Amino acid dipepetide frequency for Rhizobium sp. Root564

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.137AlaAla: 14.137 ± 0.153
0.863AlaCys: 0.863 ± 0.025
6.327AlaAsp: 6.327 ± 0.062
7.013AlaGlu: 7.013 ± 0.079
4.503AlaPhe: 4.503 ± 0.06
9.175AlaGly: 9.175 ± 0.097
2.003AlaHis: 2.003 ± 0.037
6.786AlaIle: 6.786 ± 0.08
4.824AlaLys: 4.824 ± 0.07
12.233AlaLeu: 12.233 ± 0.137
3.474AlaMet: 3.474 ± 0.053
3.1AlaAsn: 3.1 ± 0.051
4.538AlaPro: 4.538 ± 0.073
3.684AlaGln: 3.684 ± 0.06
6.905AlaArg: 6.905 ± 0.081
6.831AlaSer: 6.831 ± 0.07
5.7AlaThr: 5.7 ± 0.074
8.052AlaVal: 8.052 ± 0.082
1.27AlaTrp: 1.27 ± 0.032
2.492AlaTyr: 2.492 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.836CysAla: 0.836 ± 0.023
0.105CysCys: 0.105 ± 0.009
0.458CysAsp: 0.458 ± 0.02
0.44CysGlu: 0.44 ± 0.018
0.319CysPhe: 0.319 ± 0.014
0.843CysGly: 0.843 ± 0.027
0.211CysHis: 0.211 ± 0.011
0.396CysIle: 0.396 ± 0.018
0.215CysLys: 0.215 ± 0.014
0.778CysLeu: 0.778 ± 0.025
0.167CysMet: 0.167 ± 0.01
0.205CysAsn: 0.205 ± 0.011
0.356CysPro: 0.356 ± 0.017
0.206CysGln: 0.206 ± 0.012
0.504CysArg: 0.504 ± 0.017
0.449CysSer: 0.449 ± 0.018
0.364CysThr: 0.364 ± 0.016
0.565CysVal: 0.565 ± 0.019
0.095CysTrp: 0.095 ± 0.008
0.188CysTyr: 0.188 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.393AspAla: 6.393 ± 0.07
0.468AspCys: 0.468 ± 0.021
3.136AspAsp: 3.136 ± 0.058
3.633AspGlu: 3.633 ± 0.06
2.336AspPhe: 2.336 ± 0.044
4.876AspGly: 4.876 ± 0.05
1.27AspHis: 1.27 ± 0.035
3.588AspIle: 3.588 ± 0.052
2.144AspLys: 2.144 ± 0.04
5.658AspLeu: 5.658 ± 0.065
1.502AspMet: 1.502 ± 0.033
1.547AspAsn: 1.547 ± 0.032
3.152AspPro: 3.152 ± 0.046
1.83AspGln: 1.83 ± 0.038
3.943AspArg: 3.943 ± 0.053
2.197AspSer: 2.197 ± 0.043
2.63AspThr: 2.63 ± 0.047
4.379AspVal: 4.379 ± 0.064
0.916AspTrp: 0.916 ± 0.028
1.571AspTyr: 1.571 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.175GluAla: 7.175 ± 0.087
0.346GluCys: 0.346 ± 0.015
2.984GluAsp: 2.984 ± 0.049
3.608GluGlu: 3.608 ± 0.059
1.887GluPhe: 1.887 ± 0.036
4.189GluGly: 4.189 ± 0.059
1.195GluHis: 1.195 ± 0.028
3.716GluIle: 3.716 ± 0.054
3.147GluLys: 3.147 ± 0.05
5.352GluLeu: 5.352 ± 0.058
1.564GluMet: 1.564 ± 0.035
2.007GluAsn: 2.007 ± 0.042
2.564GluPro: 2.564 ± 0.046
2.177GluGln: 2.177 ± 0.04
4.629GluArg: 4.629 ± 0.066
2.506GluSer: 2.506 ± 0.036
3.778GluThr: 3.778 ± 0.05
3.663GluVal: 3.663 ± 0.058
0.734GluTrp: 0.734 ± 0.024
1.036GluTyr: 1.036 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.407PheAla: 4.407 ± 0.053
0.397PheCys: 0.397 ± 0.018
2.706PheAsp: 2.706 ± 0.053
2.283PheGlu: 2.283 ± 0.041
1.674PhePhe: 1.674 ± 0.04
3.718PheGly: 3.718 ± 0.057
0.813PheHis: 0.813 ± 0.026
2.119PheIle: 2.119 ± 0.039
1.288PheLys: 1.288 ± 0.029
3.652PheLeu: 3.652 ± 0.055
0.938PheMet: 0.938 ± 0.024
1.253PheAsn: 1.253 ± 0.03
1.603PhePro: 1.603 ± 0.033
1.176PheGln: 1.176 ± 0.031
2.198PheArg: 2.198 ± 0.038
2.722PheSer: 2.722 ± 0.041
2.046PheThr: 2.046 ± 0.036
3.002PheVal: 3.002 ± 0.055
0.603PheTrp: 0.603 ± 0.02
0.984PheTyr: 0.984 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
7.862GlyAla: 7.862 ± 0.072
0.754GlyCys: 0.754 ± 0.026
4.167GlyAsp: 4.167 ± 0.057
4.684GlyGlu: 4.684 ± 0.069
3.684GlyPhe: 3.684 ± 0.051
6.473GlyGly: 6.473 ± 0.082
1.768GlyHis: 1.768 ± 0.037
4.96GlyIle: 4.96 ± 0.061
3.938GlyLys: 3.938 ± 0.05
8.427GlyLeu: 8.427 ± 0.083
2.289GlyMet: 2.289 ± 0.037
2.379GlyAsn: 2.379 ± 0.041
2.933GlyPro: 2.933 ± 0.041
2.788GlyGln: 2.788 ± 0.046
5.144GlyArg: 5.144 ± 0.059
4.656GlySer: 4.656 ± 0.055
4.398GlyThr: 4.398 ± 0.063
5.763GlyVal: 5.763 ± 0.074
1.221GlyTrp: 1.221 ± 0.029
2.35GlyTyr: 2.35 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.103HisAla: 2.103 ± 0.038
0.197HisCys: 0.197 ± 0.012
1.229HisAsp: 1.229 ± 0.031
1.114HisGlu: 1.114 ± 0.024
0.879HisPhe: 0.879 ± 0.024
1.813HisGly: 1.813 ± 0.036
0.607HisHis: 0.607 ± 0.025
1.105HisIle: 1.105 ± 0.029
0.556HisLys: 0.556 ± 0.021
2.025HisLeu: 2.025 ± 0.036
0.546HisMet: 0.546 ± 0.02
0.5HisAsn: 0.5 ± 0.02
1.206HisPro: 1.206 ± 0.032
0.63HisGln: 0.63 ± 0.021
1.31HisArg: 1.31 ± 0.032
1.085HisSer: 1.085 ± 0.025
0.82HisThr: 0.82 ± 0.02
1.446HisVal: 1.446 ± 0.03
0.283HisTrp: 0.283 ± 0.016
0.566HisTyr: 0.566 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.677IleAla: 7.677 ± 0.087
0.565IleCys: 0.565 ± 0.021
4.002IleAsp: 4.002 ± 0.048
3.866IleGlu: 3.866 ± 0.058
2.136IlePhe: 2.136 ± 0.033
5.341IleGly: 5.341 ± 0.069
0.983IleHis: 0.983 ± 0.023
3.137IleIle: 3.137 ± 0.051
1.937IleLys: 1.937 ± 0.037
5.009IleLeu: 5.009 ± 0.059
1.227IleMet: 1.227 ± 0.028
1.787IleAsn: 1.787 ± 0.037
2.489IlePro: 2.489 ± 0.039
1.39IleGln: 1.39 ± 0.034
3.476IleArg: 3.476 ± 0.052
3.657IleSer: 3.657 ± 0.061
2.929IleThr: 2.929 ± 0.049
4.748IleVal: 4.748 ± 0.062
0.665IleTrp: 0.665 ± 0.025
1.311IleTyr: 1.311 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
5.142LysAla: 5.142 ± 0.064
0.165LysCys: 0.165 ± 0.011
2.333LysAsp: 2.333 ± 0.044
2.133LysGlu: 2.133 ± 0.041
1.133LysPhe: 1.133 ± 0.033
3.062LysGly: 3.062 ± 0.05
0.728LysHis: 0.728 ± 0.023
2.386LysIle: 2.386 ± 0.046
1.833LysLys: 1.833 ± 0.044
3.971LysLeu: 3.971 ± 0.055
1.026LysMet: 1.026 ± 0.026
1.289LysAsn: 1.289 ± 0.029
2.441LysPro: 2.441 ± 0.048
1.303LysGln: 1.303 ± 0.029
2.741LysArg: 2.741 ± 0.047
2.543LysSer: 2.543 ± 0.043
2.543LysThr: 2.543 ± 0.04
2.892LysVal: 2.892 ± 0.042
0.418LysTrp: 0.418 ± 0.018
0.706LysTyr: 0.706 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
11.802LeuAla: 11.802 ± 0.101
0.847LeuCys: 0.847 ± 0.025
5.774LeuAsp: 5.774 ± 0.064
5.259LeuGlu: 5.259 ± 0.064
3.788LeuPhe: 3.788 ± 0.059
7.634LeuGly: 7.634 ± 0.08
1.811LeuHis: 1.811 ± 0.036
5.446LeuIle: 5.446 ± 0.065
4.418LeuLys: 4.418 ± 0.052
9.237LeuLeu: 9.237 ± 0.11
2.514LeuMet: 2.514 ± 0.037
2.882LeuAsn: 2.882 ± 0.046
5.216LeuPro: 5.216 ± 0.067
2.949LeuGln: 2.949 ± 0.042
5.968LeuArg: 5.968 ± 0.073
7.444LeuSer: 7.444 ± 0.101
5.724LeuThr: 5.724 ± 0.084
7.104LeuVal: 7.104 ± 0.074
1.105LeuTrp: 1.105 ± 0.028
2.158LeuTyr: 2.158 ± 0.046
0.001LeuXaa: 0.001 ± 0.001
Met
3.076MetAla: 3.076 ± 0.044
0.145MetCys: 0.145 ± 0.01
1.269MetAsp: 1.269 ± 0.03
1.33MetGlu: 1.33 ± 0.031
0.759MetPhe: 0.759 ± 0.022
1.735MetGly: 1.735 ± 0.038
0.424MetHis: 0.424 ± 0.018
1.631MetIle: 1.631 ± 0.031
1.186MetLys: 1.186 ± 0.029
2.596MetLeu: 2.596 ± 0.045
0.74MetMet: 0.74 ± 0.024
0.907MetAsn: 0.907 ± 0.022
1.496MetPro: 1.496 ± 0.035
0.968MetGln: 0.968 ± 0.027
1.833MetArg: 1.833 ± 0.039
1.859MetSer: 1.859 ± 0.039
2.111MetThr: 2.111 ± 0.037
1.801MetVal: 1.801 ± 0.033
0.224MetTrp: 0.224 ± 0.013
0.324MetTyr: 0.324 ± 0.014
0.001MetXaa: 0.001 ± 0.001
Asn
3.544AsnAla: 3.544 ± 0.048
0.225AsnCys: 0.225 ± 0.013
1.668AsnAsp: 1.668 ± 0.035
1.547AsnGlu: 1.547 ± 0.031
1.157AsnPhe: 1.157 ± 0.026
2.762AsnGly: 2.762 ± 0.046
0.591AsnHis: 0.591 ± 0.019
1.748AsnIle: 1.748 ± 0.034
0.895AsnLys: 0.895 ± 0.027
2.854AsnLeu: 2.854 ± 0.047
0.742AsnMet: 0.742 ± 0.024
0.907AsnAsn: 0.907 ± 0.03
1.882AsnPro: 1.882 ± 0.038
0.895AsnGln: 0.895 ± 0.026
2.033AsnArg: 2.033 ± 0.043
1.53AsnSer: 1.53 ± 0.035
1.486AsnThr: 1.486 ± 0.032
2.13AsnVal: 2.13 ± 0.042
0.478AsnTrp: 0.478 ± 0.019
0.741AsnTyr: 0.741 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.194ProAla: 5.194 ± 0.071
0.272ProCys: 0.272 ± 0.015
3.324ProAsp: 3.324 ± 0.045
3.436ProGlu: 3.436 ± 0.047
2.007ProPhe: 2.007 ± 0.033
3.764ProGly: 3.764 ± 0.051
1.037ProHis: 1.037 ± 0.026
2.365ProIle: 2.365 ± 0.038
1.945ProLys: 1.945 ± 0.036
4.387ProLeu: 4.387 ± 0.053
1.135ProMet: 1.135 ± 0.03
1.401ProAsn: 1.401 ± 0.026
2.037ProPro: 2.037 ± 0.047
1.705ProGln: 1.705 ± 0.036
2.396ProArg: 2.396 ± 0.048
2.935ProSer: 2.935 ± 0.055
2.4ProThr: 2.4 ± 0.046
4.133ProVal: 4.133 ± 0.047
0.592ProTrp: 0.592 ± 0.02
1.217ProTyr: 1.217 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.851GlnAla: 3.851 ± 0.055
0.187GlnCys: 0.187 ± 0.01
1.607GlnAsp: 1.607 ± 0.032
1.7GlnGlu: 1.7 ± 0.039
1.109GlnPhe: 1.109 ± 0.026
2.289GlnGly: 2.289 ± 0.037
0.644GlnHis: 0.644 ± 0.021
2.039GlnIle: 2.039 ± 0.048
1.476GlnLys: 1.476 ± 0.031
2.925GlnLeu: 2.925 ± 0.043
0.971GlnMet: 0.971 ± 0.026
1.067GlnAsn: 1.067 ± 0.028
1.744GlnPro: 1.744 ± 0.037
1.468GlnGln: 1.468 ± 0.046
2.352GlnArg: 2.352 ± 0.04
2.099GlnSer: 2.099 ± 0.039
1.891GlnThr: 1.891 ± 0.037
2.189GlnVal: 2.189 ± 0.049
0.395GlnTrp: 0.395 ± 0.018
0.654GlnTyr: 0.654 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
6.207ArgAla: 6.207 ± 0.062
0.407ArgCys: 0.407 ± 0.017
3.78ArgAsp: 3.78 ± 0.054
3.804ArgGlu: 3.804 ± 0.051
2.872ArgPhe: 2.872 ± 0.045
4.065ArgGly: 4.065 ± 0.054
1.538ArgHis: 1.538 ± 0.033
3.975ArgIle: 3.975 ± 0.053
2.655ArgLys: 2.655 ± 0.047
6.9ArgLeu: 6.9 ± 0.073
1.812ArgMet: 1.812 ± 0.039
2.057ArgAsn: 2.057 ± 0.037
2.891ArgPro: 2.891 ± 0.054
2.64ArgGln: 2.64 ± 0.047
4.562ArgArg: 4.562 ± 0.067
3.8ArgSer: 3.8 ± 0.057
3.085ArgThr: 3.085 ± 0.048
4.175ArgVal: 4.175 ± 0.059
0.845ArgTrp: 0.845 ± 0.027
1.738ArgTyr: 1.738 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.566SerAla: 6.566 ± 0.088
0.414SerCys: 0.414 ± 0.017
3.352SerAsp: 3.352 ± 0.043
3.249SerGlu: 3.249 ± 0.051
2.704SerPhe: 2.704 ± 0.04
5.848SerGly: 5.848 ± 0.067
1.241SerHis: 1.241 ± 0.031
3.383SerIle: 3.383 ± 0.049
2.215SerLys: 2.215 ± 0.041
6.151SerLeu: 6.151 ± 0.073
1.588SerMet: 1.588 ± 0.037
1.758SerAsn: 1.758 ± 0.034
2.779SerPro: 2.779 ± 0.047
1.911SerGln: 1.911 ± 0.037
3.768SerArg: 3.768 ± 0.06
3.876SerSer: 3.876 ± 0.062
3.151SerThr: 3.151 ± 0.065
4.481SerVal: 4.481 ± 0.059
0.774SerTrp: 0.774 ± 0.024
1.488SerTyr: 1.488 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
5.944ThrAla: 5.944 ± 0.081
0.39ThrCys: 0.39 ± 0.017
2.945ThrAsp: 2.945 ± 0.043
2.752ThrGlu: 2.752 ± 0.044
2.183ThrPhe: 2.183 ± 0.038
4.876ThrGly: 4.876 ± 0.055
1.027ThrHis: 1.027 ± 0.028
3.365ThrIle: 3.365 ± 0.046
1.903ThrLys: 1.903 ± 0.037
5.836ThrLeu: 5.836 ± 0.061
1.369ThrMet: 1.369 ± 0.03
1.477ThrAsn: 1.477 ± 0.036
3.05ThrPro: 3.05 ± 0.046
1.54ThrGln: 1.54 ± 0.029
2.982ThrArg: 2.982 ± 0.041
3.351ThrSer: 3.351 ± 0.05
2.987ThrThr: 2.987 ± 0.063
4.527ThrVal: 4.527 ± 0.067
0.621ThrTrp: 0.621 ± 0.021
1.253ThrTyr: 1.253 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.496ValAla: 8.496 ± 0.076
0.599ValCys: 0.599 ± 0.019
4.001ValAsp: 4.001 ± 0.051
4.565ValGlu: 4.565 ± 0.056
2.886ValPhe: 2.886 ± 0.046
5.308ValGly: 5.308 ± 0.061
1.339ValHis: 1.339 ± 0.033
4.397ValIle: 4.397 ± 0.068
2.83ValLys: 2.83 ± 0.047
7.162ValLeu: 7.162 ± 0.08
1.95ValMet: 1.95 ± 0.038
2.141ValAsn: 2.141 ± 0.04
3.544ValPro: 3.544 ± 0.049
2.086ValGln: 2.086 ± 0.039
4.328ValArg: 4.328 ± 0.055
4.994ValSer: 4.994 ± 0.063
4.52ValThr: 4.52 ± 0.061
5.744ValVal: 5.744 ± 0.07
0.827ValTrp: 0.827 ± 0.023
1.496ValTyr: 1.496 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.032
0.122TrpCys: 0.122 ± 0.01
0.618TrpAsp: 0.618 ± 0.023
0.534TrpGlu: 0.534 ± 0.02
0.564TrpPhe: 0.564 ± 0.017
0.794TrpGly: 0.794 ± 0.025
0.302TrpHis: 0.302 ± 0.014
0.702TrpIle: 0.702 ± 0.022
0.598TrpLys: 0.598 ± 0.02
1.546TrpLeu: 1.546 ± 0.038
0.343TrpMet: 0.343 ± 0.017
0.485TrpAsn: 0.485 ± 0.019
0.631TrpPro: 0.631 ± 0.021
0.571TrpGln: 0.571 ± 0.019
0.971TrpArg: 0.971 ± 0.028
0.845TrpSer: 0.845 ± 0.025
0.688TrpThr: 0.688 ± 0.02
0.75TrpVal: 0.75 ± 0.024
0.228TrpTrp: 0.228 ± 0.013
0.292TrpTyr: 0.292 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.412TyrAla: 2.412 ± 0.05
0.234TyrCys: 0.234 ± 0.012
1.49TyrAsp: 1.49 ± 0.034
1.305TyrGlu: 1.305 ± 0.025
1.005TyrPhe: 1.005 ± 0.026
2.074TyrGly: 2.074 ± 0.037
0.488TyrHis: 0.488 ± 0.018
1.084TyrIle: 1.084 ± 0.027
0.788TyrLys: 0.788 ± 0.024
2.383TyrLeu: 2.383 ± 0.04
0.515TyrMet: 0.515 ± 0.017
0.664TyrAsn: 0.664 ± 0.023
1.129TyrPro: 1.129 ± 0.026
0.742TyrGln: 0.742 ± 0.022
1.766TyrArg: 1.766 ± 0.034
1.32TyrSer: 1.32 ± 0.03
1.125TyrThr: 1.125 ± 0.027
1.67TyrVal: 1.67 ± 0.033
0.372TyrTrp: 0.372 ± 0.017
0.624TyrTyr: 0.624 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.001
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4726 proteins (1499049 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski