Amino acid dipepetide frequency for Candidatus Mcinerneyibacterium aminivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.765AlaAla: 2.765 ± 0.079
0.34AlaCys: 0.34 ± 0.025
2.382AlaAsp: 2.382 ± 0.062
3.366AlaGlu: 3.366 ± 0.079
2.203AlaPhe: 2.203 ± 0.068
3.46AlaGly: 3.46 ± 0.081
0.742AlaHis: 0.742 ± 0.037
4.012AlaIle: 4.012 ± 0.1
4.033AlaLys: 4.033 ± 0.09
4.169AlaLeu: 4.169 ± 0.091
1.021AlaMet: 1.021 ± 0.046
2.181AlaAsn: 2.181 ± 0.064
1.105AlaPro: 1.105 ± 0.047
1.109AlaGln: 1.109 ± 0.044
1.762AlaArg: 1.762 ± 0.049
2.517AlaSer: 2.517 ± 0.073
1.822AlaThr: 1.822 ± 0.057
3.273AlaVal: 3.273 ± 0.093
0.264AlaTrp: 0.264 ± 0.018
1.927AlaTyr: 1.927 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.309CysAla: 0.309 ± 0.021
0.105CysCys: 0.105 ± 0.014
0.406CysAsp: 0.406 ± 0.025
0.48CysGlu: 0.48 ± 0.03
0.317CysPhe: 0.317 ± 0.023
0.723CysGly: 0.723 ± 0.044
0.108CysHis: 0.108 ± 0.014
0.585CysIle: 0.585 ± 0.029
0.631CysLys: 0.631 ± 0.036
0.499CysLeu: 0.499 ± 0.03
0.16CysMet: 0.16 ± 0.016
0.447CysAsn: 0.447 ± 0.028
0.49CysPro: 0.49 ± 0.041
0.149CysGln: 0.149 ± 0.015
0.276CysArg: 0.276 ± 0.018
0.501CysSer: 0.501 ± 0.032
0.304CysThr: 0.304 ± 0.025
0.384CysVal: 0.384 ± 0.028
0.06CysTrp: 0.06 ± 0.009
0.298CysTyr: 0.298 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.026AspAla: 2.026 ± 0.064
0.384AspCys: 0.384 ± 0.026
2.854AspAsp: 2.854 ± 0.076
4.379AspGlu: 4.379 ± 0.102
3.341AspPhe: 3.341 ± 0.069
2.664AspGly: 2.664 ± 0.09
0.646AspHis: 0.646 ± 0.034
6.595AspIle: 6.595 ± 0.111
6.62AspLys: 6.62 ± 0.109
5.101AspLeu: 5.101 ± 0.104
1.37AspMet: 1.37 ± 0.05
3.596AspAsn: 3.596 ± 0.081
1.487AspPro: 1.487 ± 0.053
0.926AspGln: 0.926 ± 0.039
2.156AspArg: 2.156 ± 0.055
3.122AspSer: 3.122 ± 0.079
2.09AspThr: 2.09 ± 0.059
3.006AspVal: 3.006 ± 0.078
0.436AspTrp: 0.436 ± 0.028
3.317AspTyr: 3.317 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
3.031GluAla: 3.031 ± 0.074
0.378GluCys: 0.378 ± 0.028
4.35GluAsp: 4.35 ± 0.097
6.692GluGlu: 6.692 ± 0.183
3.09GluPhe: 3.09 ± 0.08
3.618GluGly: 3.618 ± 0.09
0.88GluHis: 0.88 ± 0.036
7.891GluIle: 7.891 ± 0.123
10.888GluLys: 10.888 ± 0.161
6.141GluLeu: 6.141 ± 0.122
1.905GluMet: 1.905 ± 0.06
6.466GluAsn: 6.466 ± 0.119
1.331GluPro: 1.331 ± 0.048
1.462GluGln: 1.462 ± 0.055
2.522GluArg: 2.522 ± 0.065
3.229GluSer: 3.229 ± 0.079
2.875GluThr: 2.875 ± 0.075
4.056GluVal: 4.056 ± 0.101
