Amino acid dipepetide frequency for Penicillium expansum (Blue mold rot fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.447AlaAla: 8.447 ± 0.056	1.034AlaCys: 1.034 ± 0.015	4.204AlaAsp: 4.204 ± 0.035	4.995AlaGlu: 4.995 ± 0.05	3.193AlaPhe: 3.193 ± 0.03	5.655AlaGly: 5.655 ± 0.037	1.802AlaHis: 1.802 ± 0.02	4.527AlaIle: 4.527 ± 0.033	3.831AlaLys: 3.831 ± 0.032	7.753AlaLeu: 7.753 ± 0.043	2.029AlaMet: 2.029 ± 0.019	2.947AlaAsn: 2.947 ± 0.024	4.622AlaPro: 4.622 ± 0.043	3.395AlaGln: 3.395 ± 0.03	4.623AlaArg: 4.623 ± 0.033	7.079AlaSer: 7.079 ± 0.043	5.23AlaThr: 5.23 ± 0.031	5.326AlaVal: 5.326 ± 0.038	1.156AlaTrp: 1.156 ± 0.018	2.184AlaTyr: 2.184 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.953CysAla: 0.953 ± 0.014	0.218CysCys: 0.218 ± 0.007	0.646CysAsp: 0.646 ± 0.011	0.588CysGlu: 0.588 ± 0.011	0.571CysPhe: 0.571 ± 0.011	0.913CysGly: 0.913 ± 0.014	0.329CysHis: 0.329 ± 0.008	0.699CysIle: 0.699 ± 0.011	0.463CysLys: 0.463 ± 0.009	1.274CysLeu: 1.274 ± 0.016	0.266CysMet: 0.266 ± 0.007	0.419CysAsn: 0.419 ± 0.009	0.617CysPro: 0.617 ± 0.012	0.451CysGln: 0.451 ± 0.01	0.681CysArg: 0.681 ± 0.013	0.872CysSer: 0.872 ± 0.013	0.663CysThr: 0.663 ± 0.013	0.813CysVal: 0.813 ± 0.014	0.196CysTrp: 0.196 ± 0.007	0.343CysTyr: 0.343 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.467AspAla: 4.467 ± 0.034	0.606AspCys: 0.606 ± 0.013	3.85AspAsp: 3.85 ± 0.039	4.254AspGlu: 4.254 ± 0.04	2.211AspPhe: 2.211 ± 0.021	3.846AspGly: 3.846 ± 0.029	1.342AspHis: 1.342 ± 0.015	3.268AspIle: 3.268 ± 0.028	2.246AspLys: 2.246 ± 0.022	5.3AspLeu: 5.3 ± 0.035	1.309AspMet: 1.309 ± 0.016	1.921AspAsn: 1.921 ± 0.022	3.384AspPro: 3.384 ± 0.027	2.045AspGln: 2.045 ± 0.021	2.996AspArg: 2.996 ± 0.025	4.261AspSer: 4.261 ± 0.031	3.092AspThr: 3.092 ± 0.026	3.57AspVal: 3.57 ± 0.024	0.911AspTrp: 0.911 ± 0.013	1.611AspTyr: 1.611 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.111GluAla: 5.111 ± 0.046	0.619GluCys: 0.619 ± 0.012	4.121GluAsp: 4.121 ± 0.038	5.216GluGlu: 5.216 ± 0.059	2.059GluPhe: 2.059 ± 0.023	3.621GluGly: 3.621 ± 0.028	1.419GluHis: 1.419 ± 0.016	3.311GluIle: 3.311 ± 0.029	3.533GluLys: 3.533 ± 0.035	5.167GluLeu: 5.167 ± 0.037	1.509GluMet: 1.509 ± 0.018	2.424GluAsn: 2.424 ± 0.023	2.821GluPro: 2.821 ± 0.05	2.469GluGln: 2.469 ± 0.028	3.685GluArg: 3.685 ± 0.033	4.456GluSer: 4.456 ± 0.034	3.698GluThr: 3.698 ± 0.035	3.483GluVal: 3.483 ± 0.031	0.901GluTrp: 0.901 ± 0.014	1.716GluTyr: 1.716 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.136PheAla: 3.136 ± 0.027	0.572PheCys: 0.572 ± 0.01	2.41PheAsp: 2.41 ± 0.025	2.205PheGlu: 2.205 ± 0.02	1.738PhePhe: 1.738 ± 0.021	2.945PheGly: 2.945 ± 0.032	0.966PheHis: 0.966 ± 0.014	1.986PheIle: 1.986 ± 0.025	1.499PheLys: 1.499 ± 0.018	3.612PheLeu: 3.612 ± 0.029	0.884PheMet: 0.884 ± 0.013	1.541PheAsn: 1.541 ± 0.015	2.035PhePro: 2.035 ± 0.018	1.497PheGln: 1.497 ± 0.018	1.956PheArg: 1.956 ± 0.019	3.084PheSer: 3.084 ± 0.026	2.233PheThr: 2.233 ± 0.022	2.467PheVal: 2.467 ± 0.025	0.674PheTrp: 0.674 ± 0.011	1.179PheTyr: 1.179 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.275GlyAla: 5.275 ± 0.037	0.868GlyCys: 0.868 ± 0.014	3.546GlyAsp: 3.546 ± 0.029	3.517GlyGlu: 3.517 ± 0.025	2.94GlyPhe: 2.94 ± 0.024	5.369GlyGly: 5.369 ± 0.056	1.703GlyHis: 1.703 ± 0.02	3.728GlyIle: 3.728 ± 0.028	3.258GlyLys: 3.258 ± 0.027	6.24GlyLeu: 6.24 ± 0.043	1.615GlyMet: 1.615 ± 0.019	2.589GlyAsn: 2.589 ± 0.026	3.37GlyPro: 3.37 ± 0.031	2.535GlyGln: 2.535 ± 0.026	3.827GlyArg: 3.827 ± 0.032	5.734GlySer: 5.734 ± 0.035	3.95GlyThr: 3.95 ± 0.031	4.417GlyVal: 4.417 ± 0.032	1.183GlyTrp: 1.183 ± 0.016	2.179GlyTyr: 2.179 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.842HisAla: 1.842 ± 0.022	0.321HisCys: 0.321 ± 0.008	1.339HisAsp: 1.339 ± 0.017	1.382HisGlu: 1.382 ± 0.017	0.958HisPhe: 0.958 ± 0.012	1.732HisGly: 1.732 ± 0.019	0.82HisHis: 0.82 ± 0.015	1.302HisIle: 1.302 ± 0.017	0.897HisLys: 0.897 ± 0.012	2.28HisLeu: 2.28 ± 0.023	0.523HisMet: 0.523 ± 0.01	0.901HisAsn: 0.901 ± 0.014	1.657HisPro: 1.657 ± 0.019	1.005HisGln: 1.005 ± 0.015	1.537HisArg: 1.537 ± 0.019	1.902HisSer: 1.902 ± 0.02	1.333HisThr: 1.333 ± 0.016	1.458HisVal: 1.458 ± 0.018	0.359HisTrp: 0.359 ± 0.008	0.698HisTyr: 0.698 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.462IleAla: 4.462 ± 0.029	0.809IleCys: 0.809 ± 0.014	2.998IleAsp: 2.998 ± 0.023	3.071IleGlu: 3.071 ± 0.026	2.209IlePhe: 2.209 ± 0.023	3.491IleGly: 3.491 ± 0.031	1.299IleHis: 1.299 ± 0.016	2.784IleIle: 2.784 ± 0.028	2.212IleLys: 2.212 ± 0.023	4.858IleLeu: 4.858 ± 0.035	1.135IleMet: 1.135 ± 0.014	1.913IleAsn: 1.913 ± 0.02	3.335IlePro: 3.335 ± 0.024	2.085IleGln: 2.085 ± 0.019	2.798IleArg: 2.798 ± 0.026	4.236IleSer: 4.236 ± 0.027	2.992IleThr: 2.992 ± 0.021	3.334IleVal: 3.334 ± 0.027	0.77IleTrp: 0.77 ± 0.012	1.526IleTyr: 1.526 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.944LysAla: 3.944 ± 0.035	0.47LysCys: 0.47 ± 0.01	2.655LysAsp: 2.655 ± 0.027	3.214LysGlu: 3.214 ± 0.035	1.508LysPhe: 1.508 ± 0.018	2.834LysGly: 2.834 ± 0.025	1.074LysHis: 1.074 ± 0.015	2.312LysIle: 2.312 ± 0.023	3.007LysLys: 3.007 ± 0.043	3.965LysLeu: 3.965 ± 0.03	1.002LysMet: 1.002 ± 0.014	1.793LysAsn: 1.793 ± 0.017	2.592LysPro: 2.592 ± 0.027	1.82LysGln: 1.82 ± 0.022	3.084LysArg: 3.084 ± 0.028	3.551LysSer: 3.551 ± 0.029	2.765LysThr: 2.765 ± 0.023	2.734LysVal: 2.734 ± 0.02	0.672LysTrp: 0.672 ± 0.01	1.355LysTyr: 1.355 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.853LeuAla: 7.853 ± 0.047	1.222LeuCys: 1.222 ± 0.017	5.307LeuAsp: 5.307 ± 0.036	5.548LeuGlu: 5.548 ± 0.041	3.486LeuPhe: 3.486 ± 0.031	6.146LeuGly: 6.146 ± 0.041	2.285LeuHis: 2.285 ± 0.024	4.236LeuIle: 4.236 ± 0.033	4.088LeuLys: 4.088 ± 0.031	8.5LeuLeu: 8.5 ± 0.061	1.899LeuMet: 1.899 ± 0.02	3.335LeuAsn: 3.335 ± 0.024	5.447LeuPro: 5.447 ± 0.036	3.931LeuGln: 3.931 ± 0.04	5.607LeuArg: 5.607 ± 0.034	7.501LeuSer: 7.501 ± 0.038	4.867LeuThr: 4.867 ± 0.032	5.583LeuVal: 5.583 ± 0.036	1.226LeuTrp: 1.226 ± 0.015	2.405LeuTyr: 2.405 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.211MetAla: 2.211 ± 0.019	0.262MetCys: 0.262 ± 0.007	1.302MetAsp: 1.302 ± 0.015	1.334MetGlu: 1.334 ± 0.018	0.815MetPhe: 0.815 ± 0.012	1.587MetGly: 1.587 ± 0.019	0.512MetHis: 0.512 ± 0.01	1.131MetIle: 1.131 ± 0.016	1.009MetLys: 1.009 ± 0.016	1.931MetLeu: 1.931 ± 0.02	0.606MetMet: 0.606 ± 0.011	0.865MetAsn: 0.865 ± 0.013	1.262MetPro: 1.262 ± 0.015	0.911MetGln: 0.911 ± 0.014	1.246MetArg: 1.246 ± 0.014	1.934MetSer: 1.934 ± 0.02	1.378MetThr: 1.378 ± 0.017	1.393MetVal: 1.393 ± 0.015	0.275MetTrp: 0.275 ± 0.007	0.531MetTyr: 0.531 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.165AsnAla: 3.165 ± 0.027	0.445AsnCys: 0.445 ± 0.01	1.975AsnAsp: 1.975 ± 0.02	2.124AsnGlu: 2.124 ± 0.022	1.465AsnPhe: 1.465 ± 0.017	2.899AsnGly: 2.899 ± 0.029	0.881AsnHis: 0.881 ± 0.014	2.219AsnIle: 2.219 ± 0.02	1.564AsnLys: 1.564 ± 0.02	3.383AsnLeu: 3.383 ± 0.023	0.919AsnMet: 0.919 ± 0.013	1.483AsnAsn: 1.483 ± 0.017	2.625AsnPro: 2.625 ± 0.03	1.429AsnGln: 1.429 ± 0.019	1.932AsnArg: 1.932 ± 0.018	2.857AsnSer: 2.857 ± 0.025	2.316AsnThr: 2.316 ± 0.022	2.38AsnVal: 2.38 ± 0.022	0.605AsnTrp: 0.605 ± 0.011	1.103AsnTyr: 1.103 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.047ProAla: 5.047 ± 0.046	0.507ProCys: 0.507 ± 0.012	3.168ProAsp: 3.168 ± 0.028	3.952ProGlu: 3.952 ± 0.05	2.148ProPhe: 2.148 ± 0.021	3.817ProGly: 3.817 ± 0.031	1.346ProHis: 1.346 ± 0.018	2.758ProIle: 2.758 ± 0.024	2.612ProLys: 2.612 ± 0.025	4.724ProLeu: 4.724 ± 0.031	1.149ProMet: 1.149 ± 0.018	2.269ProAsn: 2.269 ± 0.026	4.449ProPro: 4.449 ± 0.066	2.461ProGln: 2.461 ± 0.029	3.278ProArg: 3.278 ± 0.033	5.945ProSer: 5.945 ± 0.046	4.022ProThr: 4.022 ± 0.036	3.636ProVal: 3.636 ± 0.034	0.776ProTrp: 0.776 ± 0.014	1.492ProTyr: 1.492 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	3.365GlnAla: 3.365 ± 0.03	0.436GlnCys: 0.436 ± 0.009	2.074GlnAsp: 2.074 ± 0.019	2.414GlnGlu: 2.414 ± 0.022	1.398GlnPhe: 1.398 ± 0.019	2.446GlnGly: 2.446 ± 0.023	1.048GlnHis: 1.048 ± 0.016	2.072GlnIle: 2.072 ± 0.019	1.988GlnLys: 1.988 ± 0.02	3.521GlnLeu: 3.521 ± 0.029	0.948GlnMet: 0.948 ± 0.014	1.668GlnAsn: 1.668 ± 0.02	2.521GlnPro: 2.521 ± 0.027	2.157GlnGln: 2.157 ± 0.043	2.547GlnArg: 2.547 ± 0.024	3.315GlnSer: 3.315 ± 0.028	2.458GlnThr: 2.458 ± 0.021	2.244GlnVal: 2.244 ± 0.02	0.614GlnTrp: 0.614 ± 0.01	1.212GlnTyr: 1.212 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.459ArgAla: 4.459 ± 0.033	0.632ArgCys: 0.632 ± 0.011	3.242ArgAsp: 3.242 ± 0.027	3.642ArgGlu: 3.642 ± 0.033	2.149ArgPhe: 2.149 ± 0.019	3.598ArgGly: 3.598 ± 0.031	1.468ArgHis: 1.468 ± 0.019	2.917ArgIle: 2.917 ± 0.024	3.181ArgLys: 3.181 ± 0.027	5.338ArgLeu: 5.338 ± 0.036	1.258ArgMet: 1.258 ± 0.015	2.189ArgAsn: 2.189 ± 0.02	3.269ArgPro: 3.269 ± 0.033	2.476ArgGln: 2.476 ± 0.022	4.521ArgArg: 4.521 ± 0.045	4.588ArgSer: 4.588 ± 0.042	3.168ArgThr: 3.168 ± 0.025	3.36ArgVal: 3.36 ± 0.024	0.935ArgTrp: 0.935 ± 0.014	1.598ArgTyr: 1.598 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.631SerAla: 6.631 ± 0.038	0.836SerCys: 0.836 ± 0.014	4.356SerAsp: 4.356 ± 0.034	4.359SerGlu: 4.359 ± 0.033	3.145SerPhe: 3.145 ± 0.025	5.566SerGly: 5.566 ± 0.036	2.043SerHis: 2.043 ± 0.024	4.252SerIle: 4.252 ± 0.032	3.684SerLys: 3.684 ± 0.03	7.452SerLeu: 7.452 ± 0.043	1.802SerMet: 1.802 ± 0.02	3.138SerAsn: 3.138 ± 0.028	5.483SerPro: 5.483 ± 0.047	3.409SerGln: 3.409 ± 0.027	4.808SerArg: 4.808 ± 0.038	8.529SerSer: 8.529 ± 0.073	5.678SerThr: 5.678 ± 0.047	4.784SerVal: 4.784 ± 0.031	1.173SerTrp: 1.173 ± 0.016	2.108SerTyr: 2.108 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.137ThrAla: 5.137 ± 0.03	0.716ThrCys: 0.716 ± 0.013	2.997ThrAsp: 2.997 ± 0.024	3.34ThrGlu: 3.34 ± 0.031	2.262ThrPhe: 2.262 ± 0.023	4.262ThrGly: 4.262 ± 0.032	1.308ThrHis: 1.308 ± 0.019	3.257ThrIle: 3.257 ± 0.023	2.632ThrLys: 2.632 ± 0.023	5.354ThrLeu: 5.354 ± 0.035	1.255ThrMet: 1.255 ± 0.016	2.197ThrAsn: 2.197 ± 0.022	4.346ThrPro: 4.346 ± 0.037	2.226ThrGln: 2.226 ± 0.021	3.057ThrArg: 3.057 ± 0.024	5.317ThrSer: 5.317 ± 0.045	4.224ThrThr: 4.224 ± 0.045	3.855ThrVal: 3.855 ± 0.03	0.886ThrTrp: 0.886 ± 0.014	1.637ThrTyr: 1.637 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.205ValAla: 5.205 ± 0.038	0.822ValCys: 0.822 ± 0.013	3.743ValAsp: 3.743 ± 0.028	3.784ValGlu: 3.784 ± 0.037	2.598ValPhe: 2.598 ± 0.026	4.057ValGly: 4.057 ± 0.036	1.452ValHis: 1.452 ± 0.017	3.231ValIle: 3.231 ± 0.028	2.74ValLys: 2.74 ± 0.027	5.679ValLeu: 5.679 ± 0.035	1.351ValMet: 1.351 ± 0.016	2.343ValAsn: 2.343 ± 0.019	3.585ValPro: 3.585 ± 0.032	2.432ValGln: 2.432 ± 0.022	3.294ValArg: 3.294 ± 0.024	4.853ValSer: 4.853 ± 0.035	3.599ValThr: 3.599 ± 0.029	4.272ValVal: 4.272 ± 0.034	0.86ValTrp: 0.86 ± 0.013	1.741ValTyr: 1.741 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.169TrpAla: 1.169 ± 0.014	0.19TrpCys: 0.19 ± 0.006	0.916TrpAsp: 0.916 ± 0.016	0.857TrpGlu: 0.857 ± 0.013	0.534TrpPhe: 0.534 ± 0.01	0.954TrpGly: 0.954 ± 0.016	0.359TrpHis: 0.359 ± 0.009	0.827TrpIle: 0.827 ± 0.014	0.826TrpLys: 0.826 ± 0.013	1.401TrpLeu: 1.401 ± 0.018	0.39TrpMet: 0.39 ± 0.007	0.673TrpAsn: 0.673 ± 0.011	0.592TrpPro: 0.592 ± 0.012	0.567TrpGln: 0.567 ± 0.011	0.94TrpArg: 0.94 ± 0.014	1.116TrpSer: 1.116 ± 0.018	0.936TrpThr: 0.936 ± 0.014	0.928TrpVal: 0.928 ± 0.013	0.286TrpTrp: 0.286 ± 0.007	0.45TrpTyr: 0.45 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.152TyrAla: 2.152 ± 0.022	0.39TyrCys: 0.39 ± 0.009	1.64TyrAsp: 1.64 ± 0.016	1.545TyrGlu: 1.545 ± 0.019	1.233TyrPhe: 1.233 ± 0.016	2.104TyrGly: 2.104 ± 0.021	0.787TyrHis: 0.787 ± 0.013	1.501TyrIle: 1.501 ± 0.017	1.082TyrLys: 1.082 ± 0.016	2.739TyrLeu: 2.739 ± 0.024	0.645TyrMet: 0.645 ± 0.011	1.162TyrAsn: 1.162 ± 0.016	1.545TyrPro: 1.545 ± 0.016	1.145TyrGln: 1.145 ± 0.014	1.573TyrArg: 1.573 ± 0.018	2.102TyrSer: 2.102 ± 0.019	1.661TyrThr: 1.661 ± 0.019	1.607TyrVal: 1.607 ± 0.019	0.455TyrTrp: 0.455 ± 0.009	0.946TyrTyr: 0.946 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11060 proteins (5559105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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