Amino acid dipepetide frequency for Prevotella oulorum F0390

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.083AlaAla: 7.083 ± 0.123
1.256AlaCys: 1.256 ± 0.041
4.399AlaAsp: 4.399 ± 0.072
4.6AlaGlu: 4.6 ± 0.082
3.731AlaPhe: 3.731 ± 0.075
5.224AlaGly: 5.224 ± 0.101
2.041AlaHis: 2.041 ± 0.061
5.096AlaIle: 5.096 ± 0.08
4.844AlaLys: 4.844 ± 0.078
8.253AlaLeu: 8.253 ± 0.105
2.248AlaMet: 2.248 ± 0.06
3.742AlaAsn: 3.742 ± 0.085
2.756AlaPro: 2.756 ± 0.059
4.051AlaGln: 4.051 ± 0.076
3.424AlaArg: 3.424 ± 0.063
4.205AlaSer: 4.205 ± 0.077
4.924AlaThr: 4.924 ± 0.095
4.879AlaVal: 4.879 ± 0.084
1.007AlaTrp: 1.007 ± 0.038
3.192AlaTyr: 3.192 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.976CysAla: 0.976 ± 0.037
0.263CysCys: 0.263 ± 0.02
0.666CysAsp: 0.666 ± 0.03
0.647CysGlu: 0.647 ± 0.029
0.665CysPhe: 0.665 ± 0.029
1.0CysGly: 1.0 ± 0.038
0.358CysHis: 0.358 ± 0.022
0.887CysIle: 0.887 ± 0.038
0.731CysLys: 0.731 ± 0.032
1.135CysLeu: 1.135 ± 0.037
0.341CysMet: 0.341 ± 0.023
0.662CysAsn: 0.662 ± 0.028
0.521CysPro: 0.521 ± 0.027
0.395CysGln: 0.395 ± 0.02
0.606CysArg: 0.606 ± 0.029
0.848CysSer: 0.848 ± 0.033
0.736CysThr: 0.736 ± 0.029
0.848CysVal: 0.848 ± 0.041
0.208CysTrp: 0.208 ± 0.016
0.582CysTyr: 0.582 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.723AspAla: 4.723 ± 0.078
0.672AspCys: 0.672 ± 0.03
2.901AspAsp: 2.901 ± 0.068
3.692AspGlu: 3.692 ± 0.088
2.884AspPhe: 2.884 ± 0.064
4.098AspGly: 4.098 ± 0.073
1.061AspHis: 1.061 ± 0.036
3.61AspIle: 3.61 ± 0.07
3.406AspLys: 3.406 ± 0.067
4.477AspLeu: 4.477 ± 0.081
1.42AspMet: 1.42 ± 0.043
2.601AspAsn: 2.601 ± 0.055
1.693AspPro: 1.693 ± 0.043
1.275AspGln: 1.275 ± 0.038
2.277AspArg: 2.277 ± 0.054
2.719AspSer: 2.719 ± 0.07
2.579AspThr: 2.579 ± 0.066
3.533AspVal: 3.533 ± 0.068
0.839AspTrp: 0.839 ± 0.033
2.891AspTyr: 2.891 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.926GluAla: 4.926 ± 0.1
0.55GluCys: 0.55 ± 0.029
2.648GluAsp: 2.648 ± 0.062
3.563GluGlu: 3.563 ± 0.091
1.844GluPhe: 1.844 ± 0.055
3.53GluGly: 3.53 ± 0.065
1.334GluHis: 1.334 ± 0.041
3.419GluIle: 3.419 ± 0.077
4.103GluLys: 4.103 ± 0.101
4.895GluLeu: 4.895 ± 0.096
1.763GluMet: 1.763 ± 0.046
2.762GluAsn: 2.762 ± 0.056
1.58GluPro: 1.58 ± 0.044
2.83GluGln: 2.83 ± 0.065
3.192GluArg: 3.192 ± 0.062
2.462GluSer: 2.462 ± 0.056
3.234GluThr: 3.234 ± 0.066
3.946GluVal: 3.946 ± 0.078
0.705GluTrp: 0.705 ± 0.031
1.994GluTyr: 1.994 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.442PheAla: 3.442 ± 0.07
0.772PheCys: 0.772 ± 0.03
2.719PheAsp: 2.719 ± 0.057
2.202PheGlu: 2.202 ± 0.057
2.257PhePhe: 2.257 ± 0.063
3.195PheGly: 3.195 ± 0.077
1.104PheHis: 1.104 ± 0.04
3.006PheIle: 3.006 ± 0.073
2.532PheLys: 2.532 ± 0.058
3.877PheLeu: 3.877 ± 0.081
1.278PheMet: 1.278 ± 0.037
2.358PheAsn: 2.358 ± 0.055
1.679PhePro: 1.679 ± 0.049
1.476PheGln: 1.476 ± 0.042
1.92PheArg: 1.92 ± 0.058
3.17PheSer: 3.17 ± 0.068
2.845PheThr: 2.845 ± 0.062
3.034PheVal: 3.034 ± 0.068
0.571PheTrp: 0.571 ± 0.029
1.956PheTyr: 1.956 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.746GlyAla: 4.746 ± 0.097
0.91GlyCys: 0.91 ± 0.035
3.451GlyAsp: 3.451 ± 0.057
3.74GlyGlu: 3.74 ± 0.072
3.095GlyPhe: 3.095 ± 0.072
4.804GlyGly: 4.804 ± 0.112
1.525GlyHis: 1.525 ± 0.041
4.612GlyIle: 4.612 ± 0.081
4.841GlyLys: 4.841 ± 0.087
6.003GlyLeu: 6.003 ± 0.097
2.085GlyMet: 2.085 ± 0.054
3.479GlyAsn: 3.479 ± 0.078
1.225GlyPro: 1.225 ± 0.039
2.377GlyGln: 2.377 ± 0.059
3.15GlyArg: 3.15 ± 0.063
3.813GlySer: 3.813 ± 0.083
4.405GlyThr: 4.405 ± 0.094
4.66GlyVal: 4.66 ± 0.078
1.052GlyTrp: 1.052 ± 0.04
3.275GlyTyr: 3.275 ± 0.079
0.001GlyXaa: 0.001 ± 0.001
His
1.833HisAla: 1.833 ± 0.053
0.374HisCys: 0.374 ± 0.024
1.299HisAsp: 1.299 ± 0.032
1.268HisGlu: 1.268 ± 0.045
1.321HisPhe: 1.321 ± 0.044
1.492HisGly: 1.492 ± 0.044
0.822HisHis: 0.822 ± 0.041
1.622HisIle: 1.622 ± 0.049
1.096HisLys: 1.096 ± 0.031
2.287HisLeu: 2.287 ± 0.057
0.449HisMet: 0.449 ± 0.025
1.126HisAsn: 1.126 ± 0.038
1.241HisPro: 1.241 ± 0.038
1.078HisGln: 1.078 ± 0.043
1.28HisArg: 1.28 ± 0.039
1.238HisSer: 1.238 ± 0.039
1.408HisThr: 1.408 ± 0.045
1.563HisVal: 1.563 ± 0.047
0.292HisTrp: 0.292 ± 0.017
1.352HisTyr: 1.352 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.457IleAla: 5.457 ± 0.081
0.864IleCys: 0.864 ± 0.033
4.157IleAsp: 4.157 ± 0.069
3.796IleGlu: 3.796 ± 0.081
2.45IlePhe: 2.45 ± 0.063
4.111IleGly: 4.111 ± 0.085
1.385IleHis: 1.385 ± 0.046
4.021IleIle: 4.021 ± 0.092
3.757IleLys: 3.757 ± 0.067
4.956IleLeu: 4.956 ± 0.104
1.423IleMet: 1.423 ± 0.043
3.112IleAsn: 3.112 ± 0.061
2.731IlePro: 2.731 ± 0.066
2.1IleGln: 2.1 ± 0.053
2.852IleArg: 2.852 ± 0.068
3.799IleSer: 3.799 ± 0.068
3.853IleThr: 3.853 ± 0.071
4.329IleVal: 4.329 ± 0.095
0.572IleTrp: 0.572 ± 0.023
2.484IleTyr: 2.484 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.305LysAla: 5.305 ± 0.101
0.527LysCys: 0.527 ± 0.03
3.408LysAsp: 3.408 ± 0.07
3.991LysGlu: 3.991 ± 0.09
2.136LysPhe: 2.136 ± 0.05
4.122LysGly: 4.122 ± 0.076
1.396LysHis: 1.396 ± 0.039
3.591LysIle: 3.591 ± 0.066
4.594LysLys: 4.594 ± 0.094
5.144LysLeu: 5.144 ± 0.084
1.961LysMet: 1.961 ± 0.053
3.154LysAsn: 3.154 ± 0.065
2.331LysPro: 2.331 ± 0.058
3.066LysGln: 3.066 ± 0.071
3.41LysArg: 3.41 ± 0.074
3.071LysSer: 3.071 ± 0.065
3.592LysThr: 3.592 ± 0.073
3.983LysVal: 3.983 ± 0.075
0.82LysTrp: 0.82 ± 0.035
2.402LysTyr: 2.402 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
7.158LeuAla: 7.158 ± 0.096
1.423LeuCys: 1.423 ± 0.048
4.37LeuAsp: 4.37 ± 0.077
4.063LeuGlu: 4.063 ± 0.076
4.581LeuPhe: 4.581 ± 0.111
5.599LeuGly: 5.599 ± 0.081
2.435LeuHis: 2.435 ± 0.068
4.926LeuIle: 4.926 ± 0.088
5.809LeuLys: 5.809 ± 0.084
9.649LeuLeu: 9.649 ± 0.18
2.642LeuMet: 2.642 ± 0.058
4.636LeuAsn: 4.636 ± 0.081
4.289LeuPro: 4.289 ± 0.076
4.493LeuGln: 4.493 ± 0.071
4.941LeuArg: 4.941 ± 0.083
6.683LeuSer: 6.683 ± 0.109
5.518LeuThr: 5.518 ± 0.086
5.25LeuVal: 5.25 ± 0.081
1.128LeuTrp: 1.128 ± 0.04
3.671LeuTyr: 3.671 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.527MetAla: 2.527 ± 0.058
0.282MetCys: 0.282 ± 0.019
1.333MetAsp: 1.333 ± 0.042
1.632MetGlu: 1.632 ± 0.047
0.935MetPhe: 0.935 ± 0.034
1.999MetGly: 1.999 ± 0.057
0.613MetHis: 0.613 ± 0.03
1.344MetIle: 1.344 ± 0.043
2.317MetLys: 2.317 ± 0.054
2.758MetLeu: 2.758 ± 0.063
0.841MetMet: 0.841 ± 0.036
1.43MetAsn: 1.43 ± 0.04
1.262MetPro: 1.262 ± 0.041
1.457MetGln: 1.457 ± 0.036
1.439MetArg: 1.439 ± 0.046
1.419MetSer: 1.419 ± 0.036
1.427MetThr: 1.427 ± 0.045
1.694MetVal: 1.694 ± 0.048
0.245MetTrp: 0.245 ± 0.017
0.715MetTyr: 0.715 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.051AsnAla: 4.051 ± 0.076
0.444AsnCys: 0.444 ± 0.025
2.87AsnAsp: 2.87 ± 0.059
2.747AsnGlu: 2.747 ± 0.065
2.166AsnPhe: 2.166 ± 0.054
3.715AsnGly: 3.715 ± 0.078
1.177AsnHis: 1.177 ± 0.038
3.433AsnIle: 3.433 ± 0.073
2.825AsnLys: 2.825 ± 0.063
4.282AsnLeu: 4.282 ± 0.078
1.211AsnMet: 1.211 ± 0.04
2.635AsnAsn: 2.635 ± 0.066
2.496AsnPro: 2.496 ± 0.062
1.805AsnGln: 1.805 ± 0.049
2.564AsnArg: 2.564 ± 0.067
2.509AsnSer: 2.509 ± 0.062
2.658AsnThr: 2.658 ± 0.073
3.128AsnVal: 3.128 ± 0.066
0.591AsnTrp: 0.591 ± 0.029
2.275AsnTyr: 2.275 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
3.011ProAla: 3.011 ± 0.07
0.448ProCys: 0.448 ± 0.027
2.168ProAsp: 2.168 ± 0.053
2.409ProGlu: 2.409 ± 0.054
1.963ProPhe: 1.963 ± 0.055
2.395ProGly: 2.395 ± 0.069
1.012ProHis: 1.012 ± 0.034
2.441ProIle: 2.441 ± 0.057
2.11ProLys: 2.11 ± 0.049
3.583ProLeu: 3.583 ± 0.074
1.03ProMet: 1.03 ± 0.034
1.897ProAsn: 1.897 ± 0.045
0.874ProPro: 0.874 ± 0.032
1.851ProGln: 1.851 ± 0.054
1.566ProArg: 1.566 ± 0.047
2.318ProSer: 2.318 ± 0.056
2.637ProThr: 2.637 ± 0.059
2.563ProVal: 2.563 ± 0.053
0.545ProTrp: 0.545 ± 0.026
1.674ProTyr: 1.674 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.523GlnAla: 3.523 ± 0.071
0.453GlnCys: 0.453 ± 0.024
1.6GlnAsp: 1.6 ± 0.039
2.19GlnGlu: 2.19 ± 0.061
1.63GlnPhe: 1.63 ± 0.045
2.667GlnGly: 2.667 ± 0.058
1.342GlnHis: 1.342 ± 0.043
2.273GlnIle: 2.273 ± 0.062
2.693GlnLys: 2.693 ± 0.078
4.509GlnLeu: 4.509 ± 0.093
1.22GlnMet: 1.22 ± 0.04
1.984GlnAsn: 1.984 ± 0.05
1.806GlnPro: 1.806 ± 0.048
2.999GlnGln: 2.999 ± 0.069
2.563GlnArg: 2.563 ± 0.062
2.131GlnSer: 2.131 ± 0.053
2.528GlnThr: 2.528 ± 0.058
2.48GlnVal: 2.48 ± 0.051
0.659GlnTrp: 0.659 ± 0.034
1.61GlnTyr: 1.61 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.389ArgAla: 3.389 ± 0.073
0.604ArgCys: 0.604 ± 0.031
2.315ArgAsp: 2.315 ± 0.057
2.827ArgGlu: 2.827 ± 0.07
2.333ArgPhe: 2.333 ± 0.048
2.808ArgGly: 2.808 ± 0.066
1.28ArgHis: 1.28 ± 0.048
3.128ArgIle: 3.128 ± 0.07
3.29ArgLys: 3.29 ± 0.07
4.856ArgLeu: 4.856 ± 0.088
1.588ArgMet: 1.588 ± 0.047
2.51ArgAsn: 2.51 ± 0.056
1.813ArgPro: 1.813 ± 0.05
2.346ArgGln: 2.346 ± 0.062
2.655ArgArg: 2.655 ± 0.055
2.367ArgSer: 2.367 ± 0.058
2.589ArgThr: 2.589 ± 0.062
2.889ArgVal: 2.889 ± 0.056
0.741ArgTrp: 0.741 ± 0.035
2.468ArgTyr: 2.468 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.396SerAla: 4.396 ± 0.078
0.736SerCys: 0.736 ± 0.034
2.91SerAsp: 2.91 ± 0.057
2.837SerGlu: 2.837 ± 0.06
2.925SerPhe: 2.925 ± 0.069
4.02SerGly: 4.02 ± 0.073
1.316SerHis: 1.316 ± 0.041
3.776SerIle: 3.776 ± 0.07
3.023SerLys: 3.023 ± 0.067
5.465SerLeu: 5.465 ± 0.099
1.489SerMet: 1.489 ± 0.044
2.677SerAsn: 2.677 ± 0.065
2.308SerPro: 2.308 ± 0.059
2.004SerGln: 2.004 ± 0.053
2.559SerArg: 2.559 ± 0.059
3.498SerSer: 3.498 ± 0.078
3.337SerThr: 3.337 ± 0.07
3.843SerVal: 3.843 ± 0.07
0.803SerTrp: 0.803 ± 0.031
2.598SerTyr: 2.598 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.829ThrAla: 4.829 ± 0.08
0.707ThrCys: 0.707 ± 0.03
