Amino acid dipepetide frequency for Hippea maritima (strain ATCC 700847 / DSM 10411 / MH2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.671AlaAla: 4.671 ± 0.112
0.67AlaCys: 0.67 ± 0.037
3.021AlaAsp: 3.021 ± 0.076
3.641AlaGlu: 3.641 ± 0.105
3.693AlaPhe: 3.693 ± 0.1
4.289AlaGly: 4.289 ± 0.108
0.983AlaHis: 0.983 ± 0.039
6.353AlaIle: 6.353 ± 0.119
6.26AlaLys: 6.26 ± 0.122
6.786AlaLeu: 6.786 ± 0.119
1.595AlaMet: 1.595 ± 0.059
2.702AlaAsn: 2.702 ± 0.077
1.576AlaPro: 1.576 ± 0.053
1.688AlaGln: 1.688 ± 0.056
2.547AlaArg: 2.547 ± 0.068
3.805AlaSer: 3.805 ± 0.103
3.008AlaThr: 3.008 ± 0.091
4.684AlaVal: 4.684 ± 0.119
0.345AlaTrp: 0.345 ± 0.029
2.644AlaTyr: 2.644 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.511CysAla: 0.511 ± 0.031
0.124CysCys: 0.124 ± 0.017
0.635CysAsp: 0.635 ± 0.038
0.528CysGlu: 0.528 ± 0.03
0.439CysPhe: 0.439 ± 0.029
0.948CysGly: 0.948 ± 0.043
0.18CysHis: 0.18 ± 0.019
0.751CysIle: 0.751 ± 0.041
0.751CysLys: 0.751 ± 0.036
0.666CysLeu: 0.666 ± 0.037
0.217CysMet: 0.217 ± 0.02
0.424CysAsn: 0.424 ± 0.031
0.536CysPro: 0.536 ± 0.041
0.188CysGln: 0.188 ± 0.016
0.391CysArg: 0.391 ± 0.032
0.677CysSer: 0.677 ± 0.04
0.319CysThr: 0.319 ± 0.026
0.697CysVal: 0.697 ± 0.041
0.06CysTrp: 0.06 ± 0.011
0.372CysTyr: 0.372 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.438AspAla: 3.438 ± 0.081
0.47AspCys: 0.47 ± 0.035
2.723AspAsp: 2.723 ± 0.08
4.806AspGlu: 4.806 ± 0.117
2.971AspPhe: 2.971 ± 0.079
3.368AspGly: 3.368 ± 0.084
0.561AspHis: 0.561 ± 0.033
5.561AspIle: 5.561 ± 0.111
5.474AspLys: 5.474 ± 0.118
4.583AspLeu: 4.583 ± 0.094
1.25AspMet: 1.25 ± 0.054
2.613AspAsn: 2.613 ± 0.085
1.645AspPro: 1.645 ± 0.071
0.654AspGln: 0.654 ± 0.043
2.524AspArg: 2.524 ± 0.082
2.779AspSer: 2.779 ± 0.071
2.228AspThr: 2.228 ± 0.071
4.583AspVal: 4.583 ± 0.101
0.375AspTrp: 0.375 ± 0.029
2.388AspTyr: 2.388 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
4.818GluAla: 4.818 ± 0.09
0.457GluCys: 0.457 ± 0.028
3.827GluAsp: 3.827 ± 0.101
5.7GluGlu: 5.7 ± 0.147
3.681GluPhe: 3.681 ± 0.095
4.076GluGly: 4.076 ± 0.094
0.977GluHis: 0.977 ± 0.051
6.176GluIle: 6.176 ± 0.116
6.989GluLys: 6.989 ± 0.158
6.6GluLeu: 6.6 ± 0.135
1.566GluMet: 1.566 ± 0.055
3.889GluAsn: 3.889 ± 0.082
1.765GluPro: 1.765 ± 0.054
1.574GluGln: 1.574 ± 0.049
2.93GluArg: 2.93 ± 0.085
3.149GluSer: 3.149 ± 0.084
2.776GluThr: 2.776 ± 0.076
4.338GluVal: 4.338 ± 0.088
0.48GluTrp: 0.48 ± 0.036
2.545GluTyr: 2.545 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
3.364PheAla: 3.364 ± 0.085
0.585PheCys: 0.585 ± 0.036
3.265PheAsp: 3.265 ± 0.082
3.623PheGlu: 3.623 ± 0.085
2.892PhePhe: 2.892 ± 0.098
3.683PheGly: 3.683 ± 0.086
0.631PheHis: 0.631 ± 0.041
4.487PheIle: 4.487 ± 0.122
4.154PheLys: 4.154 ± 0.088
5.325PheLeu: 5.325 ± 0.135
1.115PheMet: 1.115 ± 0.046
2.493PheAsn: 2.493 ± 0.068
1.235PhePro: 1.235 ± 0.045
0.691PheGln: 0.691 ± 0.037
1.808PheArg: 1.808 ± 0.058
3.98PheSer: 3.98 ± 0.105
2.079PheThr: 2.079 ± 0.072
4.055PheVal: 4.055 ± 0.103
0.42PheTrp: 0.42 ± 0.032
2.15PheTyr: 2.15 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
3.981GlyAla: 3.981 ± 0.096
0.811GlyCys: 0.811 ± 0.045
3.242GlyAsp: 3.242 ± 0.088
3.652GlyGlu: 3.652 ± 0.083
4.268GlyPhe: 4.268 ± 0.107
4.723GlyGly: 4.723 ± 0.116
1.032GlyHis: 1.032 ± 0.046
6.174GlyIle: 6.174 ± 0.124
5.522GlyLys: 5.522 ± 0.108
6.275GlyLeu: 6.275 ± 0.12
1.817GlyMet: 1.817 ± 0.068
2.576GlyAsn: 2.576 ± 0.078
1.299GlyPro: 1.299 ± 0.05
1.283GlyGln: 1.283 ± 0.049
2.762GlyArg: 2.762 ± 0.08
3.778GlySer: 3.778 ± 0.086
2.472GlyThr: 2.472 ± 0.079
5.46GlyVal: 5.46 ± 0.112
0.569GlyTrp: 0.569 ± 0.036
3.058GlyTyr: 3.058 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
0.834HisAla: 0.834 ± 0.039
0.207HisCys: 0.207 ± 0.023
0.6HisAsp: 0.6 ± 0.033
0.724HisGlu: 0.724 ± 0.034
0.825HisPhe: 0.825 ± 0.042
0.958HisGly: 0.958 ± 0.043
0.358HisHis: 0.358 ± 0.034
1.44HisIle: 1.44 ± 0.055
1.181HisLys: 1.181 ± 0.044
1.645HisLeu: 1.645 ± 0.055
0.341HisMet: 0.341 ± 0.027
0.753HisAsn: 0.753 ± 0.038
0.925HisPro: 0.925 ± 0.04
0.379HisGln: 0.379 ± 0.031
0.606HisArg: 0.606 ± 0.038
1.014HisSer: 1.014 ± 0.039
0.801HisThr: 0.801 ± 0.036
0.747HisVal: 0.747 ± 0.038
0.11HisTrp: 0.11 ± 0.015
0.612HisTyr: 0.612 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.54IleAla: 6.54 ± 0.13
0.79IleCys: 0.79 ± 0.047
6.012IleAsp: 6.012 ± 0.105
7.506IleGlu: 7.506 ± 0.148
3.966IlePhe: 3.966 ± 0.108
5.561IleGly: 5.561 ± 0.101
1.312IleHis: 1.312 ± 0.051
7.071IleIle: 7.071 ± 0.147
8.718IleLys: 8.718 ± 0.141
7.841IleLeu: 7.841 ± 0.134
1.767IleMet: 1.767 ± 0.061
4.556IleAsn: 4.556 ± 0.108
3.205IlePro: 3.205 ± 0.072
1.839IleGln: 1.839 ± 0.063
3.182IleArg: 3.182 ± 0.084
5.549IleSer: 5.549 ± 0.1
4.554IleThr: 4.554 ± 0.096
6.192IleVal: 6.192 ± 0.105
0.575IleTrp: 0.575 ± 0.034
3.118IleTyr: 3.118 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
6.058LysAla: 6.058 ± 0.109
0.625LysCys: 0.625 ± 0.036
5.826LysAsp: 5.826 ± 0.104
8.604LysGlu: 8.604 ± 0.139
3.025LysPhe: 3.025 ± 0.08
5.646LysGly: 5.646 ± 0.099
1.504LysHis: 1.504 ± 0.05
7.831LysIle: 7.831 ± 0.149
9.279LysLys: 9.279 ± 0.149
8.532LysLeu: 8.532 ± 0.127
1.97LysMet: 1.97 ± 0.06
5.596LysAsn: 5.596 ± 0.111
3.498LysPro: 3.498 ± 0.084
2.729LysGln: 2.729 ± 0.079
4.661LysArg: 4.661 ± 0.096
5.002LysSer: 5.002 ± 0.106
4.825LysThr: 4.825 ± 0.103
5.154LysVal: 5.154 ± 0.122
0.552LysTrp: 0.552 ± 0.034
3.147LysTyr: 3.147 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
6.161LeuAla: 6.161 ± 0.114
0.693LeuCys: 0.693 ± 0.035
5.002LeuAsp: 5.002 ± 0.101
5.648LeuGlu: 5.648 ± 0.112
4.905LeuPhe: 4.905 ± 0.149
5.915LeuGly: 5.915 ± 0.117
1.274LeuHis: 1.274 ± 0.054
7.998LeuIle: 7.998 ± 0.134
11.008LeuLys: 11.008 ± 0.167
8.344LeuLeu: 8.344 ± 0.155
2.032LeuMet: 2.032 ± 0.066
5.431LeuAsn: 5.431 ± 0.114
3.42LeuPro: 3.42 ± 0.089
1.967LeuGln: 1.967 ± 0.064
4.007LeuArg: 4.007 ± 0.097
7.539LeuSer: 7.539 ± 0.129
4.415LeuThr: 4.415 ± 0.096
5.381LeuVal: 5.381 ± 0.107
0.681LeuTrp: 0.681 ± 0.038
3.287LeuTyr: 3.287 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
1.728MetAla: 1.728 ± 0.072
0.178MetCys: 0.178 ± 0.019
1.397MetAsp: 1.397 ± 0.052
1.421MetGlu: 1.421 ± 0.057
1.21MetPhe: 1.21 ± 0.051
1.692MetGly: 1.692 ± 0.054
0.405MetHis: 0.405 ± 0.031
1.821MetIle: 1.821 ± 0.069
1.984MetLys: 1.984 ± 0.067
2.112MetLeu: 2.112 ± 0.051
0.569MetMet: 0.569 ± 0.038
0.993MetAsn: 0.993 ± 0.047
1.028MetPro: 1.028 ± 0.049
0.556MetGln: 0.556 ± 0.037
1.088MetArg: 1.088 ± 0.042
1.427MetSer: 1.427 ± 0.051
0.857MetThr: 0.857 ± 0.041
1.668MetVal: 1.668 ± 0.065
0.163MetTrp: 0.163 ± 0.018
0.683MetTyr: 0.683 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
2.971AsnAla: 2.971 ± 0.084
0.519AsnCys: 0.519 ± 0.032
2.445AsnAsp: 2.445 ± 0.067
2.915AsnGlu: 2.915 ± 0.079
2.218AsnPhe: 2.218 ± 0.061
3.229AsnGly: 3.229 ± 0.094
0.627AsnHis: 0.627 ± 0.035
5.077AsnIle: 5.077 ± 0.107
4.338AsnLys: 4.338 ± 0.11
4.814AsnLeu: 4.814 ± 0.105
1.113AsnMet: 1.113 ± 0.046
2.365AsnAsn: 2.365 ± 0.087
2.516AsnPro: 2.516 ± 0.085
1.355AsnGln: 1.355 ± 0.061
2.143AsnArg: 2.143 ± 0.066
2.965AsnSer: 2.965 ± 0.09
2.369AsnThr: 2.369 ± 0.063
3.105AsnVal: 3.105 ± 0.07
0.341AsnTrp: 0.341 ± 0.028
1.996AsnTyr: 1.996 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.835ProAla: 1.835 ± 0.062
0.273ProCys: 0.273 ± 0.022
1.885ProAsp: 1.885 ± 0.061
2.224ProGlu: 2.224 ± 0.071
2.063ProPhe: 2.063 ± 0.071
1.67ProGly: 1.67 ± 0.064
0.683ProHis: 0.683 ± 0.034
2.915ProIle: 2.915 ± 0.078
3.06ProLys: 3.06 ± 0.079
3.161ProLeu: 3.161 ± 0.077
0.741ProMet: 0.741 ± 0.042
1.643ProAsn: 1.643 ± 0.055
1.136ProPro: 1.136 ± 0.04
1.103ProGln: 1.103 ± 0.046
0.972ProArg: 0.972 ± 0.044
2.106ProSer: 2.106 ± 0.072
1.914ProThr: 1.914 ± 0.063
2.239ProVal: 2.239 ± 0.077
0.259ProTrp: 0.259 ± 0.023
1.605ProTyr: 1.605 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
1.62GlnAla: 1.62 ± 0.062
0.168GlnCys: 0.168 ± 0.021
1.034GlnAsp: 1.034 ± 0.047
1.512GlnGlu: 1.512 ± 0.056
0.964GlnPhe: 0.964 ± 0.042
1.084GlnGly: 1.084 ± 0.047
0.356GlnHis: 0.356 ± 0.022
2.447GlnIle: 2.447 ± 0.076
2.483GlnLys: 2.483 ± 0.067
2.373GlnLeu: 2.373 ± 0.066
0.745GlnMet: 0.745 ± 0.039
1.245GlnAsn: 1.245 ± 0.055
0.736GlnPro: 0.736 ± 0.039
0.817GlnGln: 0.817 ± 0.05
1.096GlnArg: 1.096 ± 0.06
1.154GlnSer: 1.154 ± 0.049
1.376GlnThr: 1.376 ± 0.061
1.183GlnVal: 1.183 ± 0.049
0.178GlnTrp: 0.178 ± 0.017
0.763GlnTyr: 0.763 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.421ArgAla: 2.421 ± 0.074
0.497ArgCys: 0.497 ± 0.034
2.081ArgAsp: 2.081 ± 0.069
2.551ArgGlu: 2.551 ± 0.084
2.64ArgPhe: 2.64 ± 0.076
2.514ArgGly: 2.514 ± 0.079
0.646ArgHis: 0.646 ± 0.035
4.181ArgIle: 4.181 ± 0.094
3.519ArgLys: 3.519 ± 0.08
4.299ArgLeu: 4.299 ± 0.092
1.117ArgMet: 1.117 ± 0.044
1.816ArgAsn: 1.816 ± 0.061
1.248ArgPro: 1.248 ± 0.052
1.13ArgGln: 1.13 ± 0.046
1.984ArgArg: 1.984 ± 0.072
1.926ArgSer: 1.926 ± 0.06
1.432ArgThr: 1.432 ± 0.052
3.151ArgVal: 3.151 ± 0.077
0.379ArgTrp: 0.379 ± 0.023
1.692ArgTyr: 1.692 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.399SerAla: 3.399 ± 0.083
0.658SerCys: 0.658 ± 0.036
2.985SerAsp: 2.985 ± 0.077
3.227SerGlu: 3.227 ± 0.079
3.676SerPhe: 3.676 ± 0.096
4.27SerGly: 4.27 ± 0.095
0.935SerHis: 0.935 ± 0.044
5.756SerIle: 5.756 ± 0.118
5.619SerLys: 5.619 ± 0.099
6.285SerLeu: 6.285 ± 0.13
1.442SerMet: 1.442 ± 0.053
2.857SerAsn: 2.857 ± 0.074
1.881SerPro: 1.881 ± 0.067
1.742SerGln: 1.742 ± 0.057
2.33SerArg: 2.33 ± 0.068
4.38SerSer: 4.38 ± 0.109
2.712SerThr: 2.712 ± 0.068
4.115SerVal: 4.115 ± 0.102
0.451SerTrp: 0.451 ± 0.032
2.485SerTyr: 2.485 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
3.072ThrAla: 3.072 ± 0.077
0.346ThrCys: 0.346 ± 0.028
2.299ThrAsp: 2.299 ± 0.077
2.234ThrGlu: 2.234 ± 0.074
2.025ThrPhe: 2.025 ± 0.067
3.188ThrGly: 3.188 ± 0.087
0.912ThrHis: 0.912 ± 0.047
4.326ThrIle: 4.326 ± 0.108
3.861ThrLys: 3.861 ± 0.1
4.262ThrLeu: 4.262 ± 0.102
0.906ThrMet: 0.906 ± 0.041
2.154ThrAsn: 2.154 ± 0.073
2.114ThrPro: 2.114 ± 0.067
1.37ThrGln: 1.37 ± 0.057
1.485ThrArg: 1.485 ± 0.05
2.543ThrSer: 2.543 ± 0.073
2.685ThrThr: 2.685 ± 0.08
3.049ThrVal: 3.049 ± 0.075
0.211ThrTrp: 0.211 ± 0.021
1.686ThrTyr: 1.686 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
4.709ValAla: 4.709 ± 0.111
0.846ValCys: 0.846 ± 0.042
4.225ValAsp: 4.225 ± 0.099
4.864ValGlu: 4.864 ± 0.104
4.08ValPhe: 4.08 ± 0.101
4.909ValGly: 4.909 ± 0.11
0.852ValHis: 0.852 ± 0.042
5.631ValIle: 5.631 ± 0.115
5.814ValLys: 5.814 ± 0.107
6.546ValLeu: 6.546 ± 0.102
1.69ValMet: 1.69 ± 0.062
3.091ValAsn: 3.091 ± 0.077
1.903ValPro: 1.903 ± 0.055
1.105ValGln: 1.105 ± 0.047
2.65ValArg: 2.65 ± 0.08
4.452ValSer: 4.452 ± 0.087
1.727ValThr: 1.727 ± 0.069
6.308ValVal: 6.308 ± 0.142
0.497ValTrp: 0.497 ± 0.036
2.977ValTyr: 2.977 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.459TrpAla: 0.459 ± 0.034
0.07TrpCys: 0.07 ± 0.013
0.461TrpAsp: 0.461 ± 0.037
0.405TrpGlu: 0.405 ± 0.028
0.391TrpPhe: 0.391 ± 0.033
0.544TrpGly: 0.544 ± 0.034
0.192TrpHis: 0.192 ± 0.019
0.621TrpIle: 0.621 ± 0.035
0.47TrpLys: 0.47 ± 0.03
0.734TrpLeu: 0.734 ± 0.041
0.213TrpMet: 0.213 ± 0.019
0.321TrpAsn: 0.321 ± 0.028
0.199TrpPro: 0.199 ± 0.019
0.225TrpGln: 0.225 ± 0.021
0.286TrpArg: 0.286 ± 0.023
0.331TrpSer: 0.331 ± 0.025
0.228TrpThr: 0.228 ± 0.022
0.519TrpVal: 0.519 ± 0.038
0.105TrpTrp: 0.105 ± 0.014
0.265TrpTyr: 0.265 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.369TyrAla: 2.369 ± 0.066
0.428TyrCys: 0.428 ± 0.029
2.032TyrAsp: 2.032 ± 0.06
2.53TyrGlu: 2.53 ± 0.076
2.102TyrPhe: 2.102 ± 0.076
2.489TyrGly: 2.489 ± 0.075
0.641TyrHis: 0.641 ± 0.032
3.238TyrIle: 3.238 ± 0.098
3.581TyrLys: 3.581 ± 0.102
3.923TyrLeu: 3.923 ± 0.104
0.77TyrMet: 0.77 ± 0.033
1.901TyrAsn: 1.901 ± 0.055
1.624TyrPro: 1.624 ± 0.064
0.937TyrGln: 0.937 ± 0.042
1.775TyrArg: 1.775 ± 0.061
2.65TyrSer: 2.65 ± 0.082
1.949TyrThr: 1.949 ± 0.062
2.247TyrVal: 2.247 ± 0.07
0.286TyrTrp: 0.286 ± 0.028
1.678TyrTyr: 1.678 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1653 proteins (516646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski