Amino acid dipepetide frequency for Fusarium sp. AF-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.758AlaAla: 8.758 ± 0.068	1.172AlaCys: 1.172 ± 0.014	4.204AlaAsp: 4.204 ± 0.025	5.157AlaGlu: 5.157 ± 0.052	3.19AlaPhe: 3.19 ± 0.021	5.625AlaGly: 5.625 ± 0.035	1.71AlaHis: 1.71 ± 0.017	4.461AlaIle: 4.461 ± 0.028	4.098AlaLys: 4.098 ± 0.03	7.752AlaLeu: 7.752 ± 0.039	2.032AlaMet: 2.032 ± 0.019	2.795AlaAsn: 2.795 ± 0.021	4.698AlaPro: 4.698 ± 0.045	3.253AlaGln: 3.253 ± 0.025	4.692AlaArg: 4.692 ± 0.029	6.964AlaSer: 6.964 ± 0.031	5.143AlaThr: 5.143 ± 0.029	5.326AlaVal: 5.326 ± 0.03	1.297AlaTrp: 1.297 ± 0.014	2.147AlaTyr: 2.147 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.011	0.273CysCys: 0.273 ± 0.007	0.751CysAsp: 0.751 ± 0.012	0.676CysGlu: 0.676 ± 0.01	0.592CysPhe: 0.592 ± 0.01	0.982CysGly: 0.982 ± 0.012	0.379CysHis: 0.379 ± 0.007	0.791CysIle: 0.791 ± 0.01	0.567CysLys: 0.567 ± 0.01	1.359CysLeu: 1.359 ± 0.013	0.284CysMet: 0.284 ± 0.006	0.456CysAsn: 0.456 ± 0.008	0.727CysPro: 0.727 ± 0.012	0.51CysGln: 0.51 ± 0.008	0.842CysArg: 0.842 ± 0.011	0.967CysSer: 0.967 ± 0.013	0.748CysThr: 0.748 ± 0.013	0.858CysVal: 0.858 ± 0.013	0.248CysTrp: 0.248 ± 0.006	0.385CysTyr: 0.385 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.772AspAla: 4.772 ± 0.026	0.7AspCys: 0.7 ± 0.011	4.676AspAsp: 4.676 ± 0.041	4.663AspGlu: 4.663 ± 0.035	2.302AspPhe: 2.302 ± 0.019	4.289AspGly: 4.289 ± 0.031	1.28AspHis: 1.28 ± 0.014	3.139AspIle: 3.139 ± 0.022	2.63AspLys: 2.63 ± 0.022	5.24AspLeu: 5.24 ± 0.028	1.381AspMet: 1.381 ± 0.015	1.96AspAsn: 1.96 ± 0.017	3.43AspPro: 3.43 ± 0.024	1.987AspGln: 1.987 ± 0.017	3.046AspArg: 3.046 ± 0.023	4.142AspSer: 4.142 ± 0.027	3.021AspThr: 3.021 ± 0.018	3.736AspVal: 3.736 ± 0.024	0.999AspTrp: 0.999 ± 0.01	1.604AspTyr: 1.604 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.7GluAla: 5.7 ± 0.05	0.709GluCys: 0.709 ± 0.011	4.266GluAsp: 4.266 ± 0.029	5.437GluGlu: 5.437 ± 0.062	2.032GluPhe: 2.032 ± 0.017	3.839GluGly: 3.839 ± 0.023	1.422GluHis: 1.422 ± 0.016	3.011GluIle: 3.011 ± 0.021	3.622GluLys: 3.622 ± 0.029	5.243GluLeu: 5.243 ± 0.033	1.527GluMet: 1.527 ± 0.015	2.203GluAsn: 2.203 ± 0.015	3.127GluPro: 3.127 ± 0.038	2.373GluGln: 2.373 ± 0.019	3.778GluArg: 3.778 ± 0.028	4.268GluSer: 4.268 ± 0.028	3.76GluThr: 3.76 ± 0.029	3.67GluVal: 3.67 ± 0.024	0.958GluTrp: 0.958 ± 0.012	1.683GluTyr: 1.683 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.054PheAla: 3.054 ± 0.024	0.612PheCys: 0.612 ± 0.009	2.361PheAsp: 2.361 ± 0.018	2.202PheGlu: 2.202 ± 0.015	1.724PhePhe: 1.724 ± 0.018	2.931PheGly: 2.931 ± 0.023	0.936PheHis: 0.936 ± 0.011	1.95PheIle: 1.95 ± 0.019	1.629PheLys: 1.629 ± 0.016	3.629PheLeu: 3.629 ± 0.026	0.846PheMet: 0.846 ± 0.011	1.488PheAsn: 1.488 ± 0.016	1.975PhePro: 1.975 ± 0.017	1.445PheGln: 1.445 ± 0.013	2.002PheArg: 2.002 ± 0.016	2.95PheSer: 2.95 ± 0.019	2.186PheThr: 2.186 ± 0.017	2.434PheVal: 2.434 ± 0.019	0.721PheTrp: 0.721 ± 0.009	1.093PheTyr: 1.093 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.199GlyAla: 5.199 ± 0.031	0.979GlyCys: 0.979 ± 0.011	3.79GlyAsp: 3.79 ± 0.027	3.663GlyGlu: 3.663 ± 0.026	2.955GlyPhe: 2.955 ± 0.023	5.496GlyGly: 5.496 ± 0.046	1.768GlyHis: 1.768 ± 0.018	3.7GlyIle: 3.7 ± 0.025	3.38GlyLys: 3.38 ± 0.027	6.237GlyLeu: 6.237 ± 0.037	1.654GlyMet: 1.654 ± 0.015	2.557GlyAsn: 2.557 ± 0.023	3.395GlyPro: 3.395 ± 0.026	2.655GlyGln: 2.655 ± 0.023	4.082GlyArg: 4.082 ± 0.026	5.661GlySer: 5.661 ± 0.054	4.042GlyThr: 4.042 ± 0.036	4.355GlyVal: 4.355 ± 0.028	1.264GlyTrp: 1.264 ± 0.014	2.176GlyTyr: 2.176 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.762HisAla: 1.762 ± 0.015	0.353HisCys: 0.353 ± 0.008	1.401HisAsp: 1.401 ± 0.014	1.358HisGlu: 1.358 ± 0.015	0.959HisPhe: 0.959 ± 0.012	1.787HisGly: 1.787 ± 0.018	0.892HisHis: 0.892 ± 0.015	1.243HisIle: 1.243 ± 0.013	0.929HisLys: 0.929 ± 0.01	2.355HisLeu: 2.355 ± 0.019	0.503HisMet: 0.503 ± 0.009	0.801HisAsn: 0.801 ± 0.01	1.579HisPro: 1.579 ± 0.015	1.023HisGln: 1.023 ± 0.012	1.532HisArg: 1.532 ± 0.017	1.707HisSer: 1.707 ± 0.018	1.19HisThr: 1.19 ± 0.016	1.494HisVal: 1.494 ± 0.015	0.381HisTrp: 0.381 ± 0.007	0.694HisTyr: 0.694 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.149IleAla: 4.149 ± 0.023	0.805IleCys: 0.805 ± 0.011	2.958IleAsp: 2.958 ± 0.022	2.946IleGlu: 2.946 ± 0.021	2.061IlePhe: 2.061 ± 0.019	3.332IleGly: 3.332 ± 0.027	1.202IleHis: 1.202 ± 0.012	2.666IleIle: 2.666 ± 0.022	2.258IleLys: 2.258 ± 0.018	4.66IleLeu: 4.66 ± 0.032	1.1IleMet: 1.1 ± 0.013	1.862IleAsn: 1.862 ± 0.018	3.021IlePro: 3.021 ± 0.023	1.958IleGln: 1.958 ± 0.018	2.852IleArg: 2.852 ± 0.022	3.788IleSer: 3.788 ± 0.023	2.929IleThr: 2.929 ± 0.03	3.225IleVal: 3.225 ± 0.023	0.833IleTrp: 0.833 ± 0.01	1.424IleTyr: 1.424 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.313LysAla: 4.313 ± 0.031	0.549LysCys: 0.549 ± 0.01	2.938LysAsp: 2.938 ± 0.024	3.317LysGlu: 3.317 ± 0.027	1.506LysPhe: 1.506 ± 0.017	3.029LysGly: 3.029 ± 0.024	1.169LysHis: 1.169 ± 0.014	2.229LysIle: 2.229 ± 0.018	3.206LysLys: 3.206 ± 0.039	4.119LysLeu: 4.119 ± 0.027	1.045LysMet: 1.045 ± 0.012	1.749LysAsn: 1.749 ± 0.016	2.819LysPro: 2.819 ± 0.024	1.742LysGln: 1.742 ± 0.017	3.172LysArg: 3.172 ± 0.024	3.328LysSer: 3.328 ± 0.026	2.914LysThr: 2.914 ± 0.022	2.886LysVal: 2.886 ± 0.023	0.731LysTrp: 0.731 ± 0.011	1.34LysTyr: 1.34 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.928LeuAla: 7.928 ± 0.037	1.328LeuCys: 1.328 ± 0.016	5.426LeuAsp: 5.426 ± 0.029	5.685LeuGlu: 5.685 ± 0.036	3.46LeuPhe: 3.46 ± 0.028	6.195LeuGly: 6.195 ± 0.038	2.216LeuHis: 2.216 ± 0.021	4.078LeuIle: 4.078 ± 0.028	4.151LeuLys: 4.151 ± 0.029	8.374LeuLeu: 8.374 ± 0.048	1.886LeuMet: 1.886 ± 0.018	3.123LeuAsn: 3.123 ± 0.022	5.339LeuPro: 5.339 ± 0.029	3.73LeuGln: 3.73 ± 0.028	5.655LeuArg: 5.655 ± 0.038	7.148LeuSer: 7.148 ± 0.038	4.812LeuThr: 4.812 ± 0.029	5.644LeuVal: 5.644 ± 0.031	1.324LeuTrp: 1.324 ± 0.016	2.389LeuTyr: 2.389 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	2.407MetAla: 2.407 ± 0.019	0.264MetCys: 0.264 ± 0.006	1.331MetAsp: 1.331 ± 0.012	1.311MetGlu: 1.311 ± 0.014	0.796MetPhe: 0.796 ± 0.012	1.536MetGly: 1.536 ± 0.016	0.478MetHis: 0.478 ± 0.008	1.064MetIle: 1.064 ± 0.011	1.013MetLys: 1.013 ± 0.011	1.869MetLeu: 1.869 ± 0.018	0.638MetMet: 0.638 ± 0.01	0.798MetAsn: 0.798 ± 0.011	1.344MetPro: 1.344 ± 0.013	0.793MetGln: 0.793 ± 0.012	1.265MetArg: 1.265 ± 0.014	1.94MetSer: 1.94 ± 0.017	1.398MetThr: 1.398 ± 0.013	1.387MetVal: 1.387 ± 0.014	0.298MetTrp: 0.298 ± 0.006	0.52MetTyr: 0.52 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.926AsnAla: 2.926 ± 0.019	0.48AsnCys: 0.48 ± 0.009	1.993AsnAsp: 1.993 ± 0.017	1.979AsnGlu: 1.979 ± 0.018	1.343AsnPhe: 1.343 ± 0.013	2.886AsnGly: 2.886 ± 0.029	0.851AsnHis: 0.851 ± 0.011	1.986AsnIle: 1.986 ± 0.016	1.62AsnLys: 1.62 ± 0.016	3.289AsnLeu: 3.289 ± 0.024	0.863AsnMet: 0.863 ± 0.011	1.464AsnAsn: 1.464 ± 0.018	2.412AsnPro: 2.412 ± 0.02	1.317AsnGln: 1.317 ± 0.013	1.876AsnArg: 1.876 ± 0.016	2.583AsnSer: 2.583 ± 0.02	2.083AsnThr: 2.083 ± 0.019	2.247AsnVal: 2.247 ± 0.017	0.596AsnTrp: 0.596 ± 0.009	1.043AsnTyr: 1.043 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.937ProAla: 4.937 ± 0.042	0.58ProCys: 0.58 ± 0.009	3.429ProAsp: 3.429 ± 0.023	4.161ProGlu: 4.161 ± 0.03	2.081ProPhe: 2.081 ± 0.017	4.04ProGly: 4.04 ± 0.043	1.269ProHis: 1.269 ± 0.014	2.582ProIle: 2.582 ± 0.022	2.738ProLys: 2.738 ± 0.023	4.672ProLeu: 4.672 ± 0.028	1.106ProMet: 1.106 ± 0.013	2.148ProAsn: 2.148 ± 0.018	4.754ProPro: 4.754 ± 0.055	2.413ProGln: 2.413 ± 0.025	3.426ProArg: 3.426 ± 0.027	5.621ProSer: 5.621 ± 0.045	3.876ProThr: 3.876 ± 0.034	3.57ProVal: 3.57 ± 0.028	0.858ProTrp: 0.858 ± 0.012	1.489ProTyr: 1.489 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.458GlnAla: 3.458 ± 0.026	0.455GlnCys: 0.455 ± 0.008	2.281GlnAsp: 2.281 ± 0.018	2.449GlnGlu: 2.449 ± 0.021	1.28GlnPhe: 1.28 ± 0.012	2.536GlnGly: 2.536 ± 0.021	1.06GlnHis: 1.06 ± 0.012	1.77GlnIle: 1.77 ± 0.016	1.808GlnLys: 1.808 ± 0.016	3.446GlnLeu: 3.446 ± 0.022	0.864GlnMet: 0.864 ± 0.013	1.376GlnAsn: 1.376 ± 0.016	2.561GlnPro: 2.561 ± 0.027	2.282GlnGln: 2.282 ± 0.035	2.519GlnArg: 2.519 ± 0.02	2.897GlnSer: 2.897 ± 0.022	2.248GlnThr: 2.248 ± 0.02	2.304GlnVal: 2.304 ± 0.017	0.596GlnTrp: 0.596 ± 0.008	1.098GlnTyr: 1.098 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.451ArgAla: 4.451 ± 0.026	0.776ArgCys: 0.776 ± 0.011	3.537ArgAsp: 3.537 ± 0.029	3.661ArgGlu: 3.661 ± 0.03	2.211ArgPhe: 2.211 ± 0.017	3.713ArgGly: 3.713 ± 0.025	1.618ArgHis: 1.618 ± 0.015	2.859ArgIle: 2.859 ± 0.02	3.165ArgLys: 3.165 ± 0.022	5.531ArgLeu: 5.531 ± 0.034	1.305ArgMet: 1.305 ± 0.014	2.169ArgAsn: 2.169 ± 0.017	3.487ArgPro: 3.487 ± 0.026	2.559ArgGln: 2.559 ± 0.021	5.0ArgArg: 5.0 ± 0.037	4.449ArgSer: 4.449 ± 0.03	3.127ArgThr: 3.127 ± 0.021	3.434ArgVal: 3.434 ± 0.022	1.026ArgTrp: 1.026 ± 0.012	1.682ArgTyr: 1.682 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.067SerAla: 6.067 ± 0.034	0.942SerCys: 0.942 ± 0.012	4.272SerAsp: 4.272 ± 0.027	4.146SerGlu: 4.146 ± 0.027	3.035SerPhe: 3.035 ± 0.02	5.416SerGly: 5.416 ± 0.06	1.878SerHis: 1.878 ± 0.017	3.966SerIle: 3.966 ± 0.027	3.603SerLys: 3.603 ± 0.027	7.109SerLeu: 7.109 ± 0.035	1.751SerMet: 1.751 ± 0.016	2.832SerAsn: 2.832 ± 0.02	5.118SerPro: 5.118 ± 0.042	3.127SerGln: 3.127 ± 0.021	4.846SerArg: 4.846 ± 0.032	7.975SerSer: 7.975 ± 0.058	5.351SerThr: 5.351 ± 0.039	4.477SerVal: 4.477 ± 0.024	1.261SerTrp: 1.261 ± 0.013	2.031SerTyr: 2.031 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	5.001ThrAla: 5.001 ± 0.03	0.819ThrCys: 0.819 ± 0.012	2.905ThrAsp: 2.905 ± 0.021	3.311ThrGlu: 3.311 ± 0.026	2.277ThrPhe: 2.277 ± 0.019	4.19ThrGly: 4.19 ± 0.035	1.24ThrHis: 1.24 ± 0.013	3.173ThrIle: 3.173 ± 0.03	2.714ThrLys: 2.714 ± 0.023	5.27ThrLeu: 5.27 ± 0.031	1.254ThrMet: 1.254 ± 0.013	2.071ThrAsn: 2.071 ± 0.015	4.214ThrPro: 4.214 ± 0.04	2.059ThrGln: 2.059 ± 0.018	3.158ThrArg: 3.158 ± 0.022	5.076ThrSer: 5.076 ± 0.04	4.377ThrThr: 4.377 ± 0.056	3.784ThrVal: 3.784 ± 0.043	0.986ThrTrp: 0.986 ± 0.01	1.622ThrTyr: 1.622 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.259ValAla: 5.259 ± 0.033	0.879ValCys: 0.879 ± 0.011	3.838ValAsp: 3.838 ± 0.025	4.004ValGlu: 4.004 ± 0.027	2.543ValPhe: 2.543 ± 0.02	4.034ValGly: 4.034 ± 0.027	1.39ValHis: 1.39 ± 0.013	3.089ValIle: 3.089 ± 0.022	2.953ValLys: 2.953 ± 0.024	5.578ValLeu: 5.578 ± 0.034	1.371ValMet: 1.371 ± 0.013	2.227ValAsn: 2.227 ± 0.017	3.599ValPro: 3.599 ± 0.027	2.344ValGln: 2.344 ± 0.018	3.362ValArg: 3.362 ± 0.022	4.615ValSer: 4.615 ± 0.026	3.676ValThr: 3.676 ± 0.04	4.431ValVal: 4.431 ± 0.028	0.924ValTrp: 0.924 ± 0.01	1.774ValTyr: 1.774 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	1.275TrpAla: 1.275 ± 0.015	0.231TrpCys: 0.231 ± 0.005	0.97TrpAsp: 0.97 ± 0.011	0.943TrpGlu: 0.943 ± 0.012	0.623TrpPhe: 0.623 ± 0.011	1.042TrpGly: 1.042 ± 0.012	0.399TrpHis: 0.399 ± 0.008	0.87TrpIle: 0.87 ± 0.012	0.892TrpLys: 0.892 ± 0.01	1.498TrpLeu: 1.498 ± 0.017	0.405TrpMet: 0.405 ± 0.007	0.67TrpAsn: 0.67 ± 0.009	0.7TrpPro: 0.7 ± 0.01	0.61TrpGln: 0.61 ± 0.008	1.017TrpArg: 1.017 ± 0.013	1.155TrpSer: 1.155 ± 0.012	1.049TrpThr: 1.049 ± 0.013	0.987TrpVal: 0.987 ± 0.012	0.314TrpTrp: 0.314 ± 0.006	0.468TrpTyr: 0.468 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.091TyrAla: 2.091 ± 0.015	0.458TyrCys: 0.458 ± 0.008	1.673TyrAsp: 1.673 ± 0.017	1.557TyrGlu: 1.557 ± 0.014	1.198TyrPhe: 1.198 ± 0.013	2.108TyrGly: 2.108 ± 0.02	0.784TyrHis: 0.784 ± 0.012	1.404TyrIle: 1.404 ± 0.014	1.127TyrLys: 1.127 ± 0.012	2.659TyrLeu: 2.659 ± 0.02	0.636TyrMet: 0.636 ± 0.01	1.088TyrAsn: 1.088 ± 0.012	1.454TyrPro: 1.454 ± 0.015	1.109TyrGln: 1.109 ± 0.012	1.638TyrArg: 1.638 ± 0.017	1.968TyrSer: 1.968 ± 0.018	1.57TyrThr: 1.57 ± 0.014	1.639TyrVal: 1.639 ± 0.017	0.503TyrTrp: 0.503 ± 0.009	0.928TyrTyr: 0.928 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 17739 proteins (7717122 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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