0.516GluTrp: 0.516 ± 0.029
3.557GluTyr: 3.557 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.211PheAla: 2.211 ± 0.069
0.388PheCys: 0.388 ± 0.027
3.215PheAsp: 3.215 ± 0.075
3.618PheGlu: 3.618 ± 0.079
3.181PhePhe: 3.181 ± 0.103
2.884PheGly: 2.884 ± 0.073
0.745PheHis: 0.745 ± 0.035
5.129PheIle: 5.129 ± 0.129
4.795PheLys: 4.795 ± 0.102
5.501PheLeu: 5.501 ± 0.128
1.178PheMet: 1.178 ± 0.047
3.463PheAsn: 3.463 ± 0.094
1.338PhePro: 1.338 ± 0.048
1.149PheGln: 1.149 ± 0.042
1.563PheArg: 1.563 ± 0.053
3.844PheSer: 3.844 ± 0.094
2.092PheThr: 2.092 ± 0.059
3.063PheVal: 3.063 ± 0.064
0.441PheTrp: 0.441 ± 0.029
2.63PheTyr: 2.63 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
2.928GlyAla: 2.928 ± 0.081
0.576GlyCys: 0.576 ± 0.037
2.859GlyAsp: 2.859 ± 0.082
3.979GlyGlu: 3.979 ± 0.092
3.097GlyPhe: 3.097 ± 0.083
3.692GlyGly: 3.692 ± 0.097
0.899GlyHis: 0.899 ± 0.036
5.812GlyIle: 5.812 ± 0.097
5.457GlyLys: 5.457 ± 0.094
4.841GlyLeu: 4.841 ± 0.109
1.516GlyMet: 1.516 ± 0.051
3.014GlyAsn: 3.014 ± 0.08
1.277GlyPro: 1.277 ± 0.046
1.196GlyGln: 1.196 ± 0.042
2.201GlyArg: 2.201 ± 0.059
3.133GlySer: 3.133 ± 0.081
2.6GlyThr: 2.6 ± 0.073
3.72GlyVal: 3.72 ± 0.082
0.551GlyTrp: 0.551 ± 0.028
2.928GlyTyr: 2.928 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.565HisAla: 0.565 ± 0.03
0.137HisCys: 0.137 ± 0.014
0.783HisAsp: 0.783 ± 0.035
0.874HisGlu: 0.874 ± 0.04
0.797HisPhe: 0.797 ± 0.04
0.844HisGly: 0.844 ± 0.038
0.337HisHis: 0.337 ± 0.026
1.37HisIle: 1.37 ± 0.041
1.258HisLys: 1.258 ± 0.048
1.318HisLeu: 1.318 ± 0.047
0.279HisMet: 0.279 ± 0.023
0.888HisAsn: 0.888 ± 0.035
0.654HisPro: 0.654 ± 0.033
0.392HisGln: 0.392 ± 0.024
0.582HisArg: 0.582 ± 0.03
0.916HisSer: 0.916 ± 0.035
0.639HisThr: 0.639 ± 0.03
0.77HisVal: 0.77 ± 0.036
0.115HisTrp: 0.115 ± 0.014
0.733HisTyr: 0.733 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
4.748IleAla: 4.748 ± 0.107
0.689IleCys: 0.689 ± 0.039
6.367IleAsp: 6.367 ± 0.112
7.397IleGlu: 7.397 ± 0.109
5.635IlePhe: 5.635 ± 0.125
5.417IleGly: 5.417 ± 0.108
1.331IleHis: 1.331 ± 0.051
9.692IleIle: 9.692 ± 0.174
10.968IleLys: 10.968 ± 0.169
9.487IleLeu: 9.487 ± 0.161
1.899IleMet: 1.899 ± 0.062
7.218IleAsn: 7.218 ± 0.149
3.192IlePro: 3.192 ± 0.076
2.081IleGln: 2.081 ± 0.058
3.228IleArg: 3.228 ± 0.071
6.805IleSer: 6.805 ± 0.113
4.26IleThr: 4.26 ± 0.084
5.346IleVal: 5.346 ± 0.109
0.581IleTrp: 0.581 ± 0.033
4.591IleTyr: 4.591 ± 0.109
0.0IleXaa: 0.0 ± 0.0
Lys
4.439LysAla: 4.439 ± 0.09
0.675LysCys: 0.675 ± 0.038
5.942LysAsp: 5.942 ± 0.092
9.234LysGlu: 9.234 ± 0.161
4.475LysPhe: 4.475 ± 0.087
5.004LysGly: 5.004 ± 0.095
1.459LysHis: 1.459 ± 0.045
12.248LysIle: 12.248 ± 0.161
15.645LysLys: 15.645 ± 0.228
9.076LysLeu: 9.076 ± 0.132
2.771LysMet: 2.771 ± 0.06
10.631LysAsn: 10.631 ± 0.172
2.222LysPro: 2.222 ± 0.064
2.496LysGln: 2.496 ± 0.073
4.458LysArg: 4.458 ± 0.09
5.545LysSer: 5.545 ± 0.101
4.386LysThr: 4.386 ± 0.08
5.297LysVal: 5.297 ± 0.087
0.8LysTrp: 0.8 ± 0.038
6.011LysTyr: 6.011 ± 0.11
0.0LysXaa: 0.0 ± 0.0
Leu
4.296LeuAla: 4.296 ± 0.102
0.516LeuCys: 0.516 ± 0.031
5.005LeuAsp: 5.005 ± 0.101
6.333LeuGlu: 6.333 ± 0.124
4.988LeuPhe: 4.988 ± 0.113
5.016LeuGly: 5.016 ± 0.116
1.243LeuHis: 1.243 ± 0.046
8.892LeuIle: 8.892 ± 0.169
10.893LeuLys: 10.893 ± 0.158
8.125LeuLeu: 8.125 ± 0.126
1.993LeuMet: 1.993 ± 0.057
6.567LeuAsn: 6.567 ± 0.141
2.658LeuPro: 2.658 ± 0.069
1.969LeuGln: 1.969 ± 0.063
2.953LeuArg: 2.953 ± 0.059
6.024LeuSer: 6.024 ± 0.102
3.968LeuThr: 3.968 ± 0.086
4.467LeuVal: 4.467 ± 0.088
0.634LeuTrp: 0.634 ± 0.033
3.948LeuTyr: 3.948 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
1.269MetAla: 1.269 ± 0.048
0.137MetCys: 0.137 ± 0.016
1.436MetAsp: 1.436 ± 0.052
1.729MetGlu: 1.729 ± 0.06
0.982MetPhe: 0.982 ± 0.042
1.712MetGly: 1.712 ± 0.056
0.325MetHis: 0.325 ± 0.022
2.001MetIle: 2.001 ± 0.066
2.925MetLys: 2.925 ± 0.066
1.878MetLeu: 1.878 ± 0.06
0.488MetMet: 0.488 ± 0.028
1.538MetAsn: 1.538 ± 0.05
0.651MetPro: 0.651 ± 0.032
0.571MetGln: 0.571 ± 0.03
0.86MetArg: 0.86 ± 0.039
1.216MetSer: 1.216 ± 0.045
0.803MetThr: 0.803 ± 0.034
1.334MetVal: 1.334 ± 0.047
0.137MetTrp: 0.137 ± 0.014
0.742MetTyr: 0.742 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.289AsnAla: 2.289 ± 0.065
0.588AsnCys: 0.588 ± 0.035
3.366AsnAsp: 3.366 ± 0.071
4.552AsnGlu: 4.552 ± 0.095
3.847AsnPhe: 3.847 ± 0.098
2.934AsnGly: 2.934 ± 0.067
0.945AsnHis: 0.945 ± 0.041
8.506AsnIle: 8.506 ± 0.145
8.233AsnLys: 8.233 ± 0.151
6.978AsnLeu: 6.978 ± 0.126
1.535AsnMet: 1.535 ± 0.05
5.401AsnAsn: 5.401 ± 0.143
2.227AsnPro: 2.227 ± 0.063
1.743AsnGln: 1.743 ± 0.066
2.649AsnArg: 2.649 ± 0.068
4.023AsnSer: 4.023 ± 0.089
2.578AsnThr: 2.578 ± 0.063
3.143AsnVal: 3.143 ± 0.066
0.565AsnTrp: 0.565 ± 0.03
4.205AsnTyr: 4.205 ± 0.114
0.0AsnXaa: 0.0 ± 0.0
Pro
1.29ProAla: 1.29 ± 0.048
0.234ProCys: 0.234 ± 0.023
1.759ProAsp: 1.759 ± 0.055
2.721ProGlu: 2.721 ± 0.073
1.6ProPhe: 1.6 ± 0.049
1.663ProGly: 1.663 ± 0.062
0.57ProHis: 0.57 ± 0.029
2.201ProIle: 2.201 ± 0.065
2.183ProLys: 2.183 ± 0.06
2.299ProLeu: 2.299 ± 0.061
0.535ProMet: 0.535 ± 0.034
1.284ProAsn: 1.284 ± 0.046
0.792ProPro: 0.792 ± 0.035
0.811ProGln: 0.811 ± 0.038
0.805ProArg: 0.805 ± 0.036
1.626ProSer: 1.626 ± 0.049
1.174ProThr: 1.174 ± 0.042
2.176ProVal: 2.176 ± 0.067
0.171ProTrp: 0.171 ± 0.016
1.309ProTyr: 1.309 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.007GlnAla: 1.007 ± 0.05
0.133GlnCys: 0.133 ± 0.015
1.023GlnAsp: 1.023 ± 0.043
1.477GlnGlu: 1.477 ± 0.051
0.952GlnPhe: 0.952 ± 0.033
0.99GlnGly: 0.99 ± 0.04
0.328GlnHis: 0.328 ± 0.022
2.34GlnIle: 2.34 ± 0.063
3.221GlnLys: 3.221 ± 0.075
1.847GlnLeu: 1.847 ± 0.055
0.612GlnMet: 0.612 ± 0.032
1.996GlnAsn: 1.996 ± 0.06
0.519GlnPro: 0.519 ± 0.029
0.657GlnGln: 0.657 ± 0.038
0.926GlnArg: 0.926 ± 0.038
1.138GlnSer: 1.138 ± 0.04
0.957GlnThr: 0.957 ± 0.047
0.996GlnVal: 0.996 ± 0.04
0.166GlnTrp: 0.166 ± 0.018
1.012GlnTyr: 1.012 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
1.712ArgAla: 1.712 ± 0.051
0.306ArgCys: 0.306 ± 0.021
2.07ArgAsp: 2.07 ± 0.063
3.016ArgGlu: 3.016 ± 0.077
1.659ArgPhe: 1.659 ± 0.047
2.17ArgGly: 2.17 ± 0.058
0.421ArgHis: 0.421 ± 0.028
3.59ArgIle: 3.59 ± 0.068
4.495ArgLys: 4.495 ± 0.088
3.094ArgLeu: 3.094 ± 0.07
0.996ArgMet: 0.996 ± 0.041
2.57ArgAsn: 2.57 ± 0.066
0.769ArgPro: 0.769 ± 0.034
0.689ArgGln: 0.689 ± 0.033
1.579ArgArg: 1.579 ± 0.054
1.589ArgSer: 1.589 ± 0.047
1.398ArgThr: 1.398 ± 0.054
2.016ArgVal: 2.016 ± 0.057
0.372ArgTrp: 0.372 ± 0.026
1.764ArgTyr: 1.764 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
2.487SerAla: 2.487 ± 0.054
0.479SerCys: 0.479 ± 0.027
3.072SerAsp: 3.072 ± 0.076
3.885SerGlu: 3.885 ± 0.073
3.612SerPhe: 3.612 ± 0.088
3.76SerGly: 3.76 ± 0.081
0.883SerHis: 0.883 ± 0.043
6.021SerIle: 6.021 ± 0.108
5.824SerLys: 5.824 ± 0.099
5.58SerLeu: 5.58 ± 0.107
1.302SerMet: 1.302 ± 0.044
3.632SerAsn: 3.632 ± 0.093
1.593SerPro: 1.593 ± 0.052
1.527SerGln: 1.527 ± 0.051
2.338SerArg: 2.338 ± 0.061
4.015SerSer: 4.015 ± 0.086
2.463SerThr: 2.463 ± 0.063
3.119SerVal: 3.119 ± 0.071
0.533SerTrp: 0.533 ± 0.031
2.769SerTyr: 2.769 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
2.216ThrAla: 2.216 ± 0.06
0.248ThrCys: 0.248 ± 0.019
2.415ThrAsp: 2.415 ± 0.06
2.882ThrGlu: 2.882 ± 0.075
1.958ThrPhe: 1.958 ± 0.058
3.207ThrGly: 3.207 ± 0.082
0.725ThrHis: 0.725 ± 0.029
3.877ThrIle: 3.877 ± 0.088
3.458ThrLys: 3.458 ± 0.076
3.568ThrLeu: 3.568 ± 0.073
0.791ThrMet: 0.791 ± 0.038
2.299ThrAsn: 2.299 ± 0.065
1.524ThrPro: 1.524 ± 0.052
0.93ThrGln: 0.93 ± 0.04
1.373ThrArg: 1.373 ± 0.048
2.354ThrSer: 2.354 ± 0.075
1.927ThrThr: 1.927 ± 0.06
2.807ThrVal: 2.807 ± 0.069
0.243ThrTrp: 0.243 ± 0.018
1.776ThrTyr: 1.776 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
2.802ValAla: 2.802 ± 0.07
0.457ValCys: 0.457 ± 0.031
3.526ValAsp: 3.526 ± 0.086
4.298ValGlu: 4.298 ± 0.107
3.058ValPhe: 3.058 ± 0.086
3.438ValGly: 3.438 ± 0.095
0.712ValHis: 0.712 ± 0.034
5.024ValIle: 5.024 ± 0.1
5.332ValLys: 5.332 ± 0.102
5.203ValLeu: 5.203 ± 0.114
1.246ValMet: 1.246 ± 0.043
3.168ValAsn: 3.168 ± 0.067
1.665ValPro: 1.665 ± 0.052
1.125ValGln: 1.125 ± 0.047
1.757ValArg: 1.757 ± 0.069
3.695ValSer: 3.695 ± 0.08
2.131ValThr: 2.131 ± 0.063
3.637ValVal: 3.637 ± 0.095
0.4ValTrp: 0.4 ± 0.026
2.501ValTyr: 2.501 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.406TrpAla: 0.406 ± 0.023
0.039TrpCys: 0.039 ± 0.009
0.491TrpAsp: 0.491 ± 0.032
0.628TrpGlu: 0.628 ± 0.033
0.315TrpPhe: 0.315 ± 0.023
0.565TrpGly: 0.565 ± 0.033
0.115TrpHis: 0.115 ± 0.013
0.759TrpIle: 0.759 ± 0.033
0.775TrpLys: 0.775 ± 0.038
0.623TrpLeu: 0.623 ± 0.036
0.217TrpMet: 0.217 ± 0.02
0.51TrpAsn: 0.51 ± 0.03
0.195TrpPro: 0.195 ± 0.018
0.21TrpGln: 0.21 ± 0.017
0.257TrpArg: 0.257 ± 0.017
0.3TrpSer: 0.3 ± 0.02
0.237TrpThr: 0.237 ± 0.021
0.421TrpVal: 0.421 ± 0.027
0.096TrpTrp: 0.096 ± 0.012
0.292TrpTyr: 0.292 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.655TyrAla: 1.655 ± 0.054
0.425TyrCys: 0.425 ± 0.028
2.798TyrAsp: 2.798 ± 0.078
3.339TyrGlu: 3.339 ± 0.075
3.32TyrPhe: 3.32 ± 0.093
2.515TyrGly: 2.515 ± 0.069
0.838TyrHis: 0.838 ± 0.04
4.382TyrIle: 4.382 ± 0.102
5.181TyrLys: 5.181 ± 0.101
5.161TyrLeu: 5.161 ± 0.124
0.918TyrMet: 0.918 ± 0.033
3.438TyrAsn: 3.438 ± 0.088
1.514TyrPro: 1.514 ± 0.055
1.105TyrGln: 1.105 ± 0.041
2.03TyrArg: 2.03 ± 0.058
3.303TyrSer: 3.303 ± 0.075
1.875TyrThr: 1.875 ± 0.05
2.142TyrVal: 2.142 ± 0.065
0.37TyrTrp: 0.37 ± 0.026
2.904TyrTyr: 2.904 ± 0.092
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2016 proteins (637312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski