Amino acid dipepetide frequency for Ajellomyces capsulatus (strain H88) (Darling s disease fungus) (Histoplasma capsulatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.951AlaAla: 7.951 ± 0.064	0.982AlaCys: 0.982 ± 0.016	3.865AlaAsp: 3.865 ± 0.032	4.808AlaGlu: 4.808 ± 0.041	2.814AlaPhe: 2.814 ± 0.025	5.43AlaGly: 5.43 ± 0.043	1.716AlaHis: 1.716 ± 0.018	4.069AlaIle: 4.069 ± 0.035	3.943AlaLys: 3.943 ± 0.037	7.084AlaLeu: 7.084 ± 0.057	1.725AlaMet: 1.725 ± 0.022	2.964AlaAsn: 2.964 ± 0.029	4.253AlaPro: 4.253 ± 0.039	3.03AlaGln: 3.03 ± 0.031	4.811AlaArg: 4.811 ± 0.037	6.996AlaSer: 6.996 ± 0.05	4.965AlaThr: 4.965 ± 0.039	4.881AlaVal: 4.881 ± 0.039	0.944AlaTrp: 0.944 ± 0.017	1.843AlaTyr: 1.843 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.889CysAla: 0.889 ± 0.014	0.277CysCys: 0.277 ± 0.008	0.67CysAsp: 0.67 ± 0.013	0.652CysGlu: 0.652 ± 0.013	0.539CysPhe: 0.539 ± 0.012	0.971CysGly: 0.971 ± 0.019	0.37CysHis: 0.37 ± 0.01	0.71CysIle: 0.71 ± 0.014	0.562CysLys: 0.562 ± 0.013	1.289CysLeu: 1.289 ± 0.019	0.27CysMet: 0.27 ± 0.009	0.454CysAsn: 0.454 ± 0.011	0.746CysPro: 0.746 ± 0.015	0.503CysGln: 0.503 ± 0.011	0.848CysArg: 0.848 ± 0.016	1.03CysSer: 1.03 ± 0.017	0.659CysThr: 0.659 ± 0.013	0.767CysVal: 0.767 ± 0.014	0.215CysTrp: 0.215 ± 0.007	0.35CysTyr: 0.35 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.147AspAla: 4.147 ± 0.035	0.644AspCys: 0.644 ± 0.014	4.153AspAsp: 4.153 ± 0.058	4.249AspGlu: 4.249 ± 0.046	2.103AspPhe: 2.103 ± 0.025	4.109AspGly: 4.109 ± 0.037	1.233AspHis: 1.233 ± 0.018	3.374AspIle: 3.374 ± 0.028	2.355AspLys: 2.355 ± 0.026	4.803AspLeu: 4.803 ± 0.044	1.249AspMet: 1.249 ± 0.017	2.043AspAsn: 2.043 ± 0.024	3.247AspPro: 3.247 ± 0.03	1.783AspGln: 1.783 ± 0.019	3.12AspArg: 3.12 ± 0.03	4.216AspSer: 4.216 ± 0.036	2.824AspThr: 2.824 ± 0.03	3.483AspVal: 3.483 ± 0.03	0.793AspTrp: 0.793 ± 0.014	1.471AspTyr: 1.471 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	4.858GluAla: 4.858 ± 0.042	0.666GluCys: 0.666 ± 0.014	3.957GluAsp: 3.957 ± 0.042	5.259GluGlu: 5.259 ± 0.06	1.994GluPhe: 1.994 ± 0.025	3.716GluGly: 3.716 ± 0.039	1.366GluHis: 1.366 ± 0.018	3.233GluIle: 3.233 ± 0.029	3.785GluLys: 3.785 ± 0.041	5.217GluLeu: 5.217 ± 0.043	1.472GluMet: 1.472 ± 0.019	2.65GluAsn: 2.65 ± 0.025	2.779GluPro: 2.779 ± 0.043	2.428GluGln: 2.428 ± 0.027	4.142GluArg: 4.142 ± 0.043	4.474GluSer: 4.474 ± 0.035	3.353GluThr: 3.353 ± 0.032	3.327GluVal: 3.327 ± 0.033	0.833GluTrp: 0.833 ± 0.014	1.668GluTyr: 1.668 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.764PheAla: 2.764 ± 0.025	0.568PheCys: 0.568 ± 0.013	2.2PheAsp: 2.2 ± 0.024	2.149PheGlu: 2.149 ± 0.024	1.487PhePhe: 1.487 ± 0.021	2.643PheGly: 2.643 ± 0.031	0.967PheHis: 0.967 ± 0.015	1.758PheIle: 1.758 ± 0.023	1.52PheLys: 1.52 ± 0.018	3.463PheLeu: 3.463 ± 0.033	0.719PheMet: 0.719 ± 0.014	1.416PheAsn: 1.416 ± 0.019	2.148PhePro: 2.148 ± 0.023	1.411PheGln: 1.411 ± 0.019	2.103PheArg: 2.103 ± 0.023	3.225PheSer: 3.225 ± 0.03	2.014PheThr: 2.014 ± 0.024	2.264PheVal: 2.264 ± 0.027	0.559PheTrp: 0.559 ± 0.013	1.045PheTyr: 1.045 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.795GlyAla: 4.795 ± 0.045	0.908GlyCys: 0.908 ± 0.015	3.722GlyAsp: 3.722 ± 0.034	3.828GlyGlu: 3.828 ± 0.033	2.602GlyPhe: 2.602 ± 0.031	5.882GlyGly: 5.882 ± 0.063	1.645GlyHis: 1.645 ± 0.022	3.529GlyIle: 3.529 ± 0.031	3.605GlyLys: 3.605 ± 0.036	5.606GlyLeu: 5.606 ± 0.039	1.585GlyMet: 1.585 ± 0.019	2.792GlyAsn: 2.792 ± 0.028	3.242GlyPro: 3.242 ± 0.034	2.431GlyGln: 2.431 ± 0.025	4.319GlyArg: 4.319 ± 0.037	5.81GlySer: 5.81 ± 0.048	3.719GlyThr: 3.719 ± 0.032	4.161GlyVal: 4.161 ± 0.035	1.087GlyTrp: 1.087 ± 0.018	1.986GlyTyr: 1.986 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.822HisAla: 1.822 ± 0.024	0.351HisCys: 0.351 ± 0.008	1.333HisAsp: 1.333 ± 0.017	1.308HisGlu: 1.308 ± 0.02	0.952HisPhe: 0.952 ± 0.015	1.725HisGly: 1.725 ± 0.022	0.965HisHis: 0.965 ± 0.022	1.345HisIle: 1.345 ± 0.018	0.967HisLys: 0.967 ± 0.018	2.338HisLeu: 2.338 ± 0.024	0.482HisMet: 0.482 ± 0.011	0.947HisAsn: 0.947 ± 0.015	1.917HisPro: 1.917 ± 0.025	1.154HisGln: 1.154 ± 0.021	1.678HisArg: 1.678 ± 0.024	2.204HisSer: 2.204 ± 0.027	1.34HisThr: 1.34 ± 0.02	1.397HisVal: 1.397 ± 0.02	0.323HisTrp: 0.323 ± 0.009	0.67HisTyr: 0.67 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.924IleAla: 3.924 ± 0.034	0.823IleCys: 0.823 ± 0.015	2.937IleAsp: 2.937 ± 0.027	2.916IleGlu: 2.916 ± 0.028	2.08IlePhe: 2.08 ± 0.028	3.084IleGly: 3.084 ± 0.032	1.362IleHis: 1.362 ± 0.02	2.623IleIle: 2.623 ± 0.029	2.275IleLys: 2.275 ± 0.024	4.849IleLeu: 4.849 ± 0.044	1.01IleMet: 1.01 ± 0.015	1.913IleAsn: 1.913 ± 0.023	3.468IlePro: 3.468 ± 0.03	2.008IleGln: 2.008 ± 0.023	3.064IleArg: 3.064 ± 0.032	4.591IleSer: 4.591 ± 0.035	2.874IleThr: 2.874 ± 0.028	3.056IleVal: 3.056 ± 0.03	0.682IleTrp: 0.682 ± 0.013	1.484IleTyr: 1.484 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.928LysAla: 3.928 ± 0.038	0.584LysCys: 0.584 ± 0.013	2.639LysAsp: 2.639 ± 0.03	3.442LysGlu: 3.442 ± 0.038	1.619LysPhe: 1.619 ± 0.023	3.036LysGly: 3.036 ± 0.032	1.212LysHis: 1.212 ± 0.02	2.513LysIle: 2.513 ± 0.028	3.37LysLys: 3.37 ± 0.045	4.372LysLeu: 4.372 ± 0.034	1.065LysMet: 1.065 ± 0.016	1.923LysAsn: 1.923 ± 0.019	2.924LysPro: 2.924 ± 0.031	2.034LysGln: 2.034 ± 0.023	3.777LysArg: 3.777 ± 0.038	3.872LysSer: 3.872 ± 0.033	2.804LysThr: 2.804 ± 0.029	2.754LysVal: 2.754 ± 0.03	0.659LysTrp: 0.659 ± 0.014	1.438LysTyr: 1.438 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.247LeuAla: 7.247 ± 0.049	1.235LeuCys: 1.235 ± 0.017	5.0LeuAsp: 5.0 ± 0.041	5.533LeuGlu: 5.533 ± 0.046	3.265LeuPhe: 3.265 ± 0.035	5.667LeuGly: 5.667 ± 0.038	2.328LeuHis: 2.328 ± 0.026	4.02LeuIle: 4.02 ± 0.037	4.482LeuLys: 4.482 ± 0.037	8.454LeuLeu: 8.454 ± 0.075	1.674LeuMet: 1.674 ± 0.021	3.332LeuAsn: 3.332 ± 0.03	5.65LeuPro: 5.65 ± 0.038	3.872LeuGln: 3.872 ± 0.035	6.021LeuArg: 6.021 ± 0.044	7.836LeuSer: 7.836 ± 0.053	4.66LeuThr: 4.66 ± 0.037	5.127LeuVal: 5.127 ± 0.042	1.103LeuTrp: 1.103 ± 0.017	2.241LeuTyr: 2.241 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.084MetAla: 2.084 ± 0.027	0.237MetCys: 0.237 ± 0.007	1.248MetAsp: 1.248 ± 0.018	1.372MetGlu: 1.372 ± 0.017	0.703MetPhe: 0.703 ± 0.014	1.4MetGly: 1.4 ± 0.02	0.447MetHis: 0.447 ± 0.01	0.996MetIle: 0.996 ± 0.016	1.073MetLys: 1.073 ± 0.016	1.756MetLeu: 1.756 ± 0.02	0.504MetMet: 0.504 ± 0.01	0.817MetAsn: 0.817 ± 0.015	1.178MetPro: 1.178 ± 0.019	0.827MetGln: 0.827 ± 0.016	1.255MetArg: 1.255 ± 0.019	1.841MetSer: 1.841 ± 0.018	1.216MetThr: 1.216 ± 0.017	1.227MetVal: 1.227 ± 0.017	0.249MetTrp: 0.249 ± 0.008	0.475MetTyr: 0.475 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.052AsnAla: 3.052 ± 0.03	0.496AsnCys: 0.496 ± 0.012	2.161AsnAsp: 2.161 ± 0.025	2.216AsnGlu: 2.216 ± 0.022	1.424AsnPhe: 1.424 ± 0.019	3.114AsnGly: 3.114 ± 0.032	1.009AsnHis: 1.009 ± 0.014	2.35AsnIle: 2.35 ± 0.028	1.725AsnLys: 1.725 ± 0.019	3.403AsnLeu: 3.403 ± 0.032	0.834AsnMet: 0.834 ± 0.015	1.962AsnAsn: 1.962 ± 0.034	2.747AsnPro: 2.747 ± 0.027	1.466AsnGln: 1.466 ± 0.021	2.294AsnArg: 2.294 ± 0.024	3.292AsnSer: 3.292 ± 0.034	2.273AsnThr: 2.273 ± 0.025	2.313AsnVal: 2.313 ± 0.026	0.504AsnTrp: 0.504 ± 0.012	1.038AsnTyr: 1.038 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.972ProAla: 4.972 ± 0.047	0.611ProCys: 0.611 ± 0.013	3.159ProAsp: 3.159 ± 0.029	3.658ProGlu: 3.658 ± 0.037	2.158ProPhe: 2.158 ± 0.023	3.867ProGly: 3.867 ± 0.039	1.545ProHis: 1.545 ± 0.021	2.828ProIle: 2.828 ± 0.028	2.793ProLys: 2.793 ± 0.031	5.101ProLeu: 5.101 ± 0.04	1.034ProMet: 1.034 ± 0.018	2.487ProAsn: 2.487 ± 0.026	5.803ProPro: 5.803 ± 0.077	2.721ProGln: 2.721 ± 0.036	3.598ProArg: 3.598 ± 0.039	6.703ProSer: 6.703 ± 0.056	4.256ProThr: 4.256 ± 0.047	3.419ProVal: 3.419 ± 0.029	0.692ProTrp: 0.692 ± 0.014	1.49ProTyr: 1.49 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.056GlnAla: 3.056 ± 0.033	0.45GlnCys: 0.45 ± 0.01	1.919GlnAsp: 1.919 ± 0.023	2.375GlnGlu: 2.375 ± 0.028	1.317GlnPhe: 1.317 ± 0.018	2.324GlnGly: 2.324 ± 0.027	1.228GlnHis: 1.228 ± 0.022	1.991GlnIle: 1.991 ± 0.025	2.138GlnLys: 2.138 ± 0.024	3.584GlnLeu: 3.584 ± 0.032	0.865GlnMet: 0.865 ± 0.015	1.741GlnAsn: 1.741 ± 0.02	2.792GlnPro: 2.792 ± 0.038	2.796GlnGln: 2.796 ± 0.06	2.898GlnArg: 2.898 ± 0.029	3.33GlnSer: 3.33 ± 0.035	2.328GlnThr: 2.328 ± 0.029	2.04GlnVal: 2.04 ± 0.025	0.49GlnTrp: 0.49 ± 0.011	1.082GlnTyr: 1.082 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.637ArgAla: 4.637 ± 0.038	0.832ArgCys: 0.832 ± 0.013	3.475ArgAsp: 3.475 ± 0.038	4.051ArgGlu: 4.051 ± 0.04	2.203ArgPhe: 2.203 ± 0.023	4.061ArgGly: 4.061 ± 0.04	1.707ArgHis: 1.707 ± 0.022	3.215ArgIle: 3.215 ± 0.027	3.876ArgLys: 3.876 ± 0.037	5.627ArgLeu: 5.627 ± 0.045	1.385ArgMet: 1.385 ± 0.02	2.641ArgAsn: 2.641 ± 0.027	3.597ArgPro: 3.597 ± 0.037	2.797ArgGln: 2.797 ± 0.027	5.598ArgArg: 5.598 ± 0.048	5.299ArgSer: 5.299 ± 0.036	3.432ArgThr: 3.432 ± 0.025	3.44ArgVal: 3.44 ± 0.032	0.917ArgTrp: 0.917 ± 0.018	1.732ArgTyr: 1.732 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.579SerAla: 6.579 ± 0.041	1.007SerCys: 1.007 ± 0.017	4.247SerAsp: 4.247 ± 0.043	4.263SerGlu: 4.263 ± 0.036	3.144SerPhe: 3.144 ± 0.029	5.726SerGly: 5.726 ± 0.046	2.33SerHis: 2.33 ± 0.026	4.331SerIle: 4.331 ± 0.035	4.108SerLys: 4.108 ± 0.034	7.69SerLeu: 7.69 ± 0.049	1.774SerMet: 1.774 ± 0.018	3.549SerAsn: 3.549 ± 0.036	6.427SerPro: 6.427 ± 0.063	3.618SerGln: 3.618 ± 0.034	5.759SerArg: 5.759 ± 0.044	10.149SerSer: 10.149 ± 0.095	5.934SerThr: 5.934 ± 0.05	4.547SerVal: 4.547 ± 0.034	1.094SerTrp: 1.094 ± 0.016	2.032SerTyr: 2.032 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	4.857ThrAla: 4.857 ± 0.038	0.731ThrCys: 0.731 ± 0.016	2.777ThrAsp: 2.777 ± 0.029	3.008ThrGlu: 3.008 ± 0.032	2.153ThrPhe: 2.153 ± 0.023	3.938ThrGly: 3.938 ± 0.03	1.362ThrHis: 1.362 ± 0.019	3.085ThrIle: 3.085 ± 0.025	2.66ThrLys: 2.66 ± 0.03	5.07ThrLeu: 5.07 ± 0.041	1.116ThrMet: 1.116 ± 0.017	2.243ThrAsn: 2.243 ± 0.024	4.435ThrPro: 4.435 ± 0.046	2.107ThrGln: 2.107 ± 0.026	3.284ThrArg: 3.284 ± 0.028	5.746ThrSer: 5.746 ± 0.046	4.431ThrThr: 4.431 ± 0.047	3.392ThrVal: 3.392 ± 0.03	0.717ThrTrp: 0.717 ± 0.015	1.454ThrTyr: 1.454 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.681ValAla: 4.681 ± 0.039	0.789ValCys: 0.789 ± 0.014	3.619ValAsp: 3.619 ± 0.035	3.806ValGlu: 3.806 ± 0.035	2.25ValPhe: 2.25 ± 0.028	3.874ValGly: 3.874 ± 0.036	1.342ValHis: 1.342 ± 0.021	2.905ValIle: 2.905 ± 0.028	2.862ValLys: 2.862 ± 0.03	5.216ValLeu: 5.216 ± 0.047	1.225ValMet: 1.225 ± 0.018	2.174ValAsn: 2.174 ± 0.022	3.398ValPro: 3.398 ± 0.031	2.18ValGln: 2.18 ± 0.023	3.35ValArg: 3.35 ± 0.028	4.643ValSer: 4.643 ± 0.035	3.26ValThr: 3.26 ± 0.029	3.997ValVal: 3.997 ± 0.04	0.787ValTrp: 0.787 ± 0.016	1.51ValTyr: 1.51 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.006TrpAla: 1.006 ± 0.016	0.172TrpCys: 0.172 ± 0.006	0.807TrpAsp: 0.807 ± 0.016	0.842TrpGlu: 0.842 ± 0.017	0.46TrpPhe: 0.46 ± 0.012	0.81TrpGly: 0.81 ± 0.016	0.323TrpHis: 0.323 ± 0.008	0.7TrpIle: 0.7 ± 0.014	0.794TrpLys: 0.794 ± 0.013	1.256TrpLeu: 1.256 ± 0.018	0.342TrpMet: 0.342 ± 0.008	0.596TrpAsn: 0.596 ± 0.012	0.56TrpPro: 0.56 ± 0.013	0.497TrpGln: 0.497 ± 0.012	0.974TrpArg: 0.974 ± 0.015	0.972TrpSer: 0.972 ± 0.017	0.757TrpThr: 0.757 ± 0.014	0.798TrpVal: 0.798 ± 0.016	0.243TrpTrp: 0.243 ± 0.009	0.349TrpTyr: 0.349 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.824TyrAla: 1.824 ± 0.025	0.406TyrCys: 0.406 ± 0.009	1.512TyrAsp: 1.512 ± 0.02	1.44TyrGlu: 1.44 ± 0.02	1.154TyrPhe: 1.154 ± 0.017	1.877TyrGly: 1.877 ± 0.023	0.762TyrHis: 0.762 ± 0.014	1.448TyrIle: 1.448 ± 0.021	1.071TyrLys: 1.071 ± 0.016	2.572TyrLeu: 2.572 ± 0.027	0.577TyrMet: 0.577 ± 0.012	1.029TyrAsn: 1.029 ± 0.017	1.582TyrPro: 1.582 ± 0.026	1.082TyrGln: 1.082 ± 0.018	1.628TyrArg: 1.628 ± 0.02	2.077TyrSer: 2.077 ± 0.023	1.466TyrThr: 1.466 ± 0.019	1.482TyrVal: 1.482 ± 0.021	0.368TyrTrp: 0.368 ± 0.009	0.843TyrTyr: 0.843 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9445 proteins (4200093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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