Amino acid dipepetide frequency for Spiroplasma chinense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.312AlaAla: 3.312 ± 0.131
0.528AlaCys: 0.528 ± 0.033
2.422AlaAsp: 2.422 ± 0.089
2.827AlaGlu: 2.827 ± 0.086
2.842AlaPhe: 2.842 ± 0.083
3.128AlaGly: 3.128 ± 0.111
0.665AlaHis: 0.665 ± 0.046
5.165AlaIle: 5.165 ± 0.134
5.401AlaLys: 5.401 ± 0.135
5.1AlaLeu: 5.1 ± 0.12
1.35AlaMet: 1.35 ± 0.062
3.435AlaAsn: 3.435 ± 0.104
1.408AlaPro: 1.408 ± 0.112
1.658AlaGln: 1.658 ± 0.072
1.726AlaArg: 1.726 ± 0.072
3.374AlaSer: 3.374 ± 0.095
3.037AlaThr: 3.037 ± 0.11
3.251AlaVal: 3.251 ± 0.104
0.521AlaTrp: 0.521 ± 0.036
1.89AlaTyr: 1.89 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.439CysAla: 0.439 ± 0.035
0.113CysCys: 0.113 ± 0.02
0.395CysAsp: 0.395 ± 0.031
0.499CysGlu: 0.499 ± 0.039
0.427CysPhe: 0.427 ± 0.035
0.559CysGly: 0.559 ± 0.035
0.135CysHis: 0.135 ± 0.018
0.499CysIle: 0.499 ± 0.037
0.504CysLys: 0.504 ± 0.035
0.653CysLeu: 0.653 ± 0.041
0.14CysMet: 0.14 ± 0.02
0.342CysAsn: 0.342 ± 0.028
0.193CysPro: 0.193 ± 0.023
0.186CysGln: 0.186 ± 0.021
0.159CysArg: 0.159 ± 0.02
0.48CysSer: 0.48 ± 0.035
0.299CysThr: 0.299 ± 0.031
0.472CysVal: 0.472 ± 0.035
0.106CysTrp: 0.106 ± 0.016
0.287CysTyr: 0.287 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.656AspAla: 2.656 ± 0.097
0.335AspCys: 0.335 ± 0.032
2.962AspAsp: 2.962 ± 0.101
4.522AspGlu: 4.522 ± 0.117
3.888AspPhe: 3.888 ± 0.105
2.938AspGly: 2.938 ± 0.115
0.622AspHis: 0.622 ± 0.036
4.992AspIle: 4.992 ± 0.119
5.558AspLys: 5.558 ± 0.113
5.763AspLeu: 5.763 ± 0.118
1.224AspMet: 1.224 ± 0.053
3.596AspAsn: 3.596 ± 0.101
1.49AspPro: 1.49 ± 0.061
1.656AspGln: 1.656 ± 0.06
1.47AspArg: 1.47 ± 0.063
3.345AspSer: 3.345 ± 0.091
2.21AspThr: 2.21 ± 0.075
3.541AspVal: 3.541 ± 0.106
0.733AspTrp: 0.733 ± 0.039
2.839AspTyr: 2.839 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
3.56GluAla: 3.56 ± 0.122
0.388GluCys: 0.388 ± 0.029
3.504GluAsp: 3.504 ± 0.106
5.961GluGlu: 5.961 ± 0.211
3.76GluPhe: 3.76 ± 0.101
3.273GluGly: 3.273 ± 0.099
0.81GluHis: 0.81 ± 0.044
7.334GluIle: 7.334 ± 0.152
8.055GluLys: 8.055 ± 0.165
7.103GluLeu: 7.103 ± 0.137
1.897GluMet: 1.897 ± 0.077
6.103GluAsn: 6.103 ± 0.135
1.675GluPro: 1.675 ± 0.079
2.793GluGln: 2.793 ± 0.105
2.191GluArg: 2.191 ± 0.087
3.731GluSer: 3.731 ± 0.1
3.529GluThr: 3.529 ± 0.087
4.799GluVal: 4.799 ± 0.127
0.706GluTrp: 0.706 ± 0.04
