Amino acid dipepetide frequency for Ideonella sp. MAG2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.828AlaAla: 17.828 ± 0.166	1.472AlaCys: 1.472 ± 0.039	6.241AlaAsp: 6.241 ± 0.082	6.909AlaGlu: 6.909 ± 0.084	3.749AlaPhe: 3.749 ± 0.058	9.524AlaGly: 9.524 ± 0.095	2.941AlaHis: 2.941 ± 0.05	4.15AlaIle: 4.15 ± 0.062	4.295AlaLys: 4.295 ± 0.07	16.004AlaLeu: 16.004 ± 0.157	3.484AlaMet: 3.484 ± 0.054	2.877AlaAsn: 2.877 ± 0.052	6.237AlaPro: 6.237 ± 0.093	7.286AlaGln: 7.286 ± 0.091	8.293AlaArg: 8.293 ± 0.099	7.251AlaSer: 7.251 ± 0.092	6.229AlaThr: 6.229 ± 0.087	8.874AlaVal: 8.874 ± 0.088	2.47AlaTrp: 2.47 ± 0.06	2.439AlaTyr: 2.439 ± 0.047	0.004AlaXaa: 0.004 ± 0.002
Cys	1.181CysAla: 1.181 ± 0.034	0.165CysCys: 0.165 ± 0.013	0.503CysAsp: 0.503 ± 0.022	0.51CysGlu: 0.51 ± 0.024	0.345CysPhe: 0.345 ± 0.019	1.04CysGly: 1.04 ± 0.032	0.296CysHis: 0.296 ± 0.017	0.357CysIle: 0.357 ± 0.019	0.289CysLys: 0.289 ± 0.014	0.999CysLeu: 0.999 ± 0.029	0.232CysMet: 0.232 ± 0.014	0.247CysAsn: 0.247 ± 0.013	0.565CysPro: 0.565 ± 0.025	0.411CysGln: 0.411 ± 0.019	0.583CysArg: 0.583 ± 0.024	0.559CysSer: 0.559 ± 0.022	0.52CysThr: 0.52 ± 0.022	0.713CysVal: 0.713 ± 0.024	0.16CysTrp: 0.16 ± 0.013	0.205CysTyr: 0.205 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.621AspAla: 6.621 ± 0.073	0.453AspCys: 0.453 ± 0.019	2.665AspAsp: 2.665 ± 0.055	3.083AspGlu: 3.083 ± 0.054	1.887AspPhe: 1.887 ± 0.04	4.339AspGly: 4.339 ± 0.085	1.112AspHis: 1.112 ± 0.032	2.173AspIle: 2.173 ± 0.046	1.809AspLys: 1.809 ± 0.049	5.338AspLeu: 5.338 ± 0.072	1.227AspMet: 1.227 ± 0.031	1.166AspAsn: 1.166 ± 0.033	2.778AspPro: 2.778 ± 0.053	1.83AspGln: 1.83 ± 0.042	2.937AspArg: 2.937 ± 0.06	2.284AspSer: 2.284 ± 0.047	2.643AspThr: 2.643 ± 0.057	3.702AspVal: 3.702 ± 0.055	0.98AspTrp: 0.98 ± 0.03	1.228AspTyr: 1.228 ± 0.036	0.004AspXaa: 0.004 ± 0.002
Glu	7.338GluAla: 7.338 ± 0.084	0.391GluCys: 0.391 ± 0.02	2.21GluAsp: 2.21 ± 0.053	2.367GluGlu: 2.367 ± 0.051	1.712GluPhe: 1.712 ± 0.042	4.017GluGly: 4.017 ± 0.059	1.409GluHis: 1.409 ± 0.037	2.275GluIle: 2.275 ± 0.044	1.546GluLys: 1.546 ± 0.047	5.645GluLeu: 5.645 ± 0.074	1.223GluMet: 1.223 ± 0.034	1.054GluAsn: 1.054 ± 0.028	2.644GluPro: 2.644 ± 0.048	2.753GluGln: 2.753 ± 0.05	4.525GluArg: 4.525 ± 0.065	2.35GluSer: 2.35 ± 0.041	2.205GluThr: 2.205 ± 0.049	4.303GluVal: 4.303 ± 0.065	0.787GluTrp: 0.787 ± 0.023	0.911GluTyr: 0.911 ± 0.028	0.002GluXaa: 0.002 ± 0.001
Phe	3.846PheAla: 3.846 ± 0.054	0.387PheCys: 0.387 ± 0.02	2.212PheAsp: 2.212 ± 0.045	2.148PheGlu: 2.148 ± 0.043	1.237PhePhe: 1.237 ± 0.034	3.073PheGly: 3.073 ± 0.052	0.677PheHis: 0.677 ± 0.025	1.331PheIle: 1.331 ± 0.036	1.321PheLys: 1.321 ± 0.038	2.677PheLeu: 2.677 ± 0.048	0.793PheMet: 0.793 ± 0.021	1.154PheAsn: 1.154 ± 0.033	1.332PhePro: 1.332 ± 0.035	1.052PheGln: 1.052 ± 0.031	1.693PheArg: 1.693 ± 0.04	2.161PheSer: 2.161 ± 0.039	1.842PheThr: 1.842 ± 0.038	2.626PheVal: 2.626 ± 0.043	0.549PheTrp: 0.549 ± 0.024	0.804PheTyr: 0.804 ± 0.028	0.002PheXaa: 0.002 ± 0.001
Gly	8.499GlyAla: 8.499 ± 0.098	0.943GlyCys: 0.943 ± 0.029	3.911GlyAsp: 3.911 ± 0.065	4.218GlyGlu: 4.218 ± 0.056	3.064GlyPhe: 3.064 ± 0.048	6.813GlyGly: 6.813 ± 0.111	2.099GlyHis: 2.099 ± 0.044	3.094GlyIle: 3.094 ± 0.059	2.943GlyLys: 2.943 ± 0.063	9.838GlyLeu: 9.838 ± 0.112	2.075GlyMet: 2.075 ± 0.043	2.017GlyAsn: 2.017 ± 0.059	3.391GlyPro: 3.391 ± 0.058	4.242GlyGln: 4.242 ± 0.065	5.247GlyArg: 5.247 ± 0.081	4.819GlySer: 4.819 ± 0.091	4.132GlyThr: 4.132 ± 0.076	6.41GlyVal: 6.41 ± 0.074	1.549GlyTrp: 1.549 ± 0.04	2.03GlyTyr: 2.03 ± 0.041	0.002GlyXaa: 0.002 ± 0.002
His	2.838HisAla: 2.838 ± 0.052	0.33HisCys: 0.33 ± 0.018	1.086HisAsp: 1.086 ± 0.03	1.145HisGlu: 1.145 ± 0.031	0.935HisPhe: 0.935 ± 0.031	2.082HisGly: 2.082 ± 0.046	0.804HisHis: 0.804 ± 0.032	0.957HisIle: 0.957 ± 0.029	0.606HisLys: 0.606 ± 0.022	2.705HisLeu: 2.705 ± 0.048	0.503HisMet: 0.503 ± 0.018	0.525HisAsn: 0.525 ± 0.023	1.662HisPro: 1.662 ± 0.038	1.05HisGln: 1.05 ± 0.03	1.647HisArg: 1.647 ± 0.037	1.23HisSer: 1.23 ± 0.031	1.26HisThr: 1.26 ± 0.034	1.504HisVal: 1.504 ± 0.04	0.538HisTrp: 0.538 ± 0.023	0.664HisTyr: 0.664 ± 0.026	0.002HisXaa: 0.002 ± 0.001
Ile	4.797IleAla: 4.797 ± 0.077	0.372IleCys: 0.372 ± 0.018	2.604IleAsp: 2.604 ± 0.053	2.653IleGlu: 2.653 ± 0.055	1.085IlePhe: 1.085 ± 0.032	3.217IleGly: 3.217 ± 0.059	0.843IleHis: 0.843 ± 0.027	1.386IleIle: 1.386 ± 0.036	1.452IleLys: 1.452 ± 0.04	2.812IleLeu: 2.812 ± 0.055	0.652IleMet: 0.652 ± 0.026	1.288IleAsn: 1.288 ± 0.042	1.781IlePro: 1.781 ± 0.047	1.389IleGln: 1.389 ± 0.032	2.305IleArg: 2.305 ± 0.037	2.464IleSer: 2.464 ± 0.045	2.343IleThr: 2.343 ± 0.046	2.698IleVal: 2.698 ± 0.047	0.501IleTrp: 0.501 ± 0.022	0.859IleTyr: 0.859 ± 0.025	0.002IleXaa: 0.002 ± 0.001
Lys	4.575LysAla: 4.575 ± 0.077	0.165LysCys: 0.165 ± 0.013	1.653LysAsp: 1.653 ± 0.04	1.439LysGlu: 1.439 ± 0.034	0.915LysPhe: 0.915 ± 0.029	2.541LysGly: 2.541 ± 0.051	0.7LysHis: 0.7 ± 0.024	1.268LysIle: 1.268 ± 0.036	1.259LysLys: 1.259 ± 0.045	3.549LysLeu: 3.549 ± 0.06	0.738LysMet: 0.738 ± 0.025	0.797LysAsn: 0.797 ± 0.028	2.239LysPro: 2.239 ± 0.042	1.263LysGln: 1.263 ± 0.031	2.289LysArg: 2.289 ± 0.05	1.723LysSer: 1.723 ± 0.043	1.923LysThr: 1.923 ± 0.047	2.709LysVal: 2.709 ± 0.054	0.343LysTrp: 0.343 ± 0.017	0.594LysTyr: 0.594 ± 0.025	0.001LysXaa: 0.001 ± 0.001
Leu	15.351LeuAla: 15.351 ± 0.143	1.152LeuCys: 1.152 ± 0.033	5.687LeuAsp: 5.687 ± 0.079	5.089LeuGlu: 5.089 ± 0.07	3.201LeuPhe: 3.201 ± 0.059	8.924LeuGly: 8.924 ± 0.104	2.565LeuHis: 2.565 ± 0.046	4.033LeuIle: 4.033 ± 0.065	4.03LeuLys: 4.03 ± 0.051	11.464LeuLeu: 11.464 ± 0.162	2.86LeuMet: 2.86 ± 0.053	3.052LeuAsn: 3.052 ± 0.058	6.489LeuPro: 6.489 ± 0.074	4.96LeuGln: 4.96 ± 0.067	7.838LeuArg: 7.838 ± 0.079	7.309LeuSer: 7.309 ± 0.09	5.748LeuThr: 5.748 ± 0.072	7.595LeuVal: 7.595 ± 0.102	1.745LeuTrp: 1.745 ± 0.042	2.05LeuTyr: 2.05 ± 0.048	0.002LeuXaa: 0.002 ± 0.001
Met	3.378MetAla: 3.378 ± 0.058	0.186MetCys: 0.186 ± 0.012	1.187MetAsp: 1.187 ± 0.034	0.963MetGlu: 0.963 ± 0.027	0.639MetPhe: 0.639 ± 0.026	1.982MetGly: 1.982 ± 0.046	0.486MetHis: 0.486 ± 0.021	0.856MetIle: 0.856 ± 0.027	0.899MetLys: 0.899 ± 0.026	2.593MetLeu: 2.593 ± 0.047	0.571MetMet: 0.571 ± 0.022	0.84MetAsn: 0.84 ± 0.022	1.497MetPro: 1.497 ± 0.038	1.034MetGln: 1.034 ± 0.031	1.677MetArg: 1.677 ± 0.036	1.772MetSer: 1.772 ± 0.039	1.488MetThr: 1.488 ± 0.034	1.857MetVal: 1.857 ± 0.041	0.251MetTrp: 0.251 ± 0.014	0.316MetTyr: 0.316 ± 0.018	0.001MetXaa: 0.001 ± 0.001
Asn	3.15AsnAla: 3.15 ± 0.05	0.246AsnCys: 0.246 ± 0.013	1.268AsnAsp: 1.268 ± 0.042	1.239AsnGlu: 1.239 ± 0.031	0.952AsnPhe: 0.952 ± 0.031	2.122AsnGly: 2.122 ± 0.051	0.54AsnHis: 0.54 ± 0.022	1.099AsnIle: 1.099 ± 0.033	0.821AsnLys: 0.821 ± 0.03	2.551AsnLeu: 2.551 ± 0.048	0.512AsnMet: 0.512 ± 0.021	0.767AsnAsn: 0.767 ± 0.03	1.865AsnPro: 1.865 ± 0.042	0.957AsnGln: 0.957 ± 0.031	1.477AsnArg: 1.477 ± 0.034	1.295AsnSer: 1.295 ± 0.035	1.522AsnThr: 1.522 ± 0.042	1.81AsnVal: 1.81 ± 0.044	0.428AsnTrp: 0.428 ± 0.019	0.662AsnTyr: 0.662 ± 0.026	0.002AsnXaa: 0.002 ± 0.001
Pro	6.892ProAla: 6.892 ± 0.099	0.434ProCys: 0.434 ± 0.02	2.959ProAsp: 2.959 ± 0.048	3.502ProGlu: 3.502 ± 0.057	1.675ProPhe: 1.675 ± 0.041	4.512ProGly: 4.512 ± 0.063	1.312ProHis: 1.312 ± 0.032	1.715ProIle: 1.715 ± 0.035	1.76ProLys: 1.76 ± 0.042	5.887ProLeu: 5.887 ± 0.072	1.347ProMet: 1.347 ± 0.032	1.344ProAsn: 1.344 ± 0.034	2.919ProPro: 2.919 ± 0.063	2.556ProGln: 2.556 ± 0.047	2.924ProArg: 2.924 ± 0.053	3.331ProSer: 3.331 ± 0.059	2.938ProThr: 2.938 ± 0.058	4.103ProVal: 4.103 ± 0.064	1.001ProTrp: 1.001 ± 0.03	1.134ProTyr: 1.134 ± 0.032	0.003ProXaa: 0.003 ± 0.001
Gln	7.763GlnAla: 7.763 ± 0.095	0.377GlnCys: 0.377 ± 0.019	1.942GlnAsp: 1.942 ± 0.04	1.856GlnGlu: 1.856 ± 0.04	1.272GlnPhe: 1.272 ± 0.027	4.114GlnGly: 4.114 ± 0.067	1.279GlnHis: 1.279 ± 0.035	1.59GlnIle: 1.59 ± 0.036	1.071GlnLys: 1.071 ± 0.033	4.313GlnLeu: 4.313 ± 0.06	1.133GlnMet: 1.133 ± 0.032	0.821GlnAsn: 0.821 ± 0.026	2.472GlnPro: 2.472 ± 0.048	2.398GlnGln: 2.398 ± 0.052	4.166GlnArg: 4.166 ± 0.058	2.255GlnSer: 2.255 ± 0.048	2.235GlnThr: 2.235 ± 0.048	3.649GlnVal: 3.649 ± 0.059	0.936GlnTrp: 0.936 ± 0.031	0.685GlnTyr: 0.685 ± 0.025	0.002GlnXaa: 0.002 ± 0.001
Arg	7.327ArgAla: 7.327 ± 0.078	0.718ArgCys: 0.718 ± 0.025	3.222ArgAsp: 3.222 ± 0.052	3.83ArgGlu: 3.83 ± 0.062	2.636ArgPhe: 2.636 ± 0.05	4.327ArgGly: 4.327 ± 0.059	1.918ArgHis: 1.918 ± 0.039	2.855ArgIle: 2.855 ± 0.047	1.921ArgLys: 1.921 ± 0.038	8.217ArgLeu: 8.217 ± 0.095	1.843ArgMet: 1.843 ± 0.039	1.56ArgAsn: 1.56 ± 0.036	3.366ArgPro: 3.366 ± 0.052	3.464ArgGln: 3.464 ± 0.062	4.68ArgArg: 4.68 ± 0.076	3.712ArgSer: 3.712 ± 0.064	2.876ArgThr: 2.876 ± 0.05	4.955ArgVal: 4.955 ± 0.057	1.514ArgTrp: 1.514 ± 0.04	1.802ArgTyr: 1.802 ± 0.037	0.002ArgXaa: 0.002 ± 0.001
Ser	7.235SerAla: 7.235 ± 0.084	0.445SerCys: 0.445 ± 0.024	2.678SerAsp: 2.678 ± 0.05	2.576SerGlu: 2.576 ± 0.052	2.049SerPhe: 2.049 ± 0.043	5.322SerGly: 5.322 ± 0.091	1.351SerHis: 1.351 ± 0.033	2.177SerIle: 2.177 ± 0.047	1.697SerLys: 1.697 ± 0.039	6.502SerLeu: 6.502 ± 0.076	1.339SerMet: 1.339 ± 0.035	1.484SerAsn: 1.484 ± 0.037	3.431SerPro: 3.431 ± 0.06	2.313SerGln: 2.313 ± 0.05	3.513SerArg: 3.513 ± 0.059	3.539SerSer: 3.539 ± 0.058	3.382SerThr: 3.382 ± 0.06	4.213SerVal: 4.213 ± 0.065	0.829SerTrp: 0.829 ± 0.026	1.229SerTyr: 1.229 ± 0.036	0.002SerXaa: 0.002 ± 0.001
Thr	6.077ThrAla: 6.077 ± 0.084	0.453ThrCys: 0.453 ± 0.022	2.42ThrAsp: 2.42 ± 0.057	2.509ThrGlu: 2.509 ± 0.047	1.528ThrPhe: 1.528 ± 0.034	4.563ThrGly: 4.563 ± 0.075	1.237ThrHis: 1.237 ± 0.031	1.856ThrIle: 1.856 ± 0.048	1.303ThrLys: 1.303 ± 0.033	6.796ThrLeu: 6.796 ± 0.098	1.023ThrMet: 1.023 ± 0.031	1.193ThrAsn: 1.193 ± 0.034	3.747ThrPro: 3.747 ± 0.063	2.24ThrGln: 2.24 ± 0.049	3.004ThrArg: 3.004 ± 0.057	2.803ThrSer: 2.803 ± 0.052	2.849ThrThr: 2.849 ± 0.065	4.343ThrVal: 4.343 ± 0.078	0.902ThrTrp: 0.902 ± 0.032	1.034ThrTyr: 1.034 ± 0.028	0.006ThrXaa: 0.006 ± 0.002
Val	9.436ValAla: 9.436 ± 0.092	0.755ValCys: 0.755 ± 0.027	3.926ValAsp: 3.926 ± 0.055	3.909ValGlu: 3.909 ± 0.058	2.591ValPhe: 2.591 ± 0.049	5.722ValGly: 5.722 ± 0.071	1.636ValHis: 1.636 ± 0.036	3.066ValIle: 3.066 ± 0.053	2.515ValLys: 2.515 ± 0.047	8.704ValLeu: 8.704 ± 0.094	2.024ValMet: 2.024 ± 0.035	2.112ValAsn: 2.112 ± 0.046	3.778ValPro: 3.778 ± 0.059	3.169ValGln: 3.169 ± 0.056	4.834ValArg: 4.834 ± 0.075	4.431ValSer: 4.431 ± 0.059	3.796ValThr: 3.796 ± 0.063	6.344ValVal: 6.344 ± 0.081	1.164ValTrp: 1.164 ± 0.034	1.409ValTyr: 1.409 ± 0.035	0.002ValXaa: 0.002 ± 0.001
Trp	2.05TrpAla: 2.05 ± 0.044	0.231TrpCys: 0.231 ± 0.011	0.714TrpAsp: 0.714 ± 0.027	0.62TrpGlu: 0.62 ± 0.022	0.532TrpPhe: 0.532 ± 0.021	1.269TrpGly: 1.269 ± 0.038	0.432TrpHis: 0.432 ± 0.02	0.566TrpIle: 0.566 ± 0.024	0.451TrpLys: 0.451 ± 0.018	2.302TrpLeu: 2.302 ± 0.052	0.48TrpMet: 0.48 ± 0.018	0.4TrpAsn: 0.4 ± 0.02	1.021TrpPro: 1.021 ± 0.03	1.075TrpGln: 1.075 ± 0.032	1.561TrpArg: 1.561 ± 0.042	0.876TrpSer: 0.876 ± 0.028	0.783TrpThr: 0.783 ± 0.023	1.383TrpVal: 1.383 ± 0.033	0.435TrpTrp: 0.435 ± 0.022	0.283TrpTyr: 0.283 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.368TyrAla: 2.368 ± 0.042	0.209TyrCys: 0.209 ± 0.014	1.167TyrAsp: 1.167 ± 0.035	1.098TyrGlu: 1.098 ± 0.03	0.91TyrPhe: 0.91 ± 0.028	1.829TyrGly: 1.829 ± 0.041	0.436TyrHis: 0.436 ± 0.019	0.701TyrIle: 0.701 ± 0.025	0.696TyrLys: 0.696 ± 0.026	2.249TyrLeu: 2.249 ± 0.044	0.41TyrMet: 0.41 ± 0.018	0.587TyrAsn: 0.587 ± 0.022	1.032TyrPro: 1.032 ± 0.031	0.883TyrGln: 0.883 ± 0.027	1.548TyrArg: 1.548 ± 0.039	1.137TyrSer: 1.137 ± 0.036	1.172TyrThr: 1.172 ± 0.037	1.527TyrVal: 1.527 ± 0.032	0.379TyrTrp: 0.379 ± 0.019	0.537TyrTyr: 0.537 ± 0.024	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.007XaaAla: 0.007 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.005XaaPro: 0.005 ± 0.002	0.002XaaGln: 0.002 ± 0.001	0.006XaaArg: 0.006 ± 0.002	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.005XaaVal: 0.005 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3953 proteins (1228316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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