Amino acid dipepetide frequency for Halovirus HCTV-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.584AlaAla: 10.584 ± 1.048
1.189AlaCys: 1.189 ± 0.282
6.678AlaAsp: 6.678 ± 0.623
9.565AlaGlu: 9.565 ± 0.875
1.528AlaPhe: 1.528 ± 0.263
7.641AlaGly: 7.641 ± 0.789
1.981AlaHis: 1.981 ± 0.268
3.566AlaIle: 3.566 ± 0.513
2.773AlaLys: 2.773 ± 0.381
8.037AlaLeu: 8.037 ± 0.653
2.151AlaMet: 2.151 ± 0.37
3.056AlaAsn: 3.056 ± 0.406
3.792AlaPro: 3.792 ± 0.49
4.528AlaGln: 4.528 ± 0.646
5.546AlaArg: 5.546 ± 0.599
5.49AlaSer: 5.49 ± 0.56
6.282AlaThr: 6.282 ± 0.708
6.622AlaVal: 6.622 ± 0.641
2.377AlaTrp: 2.377 ± 0.345
3.169AlaTyr: 3.169 ± 0.393
0.0AlaXaa: 0.0 ± 0.0
Cys
0.792CysAla: 0.792 ± 0.204
0.226CysCys: 0.226 ± 0.107
0.736CysAsp: 0.736 ± 0.187
0.736CysGlu: 0.736 ± 0.241
0.17CysPhe: 0.17 ± 0.086
1.811CysGly: 1.811 ± 0.379
0.453CysHis: 0.453 ± 0.184
0.226CysIle: 0.226 ± 0.1
0.113CysLys: 0.113 ± 0.079
0.396CysLeu: 0.396 ± 0.152
0.226CysMet: 0.226 ± 0.109
0.057CysAsn: 0.057 ± 0.051
1.132CysPro: 1.132 ± 0.3
0.453CysGln: 0.453 ± 0.172
0.679CysArg: 0.679 ± 0.21
0.453CysSer: 0.453 ± 0.172
0.736CysThr: 0.736 ± 0.266
0.679CysVal: 0.679 ± 0.175
0.283CysTrp: 0.283 ± 0.126
0.113CysTyr: 0.113 ± 0.072
0.0CysXaa: 0.0 ± 0.0
Asp
7.867AspAla: 7.867 ± 0.527
0.736AspCys: 0.736 ± 0.254
5.886AspAsp: 5.886 ± 0.584
9.169AspGlu: 9.169 ± 0.84
1.868AspPhe: 1.868 ± 0.383
8.263AspGly: 8.263 ± 0.784
1.811AspHis: 1.811 ± 0.355
2.151AspIle: 2.151 ± 0.387
0.792AspLys: 0.792 ± 0.2
6.282AspLeu: 6.282 ± 0.547
1.698AspMet: 1.698 ± 0.336
1.698AspAsn: 1.698 ± 0.358
5.094AspPro: 5.094 ± 0.574
2.547AspGln: 2.547 ± 0.386
4.471AspArg: 4.471 ± 0.533
5.263AspSer: 5.263 ± 0.581
6.226AspThr: 6.226 ± 0.585
5.886AspVal: 5.886 ± 0.684
2.037AspTrp: 2.037 ± 0.288
1.754AspTyr: 1.754 ± 0.344
0.0AspXaa: 0.0 ± 0.0
Glu
9.848GluAla: 9.848 ± 0.781
1.358GluCys: 1.358 ± 0.337
11.149GluAsp: 11.149 ± 1.284
2.66GluGlu: 2.66 ± 0.449
2.717GluPhe: 2.717 ± 0.379
9.282GluGly: 9.282 ± 1.048
1.754GluHis: 1.754 ± 0.305
2.49GluIle: 2.49 ± 0.362
2.49GluLys: 2.49 ± 0.372
5.037GluLeu: 5.037 ± 0.533
2.83GluMet: 2.83 ± 0.372
3.452GluAsn: 3.452 ± 0.498
1.868GluPro: 1.868 ± 0.312
8.716GluGln: 8.716 ± 1.138
7.244GluArg: 7.244 ± 0.7
2.547GluSer: 2.547 ± 0.463
4.754GluThr: 4.754 ± 0.607
10.018GluVal: 10.018 ± 0.776
1.811GluTrp: 1.811 ± 0.294
3.0GluTyr: 3.0 ± 0.47
0.0GluXaa: 0.0 ± 0.0
Phe
1.754PheAla: 1.754 ± 0.289
0.226PheCys: 0.226 ± 0.123
2.49PheAsp: 2.49 ± 0.364
2.094PheGlu: 2.094 ± 0.303
0.34PhePhe: 0.34 ± 0.129
2.49PheGly: 2.49 ± 0.336
0.226PheHis: 0.226 ± 0.116
0.453PheIle: 0.453 ± 0.172
0.509PheLys: 0.509 ± 0.209
1.302PheLeu: 1.302 ± 0.232
0.566PheMet: 0.566 ± 0.174
0.396PheAsn: 0.396 ± 0.14
1.472PhePro: 1.472 ± 0.316
1.189PheGln: 1.189 ± 0.313
1.754PheArg: 1.754 ± 0.389
1.585PheSer: 1.585 ± 0.25
1.811PheThr: 1.811 ± 0.287
1.641PheVal: 1.641 ± 0.366
0.17PheTrp: 0.17 ± 0.09
0.679PheTyr: 0.679 ± 0.193
0.0PheXaa: 0.0 ± 0.0
Gly
6.056GlyAla: 6.056 ± 0.584
0.849GlyCys: 0.849 ± 0.283
7.584GlyAsp: 7.584 ± 0.594
9.282GlyGlu: 9.282 ± 0.987
2.717GlyPhe: 2.717 ± 0.382
10.81GlyGly: 10.81 ± 1.227
1.981GlyHis: 1.981 ± 0.353
2.717GlyIle: 2.717 ± 0.462
1.585GlyLys: 1.585 ± 0.35
6.169GlyLeu: 6.169 ± 0.658
2.094GlyMet: 2.094 ± 0.287
2.773GlyAsn: 2.773 ± 0.512
3.396GlyPro: 3.396 ± 0.46
3.849GlyGln: 3.849 ± 0.495
4.754GlyArg: 4.754 ± 0.58
7.075GlySer: 7.075 ± 0.839
8.32GlyThr: 8.32 ± 0.847
6.622GlyVal: 6.622 ± 0.556
1.641GlyTrp: 1.641 ± 0.3
1.981GlyTyr: 1.981 ± 0.335
0.0GlyXaa: 0.0 ± 0.0
His
2.434HisAla: 2.434 ± 0.362
0.566HisCys: 0.566 ± 0.217
1.358HisAsp: 1.358 ± 0.213
2.943HisGlu: 2.943 ± 0.415
0.509HisPhe: 0.509 ± 0.15
2.49HisGly: 2.49 ± 0.41
1.075HisHis: 1.075 ± 0.342
0.566HisIle: 0.566 ± 0.165
0.283HisLys: 0.283 ± 0.101
1.472HisLeu: 1.472 ± 0.3
0.226HisMet: 0.226 ± 0.098
0.283HisAsn: 0.283 ± 0.143
1.641HisPro: 1.641 ± 0.306
1.132HisGln: 1.132 ± 0.238
2.264HisArg: 2.264 ± 0.434
1.075HisSer: 1.075 ± 0.228
1.189HisThr: 1.189 ± 0.205
1.811HisVal: 1.811 ± 0.359
0.226HisTrp: 0.226 ± 0.113
0.396HisTyr: 0.396 ± 0.137
0.0HisXaa: 0.0 ± 0.0
Ile
1.981IleAla: 1.981 ± 0.315
0.34IleCys: 0.34 ± 0.128
2.377IleAsp: 2.377 ± 0.342
3.396IleGlu: 3.396 ± 0.464
0.679IlePhe: 0.679 ± 0.226
2.207IleGly: 2.207 ± 0.476
0.566IleHis: 0.566 ± 0.155
0.792IleIle: 0.792 ± 0.23
0.623IleLys: 0.623 ± 0.158
1.302IleLeu: 1.302 ± 0.257
0.113IleMet: 0.113 ± 0.082
0.396IleAsn: 0.396 ± 0.133
1.075IlePro: 1.075 ± 0.232
1.868IleGln: 1.868 ± 0.295
1.641IleArg: 1.641 ± 0.35
1.754IleSer: 1.754 ± 0.387
2.49IleThr: 2.49 ± 0.386
2.377IleVal: 2.377 ± 0.369
0.566IleTrp: 0.566 ± 0.209
0.623IleTyr: 0.623 ± 0.164
0.0IleXaa: 0.0 ± 0.0
Lys
2.603LysAla: 2.603 ± 0.375
