Amino acid dipepetide frequency for Streptomyces jumonjinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.52AlaAla: 21.52 ± 0.141	1.013AlaCys: 1.013 ± 0.022	8.34AlaAsp: 8.34 ± 0.061	9.143AlaGlu: 9.143 ± 0.088	3.512AlaPhe: 3.512 ± 0.046	13.302AlaGly: 13.302 ± 0.095	2.853AlaHis: 2.853 ± 0.036	3.623AlaIle: 3.623 ± 0.051	2.729AlaLys: 2.729 ± 0.042	14.668AlaLeu: 14.668 ± 0.112	2.477AlaMet: 2.477 ± 0.037	1.827AlaAsn: 1.827 ± 0.031	7.311AlaPro: 7.311 ± 0.071	3.669AlaGln: 3.669 ± 0.044	10.941AlaArg: 10.941 ± 0.082	5.882AlaSer: 5.882 ± 0.055	6.3AlaThr: 6.3 ± 0.06	12.292AlaVal: 12.292 ± 0.083	1.801AlaTrp: 1.801 ± 0.032	2.735AlaTyr: 2.735 ± 0.035	0.001AlaXaa: 0.001 ± 0.001
Cys	1.18CysAla: 1.18 ± 0.026	0.091CysCys: 0.091 ± 0.006	0.505CysAsp: 0.505 ± 0.016	0.421CysGlu: 0.421 ± 0.014	0.238CysPhe: 0.238 ± 0.01	0.971CysGly: 0.971 ± 0.02	0.201CysHis: 0.201 ± 0.008	0.166CysIle: 0.166 ± 0.009	0.105CysLys: 0.105 ± 0.007	0.784CysLeu: 0.784 ± 0.02	0.117CysMet: 0.117 ± 0.007	0.129CysAsn: 0.129 ± 0.008	0.544CysPro: 0.544 ± 0.017	0.174CysGln: 0.174 ± 0.008	0.669CysArg: 0.669 ± 0.017	0.449CysSer: 0.449 ± 0.013	0.481CysThr: 0.481 ± 0.014	0.676CysVal: 0.676 ± 0.019	0.125CysTrp: 0.125 ± 0.008	0.164CysTyr: 0.164 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.581AspAla: 7.581 ± 0.066	0.453AspCys: 0.453 ± 0.014	3.566AspAsp: 3.566 ± 0.045	3.774AspGlu: 3.774 ± 0.047	1.633AspPhe: 1.633 ± 0.028	6.527AspGly: 6.527 ± 0.059	1.422AspHis: 1.422 ± 0.029	1.871AspIle: 1.871 ± 0.032	1.055AspLys: 1.055 ± 0.026	5.874AspLeu: 5.874 ± 0.055	0.792AspMet: 0.792 ± 0.019	0.853AspAsn: 0.853 ± 0.02	4.674AspPro: 4.674 ± 0.044	1.595AspGln: 1.595 ± 0.025	5.297AspArg: 5.297 ± 0.057	2.703AspSer: 2.703 ± 0.038	3.113AspThr: 3.113 ± 0.042	4.094AspVal: 4.094 ± 0.043	0.998AspTrp: 0.998 ± 0.022	1.064AspTyr: 1.064 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.145GluAla: 7.145 ± 0.075	0.42GluCys: 0.42 ± 0.015	2.715GluAsp: 2.715 ± 0.035	3.481GluGlu: 3.481 ± 0.058	1.474GluPhe: 1.474 ± 0.023	4.247GluGly: 4.247 ± 0.048	1.476GluHis: 1.476 ± 0.025	2.435GluIle: 2.435 ± 0.036	1.483GluLys: 1.483 ± 0.032	7.157GluLeu: 7.157 ± 0.065	0.927GluMet: 0.927 ± 0.019	1.118GluAsn: 1.118 ± 0.024	3.582GluPro: 3.582 ± 0.049	2.203GluGln: 2.203 ± 0.032	6.047GluArg: 6.047 ± 0.063	2.958GluSer: 2.958 ± 0.034	3.075GluThr: 3.075 ± 0.043	4.264GluVal: 4.264 ± 0.044	0.845GluTrp: 0.845 ± 0.019	1.226GluTyr: 1.226 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.602PheAla: 3.602 ± 0.043	0.284PheCys: 0.284 ± 0.012	1.932PheAsp: 1.932 ± 0.032	1.411PheGlu: 1.411 ± 0.024	0.824PhePhe: 0.824 ± 0.021	2.915PheGly: 2.915 ± 0.04	0.606PheHis: 0.606 ± 0.016	0.819PheIle: 0.819 ± 0.019	0.469PheLys: 0.469 ± 0.016	2.531PheLeu: 2.531 ± 0.034	0.386PheMet: 0.386 ± 0.015	0.549PheAsn: 0.549 ± 0.017	1.401PhePro: 1.401 ± 0.029	0.684PheGln: 0.684 ± 0.017	1.856PheArg: 1.856 ± 0.026	1.496PheSer: 1.496 ± 0.029	2.115PheThr: 2.115 ± 0.03	1.933PheVal: 1.933 ± 0.032	0.392PheTrp: 0.392 ± 0.013	0.542PheTyr: 0.542 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.288GlyAla: 11.288 ± 0.084	0.876GlyCys: 0.876 ± 0.019	5.412GlyAsp: 5.412 ± 0.046	5.55GlyGlu: 5.55 ± 0.051	2.864GlyPhe: 2.864 ± 0.04	9.17GlyGly: 9.17 ± 0.1	2.337GlyHis: 2.337 ± 0.033	3.42GlyIle: 3.42 ± 0.041	2.296GlyLys: 2.296 ± 0.041	9.313GlyLeu: 9.313 ± 0.075	2.034GlyMet: 2.034 ± 0.034	1.642GlyAsn: 1.642 ± 0.036	5.719GlyPro: 5.719 ± 0.063	2.62GlyGln: 2.62 ± 0.042	8.257GlyArg: 8.257 ± 0.066	5.469GlySer: 5.469 ± 0.053	5.925GlyThr: 5.925 ± 0.057	7.483GlyVal: 7.483 ± 0.056	1.754GlyTrp: 1.754 ± 0.033	2.338GlyTyr: 2.338 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.575HisAla: 2.575 ± 0.032	0.219HisCys: 0.219 ± 0.009	1.329HisAsp: 1.329 ± 0.025	1.167HisGlu: 1.167 ± 0.022	0.612HisPhe: 0.612 ± 0.016	2.477HisGly: 2.477 ± 0.038	0.701HisHis: 0.701 ± 0.02	0.724HisIle: 0.724 ± 0.021	0.323HisLys: 0.323 ± 0.011	2.301HisLeu: 2.301 ± 0.036	0.331HisMet: 0.331 ± 0.013	0.347HisAsn: 0.347 ± 0.012	1.891HisPro: 1.891 ± 0.027	0.723HisGln: 0.723 ± 0.017	2.255HisArg: 2.255 ± 0.036	1.091HisSer: 1.091 ± 0.021	1.425HisThr: 1.425 ± 0.025	1.426HisVal: 1.426 ± 0.024	0.374HisTrp: 0.374 ± 0.015	0.462HisTyr: 0.462 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.232IleAla: 5.232 ± 0.056	0.342IleCys: 0.342 ± 0.013	2.344IleAsp: 2.344 ± 0.034	2.153IleGlu: 2.153 ± 0.034	0.688IlePhe: 0.688 ± 0.02	3.76IleGly: 3.76 ± 0.043	0.635IleHis: 0.635 ± 0.018	0.896IleIle: 0.896 ± 0.023	0.711IleLys: 0.711 ± 0.021	2.406IleLeu: 2.406 ± 0.037	0.458IleMet: 0.458 ± 0.016	0.648IleAsn: 0.648 ± 0.018	1.938IlePro: 1.938 ± 0.031	0.778IleGln: 0.778 ± 0.021	2.562IleArg: 2.562 ± 0.038	1.811IleSer: 1.811 ± 0.034	2.353IleThr: 2.353 ± 0.032	2.745IleVal: 2.745 ± 0.042	0.394IleTrp: 0.394 ± 0.013	0.5IleTyr: 0.5 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.779LysAla: 2.779 ± 0.04	0.126LysCys: 0.126 ± 0.008	1.207LysAsp: 1.207 ± 0.026	1.18LysGlu: 1.18 ± 0.025	0.415LysPhe: 0.415 ± 0.014	1.803LysGly: 1.803 ± 0.035	0.396LysHis: 0.396 ± 0.014	0.847LysIle: 0.847 ± 0.019	0.839LysLys: 0.839 ± 0.028	1.919LysLeu: 1.919 ± 0.03	0.335LysMet: 0.335 ± 0.014	0.519LysAsn: 0.519 ± 0.018	1.356LysPro: 1.356 ± 0.029	0.629LysGln: 0.629 ± 0.019	1.442LysArg: 1.442 ± 0.027	1.138LysSer: 1.138 ± 0.026	1.252LysThr: 1.252 ± 0.027	1.655LysVal: 1.655 ± 0.032	0.249LysTrp: 0.249 ± 0.01	0.437LysTyr: 0.437 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.998LeuAla: 14.998 ± 0.12	0.849LeuCys: 0.849 ± 0.017	6.536LeuAsp: 6.536 ± 0.061	4.763LeuGlu: 4.763 ± 0.049	2.601LeuPhe: 2.601 ± 0.042	9.035LeuGly: 9.035 ± 0.067	2.267LeuHis: 2.267 ± 0.036	3.726LeuIle: 3.726 ± 0.048	2.018LeuLys: 2.018 ± 0.032	11.178LeuLeu: 11.178 ± 0.118	1.671LeuMet: 1.671 ± 0.028	1.682LeuAsn: 1.682 ± 0.027	6.559LeuPro: 6.559 ± 0.064	2.12LeuGln: 2.12 ± 0.033	8.892LeuArg: 8.892 ± 0.079	5.624LeuSer: 5.624 ± 0.055	6.984LeuThr: 6.984 ± 0.067	7.952LeuVal: 7.952 ± 0.075	1.283LeuTrp: 1.283 ± 0.027	1.839LeuTyr: 1.839 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.277MetAla: 2.277 ± 0.034	0.135MetCys: 0.135 ± 0.008	0.927MetAsp: 0.927 ± 0.022	0.815MetGlu: 0.815 ± 0.019	0.43MetPhe: 0.43 ± 0.014	1.312MetGly: 1.312 ± 0.025	0.344MetHis: 0.344 ± 0.013	0.698MetIle: 0.698 ± 0.019	0.416MetLys: 0.416 ± 0.015	1.622MetLeu: 1.622 ± 0.028	0.308MetMet: 0.308 ± 0.012	0.435MetAsn: 0.435 ± 0.013	1.1MetPro: 1.1 ± 0.023	0.42MetGln: 0.42 ± 0.014	1.485MetArg: 1.485 ± 0.026	1.323MetSer: 1.323 ± 0.023	1.581MetThr: 1.581 ± 0.026	1.223MetVal: 1.223 ± 0.026	0.214MetTrp: 0.214 ± 0.01	0.316MetTyr: 0.316 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.127AsnAla: 2.127 ± 0.032	0.18AsnCys: 0.18 ± 0.008	0.934AsnAsp: 0.934 ± 0.023	0.799AsnGlu: 0.799 ± 0.02	0.43AsnPhe: 0.43 ± 0.014	1.876AsnGly: 1.876 ± 0.032	0.37AsnHis: 0.37 ± 0.014	0.628AsnIle: 0.628 ± 0.018	0.376AsnLys: 0.376 ± 0.014	1.549AsnLeu: 1.549 ± 0.029	0.275AsnMet: 0.275 ± 0.012	0.408AsnAsn: 0.408 ± 0.015	1.349AsnPro: 1.349 ± 0.025	0.482AsnGln: 0.482 ± 0.015	1.38AsnArg: 1.38 ± 0.021	0.883AsnSer: 0.883 ± 0.025	1.089AsnThr: 1.089 ± 0.023	1.223AsnVal: 1.223 ± 0.022	0.271AsnTrp: 0.271 ± 0.01	0.371AsnTyr: 0.371 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.049ProAla: 9.049 ± 0.086	0.379ProCys: 0.379 ± 0.013	4.416ProAsp: 4.416 ± 0.048	4.552ProGlu: 4.552 ± 0.052	1.528ProPhe: 1.528 ± 0.027	7.552ProGly: 7.552 ± 0.071	1.368ProHis: 1.368 ± 0.025	1.359ProIle: 1.359 ± 0.026	1.133ProLys: 1.133 ± 0.025	5.614ProLeu: 5.614 ± 0.058	1.041ProMet: 1.041 ± 0.024	0.832ProAsn: 0.832 ± 0.02	3.945ProPro: 3.945 ± 0.07	1.706ProGln: 1.706 ± 0.035	4.249ProArg: 4.249 ± 0.051	3.311ProSer: 3.311 ± 0.042	2.871ProThr: 2.871 ± 0.037	5.598ProVal: 5.598 ± 0.055	0.93ProTrp: 0.93 ± 0.023	1.499ProTyr: 1.499 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.417GlnAla: 3.417 ± 0.052	0.187GlnCys: 0.187 ± 0.01	1.337GlnAsp: 1.337 ± 0.025	1.476GlnGlu: 1.476 ± 0.031	0.65GlnPhe: 0.65 ± 0.017	2.324GlnGly: 2.324 ± 0.043	0.628GlnHis: 0.628 ± 0.018	1.16GlnIle: 1.16 ± 0.023	0.569GlnLys: 0.569 ± 0.019	3.075GlnLeu: 3.075 ± 0.036	0.473GlnMet: 0.473 ± 0.017	0.5GlnAsn: 0.5 ± 0.015	1.706GlnPro: 1.706 ± 0.033	1.181GlnGln: 1.181 ± 0.037	2.549GlnArg: 2.549 ± 0.035	1.379GlnSer: 1.379 ± 0.022	1.365GlnThr: 1.365 ± 0.027	2.059GlnVal: 2.059 ± 0.03	0.464GlnTrp: 0.464 ± 0.016	0.563GlnTyr: 0.563 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.536ArgAla: 10.536 ± 0.082	0.678ArgCys: 0.678 ± 0.019	4.447ArgAsp: 4.447 ± 0.051	5.134ArgGlu: 5.134 ± 0.049	2.393ArgPhe: 2.393 ± 0.036	6.068ArgGly: 6.068 ± 0.056	2.167ArgHis: 2.167 ± 0.033	3.63ArgIle: 3.63 ± 0.042	1.71ArgLys: 1.71 ± 0.028	9.269ArgLeu: 9.269 ± 0.087	1.861ArgMet: 1.861 ± 0.031	1.394ArgAsn: 1.394 ± 0.029	5.26ArgPro: 5.26 ± 0.054	2.418ArgGln: 2.418 ± 0.039	8.129ArgArg: 8.129 ± 0.075	4.439ArgSer: 4.439 ± 0.046	5.696ArgThr: 5.696 ± 0.058	5.894ArgVal: 5.894 ± 0.058	1.482ArgTrp: 1.482 ± 0.027	1.91ArgTyr: 1.91 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.115SerAla: 7.115 ± 0.069	0.444SerCys: 0.444 ± 0.015	2.719SerAsp: 2.719 ± 0.038	2.581SerGlu: 2.581 ± 0.035	1.528SerPhe: 1.528 ± 0.027	6.322SerGly: 6.322 ± 0.064	1.085SerHis: 1.085 ± 0.025	1.489SerIle: 1.489 ± 0.029	0.966SerLys: 0.966 ± 0.026	4.923SerLeu: 4.923 ± 0.048	1.044SerMet: 1.044 ± 0.024	0.82SerAsn: 0.82 ± 0.022	3.412SerPro: 3.412 ± 0.041	1.244SerGln: 1.244 ± 0.021	3.957SerArg: 3.957 ± 0.038	2.895SerSer: 2.895 ± 0.044	3.037SerThr: 3.037 ± 0.037	4.276SerVal: 4.276 ± 0.051	0.974SerTrp: 0.974 ± 0.022	1.236SerTyr: 1.236 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.291ThrAla: 9.291 ± 0.073	0.385ThrCys: 0.385 ± 0.013	3.386ThrAsp: 3.386 ± 0.044	3.308ThrGlu: 3.308 ± 0.04	1.427ThrPhe: 1.427 ± 0.026	6.921ThrGly: 6.921 ± 0.069	1.159ThrHis: 1.159 ± 0.027	1.71ThrIle: 1.71 ± 0.028	0.982ThrLys: 0.982 ± 0.024	5.552ThrLeu: 5.552 ± 0.051	0.902ThrMet: 0.902 ± 0.021	0.884ThrAsn: 0.884 ± 0.023	4.15ThrPro: 4.15 ± 0.044	1.205ThrGln: 1.205 ± 0.028	3.934ThrArg: 3.934 ± 0.044	2.902ThrSer: 2.902 ± 0.038	3.566ThrThr: 3.566 ± 0.048	6.079ThrVal: 6.079 ± 0.057	0.843ThrTrp: 0.843 ± 0.022	1.109ThrTyr: 1.109 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	9.765ValAla: 9.765 ± 0.07	0.783ValCys: 0.783 ± 0.02	4.582ValAsp: 4.582 ± 0.049	4.496ValGlu: 4.496 ± 0.046	2.374ValPhe: 2.374 ± 0.032	5.821ValGly: 5.821 ± 0.057	1.964ValHis: 1.964 ± 0.033	3.039ValIle: 3.039 ± 0.04	1.646ValLys: 1.646 ± 0.032	8.973ValLeu: 8.973 ± 0.085	1.415ValMet: 1.415 ± 0.023	1.614ValAsn: 1.614 ± 0.031	5.162ValPro: 5.162 ± 0.062	2.009ValGln: 2.009 ± 0.033	7.237ValArg: 7.237 ± 0.068	4.39ValSer: 4.39 ± 0.042	5.233ValThr: 5.233 ± 0.054	7.057ValVal: 7.057 ± 0.076	1.157ValTrp: 1.157 ± 0.021	1.617ValTyr: 1.617 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.668TrpAla: 1.668 ± 0.032	0.157TrpCys: 0.157 ± 0.008	0.835TrpAsp: 0.835 ± 0.021	0.792TrpGlu: 0.792 ± 0.022	0.489TrpPhe: 0.489 ± 0.016	1.045TrpGly: 1.045 ± 0.023	0.38TrpHis: 0.38 ± 0.014	0.575TrpIle: 0.575 ± 0.016	0.35TrpLys: 0.35 ± 0.014	1.795TrpLeu: 1.795 ± 0.032	0.279TrpMet: 0.279 ± 0.011	0.42TrpAsn: 0.42 ± 0.014	0.772TrpPro: 0.772 ± 0.018	0.583TrpGln: 0.583 ± 0.018	1.437TrpArg: 1.437 ± 0.03	0.973TrpSer: 0.973 ± 0.024	1.032TrpThr: 1.032 ± 0.022	0.93TrpVal: 0.93 ± 0.022	0.346TrpTrp: 0.346 ± 0.013	0.353TrpTyr: 0.353 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.793TyrAla: 2.793 ± 0.04	0.189TyrCys: 0.189 ± 0.01	1.47TyrAsp: 1.47 ± 0.031	1.284TyrGlu: 1.284 ± 0.022	0.639TyrPhe: 0.639 ± 0.017	2.317TyrGly: 2.317 ± 0.033	0.395TyrHis: 0.395 ± 0.013	0.54TyrIle: 0.54 ± 0.016	0.346TyrLys: 0.346 ± 0.013	2.077TyrLeu: 2.077 ± 0.031	0.256TyrMet: 0.256 ± 0.012	0.378TyrAsn: 0.378 ± 0.014	1.1TyrPro: 1.1 ± 0.024	0.62TyrGln: 0.62 ± 0.017	1.939TyrArg: 1.939 ± 0.03	0.95TyrSer: 0.95 ± 0.023	1.201TyrThr: 1.201 ± 0.025	1.474TyrVal: 1.474 ± 0.029	0.316TyrTrp: 0.316 ± 0.011	0.437TyrTyr: 0.437 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 7035 proteins (2247349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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