Amino acid dipepetide frequency for Candidatus Entotheonella gemina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.714AlaAla: 10.714 ± 0.087	1.166AlaCys: 1.166 ± 0.024	5.48AlaAsp: 5.48 ± 0.056	6.415AlaGlu: 6.415 ± 0.057	3.792AlaPhe: 3.792 ± 0.044	7.54AlaGly: 7.54 ± 0.054	2.464AlaHis: 2.464 ± 0.033	5.454AlaIle: 5.454 ± 0.052	3.205AlaLys: 3.205 ± 0.041	11.22AlaLeu: 11.22 ± 0.091	2.963AlaMet: 2.963 ± 0.038	2.663AlaAsn: 2.663 ± 0.036	4.337AlaPro: 4.337 ± 0.049	4.523AlaGln: 4.523 ± 0.059	5.949AlaArg: 5.949 ± 0.048	5.424AlaSer: 5.424 ± 0.049	5.092AlaThr: 5.092 ± 0.05	7.14AlaVal: 7.14 ± 0.063	1.545AlaTrp: 1.545 ± 0.028	3.022AlaTyr: 3.022 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.919CysAla: 0.919 ± 0.02	0.157CysCys: 0.157 ± 0.009	0.643CysAsp: 0.643 ± 0.016	0.631CysGlu: 0.631 ± 0.017	0.41CysPhe: 0.41 ± 0.013	0.977CysGly: 0.977 ± 0.024	0.396CysHis: 0.396 ± 0.013	0.523CysIle: 0.523 ± 0.014	0.255CysLys: 0.255 ± 0.01	1.112CysLeu: 1.112 ± 0.022	0.287CysMet: 0.287 ± 0.011	0.29CysAsn: 0.29 ± 0.011	0.608CysPro: 0.608 ± 0.017	0.499CysGln: 0.499 ± 0.015	0.77CysArg: 0.77 ± 0.018	0.544CysSer: 0.544 ± 0.016	0.597CysThr: 0.597 ± 0.017	0.704CysVal: 0.704 ± 0.018	0.146CysTrp: 0.146 ± 0.008	0.334CysTyr: 0.334 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.684AspAla: 5.684 ± 0.054	0.534AspCys: 0.534 ± 0.013	3.395AspAsp: 3.395 ± 0.045	3.561AspGlu: 3.561 ± 0.045	2.219AspPhe: 2.219 ± 0.034	4.42AspGly: 4.42 ± 0.063	1.54AspHis: 1.54 ± 0.026	3.508AspIle: 3.508 ± 0.043	1.503AspLys: 1.503 ± 0.028	5.909AspLeu: 5.909 ± 0.045	1.474AspMet: 1.474 ± 0.025	1.474AspAsn: 1.474 ± 0.025	3.232AspPro: 3.232 ± 0.037	2.131AspGln: 2.131 ± 0.033	3.836AspArg: 3.836 ± 0.045	2.257AspSer: 2.257 ± 0.034	3.005AspThr: 3.005 ± 0.042	4.35AspVal: 4.35 ± 0.044	0.905AspTrp: 0.905 ± 0.017	1.832AspTyr: 1.832 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.47GluAla: 7.47 ± 0.061	0.46GluCys: 0.46 ± 0.014	3.045GluAsp: 3.045 ± 0.04	3.574GluGlu: 3.574 ± 0.044	1.79GluPhe: 1.79 ± 0.03	3.958GluGly: 3.958 ± 0.046	1.75GluHis: 1.75 ± 0.029	3.357GluIle: 3.357 ± 0.037	1.939GluLys: 1.939 ± 0.032	6.292GluLeu: 6.292 ± 0.067	1.586GluMet: 1.586 ± 0.024	1.536GluAsn: 1.536 ± 0.028	3.084GluPro: 3.084 ± 0.039	3.2GluGln: 3.2 ± 0.047	4.951GluArg: 4.951 ± 0.049	2.919GluSer: 2.919 ± 0.033	3.765GluThr: 3.765 ± 0.044	4.513GluVal: 4.513 ± 0.047	0.833GluTrp: 0.833 ± 0.018	1.324GluTyr: 1.324 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.316PheAla: 3.316 ± 0.036	0.491PheCys: 0.491 ± 0.016	2.517PheAsp: 2.517 ± 0.035	2.274PheGlu: 2.274 ± 0.034	1.497PhePhe: 1.497 ± 0.027	3.096PheGly: 3.096 ± 0.041	0.968PheHis: 0.968 ± 0.021	1.789PheIle: 1.789 ± 0.026	1.066PheLys: 1.066 ± 0.023	3.523PheLeu: 3.523 ± 0.045	0.82PheMet: 0.82 ± 0.02	1.207PheAsn: 1.207 ± 0.025	1.796PhePro: 1.796 ± 0.031	1.365PheGln: 1.365 ± 0.022	2.323PheArg: 2.323 ± 0.038	2.182PheSer: 2.182 ± 0.031	2.129PheThr: 2.129 ± 0.032	2.579PheVal: 2.579 ± 0.033	0.618PheTrp: 0.618 ± 0.018	1.144PheTyr: 1.144 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	6.475GlyAla: 6.475 ± 0.061	0.908GlyCys: 0.908 ± 0.023	3.988GlyAsp: 3.988 ± 0.05	4.497GlyGlu: 4.497 ± 0.05	3.15GlyPhe: 3.15 ± 0.035	5.645GlyGly: 5.645 ± 0.072	2.114GlyHis: 2.114 ± 0.032	4.385GlyIle: 4.385 ± 0.05	2.776GlyLys: 2.776 ± 0.036	7.775GlyLeu: 7.775 ± 0.066	2.258GlyMet: 2.258 ± 0.032	2.255GlyAsn: 2.255 ± 0.037	3.12GlyPro: 3.12 ± 0.045	3.419GlyGln: 3.419 ± 0.037	4.971GlyArg: 4.971 ± 0.048	4.089GlySer: 4.089 ± 0.047	4.373GlyThr: 4.373 ± 0.05	5.599GlyVal: 5.599 ± 0.049	1.34GlyTrp: 1.34 ± 0.025	2.579GlyTyr: 2.579 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.577HisAla: 2.577 ± 0.033	0.319HisCys: 0.319 ± 0.011	1.56HisAsp: 1.56 ± 0.026	1.568HisGlu: 1.568 ± 0.026	1.072HisPhe: 1.072 ± 0.021	2.172HisGly: 2.172 ± 0.034	0.982HisHis: 0.982 ± 0.025	1.518HisIle: 1.518 ± 0.026	0.596HisLys: 0.596 ± 0.017	2.92HisLeu: 2.92 ± 0.037	0.623HisMet: 0.623 ± 0.016	0.753HisAsn: 0.753 ± 0.017	1.817HisPro: 1.817 ± 0.029	1.185HisGln: 1.185 ± 0.026	1.981HisArg: 1.981 ± 0.029	1.103HisSer: 1.103 ± 0.022	1.434HisThr: 1.434 ± 0.025	1.936HisVal: 1.936 ± 0.026	0.443HisTrp: 0.443 ± 0.011	0.921HisTyr: 0.921 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.609IleAla: 5.609 ± 0.053	0.646IleCys: 0.646 ± 0.016	3.621IleAsp: 3.621 ± 0.046	3.818IleGlu: 3.818 ± 0.053	1.783IlePhe: 1.783 ± 0.029	4.383IleGly: 4.383 ± 0.053	1.302IleHis: 1.302 ± 0.023	2.547IleIle: 2.547 ± 0.034	1.575IleLys: 1.575 ± 0.029	4.941IleLeu: 4.941 ± 0.049	1.138IleMet: 1.138 ± 0.025	1.571IleAsn: 1.571 ± 0.028	2.818IlePro: 2.818 ± 0.039	1.881IleGln: 1.881 ± 0.03	3.721IleArg: 3.721 ± 0.04	2.874IleSer: 2.874 ± 0.037	2.872IleThr: 2.872 ± 0.038	3.92IleVal: 3.92 ± 0.043	0.705IleTrp: 0.705 ± 0.017	1.47IleTyr: 1.47 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.237LysAla: 3.237 ± 0.044	0.238LysCys: 0.238 ± 0.01	1.428LysAsp: 1.428 ± 0.024	1.621LysGlu: 1.621 ± 0.028	0.895LysPhe: 0.895 ± 0.019	2.011LysGly: 2.011 ± 0.032	0.782LysHis: 0.782 ± 0.018	1.573LysIle: 1.573 ± 0.031	1.094LysLys: 1.094 ± 0.029	2.874LysLeu: 2.874 ± 0.037	0.756LysMet: 0.756 ± 0.018	0.805LysAsn: 0.805 ± 0.017	1.828LysPro: 1.828 ± 0.033	1.4LysGln: 1.4 ± 0.026	2.4LysArg: 2.4 ± 0.035	1.656LysSer: 1.656 ± 0.026	1.969LysThr: 1.969 ± 0.033	1.996LysVal: 1.996 ± 0.029	0.436LysTrp: 0.436 ± 0.013	0.814LysTyr: 0.814 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	10.911LeuAla: 10.911 ± 0.081	1.157LeuCys: 1.157 ± 0.023	6.084LeuAsp: 6.084 ± 0.05	6.166LeuGlu: 6.166 ± 0.061	3.472LeuPhe: 3.472 ± 0.047	7.748LeuGly: 7.748 ± 0.069	2.667LeuHis: 2.667 ± 0.036	5.294LeuIle: 5.294 ± 0.054	3.34LeuLys: 3.34 ± 0.041	10.077LeuLeu: 10.077 ± 0.094	2.489LeuMet: 2.489 ± 0.031	3.125LeuAsn: 3.125 ± 0.038	5.64LeuPro: 5.64 ± 0.052	4.747LeuGln: 4.747 ± 0.051	7.148LeuArg: 7.148 ± 0.061	6.644LeuSer: 6.644 ± 0.055	6.029LeuThr: 6.029 ± 0.06	6.717LeuVal: 6.717 ± 0.057	1.407LeuTrp: 1.407 ± 0.029	2.764LeuTyr: 2.764 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.197MetAla: 3.197 ± 0.04	0.231MetCys: 0.231 ± 0.009	1.241MetAsp: 1.241 ± 0.023	1.291MetGlu: 1.291 ± 0.024	0.733MetPhe: 0.733 ± 0.02	1.933MetGly: 1.933 ± 0.032	0.606MetHis: 0.606 ± 0.017	1.437MetIle: 1.437 ± 0.025	0.824MetLys: 0.824 ± 0.02	2.543MetLeu: 2.543 ± 0.032	0.722MetMet: 0.722 ± 0.02	0.719MetAsn: 0.719 ± 0.02	1.499MetPro: 1.499 ± 0.028	1.263MetGln: 1.263 ± 0.028	1.774MetArg: 1.774 ± 0.025	1.594MetSer: 1.594 ± 0.03	1.749MetThr: 1.749 ± 0.026	1.76MetVal: 1.76 ± 0.029	0.285MetTrp: 0.285 ± 0.011	0.53MetTyr: 0.53 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.802AsnAla: 2.802 ± 0.039	0.31AsnCys: 0.31 ± 0.012	1.501AsnAsp: 1.501 ± 0.035	1.367AsnGlu: 1.367 ± 0.025	1.009AsnPhe: 1.009 ± 0.022	2.247AsnGly: 2.247 ± 0.039	0.707AsnHis: 0.707 ± 0.015	1.503AsnIle: 1.503 ± 0.028	0.733AsnLys: 0.733 ± 0.018	2.991AsnLeu: 2.991 ± 0.039	0.739AsnMet: 0.739 ± 0.019	0.834AsnAsn: 0.834 ± 0.021	2.006AsnPro: 2.006 ± 0.032	1.048AsnGln: 1.048 ± 0.023	2.127AsnArg: 2.127 ± 0.029	1.196AsnSer: 1.196 ± 0.026	1.548AsnThr: 1.548 ± 0.026	1.948AsnVal: 1.948 ± 0.027	0.434AsnTrp: 0.434 ± 0.015	0.809AsnTyr: 0.809 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	4.793ProAla: 4.793 ± 0.045	0.492ProCys: 0.492 ± 0.017	3.729ProAsp: 3.729 ± 0.045	4.349ProGlu: 4.349 ± 0.043	1.991ProPhe: 1.991 ± 0.032	4.195ProGly: 4.195 ± 0.049	1.542ProHis: 1.542 ± 0.03	2.591ProIle: 2.591 ± 0.033	1.546ProLys: 1.546 ± 0.028	5.047ProLeu: 5.047 ± 0.055	1.328ProMet: 1.328 ± 0.021	1.547ProAsn: 1.547 ± 0.024	2.889ProPro: 2.889 ± 0.045	2.25ProGln: 2.25 ± 0.034	2.735ProArg: 2.735 ± 0.032	3.069ProSer: 3.069 ± 0.031	2.455ProThr: 2.455 ± 0.034	3.932ProVal: 3.932 ± 0.039	0.847ProTrp: 0.847 ± 0.02	1.628ProTyr: 1.628 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.29GlnAla: 5.29 ± 0.058	0.417GlnCys: 0.417 ± 0.014	2.202GlnAsp: 2.202 ± 0.032	2.551GlnGlu: 2.551 ± 0.046	1.428GlnPhe: 1.428 ± 0.025	3.282GlnGly: 3.282 ± 0.044	1.416GlnHis: 1.416 ± 0.024	2.019GlnIle: 2.019 ± 0.03	1.22GlnLys: 1.22 ± 0.024	4.474GlnLeu: 4.474 ± 0.05	1.031GlnMet: 1.031 ± 0.02	1.086GlnAsn: 1.086 ± 0.022	2.49GlnPro: 2.49 ± 0.035	2.548GlnGln: 2.548 ± 0.039	3.724GlnArg: 3.724 ± 0.04	2.219GlnSer: 2.219 ± 0.031	2.524GlnThr: 2.524 ± 0.035	3.208GlnVal: 3.208 ± 0.037	0.691GlnTrp: 0.691 ± 0.019	1.191GlnTyr: 1.191 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.973ArgAla: 5.973 ± 0.052	0.728ArgCys: 0.728 ± 0.017	3.822ArgAsp: 3.822 ± 0.045	4.451ArgGlu: 4.451 ± 0.051	2.844ArgPhe: 2.844 ± 0.039	4.4ArgGly: 4.4 ± 0.045	2.094ArgHis: 2.094 ± 0.027	3.774ArgIle: 3.774 ± 0.043	1.884ArgLys: 1.884 ± 0.034	7.945ArgLeu: 7.945 ± 0.067	1.846ArgMet: 1.846 ± 0.03	1.757ArgAsn: 1.757 ± 0.028	3.114ArgPro: 3.114 ± 0.039	3.996ArgGln: 3.996 ± 0.042	4.898ArgArg: 4.898 ± 0.057	3.349ArgSer: 3.349 ± 0.04	3.362ArgThr: 3.362 ± 0.042	4.806ArgVal: 4.806 ± 0.05	1.023ArgTrp: 1.023 ± 0.021	2.234ArgTyr: 2.234 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.805SerAla: 4.805 ± 0.044	0.56SerCys: 0.56 ± 0.015	3.019SerAsp: 3.019 ± 0.037	3.106SerGlu: 3.106 ± 0.04	2.01SerPhe: 2.01 ± 0.028	4.87SerGly: 4.87 ± 0.045	1.465SerHis: 1.465 ± 0.026	2.736SerIle: 2.736 ± 0.039	1.541SerLys: 1.541 ± 0.03	5.578SerLeu: 5.578 ± 0.052	1.496SerMet: 1.496 ± 0.029	1.412SerAsn: 1.412 ± 0.028	3.105SerPro: 3.105 ± 0.035	2.278SerGln: 2.278 ± 0.033	3.505SerArg: 3.505 ± 0.042	2.975SerSer: 2.975 ± 0.042	2.893SerThr: 2.893 ± 0.037	3.621SerVal: 3.621 ± 0.04	0.84SerTrp: 0.84 ± 0.018	1.523SerTyr: 1.523 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.518ThrAla: 5.518 ± 0.055	0.598ThrCys: 0.598 ± 0.017	2.853ThrAsp: 2.853 ± 0.038	2.922ThrGlu: 2.922 ± 0.037	2.211ThrPhe: 2.211 ± 0.034	4.574ThrGly: 4.574 ± 0.049	1.518ThrHis: 1.518 ± 0.027	3.043ThrIle: 3.043 ± 0.04	1.314ThrLys: 1.314 ± 0.023	6.303ThrLeu: 6.303 ± 0.05	1.347ThrMet: 1.347 ± 0.023	1.384ThrAsn: 1.384 ± 0.024	3.544ThrPro: 3.544 ± 0.041	2.229ThrGln: 2.229 ± 0.042	3.221ThrArg: 3.221 ± 0.037	2.994ThrSer: 2.994 ± 0.042	3.007ThrThr: 3.007 ± 0.042	4.265ThrVal: 4.265 ± 0.04	0.854ThrTrp: 0.854 ± 0.02	1.713ThrTyr: 1.713 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	6.973ValAla: 6.973 ± 0.063	0.826ValCys: 0.826 ± 0.019	4.003ValAsp: 4.003 ± 0.038	4.526ValGlu: 4.526 ± 0.046	2.67ValPhe: 2.67 ± 0.038	4.816ValGly: 4.816 ± 0.046	1.711ValHis: 1.711 ± 0.027	4.05ValIle: 4.05 ± 0.044	2.223ValLys: 2.223 ± 0.03	7.353ValLeu: 7.353 ± 0.06	1.991ValMet: 1.991 ± 0.028	2.182ValAsn: 2.182 ± 0.034	3.729ValPro: 3.729 ± 0.036	2.851ValGln: 2.851 ± 0.037	4.711ValArg: 4.711 ± 0.044	4.137ValSer: 4.137 ± 0.046	4.194ValThr: 4.194 ± 0.043	5.549ValVal: 5.549 ± 0.052	0.98ValTrp: 0.98 ± 0.021	1.982ValTyr: 1.982 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.024	0.197TrpCys: 0.197 ± 0.009	0.782TrpAsp: 0.782 ± 0.02	0.887TrpGlu: 0.887 ± 0.02	0.563TrpPhe: 0.563 ± 0.016	1.076TrpGly: 1.076 ± 0.024	0.527TrpHis: 0.527 ± 0.016	0.727TrpIle: 0.727 ± 0.018	0.46TrpLys: 0.46 ± 0.013	1.799TrpLeu: 1.799 ± 0.033	0.405TrpMet: 0.405 ± 0.014	0.45TrpAsn: 0.45 ± 0.014	0.763TrpPro: 0.763 ± 0.02	0.907TrpGln: 0.907 ± 0.022	1.139TrpArg: 1.139 ± 0.024	0.822TrpSer: 0.822 ± 0.02	0.783TrpThr: 0.783 ± 0.018	0.99TrpVal: 0.99 ± 0.021	0.27TrpTrp: 0.27 ± 0.011	0.401TrpTyr: 0.401 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.715TyrAla: 2.715 ± 0.032	0.366TyrCys: 0.366 ± 0.013	1.858TyrAsp: 1.858 ± 0.03	1.77TyrGlu: 1.77 ± 0.024	1.163TyrPhe: 1.163 ± 0.022	2.376TyrGly: 2.376 ± 0.033	0.93TyrHis: 0.93 ± 0.021	1.367TyrIle: 1.367 ± 0.024	0.716TyrLys: 0.716 ± 0.017	2.95TyrLeu: 2.95 ± 0.037	0.631TyrMet: 0.631 ± 0.018	0.809TyrAsn: 0.809 ± 0.021	1.536TyrPro: 1.536 ± 0.025	1.291TyrGln: 1.291 ± 0.025	2.414TyrArg: 2.414 ± 0.037	1.289TyrSer: 1.289 ± 0.026	1.636TyrThr: 1.636 ± 0.025	1.925TyrVal: 1.925 ± 0.028	0.475TyrTrp: 0.475 ± 0.014	0.891TyrTyr: 0.891 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8989 proteins (2328076 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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