0.057LysCys: 0.057 ± 0.059
1.358LysAsp: 1.358 ± 0.278
2.094LysGlu: 2.094 ± 0.461
0.509LysPhe: 0.509 ± 0.145
1.472LysGly: 1.472 ± 0.259
0.962LysHis: 0.962 ± 0.239
0.566LysIle: 0.566 ± 0.153
1.075LysLys: 1.075 ± 0.313
1.132LysLeu: 1.132 ± 0.218
0.509LysMet: 0.509 ± 0.182
0.736LysAsn: 0.736 ± 0.204
1.245LysPro: 1.245 ± 0.284
1.358LysGln: 1.358 ± 0.33
1.641LysArg: 1.641 ± 0.289
1.641LysSer: 1.641 ± 0.291
1.132LysThr: 1.132 ± 0.294
1.245LysVal: 1.245 ± 0.31
0.623LysTrp: 0.623 ± 0.228
0.623LysTyr: 0.623 ± 0.192
0.0LysXaa: 0.0 ± 0.0
Leu
8.376LeuAla: 8.376 ± 0.733
0.34LeuCys: 0.34 ± 0.148
5.32LeuAsp: 5.32 ± 0.593
7.81LeuGlu: 7.81 ± 0.821
1.189LeuPhe: 1.189 ± 0.307
6.169LeuGly: 6.169 ± 0.583
2.207LeuHis: 2.207 ± 0.377
1.132LeuIle: 1.132 ± 0.222
1.358LeuLys: 1.358 ± 0.258
5.999LeuLeu: 5.999 ± 0.859
0.736LeuMet: 0.736 ± 0.207
1.302LeuAsn: 1.302 ± 0.263
4.188LeuPro: 4.188 ± 0.552
3.113LeuGln: 3.113 ± 0.434
5.433LeuArg: 5.433 ± 0.588
2.207LeuSer: 2.207 ± 0.373
4.528LeuThr: 4.528 ± 0.512
5.829LeuVal: 5.829 ± 0.462
0.283LeuTrp: 0.283 ± 0.145
1.754LeuTyr: 1.754 ± 0.304
0.0LeuXaa: 0.0 ± 0.0
Met
3.169MetAla: 3.169 ± 0.401
0.283MetCys: 0.283 ± 0.112
1.585MetAsp: 1.585 ± 0.309
1.075MetGlu: 1.075 ± 0.261
0.17MetPhe: 0.17 ± 0.085
1.528MetGly: 1.528 ± 0.353
0.509MetHis: 0.509 ± 0.176
0.283MetIle: 0.283 ± 0.131
0.226MetLys: 0.226 ± 0.134
0.962MetLeu: 0.962 ± 0.222
0.283MetMet: 0.283 ± 0.118
0.849MetAsn: 0.849 ± 0.19
1.245MetPro: 1.245 ± 0.237
0.226MetGln: 0.226 ± 0.107
1.019MetArg: 1.019 ± 0.252
1.132MetSer: 1.132 ± 0.251
1.811MetThr: 1.811 ± 0.33
1.528MetVal: 1.528 ± 0.281
0.226MetTrp: 0.226 ± 0.117
0.396MetTyr: 0.396 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
2.32AsnAla: 2.32 ± 0.336
0.283AsnCys: 0.283 ± 0.148
1.585AsnAsp: 1.585 ± 0.278
1.868AsnGlu: 1.868 ± 0.338
0.566AsnPhe: 0.566 ± 0.232
2.49AsnGly: 2.49 ± 0.408
0.453AsnHis: 0.453 ± 0.186
1.019AsnIle: 1.019 ± 0.232
0.736AsnLys: 0.736 ± 0.221
2.49AsnLeu: 2.49 ± 0.339
0.283AsnMet: 0.283 ± 0.117
0.566AsnAsn: 0.566 ± 0.19
1.358AsnPro: 1.358 ± 0.298
1.019AsnGln: 1.019 ± 0.251
1.698AsnArg: 1.698 ± 0.285
2.264AsnSer: 2.264 ± 0.399
2.66AsnThr: 2.66 ± 0.362
1.754AsnVal: 1.754 ± 0.335
0.736AsnTrp: 0.736 ± 0.208
0.509AsnTyr: 0.509 ± 0.178
0.0AsnXaa: 0.0 ± 0.0
Pro
4.584ProAla: 4.584 ± 0.473
0.17ProCys: 0.17 ± 0.109
5.773ProAsp: 5.773 ± 0.608
6.395ProGlu: 6.395 ± 0.682
1.075ProPhe: 1.075 ± 0.26
4.018ProGly: 4.018 ± 0.422
0.962ProHis: 0.962 ± 0.242
1.075ProIle: 1.075 ± 0.238
0.906ProLys: 0.906 ± 0.172
2.83ProLeu: 2.83 ± 0.368
0.679ProMet: 0.679 ± 0.213
1.019ProAsn: 1.019 ± 0.218
3.226ProPro: 3.226 ± 0.524
2.32ProGln: 2.32 ± 0.303
2.151ProArg: 2.151 ± 0.382
3.0ProSer: 3.0 ± 0.457
2.773ProThr: 2.773 ± 0.499
3.339ProVal: 3.339 ± 0.415
1.132ProTrp: 1.132 ± 0.261
1.358ProTyr: 1.358 ± 0.269
0.0ProXaa: 0.0 ± 0.0
Gln
6.452GlnAla: 6.452 ± 0.71
0.283GlnCys: 0.283 ± 0.118
4.301GlnAsp: 4.301 ± 0.536
6.848GlnGlu: 6.848 ± 0.86
1.302GlnPhe: 1.302 ± 0.249
3.792GlnGly: 3.792 ± 0.395
1.641GlnHis: 1.641 ± 0.227
1.189GlnIle: 1.189 ± 0.257
1.472GlnLys: 1.472 ± 0.297
0.962GlnLeu: 0.962 ± 0.226
0.906GlnMet: 0.906 ± 0.194
1.811GlnAsn: 1.811 ± 0.33
2.717GlnPro: 2.717 ± 0.405
3.622GlnGln: 3.622 ± 0.531
3.735GlnArg: 3.735 ± 0.573
1.189GlnSer: 1.189 ± 0.261
1.924GlnThr: 1.924 ± 0.305
4.301GlnVal: 4.301 ± 0.522
0.962GlnTrp: 0.962 ± 0.203
1.189GlnTyr: 1.189 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
5.433ArgAla: 5.433 ± 0.687
0.679ArgCys: 0.679 ± 0.185
3.962ArgAsp: 3.962 ± 0.407
7.301ArgGlu: 7.301 ± 0.684
1.358ArgPhe: 1.358 ± 0.247
4.98ArgGly: 4.98 ± 0.516
1.641ArgHis: 1.641 ± 0.303
1.981ArgIle: 1.981 ± 0.292
2.037ArgLys: 2.037 ± 0.311
5.773ArgLeu: 5.773 ± 0.603
1.132ArgMet: 1.132 ± 0.246
2.037ArgAsn: 2.037 ± 0.353
3.283ArgPro: 3.283 ± 0.547
2.773ArgGln: 2.773 ± 0.364
4.811ArgArg: 4.811 ± 0.738
3.962ArgSer: 3.962 ± 0.509
3.905ArgThr: 3.905 ± 0.493
4.301ArgVal: 4.301 ± 0.556
1.358ArgTrp: 1.358 ± 0.247
1.698ArgTyr: 1.698 ± 0.259
0.0ArgXaa: 0.0 ± 0.0
Ser
5.094SerAla: 5.094 ± 0.61
0.736SerCys: 0.736 ± 0.254
3.905SerAsp: 3.905 ± 0.492
5.943SerGlu: 5.943 ± 0.677
1.641SerPhe: 1.641 ± 0.355
6.565SerGly: 6.565 ± 0.761
1.245SerHis: 1.245 ± 0.222
2.547SerIle: 2.547 ± 0.432
0.453SerLys: 0.453 ± 0.184
3.566SerLeu: 3.566 ± 0.425
1.245SerMet: 1.245 ± 0.261
1.189SerAsn: 1.189 ± 0.276
2.603SerPro: 2.603 ± 0.335
1.754SerGln: 1.754 ± 0.318
2.886SerArg: 2.886 ± 0.414
4.754SerSer: 4.754 ± 0.654
5.603SerThr: 5.603 ± 0.519
3.792SerVal: 3.792 ± 0.525
0.962SerTrp: 0.962 ± 0.203
1.585SerTyr: 1.585 ± 0.312
0.0SerXaa: 0.0 ± 0.0
Thr
5.943ThrAla: 5.943 ± 0.619
0.566ThrCys: 0.566 ± 0.207
5.377ThrAsp: 5.377 ± 0.645
5.207ThrGlu: 5.207 ± 0.475
1.698ThrPhe: 1.698 ± 0.285
6.905ThrGly: 6.905 ± 0.791
1.811ThrHis: 1.811 ± 0.38
2.094ThrIle: 2.094 ± 0.329
1.754ThrLys: 1.754 ± 0.322
6.169ThrLeu: 6.169 ± 0.589
0.792ThrMet: 0.792 ± 0.246
1.811ThrAsn: 1.811 ± 0.345
3.056ThrPro: 3.056 ± 0.403
2.434ThrGln: 2.434 ± 0.409
3.792ThrArg: 3.792 ± 0.496
5.037ThrSer: 5.037 ± 0.549
4.471ThrThr: 4.471 ± 0.589
5.546ThrVal: 5.546 ± 0.589
1.189ThrTrp: 1.189 ± 0.271
2.207ThrTyr: 2.207 ± 0.389
0.0ThrXaa: 0.0 ± 0.0
Val
7.018ValAla: 7.018 ± 0.577
1.132ValCys: 1.132 ± 0.264
5.886ValAsp: 5.886 ± 0.556
7.188ValGlu: 7.188 ± 0.721
2.207ValPhe: 2.207 ± 0.252
5.32ValGly: 5.32 ± 0.504
1.585ValHis: 1.585 ± 0.286
1.302ValIle: 1.302 ± 0.237
2.547ValLys: 2.547 ± 0.363
5.886ValLeu: 5.886 ± 0.567
1.189ValMet: 1.189 ± 0.255
2.264ValAsn: 2.264 ± 0.305
4.301ValPro: 4.301 ± 0.52
4.924ValGln: 4.924 ± 0.632
5.943ValArg: 5.943 ± 0.625
4.301ValSer: 4.301 ± 0.586
4.132ValThr: 4.132 ± 0.627
5.546ValVal: 5.546 ± 0.559
1.189ValTrp: 1.189 ± 0.309
3.056ValTyr: 3.056 ± 0.505
0.0ValXaa: 0.0 ± 0.0
Trp
2.094TrpAla: 2.094 ± 0.357
0.113TrpCys: 0.113 ± 0.08
1.698TrpAsp: 1.698 ± 0.343
0.849TrpGlu: 0.849 ± 0.165
0.509TrpPhe: 0.509 ± 0.169
1.132TrpGly: 1.132 ± 0.243
0.679TrpHis: 0.679 ± 0.192
0.17TrpIle: 0.17 ± 0.096
0.34TrpLys: 0.34 ± 0.136
1.754TrpLeu: 1.754 ± 0.328
0.396TrpMet: 0.396 ± 0.177
0.396TrpAsn: 0.396 ± 0.117
1.132TrpPro: 1.132 ± 0.248
1.075TrpGln: 1.075 ± 0.243
1.245TrpArg: 1.245 ± 0.227
1.358TrpSer: 1.358 ± 0.304
1.245TrpThr: 1.245 ± 0.275
1.585TrpVal: 1.585 ± 0.233
0.566TrpTrp: 0.566 ± 0.173
0.566TrpTyr: 0.566 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.151TyrAla: 2.151 ± 0.346
0.34TyrCys: 0.34 ± 0.136
2.49TyrAsp: 2.49 ± 0.376
2.603TyrGlu: 2.603 ± 0.368
0.396TyrPhe: 0.396 ± 0.141
2.886TyrGly: 2.886 ± 0.38
0.396TyrHis: 0.396 ± 0.185
0.849TyrIle: 0.849 ± 0.21
0.509TyrLys: 0.509 ± 0.169
1.754TyrLeu: 1.754 ± 0.288
0.396TyrMet: 0.396 ± 0.15
0.566TyrAsn: 0.566 ± 0.136
1.019TyrPro: 1.019 ± 0.234
1.698TyrGln: 1.698 ± 0.295
1.698TyrArg: 1.698 ± 0.308
1.981TyrSer: 1.981 ± 0.33
1.868TyrThr: 1.868 ± 0.334
2.49TyrVal: 2.49 ± 0.392
0.566TyrTrp: 0.566 ± 0.127
0.736TyrTyr: 0.736 ± 0.277
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 86 proteins (17670 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski