Amino acid dipepetide frequency for Turicibacter sp. H121

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.286AlaAla: 4.286 ± 0.106
0.811AlaCys: 0.811 ± 0.034
2.973AlaAsp: 2.973 ± 0.079
3.762AlaGlu: 3.762 ± 0.096
2.694AlaPhe: 2.694 ± 0.071
4.06AlaGly: 4.06 ± 0.099
1.32AlaHis: 1.32 ± 0.048
5.968AlaIle: 5.968 ± 0.107
4.6AlaLys: 4.6 ± 0.096
6.681AlaLeu: 6.681 ± 0.114
1.951AlaMet: 1.951 ± 0.059
3.033AlaAsn: 3.033 ± 0.072
1.811AlaPro: 1.811 ± 0.056
2.409AlaGln: 2.409 ± 0.065
2.342AlaArg: 2.342 ± 0.063
3.583AlaSer: 3.583 ± 0.079
3.612AlaThr: 3.612 ± 0.079
4.229AlaVal: 4.229 ± 0.086
0.472AlaTrp: 0.472 ± 0.028
2.658AlaTyr: 2.658 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.625CysAla: 0.625 ± 0.035
0.217CysCys: 0.217 ± 0.02
0.556CysAsp: 0.556 ± 0.031
0.776CysGlu: 0.776 ± 0.035
0.548CysPhe: 0.548 ± 0.03
1.04CysGly: 1.04 ± 0.048
0.345CysHis: 0.345 ± 0.028
0.773CysIle: 0.773 ± 0.028
0.585CysLys: 0.585 ± 0.034
1.186CysLeu: 1.186 ± 0.048
0.251CysMet: 0.251 ± 0.02
0.377CysAsn: 0.377 ± 0.025
0.484CysPro: 0.484 ± 0.034
0.474CysGln: 0.474 ± 0.025
0.4CysArg: 0.4 ± 0.026
0.631CysSer: 0.631 ± 0.032
0.51CysThr: 0.51 ± 0.028
0.657CysVal: 0.657 ± 0.032
0.073CysTrp: 0.073 ± 0.01
0.509CysTyr: 0.509 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.199AspAla: 3.199 ± 0.076
0.599AspCys: 0.599 ± 0.03
2.55AspAsp: 2.55 ± 0.075
5.017AspGlu: 5.017 ± 0.099
2.548AspPhe: 2.548 ± 0.062
3.234AspGly: 3.234 ± 0.071
1.109AspHis: 1.109 ± 0.039
4.012AspIle: 4.012 ± 0.079
2.768AspLys: 2.768 ± 0.071
5.598AspLeu: 5.598 ± 0.098
1.245AspMet: 1.245 ± 0.04
1.694AspAsn: 1.694 ± 0.046
1.609AspPro: 1.609 ± 0.049
2.018AspGln: 2.018 ± 0.055
1.957AspArg: 1.957 ± 0.06
2.602AspSer: 2.602 ± 0.066
2.325AspThr: 2.325 ± 0.055
3.826AspVal: 3.826 ± 0.084
0.518AspTrp: 0.518 ± 0.028
2.877AspTyr: 2.877 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.335GluAla: 5.335 ± 0.098
0.668GluCys: 0.668 ± 0.036
3.633GluAsp: 3.633 ± 0.074
6.522GluGlu: 6.522 ± 0.12
2.848GluPhe: 2.848 ± 0.068
4.058GluGly: 4.058 ± 0.088
1.41GluHis: 1.41 ± 0.053
5.949GluIle: 5.949 ± 0.106
5.144GluLys: 5.144 ± 0.109
7.629GluLeu: 7.629 ± 0.117
2.365GluMet: 2.365 ± 0.064
3.624GluAsn: 3.624 ± 0.08
1.664GluPro: 1.664 ± 0.054
3.551GluGln: 3.551 ± 0.088
2.976GluArg: 2.976 ± 0.084
3.719GluSer: 3.719 ± 0.086
4.052GluThr: 4.052 ± 0.095
5.858GluVal: 5.858 ± 0.121
0.591GluTrp: 0.591 ± 0.028
2.603GluTyr: 2.603 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
2.44PheAla: 2.44 ± 0.064
0.507PheCys: 0.507 ± 0.03
2.594PheAsp: 2.594 ± 0.072
3.259PheGlu: 3.259 ± 0.08
1.957PhePhe: 1.957 ± 0.075
2.966PheGly: 2.966 ± 0.071
0.724PheHis: 0.724 ± 0.036
4.197PheIle: 4.197 ± 0.121
3.123PheLys: 3.123 ± 0.08
4.22PheLeu: 4.22 ± 0.106
1.201PheMet: 1.201 ± 0.044
2.695PheAsn: 2.695 ± 0.066
1.262PhePro: 1.262 ± 0.053
1.271PheGln: 1.271 ± 0.053
1.286PheArg: 1.286 ± 0.039
2.852PheSer: 2.852 ± 0.067
2.348PheThr: 2.348 ± 0.057
2.935PheVal: 2.935 ± 0.077
0.342PheTrp: 0.342 ± 0.025
1.937PheTyr: 1.937 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
4.283GlyAla: 4.283 ± 0.091
0.944GlyCys: 0.944 ± 0.041
2.933GlyAsp: 2.933 ± 0.076
4.027GlyGlu: 4.027 ± 0.093
3.014GlyPhe: 3.014 ± 0.079
4.079GlyGly: 4.079 ± 0.111
1.369GlyHis: 1.369 ± 0.046
5.5GlyIle: 5.5 ± 0.099
3.93GlyLys: 3.93 ± 0.085
6.098GlyLeu: 6.098 ± 0.124
1.925GlyMet: 1.925 ± 0.06
2.489GlyAsn: 2.489 ± 0.067
1.364GlyPro: 1.364 ± 0.044
2.235GlyGln: 2.235 ± 0.068
2.451GlyArg: 2.451 ± 0.066
3.419GlySer: 3.419 ± 0.076
3.624GlyThr: 3.624 ± 0.081
5.024GlyVal: 5.024 ± 0.098
0.657GlyTrp: 0.657 ± 0.06
3.007GlyTyr: 3.007 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.111HisAla: 1.111 ± 0.043
0.273HisCys: 0.273 ± 0.021
1.077HisAsp: 1.077 ± 0.043
1.61HisGlu: 1.61 ± 0.054
0.973HisPhe: 0.973 ± 0.038
1.216HisGly: 1.216 ± 0.044
0.729HisHis: 0.729 ± 0.041
1.37HisIle: 1.37 ± 0.047
1.007HisLys: 1.007 ± 0.043
2.39HisLeu: 2.39 ± 0.063
0.446HisMet: 0.446 ± 0.025
0.804HisAsn: 0.804 ± 0.033
1.079HisPro: 1.079 ± 0.052
1.231HisGln: 1.231 ± 0.044
0.923HisArg: 0.923 ± 0.037
1.086HisSer: 1.086 ± 0.045
0.985HisThr: 0.985 ± 0.042
1.325HisVal: 1.325 ± 0.045
0.171HisTrp: 0.171 ± 0.018
1.019HisTyr: 1.019 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.635IleAla: 5.635 ± 0.108
0.947IleCys: 0.947 ± 0.04
4.782IleAsp: 4.782 ± 0.096
6.443IleGlu: 6.443 ± 0.123
3.511IlePhe: 3.511 ± 0.101
5.832IleGly: 5.832 ± 0.128
1.656IleHis: 1.656 ± 0.057
6.632IleIle: 6.632 ± 0.142
5.549IleLys: 5.549 ± 0.105
7.662IleLeu: 7.662 ± 0.144
1.911IleMet: 1.911 ± 0.063
4.052IleAsn: 4.052 ± 0.09
3.088IlePro: 3.088 ± 0.079
3.183IleGln: 3.183 ± 0.077
2.819IleArg: 2.819 ± 0.06
5.115IleSer: 5.115 ± 0.098
4.194IleThr: 4.194 ± 0.088
5.652IleVal: 5.652 ± 0.101
0.567IleTrp: 0.567 ± 0.028
3.189IleTyr: 3.189 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
4.075LysAla: 4.075 ± 0.095
0.599LysCys: 0.599 ± 0.028
3.395LysAsp: 3.395 ± 0.084
6.035LysGlu: 6.035 ± 0.108
2.156LysPhe: 2.156 ± 0.052
3.827LysGly: 3.827 ± 0.079
1.277LysHis: 1.277 ± 0.048
4.674LysIle: 4.674 ± 0.088
5.259LysLys: 5.259 ± 0.1
6.021LysLeu: 6.021 ± 0.111
2.202LysMet: 2.202 ± 0.062
3.306LysAsn: 3.306 ± 0.069
2.026LysPro: 2.026 ± 0.072
3.331LysGln: 3.331 ± 0.072
3.108LysArg: 3.108 ± 0.076
3.659LysSer: 3.659 ± 0.084
3.658LysThr: 3.658 ± 0.073
5.037LysVal: 5.037 ± 0.099
0.604LysTrp: 0.604 ± 0.037
2.68LysTyr: 2.68 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
6.663LeuAla: 6.663 ± 0.119
1.04LeuCys: 1.04 ± 0.038
5.358LeuAsp: 5.358 ± 0.086
6.914LeuGlu: 6.914 ± 0.109
4.651LeuPhe: 4.651 ± 0.115
6.169LeuGly: 6.169 ± 0.106
1.684LeuHis: 1.684 ± 0.055
8.402LeuIle: 8.402 ± 0.141
7.624LeuLys: 7.624 ± 0.134
9.749LeuLeu: 9.749 ± 0.173
3.013LeuMet: 3.013 ± 0.065
5.597LeuAsn: 5.597 ± 0.104
3.568LeuPro: 3.568 ± 0.096
3.309LeuGln: 3.309 ± 0.063
3.293LeuArg: 3.293 ± 0.071
7.276LeuSer: 7.276 ± 0.118
6.134LeuThr: 6.134 ± 0.105
6.833LeuVal: 6.833 ± 0.112
0.626LeuTrp: 0.626 ± 0.031
3.661LeuTyr: 3.661 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.936MetAla: 1.936 ± 0.055
0.234MetCys: 0.234 ± 0.019
1.345MetAsp: 1.345 ± 0.045
1.574MetGlu: 1.574 ± 0.047
1.063MetPhe: 1.063 ± 0.043
1.72MetGly: 1.72 ± 0.051
0.414MetHis: 0.414 ± 0.024
2.721MetIle: 2.721 ± 0.07
2.548MetLys: 2.548 ± 0.065
2.397MetLeu: 2.397 ± 0.074
1.102MetMet: 1.102 ± 0.045
1.85MetAsn: 1.85 ± 0.059
0.9MetPro: 0.9 ± 0.039
0.914MetGln: 0.914 ± 0.038
1.05MetArg: 1.05 ± 0.043
1.765MetSer: 1.765 ± 0.057
1.917MetThr: 1.917 ± 0.058
1.774MetVal: 1.774 ± 0.06
0.156MetTrp: 0.156 ± 0.017
0.849MetTyr: 0.849 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.602AsnAla: 2.602 ± 0.075
0.478AsnCys: 0.478 ± 0.026
2.367AsnAsp: 2.367 ± 0.061
3.96AsnGlu: 3.96 ± 0.089
1.901AsnPhe: 1.901 ± 0.062
3.109AsnGly: 3.109 ± 0.082
1.293AsnHis: 1.293 ± 0.049
3.684AsnIle: 3.684 ± 0.093
3.03AsnLys: 3.03 ± 0.086
4.775AsnLeu: 4.775 ± 0.091
1.167AsnMet: 1.167 ± 0.046
2.166AsnAsn: 2.166 ± 0.075
2.133AsnPro: 2.133 ± 0.059
2.741AsnGln: 2.741 ± 0.073
2.04AsnArg: 2.04 ± 0.06
2.306AsnSer: 2.306 ± 0.061
2.223AsnThr: 2.223 ± 0.069
3.163AsnVal: 3.163 ± 0.067
0.478AsnTrp: 0.478 ± 0.028
2.226AsnTyr: 2.226 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.76ProAla: 1.76 ± 0.068
0.315ProCys: 0.315 ± 0.021
1.543ProAsp: 1.543 ± 0.052
2.442ProGlu: 2.442 ± 0.08
1.624ProPhe: 1.624 ± 0.051
1.716ProGly: 1.716 ± 0.053
0.791ProHis: 0.791 ± 0.033
2.813ProIle: 2.813 ± 0.072
2.069ProLys: 2.069 ± 0.058
3.288ProLeu: 3.288 ± 0.07
0.94ProMet: 0.94 ± 0.042
1.664ProAsn: 1.664 ± 0.053
0.628ProPro: 0.628 ± 0.032
1.18ProGln: 1.18 ± 0.043
0.97ProArg: 0.97 ± 0.041
2.108ProSer: 2.108 ± 0.065
2.064ProThr: 2.064 ± 0.064
2.458ProVal: 2.458 ± 0.078
0.257ProTrp: 0.257 ± 0.019
1.574ProTyr: 1.574 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
2.82GlnAla: 2.82 ± 0.068
0.318GlnCys: 0.318 ± 0.025
1.652GlnAsp: 1.652 ± 0.054
2.779GlnGlu: 2.779 ± 0.074
1.791GlnPhe: 1.791 ± 0.054
2.014GlnGly: 2.014 ± 0.056
0.828GlnHis: 0.828 ± 0.039
3.128GlnIle: 3.128 ± 0.067
2.674GlnLys: 2.674 ± 0.07
4.984GlnLeu: 4.984 ± 0.099
1.235GlnMet: 1.235 ± 0.045
1.783GlnAsn: 1.783 ± 0.049
1.319GlnPro: 1.319 ± 0.061
1.951GlnGln: 1.951 ± 0.067
1.503GlnArg: 1.503 ± 0.054
2.474GlnSer: 2.474 ± 0.07
2.51GlnThr: 2.51 ± 0.068
2.723GlnVal: 2.723 ± 0.062
0.359GlnTrp: 0.359 ± 0.024
1.751GlnTyr: 1.751 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.073ArgAla: 2.073 ± 0.062
0.432ArgCys: 0.432 ± 0.028
1.905ArgAsp: 1.905 ± 0.058
2.764ArgGlu: 2.764 ± 0.067
1.69ArgPhe: 1.69 ± 0.055
2.05ArgGly: 2.05 ± 0.057
0.836ArgHis: 0.836 ± 0.038
3.008ArgIle: 3.008 ± 0.067
2.475ArgLys: 2.475 ± 0.072
4.093ArgLeu: 4.093 ± 0.082
1.132ArgMet: 1.132 ± 0.043
1.58ArgAsn: 1.58 ± 0.049
1.213ArgPro: 1.213 ± 0.044
1.902ArgGln: 1.902 ± 0.059
1.832ArgArg: 1.832 ± 0.061
1.922ArgSer: 1.922 ± 0.054
1.725ArgThr: 1.725 ± 0.053
2.553ArgVal: 2.553 ± 0.06
0.296ArgTrp: 0.296 ± 0.024
1.823ArgTyr: 1.823 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.225SerAla: 3.225 ± 0.074
0.628SerCys: 0.628 ± 0.034
3.005SerAsp: 3.005 ± 0.071
3.81SerGlu: 3.81 ± 0.09
3.137SerPhe: 3.137 ± 0.067
3.956SerGly: 3.956 ± 0.097
1.253SerHis: 1.253 ± 0.045
5.024SerIle: 5.024 ± 0.102
3.746SerLys: 3.746 ± 0.083
6.342SerLeu: 6.342 ± 0.108
1.589SerMet: 1.589 ± 0.051
2.805SerAsn: 2.805 ± 0.085
1.723SerPro: 1.723 ± 0.063
2.383SerGln: 2.383 ± 0.064
2.081SerArg: 2.081 ± 0.062
3.78SerSer: 3.78 ± 0.087
3.389SerThr: 3.389 ± 0.073
4.044SerVal: 4.044 ± 0.074
0.504SerTrp: 0.504 ± 0.028
2.698SerTyr: 2.698 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
3.303ThrAla: 3.303 ± 0.076
0.565ThrCys: 0.565 ± 0.03
2.788ThrAsp: 2.788 ± 0.07
3.39ThrGlu: 3.39 ± 0.087
2.648ThrPhe: 2.648 ± 0.07
3.763ThrGly: 3.763 ± 0.09
1.242ThrHis: 1.242 ± 0.045
4.726ThrIle: 4.726 ± 0.092
3.419ThrLys: 3.419 ± 0.074
5.963ThrLeu: 5.963 ± 0.103
1.329ThrMet: 1.329 ± 0.049
2.593ThrAsn: 2.593 ± 0.072
2.301ThrPro: 2.301 ± 0.075
1.885ThrGln: 1.885 ± 0.058
1.778ThrArg: 1.778 ± 0.052
3.274ThrSer: 3.274 ± 0.06
3.291ThrThr: 3.291 ± 0.072
4.18ThrVal: 4.18 ± 0.093
0.411ThrTrp: 0.411 ± 0.027
2.397ThrTyr: 2.397 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.988ValAla: 4.988 ± 0.104
0.842ValCys: 0.842 ± 0.04
3.856ValAsp: 3.856 ± 0.077
5.219ValGlu: 5.219 ± 0.101
2.912ValPhe: 2.912 ± 0.069
4.538ValGly: 4.538 ± 0.097
1.268ValHis: 1.268 ± 0.047
6.148ValIle: 6.148 ± 0.118
4.623ValLys: 4.623 ± 0.091
7.075ValLeu: 7.075 ± 0.126
1.94ValMet: 1.94 ± 0.05
3.38ValAsn: 3.38 ± 0.069
2.287ValPro: 2.287 ± 0.06
2.089ValGln: 2.089 ± 0.058
2.396ValArg: 2.396 ± 0.059
4.587ValSer: 4.587 ± 0.103
4.255ValThr: 4.255 ± 0.095
5.317ValVal: 5.317 ± 0.112
0.5ValTrp: 0.5 ± 0.031
2.628ValTyr: 2.628 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.408TrpAla: 0.408 ± 0.027
0.105TrpCys: 0.105 ± 0.012
0.454TrpAsp: 0.454 ± 0.027
0.445TrpGlu: 0.445 ± 0.027
0.422TrpPhe: 0.422 ± 0.029
0.501TrpGly: 0.501 ± 0.031
0.174TrpHis: 0.174 ± 0.018
0.72TrpIle: 0.72 ± 0.031
0.445TrpLys: 0.445 ± 0.029
0.888TrpLeu: 0.888 ± 0.041
0.332TrpMet: 0.332 ± 0.023
0.39TrpAsn: 0.39 ± 0.024
0.189TrpPro: 0.189 ± 0.016
0.335TrpGln: 0.335 ± 0.027
0.295TrpArg: 0.295 ± 0.02
0.519TrpSer: 0.519 ± 0.029
0.382TrpThr: 0.382 ± 0.026
0.492TrpVal: 0.492 ± 0.027
0.093TrpTrp: 0.093 ± 0.012
0.406TrpTyr: 0.406 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.487TyrAla: 2.487 ± 0.061
0.495TyrCys: 0.495 ± 0.027
2.541TyrAsp: 2.541 ± 0.069
3.451TyrGlu: 3.451 ± 0.077
2.031TyrPhe: 2.031 ± 0.056
2.524TyrGly: 2.524 ± 0.065
1.103TyrHis: 1.103 ± 0.048
2.97TyrIle: 2.97 ± 0.072
2.309TyrLys: 2.309 ± 0.068
4.524TyrLeu: 4.524 ± 0.108
0.952TyrMet: 0.952 ± 0.033
1.959TyrAsn: 1.959 ± 0.062
1.555TyrPro: 1.555 ± 0.05
2.202TyrGln: 2.202 ± 0.066
1.806TyrArg: 1.806 ± 0.059
2.448TyrSer: 2.448 ± 0.066
2.049TyrThr: 2.049 ± 0.066
2.77TyrVal: 2.77 ± 0.069
0.318TyrTrp: 0.318 ± 0.023
2.116TyrTyr: 2.116 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2191 proteins (654515 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski