Amino acid dipepetide frequency for Sphingomonas sp. L-1-4w-11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.796AlaAla: 23.796 ± 0.248	1.173AlaCys: 1.173 ± 0.04	8.694AlaAsp: 8.694 ± 0.122	8.33AlaGlu: 8.33 ± 0.113	4.703AlaPhe: 4.703 ± 0.066	13.242AlaGly: 13.242 ± 0.141	2.668AlaHis: 2.668 ± 0.052	7.962AlaIle: 7.962 ± 0.099	3.266AlaLys: 3.266 ± 0.068	15.683AlaLeu: 15.683 ± 0.178	4.489AlaMet: 4.489 ± 0.077	3.093AlaAsn: 3.093 ± 0.066	7.778AlaPro: 7.778 ± 0.128	4.603AlaGln: 4.603 ± 0.065	12.269AlaArg: 12.269 ± 0.16	6.518AlaSer: 6.518 ± 0.094	7.513AlaThr: 7.513 ± 0.096	9.372AlaVal: 9.372 ± 0.107	1.815AlaTrp: 1.815 ± 0.047	2.574AlaTyr: 2.574 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.044CysAla: 1.044 ± 0.034	0.082CysCys: 0.082 ± 0.011	0.525CysAsp: 0.525 ± 0.022	0.404CysGlu: 0.404 ± 0.021	0.273CysPhe: 0.273 ± 0.018	0.837CysGly: 0.837 ± 0.031	0.188CysHis: 0.188 ± 0.015	0.333CysIle: 0.333 ± 0.019	0.099CysLys: 0.099 ± 0.01	0.593CysLeu: 0.593 ± 0.026	0.144CysMet: 0.144 ± 0.012	0.18CysAsn: 0.18 ± 0.015	0.405CysPro: 0.405 ± 0.021	0.173CysGln: 0.173 ± 0.014	0.541CysArg: 0.541 ± 0.031	0.371CysSer: 0.371 ± 0.017	0.389CysThr: 0.389 ± 0.024	0.557CysVal: 0.557 ± 0.022	0.103CysTrp: 0.103 ± 0.011	0.149CysTyr: 0.149 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.752AspAla: 9.752 ± 0.115	0.455AspCys: 0.455 ± 0.023	3.738AspAsp: 3.738 ± 0.084	3.345AspGlu: 3.345 ± 0.066	2.149AspPhe: 2.149 ± 0.051	5.741AspGly: 5.741 ± 0.104	1.284AspHis: 1.284 ± 0.039	2.635AspIle: 2.635 ± 0.06	1.302AspLys: 1.302 ± 0.037	5.662AspLeu: 5.662 ± 0.072	1.362AspMet: 1.362 ± 0.041	1.226AspAsn: 1.226 ± 0.043	3.83AspPro: 3.83 ± 0.062	1.577AspGln: 1.577 ± 0.041	5.629AspArg: 5.629 ± 0.086	1.979AspSer: 1.979 ± 0.045	2.794AspThr: 2.794 ± 0.065	4.114AspVal: 4.114 ± 0.068	1.074AspTrp: 1.074 ± 0.032	1.459AspTyr: 1.459 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.73GluAla: 8.73 ± 0.098	0.304GluCys: 0.304 ± 0.018	2.468GluAsp: 2.468 ± 0.052	2.335GluGlu: 2.335 ± 0.058	1.265GluPhe: 1.265 ± 0.044	4.836GluGly: 4.836 ± 0.076	1.194GluHis: 1.194 ± 0.038	2.605GluIle: 2.605 ± 0.053	1.397GluLys: 1.397 ± 0.042	4.801GluLeu: 4.801 ± 0.078	1.283GluMet: 1.283 ± 0.038	1.14GluAsn: 1.14 ± 0.034	2.697GluPro: 2.697 ± 0.056	2.028GluGln: 2.028 ± 0.052	5.709GluArg: 5.709 ± 0.089	2.044GluSer: 2.044 ± 0.042	3.073GluThr: 3.073 ± 0.052	3.581GluVal: 3.581 ± 0.064	0.778GluTrp: 0.778 ± 0.028	0.916GluTyr: 0.916 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	5.362PheAla: 5.362 ± 0.078	0.282PheCys: 0.282 ± 0.014	2.754PheAsp: 2.754 ± 0.051	2.0PheGlu: 2.0 ± 0.046	1.181PhePhe: 1.181 ± 0.039	3.561PheGly: 3.561 ± 0.068	0.664PheHis: 0.664 ± 0.026	1.17PheIle: 1.17 ± 0.033	0.664PheLys: 0.664 ± 0.024	2.816PheLeu: 2.816 ± 0.059	0.611PheMet: 0.611 ± 0.023	0.931PheAsn: 0.931 ± 0.035	1.359PhePro: 1.359 ± 0.039	0.801PheGln: 0.801 ± 0.029	2.185PheArg: 2.185 ± 0.05	1.641PheSer: 1.641 ± 0.041	1.947PheThr: 1.947 ± 0.043	2.765PheVal: 2.765 ± 0.055	0.48PheTrp: 0.48 ± 0.026	0.84PheTyr: 0.84 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.284GlyAla: 11.284 ± 0.127	0.854GlyCys: 0.854 ± 0.028	5.594GlyAsp: 5.594 ± 0.095	5.259GlyGlu: 5.259 ± 0.072	3.57GlyPhe: 3.57 ± 0.062	8.758GlyGly: 8.758 ± 0.161	1.797GlyHis: 1.797 ± 0.042	4.527GlyIle: 4.527 ± 0.079	2.464GlyLys: 2.464 ± 0.068	8.421GlyLeu: 8.421 ± 0.084	2.287GlyMet: 2.287 ± 0.059	2.133GlyAsn: 2.133 ± 0.07	3.459GlyPro: 3.459 ± 0.064	2.666GlyGln: 2.666 ± 0.052	7.149GlyArg: 7.149 ± 0.088	4.761GlySer: 4.761 ± 0.082	4.832GlyThr: 4.832 ± 0.097	6.641GlyVal: 6.641 ± 0.077	1.826GlyTrp: 1.826 ± 0.046	2.219GlyTyr: 2.219 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.842HisAla: 2.842 ± 0.066	0.201HisCys: 0.201 ± 0.017	1.255HisAsp: 1.255 ± 0.035	0.97HisGlu: 0.97 ± 0.034	0.715HisPhe: 0.715 ± 0.027	2.016HisGly: 2.016 ± 0.054	0.552HisHis: 0.552 ± 0.027	0.776HisIle: 0.776 ± 0.03	0.368HisLys: 0.368 ± 0.018	1.802HisLeu: 1.802 ± 0.048	0.433HisMet: 0.433 ± 0.021	0.409HisAsn: 0.409 ± 0.022	1.294HisPro: 1.294 ± 0.039	0.477HisGln: 0.477 ± 0.022	1.607HisArg: 1.607 ± 0.053	0.782HisSer: 0.782 ± 0.027	0.64HisThr: 0.64 ± 0.027	1.623HisVal: 1.623 ± 0.042	0.332HisTrp: 0.332 ± 0.017	0.514HisTyr: 0.514 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.803IleAla: 8.803 ± 0.106	0.355IleCys: 0.355 ± 0.02	4.277IleAsp: 4.277 ± 0.07	3.974IleGlu: 3.974 ± 0.067	1.324IlePhe: 1.324 ± 0.035	5.02IleGly: 5.02 ± 0.076	0.727IleHis: 0.727 ± 0.027	1.525IleIle: 1.525 ± 0.044	0.837IleLys: 0.837 ± 0.035	3.639IleLeu: 3.639 ± 0.065	0.663IleMet: 0.663 ± 0.028	1.105IleAsn: 1.105 ± 0.039	1.79IlePro: 1.79 ± 0.049	0.947IleGln: 0.947 ± 0.031	2.964IleArg: 2.964 ± 0.052	1.864IleSer: 1.864 ± 0.052	2.161IleThr: 2.161 ± 0.048	4.404IleVal: 4.404 ± 0.058	0.566IleTrp: 0.566 ± 0.025	0.846IleTyr: 0.846 