Amino acid dipepetide frequency for Kozakia baliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.896AlaAla: 13.896 ± 0.163	1.226AlaCys: 1.226 ± 0.038	5.751AlaAsp: 5.751 ± 0.085	6.666AlaGlu: 6.666 ± 0.099	3.99AlaPhe: 3.99 ± 0.065	8.678AlaGly: 8.678 ± 0.092	2.772AlaHis: 2.772 ± 0.055	6.036AlaIle: 6.036 ± 0.08	3.554AlaLys: 3.554 ± 0.074	13.55AlaLeu: 13.55 ± 0.148	3.241AlaMet: 3.241 ± 0.054	2.928AlaAsn: 2.928 ± 0.058	5.753AlaPro: 5.753 ± 0.09	4.932AlaGln: 4.932 ± 0.093	8.548AlaArg: 8.548 ± 0.12	6.505AlaSer: 6.505 ± 0.092	5.815AlaThr: 5.815 ± 0.079	7.227AlaVal: 7.227 ± 0.094	1.649AlaTrp: 1.649 ± 0.043	2.399AlaTyr: 2.399 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.142CysAla: 1.142 ± 0.034	0.152CysCys: 0.152 ± 0.012	0.584CysAsp: 0.584 ± 0.023	0.469CysGlu: 0.469 ± 0.023	0.385CysPhe: 0.385 ± 0.023	1.017CysGly: 1.017 ± 0.037	0.296CysHis: 0.296 ± 0.02	0.478CysIle: 0.478 ± 0.021	0.18CysLys: 0.18 ± 0.016	0.919CysLeu: 0.919 ± 0.034	0.17CysMet: 0.17 ± 0.013	0.211CysAsn: 0.211 ± 0.013	0.48CysPro: 0.48 ± 0.023	0.309CysGln: 0.309 ± 0.017	0.701CysArg: 0.701 ± 0.026	0.535CysSer: 0.535 ± 0.026	0.456CysThr: 0.456 ± 0.02	0.711CysVal: 0.711 ± 0.029	0.125CysTrp: 0.125 ± 0.012	0.194CysTyr: 0.194 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.468AspAla: 6.468 ± 0.09	0.487AspCys: 0.487 ± 0.023	2.888AspAsp: 2.888 ± 0.068	3.228AspGlu: 3.228 ± 0.06	2.019AspPhe: 2.019 ± 0.043	4.581AspGly: 4.581 ± 0.082	1.404AspHis: 1.404 ± 0.044	3.208AspIle: 3.208 ± 0.056	1.523AspLys: 1.523 ± 0.044	5.827AspLeu: 5.827 ± 0.082	1.354AspMet: 1.354 ± 0.037	1.41AspAsn: 1.41 ± 0.035	3.198AspPro: 3.198 ± 0.059	1.78AspGln: 1.78 ± 0.045	4.006AspArg: 4.006 ± 0.06	2.318AspSer: 2.318 ± 0.044	2.617AspThr: 2.617 ± 0.046	3.923AspVal: 3.923 ± 0.068	0.926AspTrp: 0.926 ± 0.03	1.459AspTyr: 1.459 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.072GluAla: 7.072 ± 0.107	0.393GluCys: 0.393 ± 0.02	2.652GluAsp: 2.652 ± 0.061	3.182GluGlu: 3.182 ± 0.074	1.495GluPhe: 1.495 ± 0.041	4.023GluGly: 4.023 ± 0.071	1.447GluHis: 1.447 ± 0.037	3.416GluIle: 3.416 ± 0.061	2.317GluLys: 2.317 ± 0.051	4.948GluLeu: 4.948 ± 0.075	1.461GluMet: 1.461 ± 0.045	2.057GluAsn: 2.057 ± 0.044	2.289GluPro: 2.289 ± 0.053	2.333GluGln: 2.333 ± 0.062	4.762GluArg: 4.762 ± 0.093	2.483GluSer: 2.483 ± 0.044	3.504GluThr: 3.504 ± 0.059	3.135GluVal: 3.135 ± 0.065	0.701GluTrp: 0.701 ± 0.027	0.951GluTyr: 0.951 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.944PheAla: 3.944 ± 0.061	0.451PheCys: 0.451 ± 0.022	2.353PheAsp: 2.353 ± 0.051	1.82PheGlu: 1.82 ± 0.045	1.419PhePhe: 1.419 ± 0.042	3.572PheGly: 3.572 ± 0.075	0.914PheHis: 0.914 ± 0.035	1.646PheIle: 1.646 ± 0.043	0.856PheLys: 0.856 ± 0.033	3.636PheLeu: 3.636 ± 0.067	0.811PheMet: 0.811 ± 0.032	1.102PheAsn: 1.102 ± 0.039	1.606PhePro: 1.606 ± 0.04	1.049PheGln: 1.049 ± 0.032	2.32PheArg: 2.32 ± 0.05	2.604PheSer: 2.604 ± 0.053	1.854PheThr: 1.854 ± 0.045	2.691PheVal: 2.691 ± 0.054	0.577PheTrp: 0.577 ± 0.03	0.94PheTyr: 0.94 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.277GlyAla: 8.277 ± 0.103	0.891GlyCys: 0.891 ± 0.03	3.962GlyAsp: 3.962 ± 0.057	4.143GlyGlu: 4.143 ± 0.072	3.434GlyPhe: 3.434 ± 0.057	6.878GlyGly: 6.878 ± 0.115	2.081GlyHis: 2.081 ± 0.049	4.593GlyIle: 4.593 ± 0.075	3.055GlyLys: 3.055 ± 0.062	8.477GlyLeu: 8.477 ± 0.091	2.273GlyMet: 2.273 ± 0.054	2.314GlyAsn: 2.314 ± 0.053	3.266GlyPro: 3.266 ± 0.056	3.072GlyGln: 3.072 ± 0.057	5.738GlyArg: 5.738 ± 0.07	4.455GlySer: 4.455 ± 0.069	4.545GlyThr: 4.545 ± 0.065	5.863GlyVal: 5.863 ± 0.076	1.426GlyTrp: 1.426 ± 0.048	2.168GlyTyr: 2.168 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.887HisAla: 2.887 ± 0.065	0.28HisCys: 0.28 ± 0.018	1.613HisAsp: 1.613 ± 0.039	1.31HisGlu: 1.31 ± 0.042	0.945HisPhe: 0.945 ± 0.036	2.312HisGly: 2.312 ± 0.052	0.852HisHis: 0.852 ± 0.035	1.366HisIle: 1.366 ± 0.043	0.607HisLys: 0.607 ± 0.027	2.504HisLeu: 2.504 ± 0.051	0.548HisMet: 0.548 ± 0.025	0.69HisAsn: 0.69 ± 0.026	1.533HisPro: 1.533 ± 0.047	0.832HisGln: 0.832 ± 0.031	1.786HisArg: 1.786 ± 0.041	1.208HisSer: 1.208 ± 0.039	1.079HisThr: 1.079 ± 0.037	1.81HisVal: 1.81 ± 0.042	0.415HisTrp: 0.415 ± 0.02	0.693HisTyr: 0.693 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.947IleAla: 6.947 ± 0.099	0.624IleCys: 0.624 ± 0.023	3.502IleAsp: 3.502 ± 0.062	3.449IleGlu: 3.449 ± 0.07	1.774IlePhe: 1.774 ± 0.046	5.116IleGly: 5.116 ± 0.077	1.08IleHis: 1.08 ± 0.034	2.343IleIle: 2.343 ± 0.057	1.37IleLys: 1.37 ± 0.037	4.977IleLeu: 4.977 ± 0.08	1.153IleMet: 1.153 ± 0.041	1.524IleAsn: 1.524 ± 0.042	2.573IlePro: 2.573 ± 0.055	1.474IleGln: 1.474 ± 0.033	3.328IleArg: 3.328 ± 0.058	3.394IleSer: 3.394 ± 0.067	2.695IleThr: 2.695 ± 0.055	4.289IleVal: 4.289 ± 0.066	0.691IleTrp: 0.691 ± 0.03	1.145IleTyr: 1.145 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.611LysAla: 3.611 ± 0.071	0.153LysCys: 0.153 ± 0.013	1.5LysAsp: 1.5 ± 0.041	1.604LysGlu: 1.604 ± 0.046	0.9LysPhe: 0.9 ± 0.034	2.285LysGly: 2.285 ± 0.043	0.705LysHis: 0.705 ± 0.028	1.969LysIle: 1.969 ± 0.05	1.314LysLys: 1.314 ± 0.04	3.323LysLeu: 3.323 ± 0.063	0.781LysMet: 0.781 ± 0.028	1.096LysAsn: 1.096 ± 0.037	2.069LysPro: 2.069 ± 0.048	1.163LysGln: 1.163 ± 0.036	2.433LysArg: 2.433 ± 0.049	1.777LysSer: 1.777 ± 0.049	1.929LysThr: 1.929 ± 0.043	1.807LysVal: 1.807 ± 0.059	0.376LysTrp: 0.376 ± 0.021	0.529LysTyr: 0.529 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.718LeuAla: 12.718 ± 0.131	1.138LeuCys: 1.138 ± 0.03	5.844LeuAsp: 5.844 ± 0.085	5.154LeuGlu: 5.154 ± 0.081	3.67LeuPhe: 3.67 ± 0.063	8.135LeuGly: 8.135 ± 0.098	2.685LeuHis: 2.685 ± 0.048	5.113LeuIle: 5.113 ± 0.091	3.319LeuLys: 3.319 ± 0.062	10.387LeuLeu: 10.387 ± 0.134	2.32LeuMet: 2.32 ± 0.05	3.06LeuAsn: 3.06 ± 0.058	6.388LeuPro: 6.388 ± 0.096	3.383LeuGln: 3.383 ± 0.068	7.969LeuArg: 7.969 ± 0.107	7.364LeuSer: 7.364 ± 0.085	6.045LeuThr: 6.045 ± 0.075	6.505LeuVal: 6.505 ± 0.085	1.249LeuTrp: 1.249 ± 0.036	2.187LeuTyr: 2.187 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.901MetAla: 2.901 ± 0.055	0.143MetCys: 0.143 ± 0.012	1.018MetAsp: 1.018 ± 0.032	1.102MetGlu: 1.102 ± 0.033	0.733MetPhe: 0.733 ± 0.026	1.66MetGly: 1.66 ± 0.041	0.509MetHis: 0.509 ± 0.023	1.322MetIle: 1.322 ± 0.039	0.912MetLys: 0.912 ± 0.028	2.648MetLeu: 2.648 ± 0.057	0.66MetMet: 0.66 ± 0.026	0.841MetAsn: 0.841 ± 0.03	1.649MetPro: 1.649 ± 0.046	0.935MetGln: 0.935 ± 0.027	1.915MetArg: 1.915 ± 0.046	1.814MetSer: 1.814 ± 0.045	1.885MetThr: 1.885 ± 0.046	1.542MetVal: 1.542 ± 0.037	0.21MetTrp: 0.21 ± 0.016	0.269MetTyr: 0.269 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.58AsnAla: 3.58 ± 0.064	0.23AsnCys: 0.23 ± 0.017	1.663AsnAsp: 1.663 ± 0.043	1.425AsnGlu: 1.425 ± 0.041	1.129AsnPhe: 1.129 ± 0.033	2.759AsnGly: 2.759 ± 0.058	0.652AsnHis: 0.652 ± 0.029	1.722AsnIle: 1.722 ± 0.044	0.785AsnLys: 0.785 ± 0.029	2.863AsnLeu: 2.863 ± 0.061	0.693AsnMet: 0.693 ± 0.026	0.951AsnAsn: 0.951 ± 0.037	1.846AsnPro: 1.846 ± 0.045	0.935AsnGln: 0.935 ± 0.035	1.888AsnArg: 1.888 ± 0.042	1.487AsnSer: 1.487 ± 0.039	1.448AsnThr: 1.448 ± 0.046	2.156AsnVal: 2.156 ± 0.046	0.537AsnTrp: 0.537 ± 0.027	0.85AsnTyr: 0.85 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.76ProAla: 5.76 ± 0.079	0.386ProCys: 0.386 ± 0.019	3.654ProAsp: 3.654 ± 0.068	3.725ProGlu: 3.725 ± 0.07	2.083ProPhe: 2.083 ± 0.044	4.334ProGly: 4.334 ± 0.074	1.475ProHis: 1.475 ± 0.037	2.606ProIle: 2.606 ± 0.062	1.677ProLys: 1.677 ± 0.047	5.033ProLeu: 5.033 ± 0.07	1.247ProMet: 1.247 ± 0.038	1.722ProAsn: 1.722 ± 0.046	2.969ProPro: 2.969 ± 0.078	2.13ProGln: 2.13 ± 0.047	2.974ProArg: 2.974 ± 0.064	3.276ProSer: 3.276 ± 0.053	2.858ProThr: 2.858 ± 0.055	3.955ProVal: 3.955 ± 0.062	0.753ProTrp: 0.753 ± 0.03	1.283ProTyr: 1.283 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.673GlnAla: 4.673 ± 0.087	0.257GlnCys: 0.257 ± 0.018	1.935GlnAsp: 1.935 ± 0.043	1.973GlnGlu: 1.973 ± 0.045	1.199GlnPhe: 1.199 ± 0.033	2.616GlnGly: 2.616 ± 0.057	0.861GlnHis: 0.861 ± 0.033	2.282GlnIle: 2.282 ± 0.052	1.333GlnLys: 1.333 ± 0.036	3.03GlnLeu: 3.03 ± 0.06	0.832GlnMet: 0.832 ± 0.029	1.297GlnAsn: 1.297 ± 0.041	1.976GlnPro: 1.976 ± 0.052	1.495GlnGln: 1.495 ± 0.05	2.802GlnArg: 2.802 ± 0.053	2.222GlnSer: 2.222 ± 0.05	2.159GlnThr: 2.159 ± 0.052	2.222GlnVal: 2.222 ± 0.054	0.48GlnTrp: 0.48 ± 0.023	0.789GlnTyr: 0.789 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.723ArgAla: 7.723 ± 0.108	0.591ArgCys: 0.591 ± 0.026	4.037ArgAsp: 4.037 ± 0.061	4.209ArgGlu: 4.209 ± 0.081	2.993ArgPhe: 2.993 ± 0.061	4.71ArgGly: 4.71 ± 0.08	2.197ArgHis: 2.197 ± 0.044	4.053ArgIle: 4.053 ± 0.055	2.355ArgLys: 2.355 ± 0.056	8.348ArgLeu: 8.348 ± 0.103	1.764ArgMet: 1.764 ± 0.042	2.177ArgAsn: 2.177 ± 0.052	3.542ArgPro: 3.542 ± 0.067	3.028ArgGln: 3.028 ± 0.058	6.04ArgArg: 6.04 ± 0.105	3.786ArgSer: 3.786 ± 0.062	3.326ArgThr: 3.326 ± 0.049	4.593ArgVal: 4.593 ± 0.074	1.077ArgTrp: 1.077 ± 0.033	1.899ArgTyr: 1.899 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.403SerAla: 6.403 ± 0.082	0.522SerCys: 0.522 ± 0.023	3.223SerAsp: 3.223 ± 0.061	2.965SerGlu: 2.965 ± 0.055	2.416SerPhe: 2.416 ± 0.049	5.409SerGly: 5.409 ± 0.076	1.428SerHis: 1.428 ± 0.048	2.926SerIle: 2.926 ± 0.065	1.568SerLys: 1.568 ± 0.039	6.143SerLeu: 6.143 ± 0.098	1.452SerMet: 1.452 ± 0.036	1.697SerAsn: 1.697 ± 0.043	3.219SerPro: 3.219 ± 0.068	1.88SerGln: 1.88 ± 0.042	3.827SerArg: 3.827 ± 0.062	3.468SerSer: 3.468 ± 0.071	2.932SerThr: 2.932 ± 0.054	4.362SerVal: 4.362 ± 0.071	0.899SerTrp: 0.899 ± 0.031	1.492SerTyr: 1.492 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.703ThrAla: 5.703 ± 0.074	0.447ThrCys: 0.447 ± 0.02	2.828ThrAsp: 2.828 ± 0.06	2.559ThrGlu: 2.559 ± 0.051	1.714ThrPhe: 1.714 ± 0.045	4.773ThrGly: 4.773 ± 0.079	1.361ThrHis: 1.361 ± 0.041	3.029ThrIle: 3.029 ± 0.061	1.547ThrLys: 1.547 ± 0.044	6.465ThrLeu: 6.465 ± 0.088	1.237ThrMet: 1.237 ± 0.033	1.503ThrAsn: 1.503 ± 0.045	3.943ThrPro: 3.943 ± 0.072	2.042ThrGln: 2.042 ± 0.047	3.489ThrArg: 3.489 ± 0.059	2.918ThrSer: 2.918 ± 0.067	2.989ThrThr: 2.989 ± 0.064	3.838ThrVal: 3.838 ± 0.058	0.628ThrTrp: 0.628 ± 0.024	1.207ThrTyr: 1.207 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.762ValAla: 7.762 ± 0.1	0.725ValCys: 0.725 ± 0.028	3.469ValAsp: 3.469 ± 0.059	3.843ValGlu: 3.843 ± 0.08	2.446ValPhe: 2.446 ± 0.057	4.964ValGly: 4.964 ± 0.075	1.502ValHis: 1.502 ± 0.043	3.639ValIle: 3.639 ± 0.069	2.006ValLys: 2.006 ± 0.05	7.476ValLeu: 7.476 ± 0.085	1.854ValMet: 1.854 ± 0.043	1.799ValAsn: 1.799 ± 0.05	3.779ValPro: 3.779 ± 0.061	2.229ValGln: 2.229 ± 0.05	4.544ValArg: 4.544 ± 0.07	4.547ValSer: 4.547 ± 0.064	4.228ValThr: 4.228 ± 0.066	5.013ValVal: 5.013 ± 0.086	0.912ValTrp: 0.912 ± 0.027	1.259ValTyr: 1.259 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.152TrpAla: 1.152 ± 0.038	0.163TrpCys: 0.163 ± 0.012	0.603TrpAsp: 0.603 ± 0.028	0.6TrpGlu: 0.6 ± 0.025	0.574TrpPhe: 0.574 ± 0.031	0.94TrpGly: 0.94 ± 0.041	0.477TrpHis: 0.477 ± 0.024	0.684TrpIle: 0.684 ± 0.024	0.468TrpLys: 0.468 ± 0.021	1.868TrpLeu: 1.868 ± 0.045	0.377TrpMet: 0.377 ± 0.021	0.511TrpAsn: 0.511 ± 0.025	0.706TrpPro: 0.706 ± 0.032	0.614TrpGln: 0.614 ± 0.027	1.472TrpArg: 1.472 ± 0.039	0.907TrpSer: 0.907 ± 0.036	0.731TrpThr: 0.731 ± 0.025	0.845TrpVal: 0.845 ± 0.029	0.244TrpTrp: 0.244 ± 0.015	0.292TrpTyr: 0.292 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.496TyrAla: 2.496 ± 0.052	0.253TyrCys: 0.253 ± 0.016	1.543TyrAsp: 1.543 ± 0.045	1.194TyrGlu: 1.194 ± 0.038	0.848TyrPhe: 0.848 ± 0.027	2.146TyrGly: 2.146 ± 0.055	0.574TyrHis: 0.574 ± 0.025	1.018TyrIle: 1.018 ± 0.032	0.58TyrLys: 0.58 ± 0.025	2.212TyrLeu: 2.212 ± 0.052	0.438TyrMet: 0.438 ± 0.025	0.709TyrAsn: 0.709 ± 0.028	1.116TyrPro: 1.116 ± 0.031	0.82TyrGln: 0.82 ± 0.027	1.905TyrArg: 1.905 ± 0.04	1.167TyrSer: 1.167 ± 0.034	1.127TyrThr: 1.127 ± 0.038	1.51TyrVal: 1.51 ± 0.041	0.351TyrTrp: 0.351 ± 0.021	0.646TyrTyr: 0.646 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3115 proteins (985054 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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