Amino acid dipepetide frequency for Salipiger sp. IMCC34102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.105AlaAla: 17.105 ± 0.208
1.189AlaCys: 1.189 ± 0.038
7.595AlaAsp: 7.595 ± 0.119
8.109AlaGlu: 8.109 ± 0.104
4.345AlaPhe: 4.345 ± 0.066
10.958AlaGly: 10.958 ± 0.124
2.281AlaHis: 2.281 ± 0.051
5.896AlaIle: 5.896 ± 0.075
3.226AlaLys: 3.226 ± 0.073
13.952AlaLeu: 13.952 ± 0.152
3.733AlaMet: 3.733 ± 0.067
2.599AlaAsn: 2.599 ± 0.055
6.178AlaPro: 6.178 ± 0.098
4.86AlaGln: 4.86 ± 0.082
10.128AlaArg: 10.128 ± 0.119
5.645AlaSer: 5.645 ± 0.083
6.72AlaThr: 6.72 ± 0.096
8.67AlaVal: 8.67 ± 0.102
1.449AlaTrp: 1.449 ± 0.047
2.495AlaTyr: 2.495 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.2CysAla: 1.2 ± 0.032
0.093CysCys: 0.093 ± 0.01
0.655CysAsp: 0.655 ± 0.026
0.439CysGlu: 0.439 ± 0.018
0.289CysPhe: 0.289 ± 0.017
0.962CysGly: 0.962 ± 0.034
0.266CysHis: 0.266 ± 0.016
0.39CysIle: 0.39 ± 0.018
0.163CysLys: 0.163 ± 0.013
0.777CysLeu: 0.777 ± 0.028
0.155CysMet: 0.155 ± 0.012
0.175CysAsn: 0.175 ± 0.013
0.468CysPro: 0.468 ± 0.022
0.207CysGln: 0.207 ± 0.013
0.599CysArg: 0.599 ± 0.023
0.383CysSer: 0.383 ± 0.019
0.453CysThr: 0.453 ± 0.022
0.632CysVal: 0.632 ± 0.025
0.093CysTrp: 0.093 ± 0.009
0.19CysTyr: 0.19 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
8.467AspAla: 8.467 ± 0.131
0.539AspCys: 0.539 ± 0.023
3.98AspAsp: 3.98 ± 0.089
3.55AspGlu: 3.55 ± 0.069
2.352AspPhe: 2.352 ± 0.052
6.356AspGly: 6.356 ± 0.103
1.512AspHis: 1.512 ± 0.044
3.015AspIle: 3.015 ± 0.058
1.402AspLys: 1.402 ± 0.049
7.442AspLeu: 7.442 ± 0.088
1.647AspMet: 1.647 ± 0.042
1.298AspAsn: 1.298 ± 0.04
4.32AspPro: 4.32 ± 0.072
1.797AspGln: 1.797 ± 0.042
5.559AspArg: 5.559 ± 0.079
2.251AspSer: 2.251 ± 0.067
3.613AspThr: 3.613 ± 0.073
4.464AspVal: 4.464 ± 0.06
1.259AspTrp: 1.259 ± 0.034
1.611AspTyr: 1.611 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
8.193GluAla: 8.193 ± 0.098
0.306GluCys: 0.306 ± 0.016
3.825GluAsp: 3.825 ± 0.069
3.661GluGlu: 3.661 ± 0.081
1.54GluPhe: 1.54 ± 0.049
4.997GluGly: 4.997 ± 0.07
1.034GluHis: 1.034 ± 0.034
3.406GluIle: 3.406 ± 0.063
1.564GluLys: 1.564 ± 0.045
4.794GluLeu: 4.794 ± 0.071
1.791GluMet: 1.791 ± 0.037
1.471GluAsn: 1.471 ± 0.04
2.418GluPro: 2.418 ± 0.058
1.755GluGln: 1.755 ± 0.039
4.202GluArg: 4.202 ± 0.067
2.12GluSer: 2.12 ± 0.044
3.93GluThr: 3.93 ± 0.066
4.568GluVal: 4.568 ± 0.064
0.629GluTrp: 0.629 ± 0.026
0.915GluTyr: 0.915 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.496PheAla: 4.496 ± 0.07
0.395PheCys: 0.395 ± 0.019
3.053PheAsp: 3.053 ± 0.067
2.184PheGlu: 2.184 ± 0.05
1.299PhePhe: 1.299 ± 0.042
3.644PheGly: 3.644 ± 0.066
0.703PheHis: 0.703 ± 0.028
1.528PheIle: 1.528 ± 0.039
0.8PheLys: 0.8 ± 0.03
3.253PheLeu: 3.253 ± 0.073
0.831PheMet: 0.831 ± 0.029
0.91PheAsn: 0.91 ± 0.028
1.516PhePro: 1.516 ± 0.039
0.956PheGln: 0.956 ± 0.033
2.181PheArg: 2.181 ± 0.044
1.895PheSer: 1.895 ± 0.043
1.981PheThr: 1.981 ± 0.04
2.695PheVal: 2.695 ± 0.056
0.558PheTrp: 0.558 ± 0.022
0.871PheTyr: 0.871 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
10.071GlyAla: 10.071 ± 0.127
0.876GlyCys: 0.876 ± 0.031
5.19GlyAsp: 5.19 ± 0.094
4.721GlyGlu: 4.721 ± 0.08
3.533GlyPhe: 3.533 ± 0.064
7.627GlyGly: 7.627 ± 0.131
1.887GlyHis: 1.887 ± 0.047
4.532GlyIle: 4.532 ± 0.07
2.562GlyLys: 2.562 ± 0.064
9.24GlyLeu: 9.24 ± 0.107
2.505GlyMet: 2.505 ± 0.05
1.976GlyAsn: 1.976 ± 0.049
4.19GlyPro: 4.19 ± 0.065
3.27GlyGln: 3.27 ± 0.06
6.187GlyArg: 6.187 ± 0.08
4.25GlySer: 4.25 ± 0.073
5.221GlyThr: 5.221 ± 0.077
6.428GlyVal: 6.428 ± 0.098
1.53GlyTrp: 1.53 ± 0.036
2.192GlyTyr: 2.192 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.456HisAla: 2.456 ± 0.058
0.227HisCys: 0.227 ± 0.016
1.431HisAsp: 1.431 ± 0.041
0.971HisGlu: 0.971 ± 0.035
0.757HisPhe: 0.757 ± 0.028
1.841HisGly: 1.841 ± 0.046
0.558HisHis: 0.558 ± 0.033
0.818HisIle: 0.818 ± 0.03
0.444HisLys: 0.444 ± 0.02
2.068HisLeu: 2.068 ± 0.049
0.503HisMet: 0.503 ± 0.023
0.413HisAsn: 0.413 ± 0.022
1.412HisPro: 1.412 ± 0.037
0.518HisGln: 0.518 ± 0.021
1.46HisArg: 1.46 ± 0.038
0.744HisSer: 0.744 ± 0.027
0.831HisThr: 0.831 ± 0.027
1.535HisVal: 1.535 ± 0.037
0.335HisTrp: 0.335 ± 0.019
0.506HisTyr: 0.506 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.125IleAla: 7.125 ± 0.091
0.566IleCys: 0.566 ± 0.025
3.668IleAsp: 3.668 ± 0.061
3.454IleGlu: 3.454 ± 0.051
1.742IlePhe: 1.742 ± 0.05
4.604IleGly: 4.604 ± 0.069
0.907IleHis: 0.907 ± 0.032
1.761IleIle: 1.761 ± 0.046
1.16IleLys: 1.16 ± 0.036
4.631IleLeu: 4.631 ± 0.075
0.996IleMet: 0.996 ± 0.033
1.137IleAsn: 1.137 ± 0.032
2.299IlePro: 2.299 ± 0.045
1.132IleGln: 1.132 ± 0.033
3.089IleArg: 3.089 ± 0.056
2.508IleSer: 2.508 ± 0.049
2.716IleThr: 2.716 ± 0.046
4.029IleVal: 4.029 ± 0.067
0.67IleTrp: 0.67 ± 0.024