2.687GluTyr: 2.687 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
3.107PheAla: 3.107 ± 0.09
0.48PheCys: 0.48 ± 0.038
3.745PheAsp: 3.745 ± 0.11
4.464PheGlu: 4.464 ± 0.124
2.931PhePhe: 2.931 ± 0.1
3.343PheGly: 3.343 ± 0.104
0.516PheHis: 0.516 ± 0.034
4.784PheIle: 4.784 ± 0.139
5.059PheLys: 5.059 ± 0.114
5.139PheLeu: 5.139 ± 0.137
1.277PheMet: 1.277 ± 0.056
3.714PheAsn: 3.714 ± 0.113
0.991PhePro: 0.991 ± 0.049
1.15PheGln: 1.15 ± 0.048
1.427PheArg: 1.427 ± 0.056
4.003PheSer: 4.003 ± 0.119
2.928PheThr: 2.928 ± 0.076
3.786PheVal: 3.786 ± 0.104
0.646PheTrp: 0.646 ± 0.042
2.251PheTyr: 2.251 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
3.153GlyAla: 3.153 ± 0.104
0.453GlyCys: 0.453 ± 0.037
2.871GlyAsp: 2.871 ± 0.105
3.449GlyGlu: 3.449 ± 0.098
3.15GlyPhe: 3.15 ± 0.096
3.242GlyGly: 3.242 ± 0.116
0.766GlyHis: 0.766 ± 0.05
4.953GlyIle: 4.953 ± 0.118
4.591GlyLys: 4.591 ± 0.118
4.736GlyLeu: 4.736 ± 0.123
1.526GlyMet: 1.526 ± 0.061
2.772GlyAsn: 2.772 ± 0.089
1.198GlyPro: 1.198 ± 0.051
1.772GlyGln: 1.772 ± 0.07
1.627GlyArg: 1.627 ± 0.071
3.427GlySer: 3.427 ± 0.113
3.049GlyThr: 3.049 ± 0.109
4.285GlyVal: 4.285 ± 0.108
0.668GlyTrp: 0.668 ± 0.045
2.391GlyTyr: 2.391 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
0.677HisAla: 0.677 ± 0.043
0.092HisCys: 0.092 ± 0.016
0.605HisAsp: 0.605 ± 0.043
0.713HisGlu: 0.713 ± 0.041
0.721HisPhe: 0.721 ± 0.044
0.641HisGly: 0.641 ± 0.046
0.188HisHis: 0.188 ± 0.022
1.077HisIle: 1.077 ± 0.055
0.933HisLys: 0.933 ± 0.045
1.21HisLeu: 1.21 ± 0.058
0.239HisMet: 0.239 ± 0.022
0.73HisAsn: 0.73 ± 0.04
0.436HisPro: 0.436 ± 0.032
0.333HisGln: 0.333 ± 0.032
0.371HisArg: 0.371 ± 0.03
0.752HisSer: 0.752 ± 0.047
0.533HisThr: 0.533 ± 0.04
0.713HisVal: 0.713 ± 0.04
0.147HisTrp: 0.147 ± 0.018
0.591HisTyr: 0.591 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.322IleAla: 5.322 ± 0.114
0.88IleCys: 0.88 ± 0.049
5.544IleAsp: 5.544 ± 0.121
7.069IleGlu: 7.069 ± 0.161
4.943IlePhe: 4.943 ± 0.153
4.955IleGly: 4.955 ± 0.126
1.044IleHis: 1.044 ± 0.047
7.787IleIle: 7.787 ± 0.163
8.479IleLys: 8.479 ± 0.142
8.207IleLeu: 8.207 ± 0.17
1.923IleMet: 1.923 ± 0.073
6.349IleAsn: 6.349 ± 0.132
2.386IlePro: 2.386 ± 0.073
2.333IleGln: 2.333 ± 0.07
2.521IleArg: 2.521 ± 0.086
6.674IleSer: 6.674 ± 0.134
4.972IleThr: 4.972 ± 0.148
5.679IleVal: 5.679 ± 0.106
0.815IleTrp: 0.815 ± 0.046
3.497IleTyr: 3.497 ± 0.094
0.0IleXaa: 0.0 ± 0.0
Lys
4.685LysAla: 4.685 ± 0.124
0.386LysCys: 0.386 ± 0.034
5.956LysAsp: 5.956 ± 0.116
8.761LysGlu: 8.761 ± 0.169
4.331LysPhe: 4.331 ± 0.114
4.189LysGly: 4.189 ± 0.107
1.106LysHis: 1.106 ± 0.054
8.747LysIle: 8.747 ± 0.151
9.699LysLys: 9.699 ± 0.189
7.951LysLeu: 7.951 ± 0.145
2.596LysMet: 2.596 ± 0.086
7.462LysAsn: 7.462 ± 0.151
2.434LysPro: 2.434 ± 0.089
3.141LysGln: 3.141 ± 0.096
2.863LysArg: 2.863 ± 0.079
4.984LysSer: 4.984 ± 0.121
5.346LysThr: 5.346 ± 0.099
6.221LysVal: 6.221 ± 0.134
0.863LysTrp: 0.863 ± 0.045
3.97LysTyr: 3.97 ± 0.101
0.0LysXaa: 0.0 ± 0.0
Leu
5.033LeuAla: 5.033 ± 0.116
0.569LeuCys: 0.569 ± 0.041
5.368LeuAsp: 5.368 ± 0.135
7.004LeuGlu: 7.004 ± 0.157
5.136LeuPhe: 5.136 ± 0.146
4.84LeuGly: 4.84 ± 0.103
0.988LeuHis: 0.988 ± 0.048
8.433LeuIle: 8.433 ± 0.192
9.219LeuLys: 9.219 ± 0.147
7.836LeuLeu: 7.836 ± 0.158
2.225LeuMet: 2.225 ± 0.079
6.78LeuAsn: 6.78 ± 0.158
2.326LeuPro: 2.326 ± 0.072
2.432LeuGln: 2.432 ± 0.069
2.555LeuArg: 2.555 ± 0.085
6.575LeuSer: 6.575 ± 0.138
5.23LeuThr: 5.23 ± 0.113
5.77LeuVal: 5.77 ± 0.119
0.762LeuTrp: 0.762 ± 0.046
2.912LeuTyr: 2.912 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.485MetAla: 1.485 ± 0.062
0.161MetCys: 0.161 ± 0.022
1.289MetAsp: 1.289 ± 0.042
1.347MetGlu: 1.347 ± 0.066
1.379MetPhe: 1.379 ± 0.068
1.449MetGly: 1.449 ± 0.069
0.34MetHis: 0.34 ± 0.032
2.087MetIle: 2.087 ± 0.08
2.47MetLys: 2.47 ± 0.065
2.222MetLeu: 2.222 ± 0.062
0.624MetMet: 0.624 ± 0.04
1.504MetAsn: 1.504 ± 0.062
0.701MetPro: 0.701 ± 0.042
0.718MetGln: 0.718 ± 0.045
0.656MetArg: 0.656 ± 0.044
1.591MetSer: 1.591 ± 0.063
1.2MetThr: 1.2 ± 0.054
1.42MetVal: 1.42 ± 0.059
0.215MetTrp: 0.215 ± 0.022
0.918MetTyr: 0.918 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
3.237AsnAla: 3.237 ± 0.092
0.436AsnCys: 0.436 ± 0.033
4.044AsnAsp: 4.044 ± 0.112
5.081AsnGlu: 5.081 ± 0.126
4.013AsnPhe: 4.013 ± 0.114
3.57AsnGly: 3.57 ± 0.106
0.81AsnHis: 0.81 ± 0.044
6.276AsnIle: 6.276 ± 0.119
6.732AsnLys: 6.732 ± 0.131
6.578AsnLeu: 6.578 ± 0.153
1.381AsnMet: 1.381 ± 0.066
4.975AsnAsn: 4.975 ± 0.152
2.08AsnPro: 2.08 ± 0.065
2.348AsnGln: 2.348 ± 0.075
1.779AsnArg: 1.779 ± 0.068
4.447AsnSer: 4.447 ± 0.121
2.928AsnThr: 2.928 ± 0.085
4.196AsnVal: 4.196 ± 0.106
0.846AsnTrp: 0.846 ± 0.048
3.413AsnTyr: 3.413 ± 0.118
0.0AsnXaa: 0.0 ± 0.0
Pro
1.188ProAla: 1.188 ± 0.062
0.147ProCys: 0.147 ± 0.02
1.391ProAsp: 1.391 ± 0.078
2.073ProGlu: 2.073 ± 0.08
1.444ProPhe: 1.444 ± 0.071
1.574ProGly: 1.574 ± 0.056
0.301ProHis: 0.301 ± 0.03
2.415ProIle: 2.415 ± 0.08
2.027ProLys: 2.027 ± 0.069
2.196ProLeu: 2.196 ± 0.074
0.595ProMet: 0.595 ± 0.047
1.685ProAsn: 1.685 ± 0.06
0.492ProPro: 0.492 ± 0.038
0.781ProGln: 0.781 ± 0.047
0.694ProArg: 0.694 ± 0.039
1.694ProSer: 1.694 ± 0.093
1.569ProThr: 1.569 ± 0.067
1.656ProVal: 1.656 ± 0.072
0.26ProTrp: 0.26 ± 0.024
0.962ProTyr: 0.962 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.49GlnAla: 1.49 ± 0.063
0.092GlnCys: 0.092 ± 0.014
1.557GlnAsp: 1.557 ± 0.063
2.405GlnGlu: 2.405 ± 0.08
1.41GlnPhe: 1.41 ± 0.055
1.357GlnGly: 1.357 ± 0.054
0.294GlnHis: 0.294 ± 0.026
2.912GlnIle: 2.912 ± 0.075
2.979GlnLys: 2.979 ± 0.084
2.651GlnLeu: 2.651 ± 0.075
0.762GlnMet: 0.762 ± 0.045
2.304GlnAsn: 2.304 ± 0.079
0.672GlnPro: 0.672 ± 0.049
1.056GlnGln: 1.056 ± 0.06
1.169GlnArg: 1.169 ± 0.056
1.571GlnSer: 1.571 ± 0.066
1.581GlnThr: 1.581 ± 0.069
1.849GlnVal: 1.849 ± 0.071
0.304GlnTrp: 0.304 ± 0.025
1.208GlnTyr: 1.208 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
1.67ArgAla: 1.67 ± 0.07
0.145ArgCys: 0.145 ± 0.019
1.646ArgAsp: 1.646 ± 0.061
2.287ArgGlu: 2.287 ± 0.069
1.473ArgPhe: 1.473 ± 0.066
1.429ArgGly: 1.429 ± 0.064
0.41ArgHis: 0.41 ± 0.029
2.663ArgIle: 2.663 ± 0.098
2.774ArgLys: 2.774 ± 0.082
2.391ArgLeu: 2.391 ± 0.079
0.8ArgMet: 0.8 ± 0.045
2.126ArgAsn: 2.126 ± 0.07
0.752ArgPro: 0.752 ± 0.045
0.887ArgGln: 0.887 ± 0.051
1.097ArgArg: 1.097 ± 0.054
1.518ArgSer: 1.518 ± 0.064
1.499ArgThr: 1.499 ± 0.062
1.846ArgVal: 1.846 ± 0.058
0.28ArgTrp: 0.28 ± 0.026
1.208ArgTyr: 1.208 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
3.201SerAla: 3.201 ± 0.101
0.431SerCys: 0.431 ± 0.032
3.444SerAsp: 3.444 ± 0.098
4.208SerGlu: 4.208 ± 0.089
4.083SerPhe: 4.083 ± 0.121
3.852SerGly: 3.852 ± 0.112
0.752SerHis: 0.752 ± 0.049
5.989SerIle: 5.989 ± 0.136
6.161SerLys: 6.161 ± 0.142
6.202SerLeu: 6.202 ± 0.143
1.468SerMet: 1.468 ± 0.06
4.213SerAsn: 4.213 ± 0.129
1.47SerPro: 1.47 ± 0.065
1.88SerGln: 1.88 ± 0.072
1.856SerArg: 1.856 ± 0.061
4.861SerSer: 4.861 ± 0.145
3.495SerThr: 3.495 ± 0.107
4.032SerVal: 4.032 ± 0.117
0.697SerTrp: 0.697 ± 0.042
2.666SerTyr: 2.666 ± 0.094
0.0SerXaa: 0.0 ± 0.0
Thr
2.475ThrAla: 2.475 ± 0.096
0.369ThrCys: 0.369 ± 0.029
2.731ThrAsp: 2.731 ± 0.105
2.762ThrGlu: 2.762 ± 0.087
3.114ThrPhe: 3.114 ± 0.097
3.222ThrGly: 3.222 ± 0.096
0.648ThrHis: 0.648 ± 0.038
5.206ThrIle: 5.206 ± 0.136
4.594ThrLys: 4.594 ± 0.089
5.141ThrLeu: 5.141 ± 0.132
1.051ThrMet: 1.051 ± 0.051
3.37ThrAsn: 3.37 ± 0.097
1.668ThrPro: 1.668 ± 0.074
1.53ThrGln: 1.53 ± 0.063
1.502ThrArg: 1.502 ± 0.061
3.864ThrSer: 3.864 ± 0.115
3.242ThrThr: 3.242 ± 0.094
3.408ThrVal: 3.408 ± 0.115
0.475ThrTrp: 0.475 ± 0.037
2.143ThrTyr: 2.143 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
3.825ValAla: 3.825 ± 0.104
0.492ValCys: 0.492 ± 0.041
3.888ValAsp: 3.888 ± 0.102
5.035ValGlu: 5.035 ± 0.128
3.423ValPhe: 3.423 ± 0.095
3.835ValGly: 3.835 ± 0.112
0.67ValHis: 0.67 ± 0.04
5.599ValIle: 5.599 ± 0.134
5.676ValLys: 5.676 ± 0.131
5.912ValLeu: 5.912 ± 0.123
1.579ValMet: 1.579 ± 0.064
4.088ValAsn: 4.088 ± 0.092
1.61ValPro: 1.61 ± 0.072
1.516ValGln: 1.516 ± 0.058
1.743ValArg: 1.743 ± 0.069
4.514ValSer: 4.514 ± 0.111
3.406ValThr: 3.406 ± 0.118
4.572ValVal: 4.572 ± 0.118
0.607ValTrp: 0.607 ± 0.044
2.434ValTyr: 2.434 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.525TrpAla: 0.525 ± 0.041
0.06TrpCys: 0.06 ± 0.013
0.578TrpAsp: 0.578 ± 0.041
0.61TrpGlu: 0.61 ± 0.041
0.663TrpPhe: 0.663 ± 0.043
0.537TrpGly: 0.537 ± 0.039
0.14TrpHis: 0.14 ± 0.019
1.106TrpIle: 1.106 ± 0.052
0.894TrpLys: 0.894 ± 0.054
0.904TrpLeu: 0.904 ± 0.047
0.309TrpMet: 0.309 ± 0.028
0.733TrpAsn: 0.733 ± 0.042
0.176TrpPro: 0.176 ± 0.025
0.255TrpGln: 0.255 ± 0.022
0.277TrpArg: 0.277 ± 0.024
0.699TrpSer: 0.699 ± 0.041
0.552TrpThr: 0.552 ± 0.035
0.644TrpVal: 0.644 ± 0.039
0.227TrpTrp: 0.227 ± 0.026
0.446TrpTyr: 0.446 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.0TyrAla: 2.0 ± 0.065
0.33TyrCys: 0.33 ± 0.027
2.398TyrAsp: 2.398 ± 0.08
2.781TyrGlu: 2.781 ± 0.078
2.613TyrPhe: 2.613 ± 0.08
2.148TyrGly: 2.148 ± 0.07
0.497TyrHis: 0.497 ± 0.039
3.353TyrIle: 3.353 ± 0.102
3.885TyrLys: 3.885 ± 0.114
4.097TyrLeu: 4.097 ± 0.1
0.81TyrMet: 0.81 ± 0.048
2.89TyrAsn: 2.89 ± 0.093
0.986TyrPro: 0.986 ± 0.05
1.198TyrGln: 1.198 ± 0.062
1.22TyrArg: 1.22 ± 0.059
2.854TyrSer: 2.854 ± 0.099
1.909TyrThr: 1.909 ± 0.072
2.282TyrVal: 2.282 ± 0.068
0.46TyrTrp: 0.46 ± 0.032
1.738TyrTyr: 1.738 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1218 proteins (414899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski