Amino acid dipepetide frequency for Gossypium arboreum (Tree cotton) (Gossypium nanking)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.271AlaAla: 6.271 ± 0.037	1.325AlaCys: 1.325 ± 0.013	3.141AlaAsp: 3.141 ± 0.02	4.325AlaGlu: 4.325 ± 0.026	2.679AlaPhe: 2.679 ± 0.018	3.97AlaGly: 3.97 ± 0.023	1.295AlaHis: 1.295 ± 0.012	3.765AlaIle: 3.765 ± 0.023	3.996AlaLys: 3.996 ± 0.027	6.565AlaLeu: 6.565 ± 0.031	1.899AlaMet: 1.899 ± 0.015	2.627AlaAsn: 2.627 ± 0.019	2.818AlaPro: 2.818 ± 0.024	2.165AlaGln: 2.165 ± 0.016	3.377AlaArg: 3.377 ± 0.021	6.25AlaSer: 6.25 ± 0.031	3.605AlaThr: 3.605 ± 0.021	4.787AlaVal: 4.787 ± 0.026	0.777AlaTrp: 0.777 ± 0.01	1.836AlaTyr: 1.836 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.012	0.56CysCys: 0.56 ± 0.009	0.88CysAsp: 0.88 ± 0.01	0.91CysGlu: 0.91 ± 0.011	0.881CysPhe: 0.881 ± 0.011	1.286CysGly: 1.286 ± 0.015	0.536CysHis: 0.536 ± 0.008	1.097CysIle: 1.097 ± 0.011	1.241CysLys: 1.241 ± 0.014	2.04CysLeu: 2.04 ± 0.016	0.514CysMet: 0.514 ± 0.007	0.859CysAsn: 0.859 ± 0.012	1.013CysPro: 1.013 ± 0.013	0.678CysGln: 0.678 ± 0.008	1.041CysArg: 1.041 ± 0.011	1.817CysSer: 1.817 ± 0.014	0.853CysThr: 0.853 ± 0.01	1.1CysVal: 1.1 ± 0.011	0.249CysTrp: 0.249 ± 0.006	0.587CysTyr: 0.587 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.479AspAla: 3.479 ± 0.018	0.915AspCys: 0.915 ± 0.01	3.574AspAsp: 3.574 ± 0.025	3.897AspGlu: 3.897 ± 0.026	2.234AspPhe: 2.234 ± 0.016	3.675AspGly: 3.675 ± 0.022	1.224AspHis: 1.224 ± 0.013	3.012AspIle: 3.012 ± 0.019	2.755AspLys: 2.755 ± 0.019	4.941AspLeu: 4.941 ± 0.027	1.432AspMet: 1.432 ± 0.012	2.126AspAsn: 2.126 ± 0.018	2.565AspPro: 2.565 ± 0.018	1.714AspGln: 1.714 ± 0.014	2.356AspArg: 2.356 ± 0.021	4.197AspSer: 4.197 ± 0.023	2.179AspThr: 2.179 ± 0.017	3.501AspVal: 3.501 ± 0.019	0.691AspTrp: 0.691 ± 0.009	1.518AspTyr: 1.518 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.808GluAla: 4.808 ± 0.029	0.885GluCys: 0.885 ± 0.011	3.869GluAsp: 3.869 ± 0.024	5.913GluGlu: 5.913 ± 0.047	2.268GluPhe: 2.268 ± 0.015	3.566GluGly: 3.566 ± 0.022	1.261GluHis: 1.261 ± 0.013	3.648GluIle: 3.648 ± 0.019	4.818GluLys: 4.818 ± 0.036	5.93GluLeu: 5.93 ± 0.033	1.752GluMet: 1.752 ± 0.013	3.132GluAsn: 3.132 ± 0.021	2.208GluPro: 2.208 ± 0.018	2.296GluGln: 2.296 ± 0.02	3.446GluArg: 3.446 ± 0.022	4.583GluSer: 4.583 ± 0.025	3.203GluThr: 3.203 ± 0.021	4.101GluVal: 4.101 ± 0.023	0.716GluTrp: 0.716 ± 0.01	1.667GluTyr: 1.667 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.398PheAla: 2.398 ± 0.018	0.868PheCys: 0.868 ± 0.01	2.229PheAsp: 2.229 ± 0.015	2.267PheGlu: 2.267 ± 0.016	1.836PhePhe: 1.836 ± 0.018	3.016PheGly: 3.016 ± 0.022	1.065PheHis: 1.065 ± 0.011	2.134PheIle: 2.134 ± 0.018	2.143PheLys: 2.143 ± 0.016	4.081PheLeu: 4.081 ± 0.024	1.016PheMet: 1.016 ± 0.012	1.742PheAsn: 1.742 ± 0.014	2.065PhePro: 2.065 ± 0.017	1.577PheGln: 1.577 ± 0.014	2.007PheArg: 2.007 ± 0.017	3.93PheSer: 3.93 ± 0.021	1.924PheThr: 1.924 ± 0.016	2.602PheVal: 2.602 ± 0.019	0.595PheTrp: 0.595 ± 0.009	1.236PheTyr: 1.236 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.836GlyAla: 3.836 ± 0.025	1.235GlyCys: 1.235 ± 0.014	3.282GlyAsp: 3.282 ± 0.02	3.521GlyGlu: 3.521 ± 0.023	2.989GlyPhe: 2.989 ± 0.023	4.992GlyGly: 4.992 ± 0.042	1.645GlyHis: 1.645 ± 0.015	3.787GlyIle: 3.787 ± 0.024	4.176GlyLys: 4.176 ± 0.025	5.914GlyLeu: 5.914 ± 0.032	1.596GlyMet: 1.596 ± 0.013	3.174GlyAsn: 3.174 ± 0.021	2.475GlyPro: 2.475 ± 0.019	2.168GlyGln: 2.168 ± 0.015	3.597GlyArg: 3.597 ± 0.027	6.195GlySer: 6.195 ± 0.035	3.401GlyThr: 3.401 ± 0.022	4.051GlyVal: 4.051 ± 0.026	0.884GlyTrp: 0.884 ± 0.011	2.03GlyTyr: 2.03 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	1.421HisAla: 1.421 ± 0.013	0.518HisCys: 0.518 ± 0.008	1.118HisAsp: 1.118 ± 0.012	1.277HisGlu: 1.277 ± 0.014	1.051HisPhe: 1.051 ± 0.012	1.971HisGly: 1.971 ± 0.018	0.943HisHis: 0.943 ± 0.012	1.397HisIle: 1.397 ± 0.014	1.194HisLys: 1.194 ± 0.012	2.374HisLeu: 2.374 ± 0.016	0.611HisMet: 0.611 ± 0.009	0.959HisAsn: 0.959 ± 0.01	1.352HisPro: 1.352 ± 0.014	1.032HisGln: 1.032 ± 0.013	1.452HisArg: 1.452 ± 0.012	1.972HisSer: 1.972 ± 0.015	1.124HisThr: 1.124 ± 0.012	1.656HisVal: 1.656 ± 0.015	0.331HisTrp: 0.331 ± 0.006	0.72HisTyr: 0.72 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.614IleAla: 3.614 ± 0.023	1.193IleCys: 1.193 ± 0.012	2.919IleAsp: 2.919 ± 0.019	3.265IleGlu: 3.265 ± 0.021	2.238IlePhe: 2.238 ± 0.018	3.451IleGly: 3.451 ± 0.023	1.293IleHis: 1.293 ± 0.013	2.808IleIle: 2.808 ± 0.022	2.998IleLys: 2.998 ± 0.019	5.111IleLeu: 5.111 ± 0.026	1.3IleMet: 1.3 ± 0.013	2.255IleAsn: 2.255 ± 0.016	2.917IlePro: 2.917 ± 0.022	1.967IleGln: 1.967 ± 0.014	2.705IleArg: 2.705 ± 0.018	4.943IleSer: 4.943 ± 0.028	2.612IleThr: 2.612 ± 0.018	3.424IleVal: 3.424 ± 0.023	0.734IleTrp: 0.734 ± 0.01	1.532IleTyr: 1.532 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.29LysAla: 4.29 ± 0.03	0.968LysCys: 0.968 ± 0.01	3.305LysAsp: 3.305 ± 0.021	4.719LysGlu: 4.719 ± 0.032	2.151LysPhe: 2.151 ± 0.017	3.713LysGly: 3.713 ± 0.025	1.419LysHis: 1.419 ± 0.014	3.179LysIle: 3.179 ± 0.021	4.776LysLys: 4.776 ± 0.041	6.066LysLeu: 6.066 ± 0.033	1.569LysMet: 1.569 ± 0.013	2.654LysAsn: 2.654 ± 0.019	2.885LysPro: 2.885 ± 0.021	2.424LysGln: 2.424 ± 0.018	3.566LysArg: 3.566 ± 0.023	4.752LysSer: 4.752 ± 0.029	3.038LysThr: 3.038 ± 0.018	3.926LysVal: 3.926 ± 0.022	0.806LysTrp: 0.806 ± 0.009	1.69LysTyr: 1.69 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	6.549LeuAla: 6.549 ± 0.033	1.824LeuCys: 1.824 ± 0.016	4.925LeuAsp: 4.925 ± 0.027	6.238LeuGlu: 6.238 ± 0.034	3.676LeuPhe: 3.676 ± 0.024	5.847LeuGly: 5.847 ± 0.028	2.564LeuHis: 2.564 ± 0.019	4.53LeuIle: 4.53 ± 0.027	6.333LeuLys: 6.333 ± 0.031	9.599LeuLeu: 9.599 ± 0.05	2.252LeuMet: 2.252 ± 0.017	4.047LeuAsn: 4.047 ± 0.023	5.005LeuPro: 5.005 ± 0.029	4.302LeuGln: 4.302 ± 0.028	5.361LeuArg: 5.361 ± 0.03	8.484LeuSer: 8.484 ± 0.041	4.529LeuThr: 4.529 ± 0.021	6.151LeuVal: 6.151 ± 0.029	1.117LeuTrp: 1.117 ± 0.012	2.537LeuTyr: 2.537 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.26MetAla: 2.26 ± 0.017	0.487MetCys: 0.487 ± 0.008	1.468MetAsp: 1.468 ± 0.011	2.009MetGlu: 2.009 ± 0.016	0.879MetPhe: 0.879 ± 0.011	1.696MetGly: 1.696 ± 0.015	0.606MetHis: 0.606 ± 0.009	1.215MetIle: 1.215 ± 0.012	1.654MetLys: 1.654 ± 0.014	2.355MetLeu: 2.355 ± 0.019	0.746MetMet: 0.746 ± 0.009	1.072MetAsn: 1.072 ± 0.012	1.331MetPro: 1.331 ± 0.013	1.001MetGln: 1.001 ± 0.01	1.29MetArg: 1.29 ± 0.012	2.056MetSer: 2.056 ± 0.015	1.113MetThr: 1.113 ± 0.012	1.764MetVal: 1.764 ± 0.014	0.294MetTrp: 0.294 ± 0.006	0.64MetTyr: 0.64 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.72AsnAla: 2.72 ± 0.018	0.842AsnCys: 0.842 ± 0.012	2.058AsnAsp: 2.058 ± 0.017	2.61AsnGlu: 2.61 ± 0.018	1.864AsnPhe: 1.864 ± 0.014	3.402AsnGly: 3.402 ± 0.023	1.121AsnHis: 1.121 ± 0.012	2.455AsnIle: 2.455 ± 0.02	2.442AsnLys: 2.442 ± 0.015	4.502AsnLeu: 4.502 ± 0.029	1.174AsnMet: 1.174 ± 0.012	2.203AsnAsn: 2.203 ± 0.019	2.38AsnPro: 2.38 ± 0.017	1.758AsnGln: 1.758 ± 0.016	2.063AsnArg: 2.063 ± 0.016	3.914AsnSer: 3.914 ± 0.021	1.946AsnThr: 1.946 ± 0.015	2.793AsnVal: 2.793 ± 0.016	0.586AsnTrp: 0.586 ± 0.009	1.276AsnTyr: 1.276 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	3.006ProAla: 3.006 ± 0.022	1.056ProCys: 1.056 ± 0.013	2.435ProAsp: 2.435 ± 0.017	3.085ProGlu: 3.085 ± 0.022	2.065ProPhe: 2.065 ± 0.019	2.77ProGly: 2.77 ± 0.022	1.135ProHis: 1.135 ± 0.012	2.363ProIle: 2.363 ± 0.017	2.892ProLys: 2.892 ± 0.025	4.363ProLeu: 4.363 ± 0.026	1.164ProMet: 1.164 ± 0.012	2.257ProAsn: 2.257 ± 0.018	3.613ProPro: 3.613 ± 0.042	1.837ProGln: 1.837 ± 0.017	2.52ProArg: 2.52 ± 0.016	5.115ProSer: 5.115 ± 0.033	2.614ProThr: 2.614 ± 0.018	3.166ProVal: 3.166 ± 0.023	0.612ProTrp: 0.612 ± 0.008	1.37ProTyr: 1.37 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.562GlnAla: 2.562 ± 0.018	0.652GlnCys: 0.652 ± 0.009	1.647GlnAsp: 1.647 ± 0.015	2.34GlnGlu: 2.34 ± 0.02	1.413GlnPhe: 1.413 ± 0.013	2.168GlnGly: 2.168 ± 0.015	1.013GlnHis: 1.013 ± 0.011	2.072GlnIle: 2.072 ± 0.016	2.371GlnLys: 2.371 ± 0.017	3.7GlnLeu: 3.7 ± 0.021	1.034GlnMet: 1.034 ± 0.011	1.795GlnAsn: 1.795 ± 0.015	1.831GlnPro: 1.831 ± 0.018	2.204GlnGln: 2.204 ± 0.028	2.17GlnArg: 2.17 ± 0.018	3.001GlnSer: 3.001 ± 0.021	1.851GlnThr: 1.851 ± 0.016	2.395GlnVal: 2.395 ± 0.017	0.5GlnTrp: 0.5 ± 0.007	0.991GlnTyr: 0.991 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	3.357ArgAla: 3.357 ± 0.022	1.028ArgCys: 1.028 ± 0.011	2.61ArgAsp: 2.61 ± 0.021	3.322ArgGlu: 3.322 ± 0.024	2.204ArgPhe: 2.204 ± 0.018	3.137ArgGly: 3.137 ± 0.026	1.432ArgHis: 1.432 ± 0.012	2.884ArgIle: 2.884 ± 0.017	3.852ArgLys: 3.852 ± 0.024	4.984ArgLeu: 4.984 ± 0.029	1.338ArgMet: 1.338 ± 0.015	2.449ArgAsn: 2.449 ± 0.014	2.579ArgPro: 2.579 ± 0.018	1.931ArgGln: 1.931 ± 0.014	3.8ArgArg: 3.8 ± 0.029	4.379ArgSer: 4.379 ± 0.028	2.542ArgThr: 2.542 ± 0.017	3.42ArgVal: 3.42 ± 0.018	0.696ArgTrp: 0.696 ± 0.008	1.519ArgTyr: 1.519 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	5.304SerAla: 5.304 ± 0.029	1.719SerCys: 1.719 ± 0.016	4.381SerAsp: 4.381 ± 0.024	4.841SerGlu: 4.841 ± 0.028	3.942SerPhe: 3.942 ± 0.022	5.975SerGly: 5.975 ± 0.034	2.167SerHis: 2.167 ± 0.016	4.611SerIle: 4.611 ± 0.024	5.189SerLys: 5.189 ± 0.029	8.537SerLeu: 8.537 ± 0.04	2.299SerMet: 2.299 ± 0.016	4.155SerAsn: 4.155 ± 0.025	4.587SerPro: 4.587 ± 0.031	3.276SerGln: 3.276 ± 0.019	4.596SerArg: 4.596 ± 0.022	11.022SerSer: 11.022 ± 0.066	4.76SerThr: 4.76 ± 0.027	5.255SerVal: 5.255 ± 0.03	1.09SerTrp: 1.09 ± 0.01	2.512SerTyr: 2.512 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	3.465ThrAla: 3.465 ± 0.02	1.019ThrCys: 1.019 ± 0.01	2.283ThrAsp: 2.283 ± 0.016	