Amino acid dipepetide frequency for Desulfurella amilsii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.917AlaAla: 3.917 ± 0.113
0.955AlaCys: 0.955 ± 0.048
2.792AlaAsp: 2.792 ± 0.065
2.324AlaGlu: 2.324 ± 0.071
3.574AlaPhe: 3.574 ± 0.087
3.891AlaGly: 3.891 ± 0.094
1.003AlaHis: 1.003 ± 0.043
6.519AlaIle: 6.519 ± 0.121
6.412AlaLys: 6.412 ± 0.114
7.477AlaLeu: 7.477 ± 0.122
1.466AlaMet: 1.466 ± 0.053
3.5AlaAsn: 3.5 ± 0.08
1.688AlaPro: 1.688 ± 0.057
2.853AlaGln: 2.853 ± 0.075
2.145AlaArg: 2.145 ± 0.063
4.395AlaSer: 4.395 ± 0.089
3.115AlaThr: 3.115 ± 0.082
4.009AlaVal: 4.009 ± 0.103
0.411AlaTrp: 0.411 ± 0.025
2.919AlaTyr: 2.919 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.908CysAla: 0.908 ± 0.044
0.123CysCys: 0.123 ± 0.016
0.676CysAsp: 0.676 ± 0.035
0.605CysGlu: 0.605 ± 0.032
0.504CysPhe: 0.504 ± 0.032
0.897CysGly: 0.897 ± 0.04
0.244CysHis: 0.244 ± 0.033
0.915CysIle: 0.915 ± 0.043
0.804CysLys: 0.804 ± 0.034
0.885CysLeu: 0.885 ± 0.038
0.202CysMet: 0.202 ± 0.019
0.521CysAsn: 0.521 ± 0.031
0.585CysPro: 0.585 ± 0.034
0.254CysGln: 0.254 ± 0.022
0.249CysArg: 0.249 ± 0.02
0.683CysSer: 0.683 ± 0.034
0.449CysThr: 0.449 ± 0.029
0.801CysVal: 0.801 ± 0.043
0.046CysTrp: 0.046 ± 0.01
0.355CysTyr: 0.355 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.108AspAla: 3.108 ± 0.075
0.741AspCys: 0.741 ± 0.039
2.253AspAsp: 2.253 ± 0.062
3.574AspGlu: 3.574 ± 0.086
3.297AspPhe: 3.297 ± 0.08
2.551AspGly: 2.551 ± 0.062
0.635AspHis: 0.635 ± 0.031
5.691AspIle: 5.691 ± 0.108
4.859AspLys: 4.859 ± 0.103
5.02AspLeu: 5.02 ± 0.094
1.058AspMet: 1.058 ± 0.042
2.711AspAsn: 2.711 ± 0.069
1.688AspPro: 1.688 ± 0.046
1.114AspGln: 1.114 ± 0.048
1.436AspArg: 1.436 ± 0.042
2.969AspSer: 2.969 ± 0.069
2.381AspThr: 2.381 ± 0.06
3.21AspVal: 3.21 ± 0.079
0.386AspTrp: 0.386 ± 0.023
2.619AspTyr: 2.619 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
3.859GluAla: 3.859 ± 0.08
0.477GluCys: 0.477 ± 0.027
2.805GluAsp: 2.805 ± 0.074
4.208GluGlu: 4.208 ± 0.103
3.087GluPhe: 3.087 ± 0.078
3.04GluGly: 3.04 ± 0.07
1.033GluHis: 1.033 ± 0.042
5.789GluIle: 5.789 ± 0.12
6.47GluLys: 6.47 ± 0.119
5.603GluLeu: 5.603 ± 0.113
1.277GluMet: 1.277 ± 0.05
4.46GluAsn: 4.46 ± 0.093
1.711GluPro: 1.711 ± 0.057
1.906GluGln: 1.906 ± 0.062
2.066GluArg: 2.066 ± 0.059
3.506GluSer: 3.506 ± 0.072
2.629GluThr: 2.629 ± 0.071
3.669GluVal: 3.669 ± 0.081
0.431GluTrp: 0.431 ± 0.028
2.369GluTyr: 2.369 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.805PheAla: 3.805 ± 0.079
0.711PheCys: 0.711 ± 0.03
3.234PheAsp: 3.234 ± 0.081
3.453PheGlu: 3.453 ± 0.082
3.223PhePhe: 3.223 ± 0.086
3.849PheGly: 3.849 ± 0.091
0.648PheHis: 0.648 ± 0.029
4.451PheIle: 4.451 ± 0.093
3.899PheLys: 3.899 ± 0.082
5.642PheLeu: 5.642 ± 0.117
1.056PheMet: 1.056 ± 0.041
2.934PheAsn: 2.934 ± 0.075
1.275PhePro: 1.275 ± 0.046
0.99PheGln: 0.99 ± 0.036
1.427PheArg: 1.427 ± 0.046
4.067PheSer: 4.067 ± 0.094
2.152PheThr: 2.152 ± 0.06
4.012PheVal: 4.012 ± 0.078
0.458PheTrp: 0.458 ± 0.03
2.424PheTyr: 2.424 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
4.103GlyAla: 4.103 ± 0.099
0.729GlyCys: 0.729 ± 0.044
2.598GlyAsp: 2.598 ± 0.068
2.86GlyGlu: 2.86 ± 0.067
3.901GlyPhe: 3.901 ± 0.082
4.121GlyGly: 4.121 ± 0.1
0.947GlyHis: 0.947 ± 0.04
6.089GlyIle: 6.089 ± 0.117
4.682GlyLys: 4.682 ± 0.087
5.905GlyLeu: 5.905 ± 0.105
1.388GlyMet: 1.388 ± 0.052
2.644GlyAsn: 2.644 ± 0.073
1.475GlyPro: 1.475 ± 0.057
1.592GlyGln: 1.592 ± 0.061
1.827GlyArg: 1.827 ± 0.056
3.838GlySer: 3.838 ± 0.096
2.875GlyThr: 2.875 ± 0.081
4.244GlyVal: 4.244 ± 0.086
0.476GlyTrp: 0.476 ± 0.031
2.757GlyTyr: 2.757 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
0.845HisAla: 0.845 ± 0.039
0.201HisCys: 0.201 ± 0.017
0.608HisAsp: 0.608 ± 0.031
0.69HisGlu: 0.69 ± 0.032
0.864HisPhe: 0.864 ± 0.039
0.889HisGly: 0.889 ± 0.036
0.297HisHis: 0.297 ± 0.021
1.666HisIle: 1.666 ± 0.056
1.086HisLys: 1.086 ± 0.046
1.691HisLeu: 1.691 ± 0.057
0.353HisMet: 0.353 ± 0.025
0.864HisAsn: 0.864 ± 0.034
0.749HisPro: 0.749 ± 0.037
0.398HisGln: 0.398 ± 0.025
0.486HisArg: 0.486 ± 0.028
0.973HisSer: 0.973 ± 0.048
0.915HisThr: 0.915 ± 0.039
0.711HisVal: 0.711 ± 0.037
0.119HisTrp: 0.119 ± 0.015
0.786HisTyr: 0.786 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
7.13IleAla: 7.13 ± 0.122
0.884IleCys: 0.884 ± 0.039
5.874IleAsp: 5.874 ± 0.098
7.26IleGlu: 7.26 ± 0.139
4.655IlePhe: 4.655 ± 0.112
6.02IleGly: 6.02 ± 0.11
1.175IleHis: 1.175 ± 0.047
8.203IleIle: 8.203 ± 0.148
8.488IleLys: 8.488 ± 0.143
8.614IleLeu: 8.614 ± 0.135
1.892IleMet: 1.892 ± 0.064
5.96IleAsn: 5.96 ± 0.108
3.097IlePro: 3.097 ± 0.084
2.367IleGln: 2.367 ± 0.067
2.551IleArg: 2.551 ± 0.065
6.152IleSer: 6.152 ± 0.12
4.101IleThr: 4.101 ± 0.084
6.532IleVal: 6.532 ± 0.118
0.57IleTrp: 0.57 ± 0.032
3.526IleTyr: 3.526 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
5.695LysAla: 5.695 ± 0.105
0.628LysCys: 0.628 ± 0.036
5.383LysAsp: 5.383 ± 0.109
7.258LysGlu: 7.258 ± 0.136
3.455LysPhe: 3.455 ± 0.08
4.082LysGly: 4.082 ± 0.092
1.398LysHis: 1.398 ± 0.047
8.549LysIle: 8.549 ± 0.134
8.858LysLys: 8.858 ± 0.15
7.875LysLeu: 7.875 ± 0.13
1.857LysMet: 1.857 ± 0.059
6.562LysAsn: 6.562 ± 0.125
3.234LysPro: 3.234 ± 0.072
3.319LysGln: 3.319 ± 0.08
3.012LysArg: 3.012 ± 0.081
5.403LysSer: 5.403 ± 0.11
4.843LysThr: 4.843 ± 0.105
4.993LysVal: 4.993 ± 0.1
0.562LysTrp: 0.562 ± 0.035
3.249LysTyr: 3.249 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
6.61LeuAla: 6.61 ± 0.123
0.93LeuCys: 0.93 ± 0.035
5.259LeuAsp: 5.259 ± 0.112
6.431LeuGlu: 6.431 ± 0.111
4.838LeuPhe: 4.838 ± 0.112
6.167LeuGly: 6.167 ± 0.102
1.431LeuHis: 1.431 ± 0.046
8.566LeuIle: 8.566 ± 0.13
9.523LeuLys: 9.523 ± 0.153
8.745LeuLeu: 8.745 ± 0.133
2.064LeuMet: 2.064 ± 0.06
6.248LeuAsn: 6.248 ± 0.111
3.584LeuPro: 3.584 ± 0.081
2.772LeuGln: 2.772 ± 0.061
3.079LeuArg: 3.079 ± 0.074
7.78LeuSer: 7.78 ± 0.122
4.392LeuThr: 4.392 ± 0.087
5.474LeuVal: 5.474 ± 0.098
0.65LeuTrp: 0.65 ± 0.038
3.586LeuTyr: 3.586 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.394MetAla: 1.394 ± 0.05
0.212MetCys: 0.212 ± 0.018
1.102MetAsp: 1.102 ± 0.042
1.031MetGlu: 1.031 ± 0.04
1.064MetPhe: 1.064 ± 0.045
1.454MetGly: 1.454 ± 0.049
0.428MetHis: 0.428 ± 0.025
1.653MetIle: 1.653 ± 0.058
1.736MetLys: 1.736 ± 0.051
2.293MetLeu: 2.293 ± 0.062
0.436MetMet: 0.436 ± 0.031
0.986MetAsn: 0.986 ± 0.044
0.975MetPro: 0.975 ± 0.045
1.036MetGln: 1.036 ± 0.043
0.766MetArg: 0.766 ± 0.037
1.562MetSer: 1.562 ± 0.056
0.768MetThr: 0.768 ± 0.035
1.31MetVal: 1.31 ± 0.046
0.172MetTrp: 0.172 ± 0.017
0.781MetTyr: 0.781 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.775AsnAla: 3.775 ± 0.077
0.623AsnCys: 0.623 ± 0.033
2.707AsnAsp: 2.707 ± 0.074
3.292AsnGlu: 3.292 ± 0.076
3.304AsnPhe: 3.304 ± 0.088
3.052AsnGly: 3.052 ± 0.082
0.831AsnHis: 0.831 ± 0.034
6.61AsnIle: 6.61 ± 0.114
5.027AsnLys: 5.027 ± 0.103
6.321AsnLeu: 6.321 ± 0.114
1.152AsnMet: 1.152 ± 0.041
3.674AsnAsn: 3.674 ± 0.102
2.551AsnPro: 2.551 ± 0.071
2.18AsnGln: 2.18 ± 0.076
1.52AsnArg: 1.52 ± 0.054
3.498AsnSer: 3.498 ± 0.094
3.221AsnThr: 3.221 ± 0.084
3.77AsnVal: 3.77 ± 0.092
0.446AsnTrp: 0.446 ± 0.03
2.823AsnTyr: 2.823 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
1.726ProAla: 1.726 ± 0.055
0.282ProCys: 0.282 ± 0.02
1.65ProAsp: 1.65 ± 0.06
1.716ProGlu: 1.716 ± 0.062
2.046ProPhe: 2.046 ± 0.057
1.659ProGly: 1.659 ± 0.054
0.627ProHis: 0.627 ± 0.031
3.274ProIle: 3.274 ± 0.078
3.079ProLys: 3.079 ± 0.077
3.007ProLeu: 3.007 ± 0.07
0.663ProMet: 0.663 ± 0.032
2.014ProAsn: 2.014 ± 0.055
1.043ProPro: 1.043 ± 0.047
1.479ProGln: 1.479 ± 0.05
0.864ProArg: 0.864 ± 0.041
2.062ProSer: 2.062 ± 0.06
1.978ProThr: 1.978 ± 0.062
1.983ProVal: 1.983 ± 0.065
0.232ProTrp: 0.232 ± 0.02
1.572ProTyr: 1.572 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
2.367GlnAla: 2.367 ± 0.064
0.234GlnCys: 0.234 ± 0.018
1.537GlnAsp: 1.537 ± 0.05
2.359GlnGlu: 2.359 ± 0.066
1.23GlnPhe: 1.23 ± 0.045
1.308GlnGly: 1.308 ± 0.05
0.446GlnHis: 0.446 ± 0.027
2.951GlnIle: 2.951 ± 0.063
3.379GlnLys: 3.379 ± 0.09
2.725GlnLeu: 2.725 ± 0.071
0.814GlnMet: 0.814 ± 0.039
2.604GlnAsn: 2.604 ± 0.08
0.786GlnPro: 0.786 ± 0.039
1.046GlnGln: 1.046 ± 0.046
1.03GlnArg: 1.03 ± 0.044
2.157GlnSer: 2.157 ± 0.077
2.044GlnThr: 2.044 ± 0.068
1.61GlnVal: 1.61 ± 0.052
0.225GlnTrp: 0.225 ± 0.019
1.167GlnTyr: 1.167 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
1.736ArgAla: 1.736 ± 0.052
0.36ArgCys: 0.36 ± 0.027
1.499ArgAsp: 1.499 ± 0.049
1.776ArgGlu: 1.776 ± 0.052
1.79ArgPhe: 1.79 ± 0.06
1.666ArgGly: 1.666 ± 0.058
0.444ArgHis: 0.444 ± 0.027
2.977ArgIle: 2.977 ± 0.078
2.609ArgLys: 2.609 ± 0.072
3.203ArgLeu: 3.203 ± 0.071
0.779ArgMet: 0.779 ± 0.033
1.64ArgAsn: 1.64 ± 0.057
1.005ArgPro: 1.005 ± 0.045
1.197ArgGln: 1.197 ± 0.044
1.157ArgArg: 1.157 ± 0.044
1.595ArgSer: 1.595 ± 0.047
1.28ArgThr: 1.28 ± 0.048
1.931ArgVal: 1.931 ± 0.062
0.23ArgTrp: 0.23 ± 0.019
1.275ArgTyr: 1.275 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
4.012SerAla: 4.012 ± 0.078
0.761SerCys: 0.761 ± 0.04
3.142SerAsp: 3.142 ± 0.069
2.972SerGlu: 2.972 ± 0.073
3.732SerPhe: 3.732 ± 0.079
4.179SerGly: 4.179 ± 0.088
1.061SerHis: 1.061 ± 0.045
6.689SerIle: 6.689 ± 0.108
5.933SerLys: 5.933 ± 0.102
6.79SerLeu: 6.79 ± 0.113
1.47SerMet: 1.47 ± 0.047
3.912SerAsn: 3.912 ± 0.098
1.741SerPro: 1.741 ± 0.055
2.406SerGln: 2.406 ± 0.066
1.744SerArg: 1.744 ± 0.058
4.262SerSer: 4.262 ± 0.101
3.089SerThr: 3.089 ± 0.078
4.237SerVal: 4.237 ± 0.089
0.408SerTrp: 0.408 ± 0.027
2.802SerTyr: 2.802 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
2.961ThrAla: 2.961 ± 0.086
0.446ThrCys: 0.446 ± 0.027
2.195ThrAsp: 2.195 ± 0.062
1.79ThrGlu: 1.79 ± 0.056
2.387ThrPhe: 2.387 ± 0.065
3.11ThrGly: 3.11 ± 0.092
0.907ThrHis: 0.907 ± 0.041
4.773ThrIle: 4.773 ± 0.093
4.304ThrLys: 4.304 ± 0.083
4.914ThrLeu: 4.914 ± 0.099
0.957ThrMet: 0.957 ± 0.041
2.933ThrAsn: 2.933 ± 0.079
2.009ThrPro: 2.009 ± 0.053
2.238ThrGln: 2.238 ± 0.063
1.394ThrArg: 1.394 ± 0.043
2.744ThrSer: 2.744 ± 0.079
2.628ThrThr: 2.628 ± 0.076
2.783ThrVal: 2.783 ± 0.089
0.274ThrTrp: 0.274 ± 0.022
1.943ThrTyr: 1.943 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
4.166ValAla: 4.166 ± 0.096
0.844ValCys: 0.844 ± 0.038
3.445ValAsp: 3.445 ± 0.077
3.987ValGlu: 3.987 ± 0.078
3.796ValPhe: 3.796 ± 0.079
4.281ValGly: 4.281 ± 0.095
0.827ValHis: 0.827 ± 0.041
5.366ValIle: 5.366 ± 0.098
4.944ValLys: 4.944 ± 0.101
6.25ValLeu: 6.25 ± 0.124
1.313ValMet: 1.313 ± 0.054
3.387ValAsn: 3.387 ± 0.082
1.998ValPro: 1.998 ± 0.057
1.427ValGln: 1.427 ± 0.054
1.787ValArg: 1.787 ± 0.057
4.62ValSer: 4.62 ± 0.086
2.422ValThr: 2.422 ± 0.065
4.542ValVal: 4.542 ± 0.093
0.463ValTrp: 0.463 ± 0.027
2.618ValTyr: 2.618 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.496TrpAla: 0.496 ± 0.032
0.068TrpCys: 0.068 ± 0.01
0.408TrpAsp: 0.408 ± 0.027
0.393TrpGlu: 0.393 ± 0.025
0.401TrpPhe: 0.401 ± 0.027
0.486TrpGly: 0.486 ± 0.03
0.184TrpHis: 0.184 ± 0.018
0.595TrpIle: 0.595 ± 0.034
0.409TrpLys: 0.409 ± 0.028
0.784TrpLeu: 0.784 ± 0.036
0.174TrpMet: 0.174 ± 0.017
0.288TrpAsn: 0.288 ± 0.02
0.244TrpPro: 0.244 ± 0.022
0.342TrpGln: 0.342 ± 0.021
0.26TrpArg: 0.26 ± 0.021
0.429TrpSer: 0.429 ± 0.029
0.232TrpThr: 0.232 ± 0.022
0.459TrpVal: 0.459 ± 0.027
0.094TrpTrp: 0.094 ± 0.012
0.235TrpTyr: 0.235 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.75TyrAla: 2.75 ± 0.072
0.497TyrCys: 0.497 ± 0.03
2.135TyrAsp: 2.135 ± 0.064
2.417TyrGlu: 2.417 ± 0.063
2.561TyrPhe: 2.561 ± 0.062
2.347TyrGly: 2.347 ± 0.076
0.627TyrHis: 0.627 ± 0.03
3.723TyrIle: 3.723 ± 0.081
3.714TyrLys: 3.714 ± 0.085
4.382TyrLeu: 4.382 ± 0.094
0.787TyrMet: 0.787 ± 0.037
2.536TyrAsn: 2.536 ± 0.063
1.517TyrPro: 1.517 ± 0.058
1.104TyrGln: 1.104 ± 0.044
1.349TyrArg: 1.349 ± 0.047
2.649TyrSer: 2.649 ± 0.071
2.177TyrThr: 2.177 ± 0.065
2.203TyrVal: 2.203 ± 0.057
0.328TyrTrp: 0.328 ± 0.022
1.925TyrTyr: 1.925 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2019 proteins (603201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski