Amino acid dipepetide frequency for Salinarimonas sp. BN140002

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.721AlaAla: 20.721 ± 0.193	1.259AlaCys: 1.259 ± 0.028	6.983AlaAsp: 6.983 ± 0.079	8.161AlaGlu: 8.161 ± 0.09	4.973AlaPhe: 4.973 ± 0.047	12.906AlaGly: 12.906 ± 0.103	2.387AlaHis: 2.387 ± 0.046	5.986AlaIle: 5.986 ± 0.072	3.175AlaLys: 3.175 ± 0.059	15.817AlaLeu: 15.817 ± 0.144	3.606AlaMet: 3.606 ± 0.05	2.477AlaAsn: 2.477 ± 0.04	7.271AlaPro: 7.271 ± 0.097	3.848AlaGln: 3.848 ± 0.059	11.631AlaArg: 11.631 ± 0.105	6.4AlaSer: 6.4 ± 0.073	6.164AlaThr: 6.164 ± 0.067	10.391AlaVal: 10.391 ± 0.095	1.808AlaTrp: 1.808 ± 0.041	2.706AlaTyr: 2.706 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.995CysAla: 0.995 ± 0.026	0.089CysCys: 0.089 ± 0.008	0.472CysAsp: 0.472 ± 0.019	0.425CysGlu: 0.425 ± 0.019	0.267CysPhe: 0.267 ± 0.016	0.862CysGly: 0.862 ± 0.026	0.193CysHis: 0.193 ± 0.012	0.317CysIle: 0.317 ± 0.015	0.122CysLys: 0.122 ± 0.01	0.836CysLeu: 0.836 ± 0.025	0.137CysMet: 0.137 ± 0.009	0.163CysAsn: 0.163 ± 0.01	0.439CysPro: 0.439 ± 0.017	0.173CysGln: 0.173 ± 0.011	0.708CysArg: 0.708 ± 0.022	0.365CysSer: 0.365 ± 0.016	0.384CysThr: 0.384 ± 0.017	0.585CysVal: 0.585 ± 0.023	0.096CysTrp: 0.096 ± 0.008	0.151CysTyr: 0.151 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.366AspAla: 7.366 ± 0.083	0.399AspCys: 0.399 ± 0.018	2.856AspAsp: 2.856 ± 0.05	3.796AspGlu: 3.796 ± 0.053	1.699AspPhe: 1.699 ± 0.034	5.284AspGly: 5.284 ± 0.073	1.11AspHis: 1.11 ± 0.025	2.347AspIle: 2.347 ± 0.045	1.189AspLys: 1.189 ± 0.036	6.374AspLeu: 6.374 ± 0.075	1.1AspMet: 1.1 ± 0.027	0.914AspAsn: 0.914 ± 0.025	4.006AspPro: 4.006 ± 0.059	1.339AspGln: 1.339 ± 0.03	4.789AspArg: 4.789 ± 0.058	1.482AspSer: 1.482 ± 0.032	2.263AspThr: 2.263 ± 0.038	4.298AspVal: 4.298 ± 0.058	0.846AspTrp: 0.846 ± 0.025	1.212AspTyr: 1.212 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	9.23GluAla: 9.23 ± 0.101	0.321GluCys: 0.321 ± 0.015	2.548GluAsp: 2.548 ± 0.044	3.07GluGlu: 3.07 ± 0.055	1.409GluPhe: 1.409 ± 0.029	5.127GluGly: 5.127 ± 0.055	1.113GluHis: 1.113 ± 0.03	3.254GluIle: 3.254 ± 0.054	1.378GluLys: 1.378 ± 0.037	4.995GluLeu: 4.995 ± 0.066	1.317GluMet: 1.317 ± 0.029	1.199GluAsn: 1.199 ± 0.031	3.348GluPro: 3.348 ± 0.053	1.51GluGln: 1.51 ± 0.032	6.883GluArg: 6.883 ± 0.09	2.202GluSer: 2.202 ± 0.037	3.455GluThr: 3.455 ± 0.045	4.164GluVal: 4.164 ± 0.07	0.601GluTrp: 0.601 ± 0.02	0.75GluTyr: 0.75 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.488PheAla: 4.488 ± 0.064	0.349PheCys: 0.349 ± 0.015	2.262PheAsp: 2.262 ± 0.041	2.071PheGlu: 2.071 ± 0.036	1.188PhePhe: 1.188 ± 0.029	3.524PheGly: 3.524 ± 0.05	0.627PheHis: 0.627 ± 0.022	1.276PheIle: 1.276 ± 0.027	0.817PheLys: 0.817 ± 0.024	3.225PheLeu: 3.225 ± 0.057	0.719PheMet: 0.719 ± 0.021	0.801PheAsn: 0.801 ± 0.022	1.528PhePro: 1.528 ± 0.031	0.928PheGln: 0.928 ± 0.025	2.466PheArg: 2.466 ± 0.045	1.687PheSer: 1.687 ± 0.032	1.822PheThr: 1.822 ± 0.04	2.912PheVal: 2.912 ± 0.046	0.48PheTrp: 0.48 ± 0.019	0.764PheTyr: 0.764 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.511GlyAla: 11.511 ± 0.105	0.848GlyCys: 0.848 ± 0.023	4.509GlyAsp: 4.509 ± 0.056	5.417GlyGlu: 5.417 ± 0.074	3.729GlyPhe: 3.729 ± 0.054	8.32GlyGly: 8.32 ± 0.102	1.911GlyHis: 1.911 ± 0.037	4.187GlyIle: 4.187 ± 0.06	2.218GlyLys: 2.218 ± 0.047	10.392GlyLeu: 10.392 ± 0.099	2.125GlyMet: 2.125 ± 0.034	1.708GlyAsn: 1.708 ± 0.037	4.439GlyPro: 4.439 ± 0.054	2.73GlyGln: 2.73 ± 0.047	8.013GlyArg: 8.013 ± 0.082	4.588GlySer: 4.588 ± 0.056	4.943GlyThr: 4.943 ± 0.061	6.855GlyVal: 6.855 ± 0.064	1.347GlyTrp: 1.347 ± 0.03	2.119GlyTyr: 2.119 ± 0.037	0.001GlyXaa: 0.001 ± 0.001
His	2.563HisAla: 2.563 ± 0.045	0.188HisCys: 0.188 ± 0.012	1.143HisAsp: 1.143 ± 0.029	1.1HisGlu: 1.1 ± 0.03	0.67HisPhe: 0.67 ± 0.019	2.008HisGly: 2.008 ± 0.041	0.506HisHis: 0.506 ± 0.023	0.69HisIle: 0.69 ± 0.022	0.328HisLys: 0.328 ± 0.016	2.074HisLeu: 2.074 ± 0.038	0.409HisMet: 0.409 ± 0.017	0.359HisAsn: 0.359 ± 0.015	1.451HisPro: 1.451 ± 0.033	0.472HisGln: 0.472 ± 0.017	1.636HisArg: 1.636 ± 0.038	0.665HisSer: 0.665 ± 0.021	0.715HisThr: 0.715 ± 0.022	1.591HisVal: 1.591 ± 0.034	0.302HisTrp: 0.302 ± 0.014	0.422HisTyr: 0.422 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.582IleAla: 6.582 ± 0.072	0.376IleCys: 0.376 ± 0.016	2.913IleAsp: 2.913 ± 0.042	3.162IleGlu: 3.162 ± 0.046	1.296IlePhe: 1.296 ± 0.03	4.46IleGly: 4.46 ± 0.062	0.804IleHis: 0.804 ± 0.022	1.452IleIle: 1.452 ± 0.039	1.016IleLys: 1.016 ± 0.028	4.276IleLeu: 4.276 ± 0.056	0.769IleMet: 0.769 ± 0.024	0.935IleAsn: 0.935 ± 0.027	2.248IlePro: 2.248 ± 0.039	1.061IleGln: 1.061 ± 0.029	3.208IleArg: 3.208 ± 0.048	1.84IleSer: 1.84 ± 0.037	2.185IleThr: 2.185 ± 0.043	4.099IleVal: 4.099 ± 0.064	0.475IleTrp: 0.475 ± 0.019	0.884IleTyr: 0.884 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.528LysAla: 3.528 ± 0.056	0.115LysCys: 0.115 ± 0.009	1.213LysAsp: 1.213 ± 0.035	1.199LysGlu: 1.199 ± 0.037	0.543LysPhe: 0.543 ± 0.02	2.198LysGly: 2.198 ± 0.041	0.394LysHis: 0.394 ± 0.015	1.108LysIle: 1.108 ± 0.03	0.746LysLys: 0.746 ± 0.028	2.188LysLeu: 2.188 ± 0.035	0.475LysMet: 0.475 ± 0.021	0.581LysAsn: 0.581 ± 0.022	1.791LysPro: 1.791 ± 0.035	0.603LysGln: 0.603 ± 0.025	2.078LysArg: 2.078 ± 0.041	1.202LysSer: 1.202 ± 0.031	1.415LysThr: 1.415 ± 0.035	1.826LysVal: 1.826 ± 0.042	0.227LysTrp: 0.227 ± 0.012	0.399LysTyr: 0.399 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	16.24LeuAla: 16.24 ± 0.132	0.832LeuCys: 0.832 ± 0.026	6.595LeuAsp: 6.595 ± 0.067	5.212LeuGlu: 5.212 ± 0.059	3.32LeuPhe: 3.32 ± 0.052	9.091LeuGly: 9.091 ± 0.092	1.871LeuHis: 1.871 ± 0.034	4.028LeuIle: 4.028 ± 0.061	2.929LeuLys: 2.929 ± 0.05	9.57LeuLeu: 9.57 ± 0.095	2.225LeuMet: 2.225 ± 0.04	2.094LeuAsn: 2.094 ± 0.041	5.881LeuPro: 5.881 ± 0.067	2.636LeuGln: 2.636 ± 0.045	8.12LeuArg: 8.12 ± 0.081	5.946LeuSer: 5.946 ± 0.065	5.454LeuThr: 5.454 ± 0.061	9.212LeuVal: 9.212 ± 0.104	1.244LeuTrp: 1.244 ± 0.03	1.927LeuTyr: 1.927 ± 0.035	0.001LeuXaa: 0.001 ± 0.001
Met	2.874MetAla: 2.874 ± 0.042	0.126MetCys: 0.126 ± 0.009	0.983MetAsp: 0.983 ± 0.025	0.981MetGlu: 0.981 ± 0.025	0.566MetPhe: 0.566 ± 0.018	1.845MetGly: 1.845 ± 0.037	0.359MetHis: 0.359 ± 0.016	1.092MetIle: 1.092 ± 0.027	0.695MetLys: 0.695 ± 0.021	2.143MetLeu: 2.143 ± 0.036	0.497MetMet: 0.497 ± 0.021	0.666MetAsn: 0.666 ± 0.021	1.611MetPro: 1.611 ± 0.035	0.643MetGln: 0.643 ± 0.018	2.019MetArg: 2.019 ± 0.034	1.487MetSer: 1.487 ± 0.031	1.676MetThr: 1.676 ± 0.035	1.503MetVal: 1.503 ± 0.033	0.174MetTrp: 0.174 ± 0.013	0.249MetTyr: 0.249 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.71AsnAla: 2.71 ± 0.043	0.15AsnCys: 0.15 ± 0.009	1.04AsnAsp: 1.04 ± 0.024	1.042AsnGlu: 1.042 ± 0.024	0.637AsnPhe: 0.637 ± 0.022	1.918AsnGly: 1.918 ± 0.034	0.399AsnHis: 0.399 ± 0.017	0.877AsnIle: 0.877 ± 0.026	0.484AsnLys: 0.484 ± 0.021	2.282AsnLeu: 2.282 ± 0.044	0.428AsnMet: 0.428 ± 0.018	0.527AsnAsn: 0.527 ± 0.021	1.659AsnPro: 1.659 ± 0.034	0.586AsnGln: 0.586 ± 0.02	1.689AsnArg: 1.689 ± 0.033	0.788AsnSer: 0.788 ± 0.028	0.962AsnThr: 0.962 ± 0.029	1.77AsnVal: 1.77 ± 0.037	0.262AsnTrp: 0.262 ± 0.015	0.455AsnTyr: 0.455 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.248ProAla: 8.248 ± 0.101	0.342ProCys: 0.342 ± 0.017	3.985ProAsp: 3.985 ± 0.056	4.034ProGlu: 4.034 ± 0.053	2.099ProPhe: 2.099 ± 0.038	5.793ProGly: 5.793 ± 0.063	1.181ProHis: 1.181 ± 0.03	2.199ProIle: 2.199 ± 0.038	1.45ProLys: 1.45 ± 0.032	5.361ProLeu: 5.361 ± 0.06	1.268ProMet: 1.268 ± 0.032	1.208ProAsn: 1.208 ± 0.03	3.496ProPro: 3.496 ± 0.08	1.534ProGln: 1.534 ± 0.036	4.003ProArg: 4.003 ± 0.057	2.904ProSer: 2.904 ± 0.051	2.647ProThr: 2.647 ± 0.045	4.944ProVal: 4.944 ± 0.063	0.735ProTrp: 0.735 ± 0.023	1.148ProTyr: 1.148 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	4.306GlnAla: 4.306 ± 0.059	0.158GlnCys: 0.158 ± 0.011	1.219GlnAsp: 1.219 ± 0.033	1.344GlnGlu: 1.344 ± 0.031	0.749GlnPhe: 0.749 ± 0.021	2.505GlnGly: 2.505 ± 0.045	0.454GlnHis: 0.454 ± 0.016	1.421GlnIle: 1.421 ± 0.033	0.699GlnLys: 0.699 ± 0.024	2.212GlnLeu: 2.212 ± 0.044	0.631GlnMet: 0.631 ± 0.021	0.629GlnAsn: 0.629 ± 0.024	1.615GlnPro: 1.615 ± 0.036	0.862GlnGln: 0.862 ± 0.039	2.333GlnArg: 2.333 ± 0.046	1.295GlnSer: 1.295 ± 0.031	1.481GlnThr: 1.481 ± 0.034	2.156GlnVal: 2.156 ± 0.042	0.284GlnTrp: 0.284 ± 0.013	0.458GlnTyr: 0.458 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.769ArgAla: 10.769 ± 0.11	0.583ArgCys: 0.583 ± 0.02	4.69ArgAsp: 4.69 ± 0.064	5.178ArgGlu: 5.178 ± 0.066	3.314ArgPhe: 3.314 ± 0.055	6.469ArgGly: 6.469 ± 0.073	1.906ArgHis: 1.906 ± 0.037	4.281ArgIle: 4.281 ± 0.053	1.779ArgLys: 1.779 ± 0.038	9.767ArgLeu: 9.767 ± 0.099	1.986ArgMet: 1.986 ± 0.033	1.652ArgAsn: 1.652 ± 0.033	4.994ArgPro: 4.994 ± 0.073	2.407ArgGln: 2.407 ± 0.046	8.125ArgArg: 8.125 ± 0.102	3.882ArgSer: 3.882 ± 0.058	4.15ArgThr: 4.15 ± 0.061	6.244ArgVal: 6.244 ± 0.073	1.107ArgTrp: 1.107 ± 0.031	1.651ArgTyr: 1.651 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.656SerAla: 5.656 ± 0.067	0.333SerCys: 0.333 ± 0.014	2.441SerAsp: 2.441 ± 0.041	2.346SerGlu: 2.346 ± 0.046	1.877SerPhe: 1.877 ± 0.031	5.017SerGly: 5.017 ± 0.069	0.977SerHis: 0.977 ± 0.027	2.146SerIle: 2.146 ± 0.043	1.066SerLys: 1.066 ± 0.029	5.202SerLeu: 5.202 ± 0.063	1.071SerMet: 1.071 ± 0.024	1.006SerAsn: 1.006 ± 0.026	3.13SerPro: 3.13 ± 0.047	1.249SerGln: 1.249 ± 0.026	3.862SerArg: 3.862 ± 0.054	2.266SerSer: 2.266 ± 0.047	2.378SerThr: 2.378 ± 0.046	3.547SerVal: 3.547 ± 0.049	0.637SerTrp: 0.637 ± 0.023	1.076SerTyr: 1.076 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.259ThrAla: 6.259 ± 0.074	0.388ThrCys: 0.388 ± 0.018	2.526ThrAsp: 2.526 ± 0.043	2.329ThrGlu: 2.329 ± 0.045	1.849ThrPhe: 1.849 ± 0.037	5.353ThrGly: 5.353 ± 0.064	0.956ThrHis: 0.956 ± 0.027	2.589ThrIle: 2.589 ± 0.044	1.128ThrLys: 1.128 ± 0.026	5.886ThrLeu: 5.886 ± 0.06	1.053ThrMet: 1.053 ± 0.028	1.103ThrAsn: 1.103 ± 0.028	3.51ThrPro: 3.51 ± 0.048	1.249ThrGln: 1.249 ± 0.033	3.889ThrArg: 3.889 ± 0.055	2.421ThrSer: 2.421 ± 0.039	2.624ThrThr: 2.624 ± 0.042	4.218ThrVal: 4.218 ± 0.062	0.687ThrTrp: 0.687 ± 0.024	1.128ThrTyr: 1.128 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.861ValAla: 10.861 ± 0.101	0.6ValCys: 0.6 ± 0.02	4.404ValAsp: 4.404 ± 0.065	5.259ValGlu: 5.259 ± 0.065	2.53ValPhe: 2.53 ± 0.045	6.309ValGly: 6.309 ± 0.078	1.462ValHis: 1.462 ± 0.034	3.516ValIle: 3.516 ± 0.058	1.857ValLys: 1.857 ± 0.04	8.255ValLeu: 8.255 ± 0.075	1.748ValMet: 1.748 ± 0.036	1.845ValAsn: 1.845 ± 0.035	4.398ValPro: 4.398 ± 0.05	2.036ValGln: 2.036 ± 0.041	6.268ValArg: 6.268 ± 0.073	4.201ValSer: 4.201 ± 0.054	4.678ValThr: 4.678 ± 0.059	6.931ValVal: 6.931 ± 0.078	0.897ValTrp: 0.897 ± 0.024	1.473ValTyr: 1.473 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.28TrpAla: 1.28 ± 0.029	0.139TrpCys: 0.139 ± 0.009	0.62TrpAsp: 0.62 ± 0.024	0.556TrpGlu: 0.556 ± 0.019	0.507TrpPhe: 0.507 ± 0.021	0.915TrpGly: 0.915 ± 0.026	0.271TrpHis: 0.271 ± 0.012	0.637TrpIle: 0.637 ± 0.021	0.285TrpLys: 0.285 ± 0.017	1.556TrpLeu: 1.556 ± 0.039	0.281TrpMet: 0.281 ± 0.012	0.333TrpAsn: 0.333 ± 0.015	0.723TrpPro: 0.723 ± 0.024	0.4TrpGln: 0.4 ± 0.016	1.387TrpArg: 1.387 ± 0.031	0.81TrpSer: 0.81 ± 0.026	0.831TrpThr: 0.831 ± 0.026	0.738TrpVal: 0.738 ± 0.021	0.232TrpTrp: 0.232 ± 0.014	0.253TrpTyr: 0.253 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.044	0.183TyrCys: 0.183 ± 0.011	1.268TyrAsp: 1.268 ± 0.031	1.191TyrGlu: 1.191 ± 0.03	0.71TyrPhe: 0.71 ± 0.021	2.006TyrGly: 2.006 ± 0.038	0.408TyrHis: 0.408 ± 0.019	0.639TyrIle: 0.639 ± 0.024	0.471TyrLys: 0.471 ± 0.02	2.017TyrLeu: 2.017 ± 0.039	0.344TyrMet: 0.344 ± 0.016	0.463TyrAsn: 0.463 ± 0.019	1.044TyrPro: 1.044 ± 0.027	0.545TyrGln: 0.545 ± 0.02	1.826TyrArg: 1.826 ± 0.036	0.854TyrSer: 0.854 ± 0.026	0.918TyrThr: 0.918 ± 0.024	1.543TyrVal: 1.543 ± 0.031	0.311TyrTrp: 0.311 ± 0.014	0.461TyrTyr: 0.461 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 5046 proteins (1511247 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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