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.362LysAla: 3.362 ± 0.087	0.117LysCys: 0.117 ± 0.012	1.08LysAsp: 1.08 ± 0.04	0.833LysGlu: 0.833 ± 0.036	0.596LysPhe: 0.596 ± 0.026	1.999LysGly: 1.999 ± 0.054	0.394LysHis: 0.394 ± 0.024	0.948LysIle: 0.948 ± 0.031	0.774LysLys: 0.774 ± 0.035	2.532LysLeu: 2.532 ± 0.06	0.53LysMet: 0.53 ± 0.025	0.475LysAsn: 0.475 ± 0.023	1.51LysPro: 1.51 ± 0.04	0.682LysGln: 0.682 ± 0.033	1.948LysArg: 1.948 ± 0.051	1.062LysSer: 1.062 ± 0.034	1.149LysThr: 1.149 ± 0.039	1.601LysVal: 1.601 ± 0.048	0.313LysTrp: 0.313 ± 0.021	0.429LysTyr: 0.429 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.13LeuAla: 16.13 ± 0.17	0.729LeuCys: 0.729 ± 0.029	6.342LeuAsp: 6.342 ± 0.093	4.4LeuGlu: 4.4 ± 0.072	3.457LeuPhe: 3.457 ± 0.076	8.586LeuGly: 8.586 ± 0.109	1.811LeuHis: 1.811 ± 0.048	4.315LeuIle: 4.315 ± 0.067	2.322LeuLys: 2.322 ± 0.063	9.658LeuLeu: 9.658 ± 0.137	2.092LeuMet: 2.092 ± 0.046	2.158LeuAsn: 2.158 ± 0.057	5.777LeuPro: 5.777 ± 0.079	2.229LeuGln: 2.229 ± 0.047	7.51LeuArg: 7.51 ± 0.09	5.171LeuSer: 5.171 ± 0.081	5.202LeuThr: 5.202 ± 0.078	7.594LeuVal: 7.594 ± 0.102	1.248LeuTrp: 1.248 ± 0.035	1.938LeuTyr: 1.938 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.441MetAla: 3.441 ± 0.068	0.132MetCys: 0.132 ± 0.011	0.942MetAsp: 0.942 ± 0.029	0.852MetGlu: 0.852 ± 0.036	0.66MetPhe: 0.66 ± 0.026	1.851MetGly: 1.851 ± 0.048	0.496MetHis: 0.496 ± 0.022	1.217MetIle: 1.217 ± 0.036	0.67MetLys: 0.67 ± 0.029	2.869MetLeu: 2.869 ± 0.056	0.592MetMet: 0.592 ± 0.031	0.556MetAsn: 0.556 ± 0.021	1.533MetPro: 1.533 ± 0.04	0.815MetGln: 0.815 ± 0.031	2.083MetArg: 2.083 ± 0.048	1.227MetSer: 1.227 ± 0.028	1.582MetThr: 1.582 ± 0.042	1.591MetVal: 1.591 ± 0.042	0.227MetTrp: 0.227 ± 0.014	0.268MetTyr: 0.268 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.136AsnAla: 3.136 ± 0.062	0.194AsnCys: 0.194 ± 0.014	1.292AsnAsp: 1.292 ± 0.049	1.021AsnGlu: 1.021 ± 0.033	0.773AsnPhe: 0.773 ± 0.034	2.092AsnGly: 2.092 ± 0.072	0.414AsnHis: 0.414 ± 0.022	1.083AsnIle: 1.083 ± 0.031	0.455AsnLys: 0.455 ± 0.02	2.298AsnLeu: 2.298 ± 0.053	0.454AsnMet: 0.454 ± 0.022	0.577AsnAsn: 0.577 ± 0.031	1.569AsnPro: 1.569 ± 0.043	0.677AsnGln: 0.677 ± 0.036	1.791AsnArg: 1.791 ± 0.042	0.953AsnSer: 0.953 ± 0.042	1.019AsnThr: 1.019 ± 0.039	1.769AsnVal: 1.769 ± 0.045	0.355AsnTrp: 0.355 ± 0.019	0.57AsnTyr: 0.57 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.349ProAla: 8.349 ± 0.127	0.286ProCys: 0.286 ± 0.017	3.827ProAsp: 3.827 ± 0.075	3.426ProGlu: 3.426 ± 0.058	1.892ProPhe: 1.892 ± 0.047	5.052ProGly: 5.052 ± 0.071	1.065ProHis: 1.065 ± 0.034	2.42ProIle: 2.42 ± 0.049	1.124ProLys: 1.124 ± 0.041	5.031ProLeu: 5.031 ± 0.078	1.238ProMet: 1.238 ± 0.036	1.135ProAsn: 1.135 ± 0.037	3.437ProPro: 3.437 ± 0.098	1.709ProGln: 1.709 ± 0.046	3.73ProArg: 3.73 ± 0.062	2.381ProSer: 2.381 ± 0.047	2.422ProThr: 2.422 ± 0.051	4.363ProVal: 4.363 ± 0.068	0.705ProTrp: 0.705 ± 0.025	1.046ProTyr: 1.046 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.33GlnAla: 4.33 ± 0.073	0.193GlnCys: 0.193 ± 0.015	1.177GlnAsp: 1.177 ± 0.038	1.052GlnGlu: 1.052 ± 0.035	0.987GlnPhe: 0.987 ± 0.035	2.292GlnGly: 2.292 ± 0.053	0.584GlnHis: 0.584 ± 0.024	1.44GlnIle: 1.44 ± 0.035	0.683GlnLys: 0.683 ± 0.031	2.885GlnLeu: 2.885 ± 0.051	0.727GlnMet: 0.727 ± 0.031	0.619GlnAsn: 0.619 ± 0.026	1.919GlnPro: 1.919 ± 0.048	1.121GlnGln: 1.121 ± 0.042	2.721GlnArg: 2.721 ± 0.053	1.536GlnSer: 1.536 ± 0.04	1.56GlnThr: 1.56 ± 0.04	2.164GlnVal: 2.164 ± 0.052	0.392GlnTrp: 0.392 ± 0.021	0.563GlnTyr: 0.563 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	11.073ArgAla: 11.073 ± 0.13	0.528ArgCys: 0.528 ± 0.026	4.984ArgAsp: 4.984 ± 0.074	4.404ArgGlu: 4.404 ± 0.074	3.405ArgPhe: 3.405 ± 0.056	5.848ArgGly: 5.848 ± 0.083	1.868ArgHis: 1.868 ± 0.051	4.592ArgIle: 4.592 ± 0.072	1.603ArgLys: 1.603 ± 0.05	8.933ArgLeu: 8.933 ± 0.127	2.151ArgMet: 2.151 ± 0.046	1.726ArgAsn: 1.726 ± 0.037	4.068ArgPro: 4.068 ± 0.066	2.562ArgGln: 2.562 ± 0.052	6.943ArgArg: 6.943 ± 0.116	3.621ArgSer: 3.621 ± 0.065	3.867ArgThr: 3.867 ± 0.06	5.748ArgVal: 5.748 ± 0.076	1.36ArgTrp: 1.36 ± 0.037	1.922ArgTyr: 1.922 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.045SerAla: 6.045 ± 0.085	0.304SerCys: 0.304 ± 0.021	2.801SerAsp: 2.801 ± 0.053	2.269SerGlu: 2.269 ± 0.05	1.999SerPhe: 1.999 ± 0.045	4.977SerGly: 4.977 ± 0.077	0.813SerHis: 0.813 ± 0.023	2.338SerIle: 2.338 ± 0.053	0.98SerLys: 0.98 ± 0.034	4.378SerLeu: 4.378 ± 0.071	1.055SerMet: 1.055 ± 0.035	1.202SerAsn: 1.202 ± 0.038	2.643SerPro: 2.643 ± 0.055	1.249SerGln: 1.249 ± 0.039	3.211SerArg: 3.211 ± 0.057	2.188SerSer: 2.188 ± 0.059	2.382SerThr: 2.382 ± 0.049	3.442SerVal: 3.442 ± 0.058	0.619SerTrp: 0.619 ± 0.024	1.138SerTyr: 1.138 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.539ThrAla: 6.539 ± 0.096	0.352ThrCys: 0.352 ± 0.021	2.821ThrAsp: 2.821 ± 0.064	2.162ThrGlu: 2.162 ± 0.054	1.61ThrPhe: 1.61 ± 0.043	5.249ThrGly: 5.249 ± 0.086	0.958ThrHis: 0.958 ± 0.031	3.006ThrIle: 3.006 ± 0.067	0.947ThrLys: 0.947 ± 0.032	6.183ThrLeu: 6.183 ± 0.083	1.194ThrMet: 1.194 ± 0.034	1.166ThrAsn: 1.166 ± 0.033	3.665ThrPro: 3.665 ± 0.065	1.424ThrGln: 1.424 ± 0.036	3.938ThrArg: 3.938 ± 0.059	2.319ThrSer: 2.319 ± 0.055	2.648ThrThr: 2.648 ± 0.064	3.764ThrVal: 3.764 ± 0.086	0.537ThrTrp: 0.537 ± 0.025	0.992ThrTyr: 0.992 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.213ValAla: 11.213 ± 0.107	0.507ValCys: 0.507 ± 0.023	4.489ValAsp: 4.489 ± 0.075	4.541ValGlu: 4.541 ± 0.075	2.08ValPhe: 2.08 ± 0.048	5.514ValGly: 5.514 ± 0.08	1.344ValHis: 1.344 ± 0.043	3.55ValIle: 3.55 ± 0.074	1.602ValLys: 1.602 ± 0.055	6.825ValLeu: 6.825 ± 0.101	1.561ValMet: 1.561 ± 0.046	1.793ValAsn: 1.793 ± 0.048	4.241ValPro: 4.241 ± 0.061	2.003ValGln: 2.003 ± 0.044	5.729ValArg: 5.729 ± 0.068	3.771ValSer: 3.771 ± 0.06	4.626ValThr: 4.626 ± 0.073	5.375ValVal: 5.375 ± 0.085	0.787ValTrp: 0.787 ± 0.029	1.311ValTyr: 1.311 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.512TrpAla: 1.512 ± 0.044	0.142TrpCys: 0.142 ± 0.012	0.651TrpAsp: 0.651 ± 0.028	0.597TrpGlu: 0.597 ± 0.027	0.58TrpPhe: 0.58 ± 0.026	0.959TrpGly: 0.959 ± 0.033	0.337TrpHis: 0.337 ± 0.018	0.653TrpIle: 0.653 ± 0.028	0.386TrpLys: 0.386 ± 0.024	1.706TrpLeu: 1.706 ± 0.051	0.337TrpMet: 0.337 ± 0.018	0.374TrpAsn: 0.374 ± 0.02	0.692TrpPro: 0.692 ± 0.028	0.603TrpGln: 0.603 ± 0.025	1.545TrpArg: 1.545 ± 0.044	0.829TrpSer: 0.829 ± 0.031	0.789TrpThr: 0.789 ± 0.031	0.857TrpVal: 0.857 ± 0.031	0.282TrpTrp: 0.282 ± 0.018	0.287TrpTyr: 0.287 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.797TyrAla: 2.797 ± 0.066	0.2TyrCys: 0.2 ± 0.014	1.395TyrAsp: 1.395 ± 0.039	1.01TyrGlu: 1.01 ± 0.036	0.795TyrPhe: 0.795 ± 0.03	2.071TyrGly: 2.071 ± 0.048	0.452TyrHis: 0.452 ± 0.021	0.694TyrIle: 0.694 ± 0.027	0.39TyrLys: 0.39 ± 0.021	1.956TyrLeu: 1.956 ± 0.047	0.399TyrMet: 0.399 ± 0.021	0.494TyrAsn: 0.494 ± 0.023	0.972TyrPro: 0.972 ± 0.032	0.601TyrGln: 0.601 ± 0.027	2.004TyrArg: 2.004 ± 0.049	1.017TyrSer: 1.017 ± 0.035	0.88TyrThr: 0.88 ± 0.028	1.537TyrVal: 1.537 ± 0.038	0.317TyrTrp: 0.317 ± 0.019	0.507TyrTyr: 0.507 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3108 proteins (998105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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