2.794ThrGlu: 2.794 ± 0.02	1.959ThrPhe: 1.959 ± 0.017	3.405ThrGly: 3.405 ± 0.021	1.088ThrHis: 1.088 ± 0.013	2.724ThrIle: 2.724 ± 0.02	2.737ThrLys: 2.737 ± 0.016	4.623ThrLeu: 4.623 ± 0.024	1.353ThrMet: 1.353 ± 0.013	2.029ThrAsn: 2.029 ± 0.015	2.584ThrPro: 2.584 ± 0.02	1.591ThrGln: 1.591 ± 0.013	2.517ThrArg: 2.517 ± 0.018	4.718ThrSer: 4.718 ± 0.027	2.889ThrThr: 2.889 ± 0.023	3.396ThrVal: 3.396 ± 0.02	0.75ThrTrp: 0.75 ± 0.01	1.477ThrTyr: 1.477 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	4.766ValAla: 4.766 ± 0.024	1.165ValCys: 1.165 ± 0.012	3.624ValAsp: 3.624 ± 0.021	4.369ValGlu: 4.369 ± 0.025	2.57ValPhe: 2.57 ± 0.017	4.051ValGly: 4.051 ± 0.025	1.488ValHis: 1.488 ± 0.012	3.387ValIle: 3.387 ± 0.022	3.886ValLys: 3.886 ± 0.021	6.181ValLeu: 6.181 ± 0.029	1.674ValMet: 1.674 ± 0.013	2.664ValAsn: 2.664 ± 0.017	3.343ValPro: 3.343 ± 0.024	2.322ValGln: 2.322 ± 0.019	3.222ValArg: 3.222 ± 0.02	5.545ValSer: 5.545 ± 0.026	3.186ValThr: 3.186 ± 0.018	4.638ValVal: 4.638 ± 0.028	0.775ValTrp: 0.775 ± 0.01	1.861ValTyr: 1.861 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.752TrpAla: 0.752 ± 0.009	0.232TrpCys: 0.232 ± 0.005	0.727TrpAsp: 0.727 ± 0.009	0.735TrpGlu: 0.735 ± 0.009	0.548TrpPhe: 0.548 ± 0.009	0.724TrpGly: 0.724 ± 0.011	0.42TrpHis: 0.42 ± 0.009	0.686TrpIle: 0.686 ± 0.009	0.895TrpLys: 0.895 ± 0.012	1.233TrpLeu: 1.233 ± 0.014	0.343TrpMet: 0.343 ± 0.006	0.63TrpAsn: 0.63 ± 0.01	0.569TrpPro: 0.569 ± 0.008	0.473TrpGln: 0.473 ± 0.009	0.814TrpArg: 0.814 ± 0.01	1.064TrpSer: 1.064 ± 0.01	0.617TrpThr: 0.617 ± 0.008	0.774TrpVal: 0.774 ± 0.01	0.246TrpTrp: 0.246 ± 0.006	0.364TrpTyr: 0.364 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.649TyrAla: 1.649 ± 0.014	0.616TyrCys: 0.616 ± 0.009	1.509TyrAsp: 1.509 ± 0.014	1.631TyrGlu: 1.631 ± 0.016	1.284TyrPhe: 1.284 ± 0.013	2.133TyrGly: 2.133 ± 0.018	0.758TyrHis: 0.758 ± 0.008	1.525TyrIle: 1.525 ± 0.014	1.546TyrLys: 1.546 ± 0.015	2.773TyrLeu: 2.773 ± 0.017	0.873TyrMet: 0.873 ± 0.011	1.278TyrAsn: 1.278 ± 0.013	1.321TyrPro: 1.321 ± 0.014	0.992TyrGln: 0.992 ± 0.01	1.564TyrArg: 1.564 ± 0.015	2.282TyrSer: 2.282 ± 0.017	1.416TyrThr: 1.416 ± 0.014	1.817TyrVal: 1.817 ± 0.015	0.396TyrTrp: 0.396 ± 0.006	0.966TyrTyr: 0.966 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 31431 proteins (9014226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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