1.141IleTyr: 1.141 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.199LysAla: 3.199 ± 0.073
0.139LysCys: 0.139 ± 0.011
1.595LysAsp: 1.595 ± 0.048
1.202LysGlu: 1.202 ± 0.04
0.749LysPhe: 0.749 ± 0.025
2.341LysGly: 2.341 ± 0.051
0.535LysHis: 0.535 ± 0.023
1.385LysIle: 1.385 ± 0.042
0.916LysLys: 0.916 ± 0.041
2.563LysLeu: 2.563 ± 0.044
0.72LysMet: 0.72 ± 0.031
0.617LysAsn: 0.617 ± 0.03
1.505LysPro: 1.505 ± 0.048
0.703LysGln: 0.703 ± 0.029
1.902LysArg: 1.902 ± 0.05
1.592LysSer: 1.592 ± 0.042
1.722LysThr: 1.722 ± 0.04
1.864LysVal: 1.864 ± 0.052
0.306LysTrp: 0.306 ± 0.019
0.468LysTyr: 0.468 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.106LeuAla: 13.106 ± 0.148
0.942LeuCys: 0.942 ± 0.03
6.812LeuAsp: 6.812 ± 0.086
4.987LeuGlu: 4.987 ± 0.068
3.393LeuPhe: 3.393 ± 0.066
8.499LeuGly: 8.499 ± 0.112
1.882LeuHis: 1.882 ± 0.046
4.868LeuIle: 4.868 ± 0.064
2.781LeuLys: 2.781 ± 0.052
8.826LeuLeu: 8.826 ± 0.155
2.537LeuMet: 2.537 ± 0.05
2.429LeuAsn: 2.429 ± 0.051
5.477LeuPro: 5.477 ± 0.075
2.757LeuGln: 2.757 ± 0.055
7.409LeuArg: 7.409 ± 0.096
6.629LeuSer: 6.629 ± 0.086
6.446LeuThr: 6.446 ± 0.086
7.007LeuVal: 7.007 ± 0.091
1.266LeuTrp: 1.266 ± 0.035
1.862LeuTyr: 1.862 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
3.302MetAla: 3.302 ± 0.062
0.182MetCys: 0.182 ± 0.012
1.545MetAsp: 1.545 ± 0.041
1.294MetGlu: 1.294 ± 0.035
0.766MetPhe: 0.766 ± 0.028
2.281MetGly: 2.281 ± 0.051
0.422MetHis: 0.422 ± 0.019
1.5MetIle: 1.5 ± 0.036
0.897MetLys: 0.897 ± 0.029
2.328MetLeu: 2.328 ± 0.049
0.755MetMet: 0.755 ± 0.028
0.775MetAsn: 0.775 ± 0.028
1.493MetPro: 1.493 ± 0.032
0.932MetGln: 0.932 ± 0.028
1.871MetArg: 1.871 ± 0.043
1.623MetSer: 1.623 ± 0.038
2.342MetThr: 2.342 ± 0.05
1.769MetVal: 1.769 ± 0.042
0.258MetTrp: 0.258 ± 0.016
0.309MetTyr: 0.309 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.014AsnAla: 3.014 ± 0.051
0.222AsnCys: 0.222 ± 0.014
1.435AsnAsp: 1.435 ± 0.043
1.144AsnGlu: 1.144 ± 0.038
0.933AsnPhe: 0.933 ± 0.033
2.069AsnGly: 2.069 ± 0.056
0.48AsnHis: 0.48 ± 0.022
1.18AsnIle: 1.18 ± 0.039
0.523AsnLys: 0.523 ± 0.021
2.337AsnLeu: 2.337 ± 0.051
0.602AsnMet: 0.602 ± 0.025
0.596AsnAsn: 0.596 ± 0.028
1.713AsnPro: 1.713 ± 0.041
0.598AsnGln: 0.598 ± 0.024
1.671AsnArg: 1.671 ± 0.041
1.0AsnSer: 1.0 ± 0.035
1.287AsnThr: 1.287 ± 0.039
1.733AsnVal: 1.733 ± 0.038
0.389AsnTrp: 0.389 ± 0.018
0.564AsnTyr: 0.564 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.363ProAla: 6.363 ± 0.089
0.353ProCys: 0.353 ± 0.019
4.44ProAsp: 4.44 ± 0.067
3.819ProGlu: 3.819 ± 0.073
1.894ProPhe: 1.894 ± 0.046
4.769ProGly: 4.769 ± 0.078
1.067ProHis: 1.067 ± 0.038
2.202ProIle: 2.202 ± 0.046
1.407ProLys: 1.407 ± 0.04
4.752ProLeu: 4.752 ± 0.073
1.31ProMet: 1.31 ± 0.032
1.199ProAsn: 1.199 ± 0.033
2.463ProPro: 2.463 ± 0.064
1.836ProGln: 1.836 ± 0.043
3.213ProArg: 3.213 ± 0.051
2.48ProSer: 2.48 ± 0.05
2.585ProThr: 2.585 ± 0.05
4.443ProVal: 4.443 ± 0.07
0.72ProTrp: 0.72 ± 0.027
1.117ProTyr: 1.117 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.338GlnAla: 4.338 ± 0.077
0.183GlnCys: 0.183 ± 0.013
1.897GlnAsp: 1.897 ± 0.04
1.544GlnGlu: 1.544 ± 0.038
1.0GlnPhe: 1.0 ± 0.032
2.58GlnGly: 2.58 ± 0.052
0.545GlnHis: 0.545 ± 0.024
2.042GlnIle: 2.042 ± 0.044
0.833GlnLys: 0.833 ± 0.031
2.705GlnLeu: 2.705 ± 0.048
1.018GlnMet: 1.018 ± 0.031
0.78GlnAsn: 0.78 ± 0.025
1.547GlnPro: 1.547 ± 0.042
1.026GlnGln: 1.026 ± 0.035
2.181GlnArg: 2.181 ± 0.049
1.726GlnSer: 1.726 ± 0.039
2.078GlnThr: 2.078 ± 0.044
2.562GlnVal: 2.562 ± 0.052
0.362GlnTrp: 0.362 ± 0.016
0.491GlnTyr: 0.491 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
9.287ArgAla: 9.287 ± 0.119
0.502ArgCys: 0.502 ± 0.022
5.048ArgAsp: 5.048 ± 0.076
3.727ArgGlu: 3.727 ± 0.067
2.615ArgPhe: 2.615 ± 0.053
4.986ArgGly: 4.986 ± 0.069
1.597ArgHis: 1.597 ± 0.046
4.235ArgIle: 4.235 ± 0.062
1.989ArgLys: 1.989 ± 0.05
7.662ArgLeu: 7.662 ± 0.113
2.122ArgMet: 2.122 ± 0.045
1.772ArgAsn: 1.772 ± 0.043
3.649ArgPro: 3.649 ± 0.067
2.336ArgGln: 2.336 ± 0.046
5.418ArgArg: 5.418 ± 0.091
3.414ArgSer: 3.414 ± 0.063
3.698ArgThr: 3.698 ± 0.06
4.996ArgVal: 4.996 ± 0.068
0.98ArgTrp: 0.98 ± 0.027
1.42ArgTyr: 1.42 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.569SerAla: 5.569 ± 0.077
0.399SerCys: 0.399 ± 0.02
3.543SerAsp: 3.543 ± 0.076
2.714SerGlu: 2.714 ± 0.049
2.172SerPhe: 2.172 ± 0.045
5.08SerGly: 5.08 ± 0.077
0.973SerHis: 0.973 ± 0.031
2.196SerIle: 2.196 ± 0.052
1.324SerLys: 1.324 ± 0.04
4.743SerLeu: 4.743 ± 0.078
1.25SerMet: 1.25 ± 0.04
1.274SerAsn: 1.274 ± 0.044
2.481SerPro: 2.481 ± 0.051
1.587SerGln: 1.587 ± 0.037
3.311SerArg: 3.311 ± 0.055
2.44SerSer: 2.44 ± 0.06
2.615SerThr: 2.615 ± 0.05
3.734SerVal: 3.734 ± 0.057
0.625SerTrp: 0.625 ± 0.026
1.245SerTyr: 1.245 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.923ThrAla: 6.923 ± 0.098
0.501ThrCys: 0.501 ± 0.023
3.878ThrAsp: 3.878 ± 0.071
3.11ThrGlu: 3.11 ± 0.047
2.229ThrPhe: 2.229 ± 0.048
5.816ThrGly: 5.816 ± 0.086
1.118ThrHis: 1.118 ± 0.031
2.772ThrIle: 2.772 ± 0.056
1.268ThrLys: 1.268 ± 0.042
6.554ThrLeu: 6.554 ± 0.086
1.299ThrMet: 1.299 ± 0.037
1.216ThrAsn: 1.216 ± 0.038
3.698ThrPro: 3.698 ± 0.064
1.741ThrGln: 1.741 ± 0.046
3.889ThrArg: 3.889 ± 0.065
2.739ThrSer: 2.739 ± 0.053
3.06ThrThr: 3.06 ± 0.056
4.648ThrVal: 4.648 ± 0.082
0.709ThrTrp: 0.709 ± 0.025
1.364ThrTyr: 1.364 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
9.038ValAla: 9.038 ± 0.108
0.633ValCys: 0.633 ± 0.026
4.332ValAsp: 4.332 ± 0.063
4.732ValGlu: 4.732 ± 0.064
2.722ValPhe: 2.722 ± 0.055
5.599ValGly: 5.599 ± 0.075
1.305ValHis: 1.305 ± 0.036
3.995ValIle: 3.995 ± 0.067
1.915ValLys: 1.915 ± 0.048
7.599ValLeu: 7.599 ± 0.105
2.044ValMet: 2.044 ± 0.047
1.931ValAsn: 1.931 ± 0.043
3.817ValPro: 3.817 ± 0.065
2.195ValGln: 2.195 ± 0.046
4.521ValArg: 4.521 ± 0.074
4.044ValSer: 4.044 ± 0.061
5.213ValThr: 5.213 ± 0.086
5.758ValVal: 5.758 ± 0.088
1.034ValTrp: 1.034 ± 0.037
1.441ValTyr: 1.441 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.32TrpAla: 1.32 ± 0.04
0.133TrpCys: 0.133 ± 0.011
0.886TrpAsp: 0.886 ± 0.029
0.622TrpGlu: 0.622 ± 0.023
0.544TrpPhe: 0.544 ± 0.023
1.025TrpGly: 1.025 ± 0.033
0.279TrpHis: 0.279 ± 0.015
0.749TrpIle: 0.749 ± 0.028
0.38TrpLys: 0.38 ± 0.019
1.558TrpLeu: 1.558 ± 0.044
0.38TrpMet: 0.38 ± 0.018
0.393TrpAsn: 0.393 ± 0.02
0.736TrpPro: 0.736 ± 0.028
0.571TrpGln: 0.571 ± 0.025
1.109TrpArg: 1.109 ± 0.029
0.799TrpSer: 0.799 ± 0.027
0.893TrpThr: 0.893 ± 0.028
0.879TrpVal: 0.879 ± 0.027
0.231TrpTrp: 0.231 ± 0.014
0.248TrpTyr: 0.248 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.562TyrAla: 2.562 ± 0.052
0.209TyrCys: 0.209 ± 0.013
1.625TyrAsp: 1.625 ± 0.045
1.135TyrGlu: 1.135 ± 0.038
0.878TyrPhe: 0.878 ± 0.029
1.955TyrGly: 1.955 ± 0.045
0.475TyrHis: 0.475 ± 0.022
0.866TyrIle: 0.866 ± 0.028
0.467TyrLys: 0.467 ± 0.02
2.132TyrLeu: 2.132 ± 0.05
0.447TyrMet: 0.447 ± 0.022
0.527TyrAsn: 0.527 ± 0.026
1.048TyrPro: 1.048 ± 0.027
0.661TyrGln: 0.661 ± 0.027
1.551TyrArg: 1.551 ± 0.035
0.998TyrSer: 0.998 ± 0.031
1.129TyrThr: 1.129 ± 0.034
1.453TyrVal: 1.453 ± 0.035
0.331TyrTrp: 0.331 ± 0.017
0.571TyrTyr: 0.571 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3341 proteins (1060431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski