
1.225SerAsn: 1.225 ± 0.039
3.315SerPro: 3.315 ± 0.061
2.053SerGln: 2.053 ± 0.043
3.26SerArg: 3.26 ± 0.057
2.952SerSer: 2.952 ± 0.067
2.825SerThr: 2.825 ± 0.047
3.713SerVal: 3.713 ± 0.057
0.859SerTrp: 0.859 ± 0.03
1.156SerTyr: 1.156 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.646ThrAla: 6.646 ± 0.079
0.456ThrCys: 0.456 ± 0.021
2.55ThrAsp: 2.55 ± 0.048
2.275ThrGlu: 2.275 ± 0.045
1.565ThrPhe: 1.565 ± 0.039
4.777ThrGly: 4.777 ± 0.076
1.32ThrHis: 1.32 ± 0.03
1.817ThrIle: 1.817 ± 0.039
1.136ThrLys: 1.136 ± 0.036
6.295ThrLeu: 6.295 ± 0.074
0.963ThrMet: 0.963 ± 0.031
1.136ThrAsn: 1.136 ± 0.034
4.114ThrPro: 4.114 ± 0.068
2.409ThrGln: 2.409 ± 0.044
3.644ThrArg: 3.644 ± 0.059
2.649ThrSer: 2.649 ± 0.052
2.857ThrThr: 2.857 ± 0.057
4.455ThrVal: 4.455 ± 0.069
0.818ThrTrp: 0.818 ± 0.026
1.066ThrTyr: 1.066 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
10.102ValAla: 10.102 ± 0.114
0.777ValCys: 0.777 ± 0.025
4.045ValAsp: 4.045 ± 0.062
3.373ValGlu: 3.373 ± 0.054
2.605ValPhe: 2.605 ± 0.046
5.846ValGly: 5.846 ± 0.073
1.755ValHis: 1.755 ± 0.041
3.198ValIle: 3.198 ± 0.063
2.29ValLys: 2.29 ± 0.055
8.764ValLeu: 8.764 ± 0.113
1.925ValMet: 1.925 ± 0.041
2.23ValAsn: 2.23 ± 0.048
4.529ValPro: 4.529 ± 0.061
3.551ValGln: 3.551 ± 0.065
5.125ValArg: 5.125 ± 0.073
4.168ValSer: 4.168 ± 0.057
4.258ValThr: 4.258 ± 0.07
6.497ValVal: 6.497 ± 0.102
1.113ValTrp: 1.113 ± 0.032
1.527ValTyr: 1.527 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.741TrpAla: 1.741 ± 0.044
0.189TrpCys: 0.189 ± 0.012
0.644TrpAsp: 0.644 ± 0.026
0.476TrpGlu: 0.476 ± 0.019
0.536TrpPhe: 0.536 ± 0.023
1.16TrpGly: 1.16 ± 0.031
0.406TrpHis: 0.406 ± 0.02
0.533TrpIle: 0.533 ± 0.021
0.302TrpLys: 0.302 ± 0.015
2.516TrpLeu: 2.516 ± 0.062
0.402TrpMet: 0.402 ± 0.019
0.359TrpAsn: 0.359 ± 0.019
0.996TrpPro: 0.996 ± 0.033
1.024TrpGln: 1.024 ± 0.031
1.558TrpArg: 1.558 ± 0.047
0.83TrpSer: 0.83 ± 0.029
0.77TrpThr: 0.77 ± 0.027
1.228TrpVal: 1.228 ± 0.036
0.319TrpTrp: 0.319 ± 0.019
0.263TrpTyr: 0.263 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.513TyrAla: 2.513 ± 0.051
0.209TyrCys: 0.209 ± 0.014
1.117TyrAsp: 1.117 ± 0.036
0.993TyrGlu: 0.993 ± 0.028
0.804TyrPhe: 0.804 ± 0.026
1.898TyrGly: 1.898 ± 0.044
0.397TyrHis: 0.397 ± 0.018
0.724TyrIle: 0.724 ± 0.026
0.616TyrLys: 0.616 ± 0.024
2.07TyrLeu: 2.07 ± 0.043
0.411TyrMet: 0.411 ± 0.019
0.55TyrAsn: 0.55 ± 0.024
1.044TyrPro: 1.044 ± 0.03
0.853TyrGln: 0.853 ± 0.027
1.449TyrArg: 1.449 ± 0.037
1.038TyrSer: 1.038 ± 0.035
1.23TyrThr: 1.23 ± 0.038
1.507TyrVal: 1.507 ± 0.04
0.34TyrTrp: 0.34 ± 0.018
0.45TyrTyr: 0.45 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3699 proteins (1213414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski