Amino acid dipepetide frequency for Thermosinus carboxydivorans Nor1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.229AlaAla: 14.229 ± 0.224	1.296AlaCys: 1.296 ± 0.044	5.096AlaAsp: 5.096 ± 0.083	6.716AlaGlu: 6.716 ± 0.1	3.453AlaPhe: 3.453 ± 0.073	9.074AlaGly: 9.074 ± 0.131	1.66AlaHis: 1.66 ± 0.046	6.823AlaIle: 6.823 ± 0.105	5.807AlaLys: 5.807 ± 0.092	10.671AlaLeu: 10.671 ± 0.134	2.884AlaMet: 2.884 ± 0.056	3.181AlaAsn: 3.181 ± 0.066	3.577AlaPro: 3.577 ± 0.09	3.616AlaGln: 3.616 ± 0.067	5.738AlaArg: 5.738 ± 0.085	4.448AlaSer: 4.448 ± 0.082	4.806AlaThr: 4.806 ± 0.081	9.482AlaVal: 9.482 ± 0.126	1.01AlaTrp: 1.01 ± 0.041	2.854AlaTyr: 2.854 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.937CysAla: 0.937 ± 0.032	0.209CysCys: 0.209 ± 0.019	0.575CysAsp: 0.575 ± 0.028	0.542CysGlu: 0.542 ± 0.028	0.358CysPhe: 0.358 ± 0.023	1.381CysGly: 1.381 ± 0.044	0.278CysHis: 0.278 ± 0.02	0.677CysIle: 0.677 ± 0.032	0.391CysLys: 0.391 ± 0.02	1.124CysLeu: 1.124 ± 0.042	0.252CysMet: 0.252 ± 0.017	0.333CysAsn: 0.333 ± 0.023	0.797CysPro: 0.797 ± 0.036	0.463CysGln: 0.463 ± 0.029	0.856CysArg: 0.856 ± 0.038	0.581CysSer: 0.581 ± 0.029	0.526CysThr: 0.526 ± 0.027	0.717CysVal: 0.717 ± 0.028	0.107CysTrp: 0.107 ± 0.012	0.381CysTyr: 0.381 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.458AspAla: 4.458 ± 0.076	0.591AspCys: 0.591 ± 0.026	2.326AspAsp: 2.326 ± 0.055	3.443AspGlu: 3.443 ± 0.073	1.973AspPhe: 1.973 ± 0.049	3.703AspGly: 3.703 ± 0.08	0.876AspHis: 0.876 ± 0.035	4.027AspIle: 4.027 ± 0.084	2.99AspLys: 2.99 ± 0.07	4.736AspLeu: 4.736 ± 0.084	1.317AspMet: 1.317 ± 0.038	1.748AspAsn: 1.748 ± 0.045	2.09AspPro: 2.09 ± 0.06	1.363AspGln: 1.363 ± 0.042	2.814AspArg: 2.814 ± 0.063	1.866AspSer: 1.866 ± 0.048	2.212AspThr: 2.212 ± 0.051	3.751AspVal: 3.751 ± 0.076	0.627AspTrp: 0.627 ± 0.03	1.95AspTyr: 1.95 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.907GluAla: 5.907 ± 0.087	0.551GluCys: 0.551 ± 0.026	2.409GluAsp: 2.409 ± 0.066	4.32GluGlu: 4.32 ± 0.083	2.069GluPhe: 2.069 ± 0.045	3.654GluGly: 3.654 ± 0.068	1.166GluHis: 1.166 ± 0.039	4.801GluIle: 4.801 ± 0.091	3.99GluLys: 3.99 ± 0.076	6.571GluLeu: 6.571 ± 0.088	1.778GluMet: 1.778 ± 0.052	2.118GluAsn: 2.118 ± 0.056	2.071GluPro: 2.071 ± 0.051	2.75GluGln: 2.75 ± 0.071	4.08GluArg: 4.08 ± 0.084	1.888GluSer: 1.888 ± 0.051	3.079GluThr: 3.079 ± 0.067	4.899GluVal: 4.899 ± 0.09	0.6GluTrp: 0.6 ± 0.03	1.892GluTyr: 1.892 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.812PheAla: 3.812 ± 0.071	0.462PheCys: 0.462 ± 0.023	2.011PheAsp: 2.011 ± 0.052	1.684PheGlu: 1.684 ± 0.045	1.622PhePhe: 1.622 ± 0.053	3.23PheGly: 3.23 ± 0.071	0.68PheHis: 0.68 ± 0.031	2.615PheIle: 2.615 ± 0.069	1.592PheLys: 1.592 ± 0.049	3.575PheLeu: 3.575 ± 0.077	0.876PheMet: 0.876 ± 0.033	1.331PheAsn: 1.331 ± 0.048	1.465PhePro: 1.465 ± 0.045	0.916PheGln: 0.916 ± 0.034	1.771PheArg: 1.771 ± 0.047	2.099PheSer: 2.099 ± 0.06	2.278PheThr: 2.278 ± 0.056	2.803PheVal: 2.803 ± 0.067	0.447PheTrp: 0.447 ± 0.024	1.127PheTyr: 1.127 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	7.252GlyAla: 7.252 ± 0.108	1.139GlyCys: 1.139 ± 0.041	3.494GlyAsp: 3.494 ± 0.064	4.425GlyGlu: 4.425 ± 0.075	2.955GlyPhe: 2.955 ± 0.066	6.156GlyGly: 6.156 ± 0.095	1.621GlyHis: 1.621 ± 0.053	6.016GlyIle: 6.016 ± 0.093	4.585GlyLys: 4.585 ± 0.081	8.288GlyLeu: 8.288 ± 0.106	2.447GlyMet: 2.447 ± 0.057	2.35GlyAsn: 2.35 ± 0.054	2.604GlyPro: 2.604 ± 0.065	2.974GlyGln: 2.974 ± 0.061	4.768GlyArg: 4.768 ± 0.088	3.734GlySer: 3.734 ± 0.078	4.027GlyThr: 4.027 ± 0.077	6.416GlyVal: 6.416 ± 0.093	0.883GlyTrp: 0.883 ± 0.032	2.797GlyTyr: 2.797 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.547HisAla: 1.547 ± 0.041	0.281HisCys: 0.281 ± 0.019	0.966HisAsp: 0.966 ± 0.033	1.024HisGlu: 1.024 ± 0.035	0.73HisPhe: 0.73 ± 0.028	1.708HisGly: 1.708 ± 0.045	0.526HisHis: 0.526 ± 0.035	1.408HisIle: 1.408 ± 0.043	0.804HisLys: 0.804 ± 0.035	1.861HisLeu: 1.861 ± 0.046	0.47HisMet: 0.47 ± 0.026	0.732HisAsn: 0.732 ± 0.028	1.146HisPro: 1.146 ± 0.039	0.615HisGln: 0.615 ± 0.026	1.13HisArg: 1.13 ± 0.038	0.901HisSer: 0.901 ± 0.034	0.984HisThr: 0.984 ± 0.038	1.255HisVal: 1.255 ± 0.042	0.213HisTrp: 0.213 ± 0.016	0.646HisTyr: 0.646 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.576IleAla: 7.576 ± 0.102	0.715IleCys: 0.715 ± 0.031	3.873IleAsp: 3.873 ± 0.075	3.905IleGlu: 3.905 ± 0.079	2.36IlePhe: 2.36 ± 0.054	5.544IleGly: 5.544 ± 0.099	1.203IleHis: 1.203 ± 0.035	5.195IleIle: 5.195 ± 0.092	3.487IleLys: 3.487 ± 0.073	6.234IleLeu: 6.234 ± 0.092	1.656IleMet: 1.656 ± 0.05	2.645IleAsn: 2.645 ± 0.063	3.25IlePro: 3.25 ± 0.054	1.742IleGln: 1.742 ± 0.045	3.678IleArg: 3.678 ± 0.071	3.306IleSer: 3.306 ± 0.065	4.069IleThr: 4.069 ± 0.074	5.709IleVal: 5.709 ± 0.092	0.547IleTrp: 0.547 ± 0.028	1.898IleTyr: 1.898 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.011LysAla: 5.011 ± 0.095	0.481LysCys: 0.481 ± 0.03	2.424LysAsp: 2.424 ± 0.063	3.626LysGlu: 3.626 ± 0.073	1.632LysPhe: 1.632 ± 0.048	3.448LysGly: 3.448 ± 0.067	0.903LysHis: 0.903 ± 0.031	3.704LysIle: 3.704 ± 0.076	2.957LysLys: 2.957 ± 0.072	5.189LysLeu: 5.189 ± 0.093	1.639LysMet: 1.639 ± 0.039	1.907LysAsn: 1.907 ± 0.057	2.256LysPro: 2.256 ± 0.059	2.036LysGln: 2.036 ± 0.058	2.797LysArg: 2.797 ± 0.057	2.09LysSer: 2.09 ± 0.053	2.904LysThr: 2.904 ± 0.06	4.407LysVal: 4.407 ± 0.073	0.47LysTrp: 0.47 ± 0.027	1.663LysTyr: 1.663 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	13.331LeuAla: 13.331 ± 0.154	1.077LeuCys: 1.077 ± 0.043	5.05LeuAsp: 5.05 ± 0.083	5.66LeuGlu: 5.66 ± 0.089	3.742LeuPhe: 3.742 ± 0.086	7.798LeuGly: 7.798 ± 0.105	1.732LeuHis: 1.732 ± 0.051	5.924LeuIle: 5.924 ± 0.095	5.15LeuLys: 5.15 ± 0.071	10.193LeuLeu: 10.193 ± 0.143	2.415LeuMet: 2.415 ± 0.052	3.142LeuAsn: 3.142 ± 0.057	5.034LeuPro: 5.034 ± 0.079	2.944LeuGln: 2.944 ± 0.057	5.695LeuArg: 5.695 ± 0.097	5.465LeuSer: 5.465 ± 0.092	5.997LeuThr: 5.997 ± 0.087	7.84LeuVal: 7.84 ± 0.1	0.99LeuTrp: 0.99 ± 0.039	2.755LeuTyr: 2.755 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.195MetAla: 3.195 ± 0.074	0.24MetCys: 0.24 ± 0.016	1.201MetAsp: 1.201 ± 0.039	1.464MetGlu: 1.464 ± 0.046	0.803MetPhe: 0.803 ± 0.032	2.001MetGly: 2.001 ± 0.059	0.418MetHis: 0.418 ± 0.026	1.449MetIle: 1.449 ± 0.047	1.314MetLys: 1.314 ± 0.044	2.877MetLeu: 2.877 ± 0.074	0.686MetMet: 0.686 ± 0.029	0.833MetAsn: 0.833 ± 0.033	1.23MetPro: 1.23 ± 0.042	0.985MetGln: 0.985 ± 0.035	1.522MetArg: 1.522 ± 0.046	1.296MetSer: 1.296 ± 0.042	1.479MetThr: 1.479 ± 0.043	2.174MetVal: 2.174 ± 0.051	0.174MetTrp: 0.174 ± 0.013	0.596MetTyr: 0.596 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.941AsnAla: 2.941 ± 0.066	0.414AsnCys: 0.414 ± 0.024	1.302AsnAsp: 1.302 ± 0.042	1.641AsnGlu: 1.641 ± 0.056	1.3AsnPhe: 1.3 ± 0.042	2.323AsnGly: 2.323 ± 0.062	0.643AsnHis: 0.643 ± 0.03	2.8AsnIle: 2.8 ± 0.066	1.8AsnLys: 1.8 ± 0.049	3.396AsnLeu: 3.396 ± 0.06	0.911AsnMet: 0.911 ± 0.043	1.217AsnAsn: 1.217 ± 0.044	2.054AsnPro: 2.054 ± 0.047	0.979AsnGln: 0.979 ± 0.04	1.868AsnArg: 1.868 ± 0.053	1.501AsnSer: 1.501 ± 0.046	1.717AsnThr: 1.717 ± 0.047	2.546AsnVal: 2.546 ± 0.058	0.419AsnTrp: 0.419 ± 0.024	1.15AsnTyr: 1.15 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.714ProAla: 4.714 ± 0.088	0.469ProCys: 0.469 ± 0.026	2.738ProAsp: 2.738 ± 0.062	3.212ProGlu: 3.212 ± 0.064	1.687ProPhe: 1.687 ± 0.044	4.011ProGly: 4.011 ± 0.078	0.96ProHis: 0.96 ± 0.035	2.382ProIle: 2.382 ± 0.059	1.86ProLys: 1.86 ± 0.057	4.348ProLeu: 4.348 ± 0.073	0.829ProMet: 0.829 ± 0.032	1.289ProAsn: 1.289 ± 0.037	1.923ProPro: 1.923 ± 0.052	1.538ProGln: 1.538 ± 0.047	2.118ProArg: 2.118 ± 0.049	1.838ProSer: 1.838 ± 0.049	2.051ProThr: 2.051 ± 0.052	4.183ProVal: 4.183 ± 0.073	0.465ProTrp: 0.465 ± 0.026	1.419ProTyr: 1.419 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.312GlnAla: 4.312 ± 0.085	0.348GlnCys: 0.348 ± 0.026	1.548GlnAsp: 1.548 ± 0.047	2.445GlnGlu: 2.445 ± 0.065	1.073GlnPhe: 1.073 ± 0.034	2.419GlnGly: 2.419 ± 0.057	0.719GlnHis: 0.719 ± 0.031	2.17GlnIle: 2.17 ± 0.053	1.987GlnLys: 1.987 ± 0.05	3.281GlnLeu: 3.281 ± 0.069	0.879GlnMet: 0.879 ± 0.035	1.134GlnAsn: 1.134 ± 0.041	1.591GlnPro: 1.591 ± 0.048	1.625GlnGln: 1.625 ± 0.062	2.018GlnArg: 2.018 ± 0.049	1.382GlnSer: 1.382 ± 0.046	1.784GlnThr: 1.784 ± 0.051	2.77GlnVal: 2.77 ± 0.06	0.286GlnTrp: 0.286 ± 0.019	1.074GlnTyr: 1.074 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.634ArgAla: 4.634 ± 0.078	0.614ArgCys: 0.614 ± 0.03	2.817ArgAsp: 2.817 ± 0.065	4.233ArgGlu: 4.233 ± 0.077	2.139ArgPhe: 2.139 ± 0.057	3.716ArgGly: 3.716 ± 0.068	1.29ArgHis: 1.29 ± 0.04	3.831ArgIle: 3.831 ± 0.073	2.721ArgLys: 2.721 ± 0.055	6.664ArgLeu: 6.664 ± 0.115	1.555ArgMet: 1.555 ± 0.05	1.686ArgAsn: 1.686 ± 0.043	2.66ArgPro: 2.66 ± 0.063	3.175ArgGln: 3.175 ± 0.079	4.24ArgArg: 4.24 ± 0.093	2.409ArgSer: 2.409 ± 0.06	2.821ArgThr: 2.821 ± 0.057	4.013ArgVal: 4.013 ± 0.079	0.619ArgTrp: 0.619 ± 0.029	2.095ArgTyr: 2.095 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.365SerAla: 4.365 ± 0.085	0.538SerCys: 0.538 ± 0.031	2.144SerAsp: 2.144 ± 0.049	2.463SerGlu: 2.463 ± 0.06	1.859SerPhe: 1.859 ± 0.048	4.381SerGly: 4.381 ± 0.078	0.974SerHis: 0.974 ± 0.03	2.922SerIle: 2.922 ± 0.057	1.907SerLys: 1.907 ± 0.058	5.109SerLeu: 5.109 ± 0.081	1.138SerMet: 1.138 ± 0.046	1.234SerAsn: 1.234 ± 0.042	2.201SerPro: 2.201 ± 0.056	1.53SerGln: 1.53 ± 0.044	2.888SerArg: 2.888 ± 0.067	2.359SerSer: 2.359 ± 0.061	2.231SerThr: 2.231 ± 0.053	3.362SerVal: 3.362 ± 0.058	0.458SerTrp: 0.458 ± 0.028	1.365SerTyr: 1.365 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.951ThrAla: 5.951 ± 0.09	0.561ThrCys: 0.561 ± 0.028	2.507ThrAsp: 2.507 ± 0.058	2.697ThrGlu: 2.697 ± 0.059	1.904ThrPhe: 1.904 ± 0.058	5.22ThrGly: 5.22 ± 0.078	0.9ThrHis: 0.9 ± 0.035	3.671ThrIle: 3.671 ± 0.061	2.297ThrLys: 2.297 ± 0.05	5.04ThrLeu: 5.04 ± 0.089	1.202ThrMet: 1.202 ± 0.038	1.694ThrAsn: 1.694 ± 0.045	2.756ThrPro: 2.756 ± 0.052	1.332ThrGln: 1.332 ± 0.047	2.55ThrArg: 2.55 ± 0.057	2.332ThrSer: 2.332 ± 0.055	2.811ThrThr: 2.811 ± 0.064	5.186ThrVal: 5.186 ± 0.081	0.502ThrTrp: 0.502 ± 0.024	1.498ThrTyr: 1.498 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.707ValAla: 8.707 ± 0.121	0.956ValCys: 0.956 ± 0.038	4.198ValAsp: 4.198 ± 0.079	4.807ValGlu: 4.807 ± 0.087	2.972ValPhe: 2.972 ± 0.07	5.749ValGly: 5.749 ± 0.092	1.408ValHis: 1.408 ± 0.044	5.704ValIle: 5.704 ± 0.081	4.161ValLys: 4.161 ± 0.074	8.117ValLeu: 8.117 ± 0.112	2.169ValMet: 2.169 ± 0.062	2.893ValAsn: 2.893 ± 0.057	3.413ValPro: 3.413 ± 0.058	2.415ValGln: 2.415 ± 0.061	4.522ValArg: 4.522 ± 0.094	4.007ValSer: 4.007 ± 0.066	4.81ValThr: 4.81 ± 0.088	7.077ValVal: 7.077 ± 0.119	0.715ValTrp: 0.715 ± 0.033	2.481ValTyr: 2.481 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.85TrpAla: 0.85 ± 0.036	0.11TrpCys: 0.11 ± 0.012	0.507TrpAsp: 0.507 ± 0.027	0.596TrpGlu: 0.596 ± 0.032	0.42TrpPhe: 0.42 ± 0.023	0.725TrpGly: 0.725 ± 0.032	0.225TrpHis: 0.225 ± 0.016	0.447TrpIle: 0.447 ± 0.025	0.402TrpLys: 0.402 ± 0.023	1.373TrpLeu: 1.373 ± 0.047	0.242TrpMet: 0.242 ± 0.019	0.319TrpAsn: 0.319 ± 0.021	0.475TrpPro: 0.475 ± 0.028	0.627TrpGln: 0.627 ± 0.028	0.733TrpArg: 0.733 ± 0.033	0.423TrpSer: 0.423 ± 0.027	0.443TrpThr: 0.443 ± 0.027	0.659TrpVal: 0.659 ± 0.03	0.185TrpTrp: 0.185 ± 0.015	0.337TrpTyr: 0.337 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.693TyrAla: 2.693 ± 0.059	0.434TyrCys: 0.434 ± 0.024	1.674TyrAsp: 1.674 ± 0.048	1.692TyrGlu: 1.692 ± 0.05	1.345TyrPhe: 1.345 ± 0.036	2.691TyrGly: 2.691 ± 0.057	0.766TyrHis: 0.766 ± 0.033	2.026TyrIle: 2.026 ± 0.049	1.341TyrLys: 1.341 ± 0.041	3.289TyrLeu: 3.289 ± 0.063	0.588TyrMet: 0.588 ± 0.028	1.136TyrAsn: 1.136 ± 0.037	1.442TyrPro: 1.442 ± 0.04	1.218TyrGln: 1.218 ± 0.039	2.142TyrArg: 2.142 ± 0.055	1.503TyrSer: 1.503 ± 0.049	1.583TyrThr: 1.583 ± 0.044	2.034TyrVal: 2.034 ± 0.06	0.38TyrTrp: 0.38 ± 0.021	1.224TyrTyr: 1.224 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2738 proteins (821021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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