3.181ThrAsp: 3.181 ± 0.069
2.797ThrGlu: 2.797 ± 0.064
3.059ThrPhe: 3.059 ± 0.054
4.122ThrGly: 4.122 ± 0.077
1.429ThrHis: 1.429 ± 0.048
4.131ThrIle: 4.131 ± 0.072
3.114ThrLys: 3.114 ± 0.065
6.107ThrLeu: 6.107 ± 0.1
1.487ThrMet: 1.487 ± 0.038
2.534ThrAsn: 2.534 ± 0.062
3.177ThrPro: 3.177 ± 0.08
2.342ThrGln: 2.342 ± 0.05
2.352ThrArg: 2.352 ± 0.055
3.156ThrSer: 3.156 ± 0.068
3.978ThrThr: 3.978 ± 0.087
3.401ThrVal: 3.401 ± 0.071
0.743ThrTrp: 0.743 ± 0.03
2.367ThrTyr: 2.367 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
5.363ValAla: 5.363 ± 0.086
1.038ValCys: 1.038 ± 0.044
3.749ValAsp: 3.749 ± 0.068
3.493ValGlu: 3.493 ± 0.068
2.692ValPhe: 2.692 ± 0.061
4.43ValGly: 4.43 ± 0.08
1.353ValHis: 1.353 ± 0.037
3.829ValIle: 3.829 ± 0.081
3.848ValLys: 3.848 ± 0.076
5.934ValLeu: 5.934 ± 0.096
1.737ValMet: 1.737 ± 0.043
3.124ValAsn: 3.124 ± 0.063
2.611ValPro: 2.611 ± 0.065
2.272ValGln: 2.272 ± 0.053
2.946ValArg: 2.946 ± 0.059
4.077ValSer: 4.077 ± 0.074
3.525ValThr: 3.525 ± 0.074
4.962ValVal: 4.962 ± 0.09
0.751ValTrp: 0.751 ± 0.029
2.544ValTyr: 2.544 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.83TrpAla: 0.83 ± 0.036
0.183TrpCys: 0.183 ± 0.016
0.734TrpAsp: 0.734 ± 0.03
0.673TrpGlu: 0.673 ± 0.028
0.614TrpPhe: 0.614 ± 0.029
0.947TrpGly: 0.947 ± 0.038
0.357TrpHis: 0.357 ± 0.023
0.668TrpIle: 0.668 ± 0.03
0.885TrpLys: 0.885 ± 0.033
1.363TrpLeu: 1.363 ± 0.047
0.427TrpMet: 0.427 ± 0.025
0.774TrpAsn: 0.774 ± 0.039
0.331TrpPro: 0.331 ± 0.021
0.73TrpGln: 0.73 ± 0.033
0.707TrpArg: 0.707 ± 0.034
0.673TrpSer: 0.673 ± 0.034
0.667TrpThr: 0.667 ± 0.03
0.737TrpVal: 0.737 ± 0.031
0.181TrpTrp: 0.181 ± 0.016
0.505TrpTyr: 0.505 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.387TyrAla: 3.387 ± 0.069
0.57TyrCys: 0.57 ± 0.028
2.473TyrAsp: 2.473 ± 0.057
2.113TyrGlu: 2.113 ± 0.051
2.115TyrPhe: 2.115 ± 0.056
2.97TyrGly: 2.97 ± 0.07
1.102TyrHis: 1.102 ± 0.039
2.392TyrIle: 2.392 ± 0.064
2.186TyrLys: 2.186 ± 0.059
3.727TyrLeu: 3.727 ± 0.063
1.029TyrMet: 1.029 ± 0.032
2.384TyrAsn: 2.384 ± 0.068
1.771TyrPro: 1.771 ± 0.043
1.912TyrGln: 1.912 ± 0.049
2.394TyrArg: 2.394 ± 0.068
2.366TyrSer: 2.366 ± 0.06
2.575TyrThr: 2.575 ± 0.064
2.555TyrVal: 2.555 ± 0.059
0.533TyrTrp: 0.533 ± 0.026
2.022TyrTyr: 2.022 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2483 proteins (812405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski