Amino acid dipepetide frequency for Syncephalis pseudoplumigaleata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.374AlaAla: 13.374 ± 0.141	1.536AlaCys: 1.536 ± 0.03	5.639AlaAsp: 5.639 ± 0.052	5.388AlaGlu: 5.388 ± 0.071	3.16AlaPhe: 3.16 ± 0.048	6.511AlaGly: 6.511 ± 0.067	2.787AlaHis: 2.787 ± 0.041	4.965AlaIle: 4.965 ± 0.058	3.839AlaLys: 3.839 ± 0.051	9.049AlaLeu: 9.049 ± 0.079	3.023AlaMet: 3.023 ± 0.034	3.305AlaAsn: 3.305 ± 0.038	4.876AlaPro: 4.876 ± 0.064	3.775AlaGln: 3.775 ± 0.042	6.648AlaArg: 6.648 ± 0.067	8.926AlaSer: 8.926 ± 0.099	7.14AlaThr: 7.14 ± 0.086	6.366AlaVal: 6.366 ± 0.064	1.212AlaTrp: 1.212 ± 0.027	2.942AlaTyr: 2.942 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.259CysAla: 1.259 ± 0.026	0.352CysCys: 0.352 ± 0.016	0.733CysAsp: 0.733 ± 0.02	0.668CysGlu: 0.668 ± 0.02	0.583CysPhe: 0.583 ± 0.018	1.05CysGly: 1.05 ± 0.027	0.473CysHis: 0.473 ± 0.018	0.828CysIle: 0.828 ± 0.021	0.51CysLys: 0.51 ± 0.017	1.449CysLeu: 1.449 ± 0.025	0.428CysMet: 0.428 ± 0.015	0.472CysAsn: 0.472 ± 0.018	0.747CysPro: 0.747 ± 0.021	0.569CysGln: 0.569 ± 0.016	1.07CysArg: 1.07 ± 0.027	0.99CysSer: 0.99 ± 0.022	0.908CysThr: 0.908 ± 0.023	1.024CysVal: 1.024 ± 0.022	0.209CysTrp: 0.209 ± 0.009	0.502CysTyr: 0.502 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.558AspAla: 6.558 ± 0.068	0.662AspCys: 0.662 ± 0.021	4.924AspAsp: 4.924 ± 0.082	4.361AspGlu: 4.361 ± 0.061	1.664AspPhe: 1.664 ± 0.029	4.273AspGly: 4.273 ± 0.054	1.508AspHis: 1.508 ± 0.029	2.831AspIle: 2.831 ± 0.039	2.161AspLys: 2.161 ± 0.034	4.306AspLeu: 4.306 ± 0.049	1.59AspMet: 1.59 ± 0.028	1.768AspAsn: 1.768 ± 0.029	2.689AspPro: 2.689 ± 0.035	1.863AspGln: 1.863 ± 0.028	3.435AspArg: 3.435 ± 0.042	2.893AspSer: 2.893 ± 0.039	3.21AspThr: 3.21 ± 0.044	3.844AspVal: 3.844 ± 0.043	0.749AspTrp: 0.749 ± 0.017	1.784AspTyr: 1.784 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.085GluAla: 6.085 ± 0.083	0.686GluCys: 0.686 ± 0.02	3.468GluAsp: 3.468 ± 0.053	5.559GluGlu: 5.559 ± 0.1	1.663GluPhe: 1.663 ± 0.027	3.048GluGly: 3.048 ± 0.043	2.028GluHis: 2.028 ± 0.034	2.298GluIle: 2.298 ± 0.037	2.822GluLys: 2.822 ± 0.048	5.594GluLeu: 5.594 ± 0.06	1.54GluMet: 1.54 ± 0.028	1.612GluAsn: 1.612 ± 0.031	2.353GluPro: 2.353 ± 0.045	3.428GluGln: 3.428 ± 0.048	4.553GluArg: 4.553 ± 0.055	3.03GluSer: 3.03 ± 0.042	2.845GluThr: 2.845 ± 0.045	3.095GluVal: 3.095 ± 0.042	0.709GluTrp: 0.709 ± 0.019	1.544GluTyr: 1.544 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.035PheAla: 3.035 ± 0.044	0.563PheCys: 0.563 ± 0.017	2.052PheAsp: 2.052 ± 0.039	1.8PheGlu: 1.8 ± 0.028	1.285PhePhe: 1.285 ± 0.027	2.445PheGly: 2.445 ± 0.043	0.927PheHis: 0.927 ± 0.023	1.793PheIle: 1.793 ± 0.034	1.196PheLys: 1.196 ± 0.027	2.974PheLeu: 2.974 ± 0.049	0.848PheMet: 0.848 ± 0.023	1.185PheAsn: 1.185 ± 0.023	1.468PhePro: 1.468 ± 0.029	1.058PheGln: 1.058 ± 0.028	1.949PheArg: 1.949 ± 0.034	2.347PheSer: 2.347 ± 0.036	1.904PheThr: 1.904 ± 0.033	2.324PheVal: 2.324 ± 0.037	0.439PheTrp: 0.439 ± 0.016	1.212PheTyr: 1.212 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	5.665GlyAla: 5.665 ± 0.063	0.981GlyCys: 0.981 ± 0.024	3.556GlyAsp: 3.556 ± 0.047	3.391GlyGlu: 3.391 ± 0.046	2.199GlyPhe: 2.199 ± 0.036	5.576GlyGly: 5.576 ± 0.086	2.261GlyHis: 2.261 ± 0.041	3.298GlyIle: 3.298 ± 0.051	2.878GlyLys: 2.878 ± 0.042	4.994GlyLeu: 4.994 ± 0.06	1.807GlyMet: 1.807 ± 0.037	2.284GlyAsn: 2.284 ± 0.037	2.286GlyPro: 2.286 ± 0.039	2.731GlyGln: 2.731 ± 0.039	4.552GlyArg: 4.552 ± 0.052	4.622GlySer: 4.622 ± 0.061	3.705GlyThr: 3.705 ± 0.046	4.105GlyVal: 4.105 ± 0.053	0.982GlyTrp: 0.982 ± 0.024	2.043GlyTyr: 2.043 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	3.266HisAla: 3.266 ± 0.044	0.521HisCys: 0.521 ± 0.016	1.691HisAsp: 1.691 ± 0.03	1.468HisGlu: 1.468 ± 0.031	0.877HisPhe: 0.877 ± 0.021	2.361HisGly: 2.361 ± 0.041	1.399HisHis: 1.399 ± 0.048	1.322HisIle: 1.322 ± 0.026	0.933HisLys: 0.933 ± 0.022	2.596HisLeu: 2.596 ± 0.042	0.703HisMet: 0.703 ± 0.019	0.81HisAsn: 0.81 ± 0.023	1.822HisPro: 1.822 ± 0.036	1.287HisGln: 1.287 ± 0.029	2.563HisArg: 2.563 ± 0.034	1.819HisSer: 1.819 ± 0.035	1.642HisThr: 1.642 ± 0.029	1.833HisVal: 1.833 ± 0.03	0.41HisTrp: 0.41 ± 0.016	0.992HisTyr: 0.992 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.819IleAla: 4.819 ± 0.056	0.792IleCys: 0.792 ± 0.021	3.072IleAsp: 3.072 ± 0.038	2.764IleGlu: 2.764 ± 0.036	1.572IlePhe: 1.572 ± 0.033	3.18IleGly: 3.18 ± 0.049	1.283IleHis: 1.283 ± 0.026	2.436IleIle: 2.436 ± 0.04	1.936IleLys: 1.936 ± 0.033	3.991IleLeu: 3.991 ± 0.049	1.175IleMet: 1.175 ± 0.024	1.546IleAsn: 1.546 ± 0.025	2.19IlePro: 2.19 ± 0.037	1.577IleGln: 1.577 ± 0.031	3.126IleArg: 3.126 ± 0.04	2.922IleSer: 2.922 ± 0.037	2.714IleThr: 2.714 ± 0.032	3.408IleVal: 3.408 ± 0.042	0.61IleTrp: 0.61 ± 0.017	1.543IleTyr: 1.543 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.567LysAla: 3.567 ± 0.049	0.5LysCys: 0.5 ± 0.018	2.082LysAsp: 2.082 ± 0.04	2.945LysGlu: 2.945 ± 0.05	1.022LysPhe: 1.022 ± 0.022	2.034LysGly: 2.034 ± 0.033	1.29LysHis: 1.29 ± 0.024	1.658LysIle: 1.658 ± 0.031	2.431LysLys: 2.431 ± 0.056	3.757LysLeu: 3.757 ± 0.045	0.943LysMet: 0.943 ± 0.023	1.183LysAsn: 1.183 ± 0.027	2.179LysPro: 2.179 ± 0.042	2.192LysGln: 2.192 ± 0.035	3.277LysArg: 3.277 ± 0.042	2.332LysSer: 2.332 ± 0.041	2.082LysThr: 2.082 ± 0.033	2.227LysVal: 2.227 ± 0.04	0.403LysTrp: 0.403 ± 0.014	1.228LysTyr: 1.228 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.669LeuAla: 9.669 ± 0.082	1.567LeuCys: 1.567 ± 0.027	5.377LeuAsp: 5.377 ± 0.053	4.966LeuGlu: 4.966 ± 0.059	3.495LeuPhe: 3.495 ± 0.045	5.364LeuGly: 5.364 ± 0.061	2.617LeuHis: 2.617 ± 0.039	3.737LeuIle: 3.737 ± 0.05	3.483LeuLys: 3.483 ± 0.047	10.156LeuLeu: 10.156 ± 0.097	2.203LeuMet: 2.203 ± 0.034	2.823LeuAsn: 2.823 ± 0.037	5.466LeuPro: 5.466 ± 0.062	3.814LeuGln: 3.814 ± 0.045	6.555LeuArg: 6.555 ± 0.057	6.479LeuSer: 6.479 ± 0.066	4.859LeuThr: 4.859 ± 0.055	6.361LeuVal: 6.361 ± 0.071	1.169LeuTrp: 1.169 ± 0.027	2.585LeuTyr: 2.585 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.363MetAla: 3.363 ± 0.045	0.314MetCys: 0.314 ± 0.012	1.574MetAsp: 1.574 ± 0.03	1.565MetGlu: 1.565 ± 0.028	0.723MetPhe: 0.723 ± 0.02	1.432MetGly: 1.432 ± 0.027	0.848MetHis: 0.848 ± 0.023	1.055MetIle: 1.055 ± 0.024	0.935MetLys: 0.935 ± 0.022	2.953MetLeu: 2.953 ± 0.043	0.75MetMet: 0.75 ± 0.024	0.859MetAsn: 0.859 ± 0.022	1.766MetPro: 1.766 ± 0.031	1.157MetGln: 1.157 ± 0.026	1.717MetArg: 1.717 ± 0.029	1.904MetSer: 1.904 ± 0.031	1.545MetThr: 1.545 ± 0.031	1.688MetVal: 1.688 ± 0.03	0.213MetTrp: 0.213 ± 0.01	0.539MetTyr: 0.539 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.404AsnAla: 3.404 ± 0.044	0.428AsnCys: 0.428 ± 0.015	1.995AsnAsp: 1.995 ± 0.035	1.954AsnGlu: 1.954 ± 0.031	0.935AsnPhe: 0.935 ± 0.02	2.563AsnGly: 2.563 ± 0.041	0.79AsnHis: 0.79 ± 0.02	1.697AsnIle: 1.697 ± 0.029	1.303AsnLys: 1.303 ± 0.028	2.402AsnLeu: 2.402 ± 0.033	0.82AsnMet: 0.82 ± 0.019	1.457AsnAsn: 1.457 ± 0.038	1.66AsnPro: 1.66 ± 0.028	1.088AsnGln: 1.088 ± 0.025	1.813AsnArg: 1.813 ± 0.028	1.83AsnSer: 1.83 ± 0.036	1.838AsnThr: 1.838 ± 0.033	2.149AsnVal: 2.149 ± 0.032	0.411AsnTrp: 0.411 ± 0.013	1.055AsnTyr: 1.055 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.02ProAla: 6.02 ± 0.083	0.647ProCys: 0.647 ± 0.024	2.815ProAsp: 2.815 ± 0.043	2.928ProGlu: 2.928 ± 0.054	1.74ProPhe: 1.74 ± 0.035	3.069ProGly: 3.069 ± 0.045	1.454ProHis: 1.454 ± 0.035	2.187ProIle: 2.187 ± 0.033	1.732ProLys: 1.732 ± 0.032	4.692ProLeu: 4.692 ± 0.046	1.358ProMet: 1.358 ± 0.03	1.565ProAsn: 1.565 ± 0.029	4.423ProPro: 4.423 ± 0.09	1.772ProGln: 1.772 ± 0.033	3.05ProArg: 3.05 ± 0.047	5.157ProSer: 5.157 ± 0.074	3.263ProThr: 3.263 ± 0.046	3.529ProVal: 3.529 ± 0.044	0.64ProTrp: 0.64 ± 0.022	1.393ProTyr: 1.393 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.903GlnAla: 3.903 ± 0.047	0.647GlnCys: 0.647 ± 0.017	1.588GlnAsp: 1.588 ± 0.031	2.191GlnGlu: 2.191 ± 0.039	1.375GlnPhe: 1.375 ± 0.025	1.967GlnGly: 1.967 ± 0.032	1.735GlnHis: 1.735 ± 0.034	1.535GlnIle: 1.535 ± 0.027	1.38GlnLys: 1.38 ± 0.029	5.042GlnLeu: 5.042 ± 0.061	1.122GlnMet: 1.122 ± 0.023	0.964GlnAsn: 0.964 ± 0.019	2.486GlnPro: 2.486 ± 0.039	3.683GlnGln: 3.683 ± 0.081	3.344GlnArg: 3.344 ± 0.042	2.652GlnSer: 2.652 ± 0.039	1.961GlnThr: 1.961 ± 0.032	2.3GlnVal: 2.3 ± 0.036	0.673GlnTrp: 0.673 ± 0.016	1.193GlnTyr: 1.193 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.231ArgAla: 6.231 ± 0.058	1.093ArgCys: 1.093 ± 0.029	3.506ArgAsp: 3.506 ± 0.045	3.864ArgGlu: 3.864 ± 0.051	2.364ArgPhe: 2.364 ± 0.03	3.744ArgGly: 3.744 ± 0.053	2.375ArgHis: 2.375 ± 0.04	3.333ArgIle: 3.333 ± 0.045	3.087ArgLys: 3.087 ± 0.041	6.802ArgLeu: 6.802 ± 0.072	1.92ArgMet: 1.92 ± 0.032	2.039ArgAsn: 2.039 ± 0.032	3.607ArgPro: 3.607 ± 0.044	3.376ArgGln: 3.376 ± 0.047	6.235ArgArg: 6.235 ± 0.083	4.535ArgSer: 4.535 ± 0.065	3.489ArgThr: 3.489 ± 0.043	4.276ArgVal: 4.276 ± 0.051	1.063ArgTrp: 1.063 ± 0.025	2.054ArgTyr: 2.054 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.022SerAla: 7.022 ± 0.08	0.833SerCys: 0.833 ± 0.02	3.724SerAsp: 3.724 ± 0.047	3.219SerGlu: 3.219 ± 0.046	2.26SerPhe: 2.26 ± 0.037	4.75SerGly: 4.75 ± 0.056	1.83SerHis: 1.83 ± 0.036	3.668SerIle: 3.668 ± 0.051	2.656SerLys: 2.656 ± 0.04	6.294SerLeu: 6.294 ± 0.066	2.302SerMet: 2.302 ± 0.035	2.557SerAsn: 2.557 ± 0.039	4.341SerPro: 4.341 ± 0.073	2.3SerGln: 2.3 ± 0.038	4.188SerArg: 4.188 ± 0.061	7.97SerSer: 7.97 ± 0.145	5.242SerThr: 5.242 ± 0.067	4.182SerVal: 4.182 ± 0.052	0.794SerTrp: 0.794 ± 0.021	1.787SerTyr: 1.787 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.814ThrAla: 6.814 ± 0.071	0.815ThrCys: 0.815 ± 0.022	2.897ThrAsp: 2.897 ± 0.041	2.907ThrGlu: 2.907 ± 0.046	1.928ThrPhe: 1.928 ± 0.036	3.995ThrGly: 3.995 ± 0.049	1.423ThrHis: 1.423 ± 0.027	2.995ThrIle: 2.995 ± 0.043	2.007ThrLys: 2.007 ± 0.034	5.406ThrLeu: 5.406 ± 0.054	1.63ThrMet: 1.63 ± 0.031	1.634ThrAsn: 1.634 ± 0.029	3.673ThrPro: 3.673 ± 0.056	1.75ThrGln: 1.75 ± 0.03	3.546ThrArg: 3.546 ± 0.042	4.9ThrSer: 4.9 ± 0.063	4.923ThrThr: 4.923 ± 0.082	3.926ThrVal: 3.926 ± 0.048	0.667ThrTrp: 0.667 ± 0.019	1.395ThrTyr: 1.395 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	6.786ValAla: 6.786 ± 0.064	1.084ValCys: 1.084 ± 0.024	4.031ValAsp: 4.031 ± 0.045	3.812ValGlu: 3.812 ± 0.049	2.325ValPhe: 2.325 ± 0.042	3.799ValGly: 3.799 ± 0.053	1.939ValHis: 1.939 ± 0.034	2.953ValIle: 2.953 ± 0.041	2.515ValLys: 2.515 ± 0.041	5.995ValLeu: 5.995 ± 0.06	1.574ValMet: 1.574 ± 0.027	2.09ValAsn: 2.09 ± 0.028	3.354ValPro: 3.354 ± 0.044	2.567ValGln: 2.567 ± 0.041	4.043ValArg: 4.043 ± 0.045	3.952ValSer: 3.952 ± 0.049	3.373ValThr: 3.373 ± 0.042	4.828ValVal: 4.828 ± 0.061	0.849ValTrp: 0.849 ± 0.024	2.006ValTyr: 2.006 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.861TrpAla: 0.861 ± 0.024	0.272TrpCys: 0.272 ± 0.012	0.667TrpAsp: 0.667 ± 0.019	0.575TrpGlu: 0.575 ± 0.017	0.47TrpPhe: 0.47 ± 0.015	0.555TrpGly: 0.555 ± 0.017	0.483TrpHis: 0.483 ± 0.016	0.685TrpIle: 0.685 ± 0.018	0.474TrpLys: 0.474 ± 0.016	1.5TrpLeu: 1.5 ± 0.031	0.433TrpMet: 0.433 ± 0.015	0.442TrpAsn: 0.442 ± 0.015	0.627TrpPro: 0.627 ± 0.018	0.662TrpGln: 0.662 ± 0.019	1.143TrpArg: 1.143 ± 0.031	1.004TrpSer: 1.004 ± 0.022	0.825TrpThr: 0.825 ± 0.02	0.578TrpVal: 0.578 ± 0.018	0.269TrpTrp: 0.269 ± 0.014	0.391TrpTyr: 0.391 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.759TyrAla: 2.759 ± 0.036	0.533TyrCys: 0.533 ± 0.016	1.684TyrAsp: 1.684 ± 0.03	1.636TyrGlu: 1.636 ± 0.032	1.165TyrPhe: 1.165 ± 0.028	2.2TyrGly: 2.2 ± 0.034	0.865TyrHis: 0.865 ± 0.023	1.379TyrIle: 1.379 ± 0.028	1.055TyrLys: 1.055 ± 0.035	2.794TyrLeu: 2.794 ± 0.04	0.726TyrMet: 0.726 ± 0.019	0.996TyrAsn: 0.996 ± 0.023	1.421TyrPro: 1.421 ± 0.026	1.091TyrGln: 1.091 ± 0.023	2.187TyrArg: 2.187 ± 0.029	1.656TyrSer: 1.656 ± 0.028	1.763TyrThr: 1.763 ± 0.03	1.832TyrVal: 1.832 ± 0.032	0.446TyrTrp: 0.446 ± 0.015	1.133TyrTyr: 1.133 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5997 proteins (2091956 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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