Amino acid dipepetide frequency for Mycobacterium sp. NAZ190054

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.246AlaAla: 19.246 ± 0.154
0.945AlaCys: 0.945 ± 0.024
8.508AlaAsp: 8.508 ± 0.076
8.043AlaGlu: 8.043 ± 0.082
3.62AlaPhe: 3.62 ± 0.052
11.797AlaGly: 11.797 ± 0.08
2.438AlaHis: 2.438 ± 0.037
4.866AlaIle: 4.866 ± 0.057
2.808AlaLys: 2.808 ± 0.049
12.716AlaLeu: 12.716 ± 0.095
2.923AlaMet: 2.923 ± 0.043
2.395AlaAsn: 2.395 ± 0.039
5.984AlaPro: 5.984 ± 0.064
3.861AlaGln: 3.861 ± 0.051
8.571AlaArg: 8.571 ± 0.093
5.648AlaSer: 5.648 ± 0.07
7.105AlaThr: 7.105 ± 0.069
12.095AlaVal: 12.095 ± 0.099
1.589AlaTrp: 1.589 ± 0.033
2.339AlaTyr: 2.339 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.027
0.095CysCys: 0.095 ± 0.008
0.571CysAsp: 0.571 ± 0.021
0.419CysGlu: 0.419 ± 0.016
0.227CysPhe: 0.227 ± 0.012
0.958CysGly: 0.958 ± 0.027
0.188CysHis: 0.188 ± 0.009
0.289CysIle: 0.289 ± 0.013
0.112CysLys: 0.112 ± 0.008
0.668CysLeu: 0.668 ± 0.019
0.14CysMet: 0.14 ± 0.01
0.153CysAsn: 0.153 ± 0.011
0.459CysPro: 0.459 ± 0.018
0.195CysGln: 0.195 ± 0.012
0.635CysArg: 0.635 ± 0.02
0.461CysSer: 0.461 ± 0.016
0.483CysThr: 0.483 ± 0.019
0.697CysVal: 0.697 ± 0.022
0.124CysTrp: 0.124 ± 0.008
0.19CysTyr: 0.19 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.916AspAla: 7.916 ± 0.075
0.452AspCys: 0.452 ± 0.016
4.589AspAsp: 4.589 ± 0.067
4.401AspGlu: 4.401 ± 0.055
1.841AspPhe: 1.841 ± 0.035
6.291AspGly: 6.291 ± 0.068
1.415AspHis: 1.415 ± 0.03
2.665AspIle: 2.665 ± 0.042
1.341AspLys: 1.341 ± 0.033
6.12AspLeu: 6.12 ± 0.067
1.121AspMet: 1.121 ± 0.029
1.225AspAsn: 1.225 ± 0.027
4.443AspPro: 4.443 ± 0.053
1.679AspGln: 1.679 ± 0.031
4.791AspArg: 4.791 ± 0.052
2.908AspSer: 2.908 ± 0.047
3.387AspThr: 3.387 ± 0.048
5.711AspVal: 5.711 ± 0.057
0.989AspTrp: 0.989 ± 0.028
1.398AspTyr: 1.398 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.199GluAla: 6.199 ± 0.065
0.394GluCys: 0.394 ± 0.014
2.758GluAsp: 2.758 ± 0.048
2.708GluGlu: 2.708 ± 0.053
1.985GluPhe: 1.985 ± 0.038
3.412GluGly: 3.412 ± 0.053
1.57GluHis: 1.57 ± 0.028
2.827GluIle: 2.827 ± 0.039
1.395GluLys: 1.395 ± 0.034
6.63GluLeu: 6.63 ± 0.06
1.163GluMet: 1.163 ± 0.027
1.215GluAsn: 1.215 ± 0.028
3.224GluPro: 3.224 ± 0.053
2.254GluGln: 2.254 ± 0.037
4.479GluArg: 4.479 ± 0.053
2.787GluSer: 2.787 ± 0.041
2.816GluThr: 2.816 ± 0.042
4.744GluVal: 4.744 ± 0.057
0.766GluTrp: 0.766 ± 0.024
1.172GluTyr: 1.172 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.116PheAla: 4.116 ± 0.047
0.364PheCys: 0.364 ± 0.014
2.524PheAsp: 2.524 ± 0.035
1.594PheGlu: 1.594 ± 0.033
1.067PhePhe: 1.067 ± 0.031
3.613PheGly: 3.613 ± 0.054
0.669PheHis: 0.669 ± 0.018
1.128PheIle: 1.128 ± 0.029
0.558PheLys: 0.558 ± 0.02
2.724PheLeu: 2.724 ± 0.049
0.536PheMet: 0.536 ± 0.017
0.768PheAsn: 0.768 ± 0.021
1.522PhePro: 1.522 ± 0.033
0.719PheGln: 0.719 ± 0.021
1.738PheArg: 1.738 ± 0.037
1.763PheSer: 1.763 ± 0.032
2.246PheThr: 2.246 ± 0.041
2.766PheVal: 2.766 ± 0.037
0.456PheTrp: 0.456 ± 0.018
0.731PheTyr: 0.731 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
10.119GlyAla: 10.119 ± 0.088
0.812GlyCys: 0.812 ± 0.023
5.331GlyAsp: 5.331 ± 0.063
4.602GlyGlu: 4.602 ± 0.051
3.196GlyPhe: 3.196 ± 0.046
7.703GlyGly: 7.703 ± 0.08
2.082GlyHis: 2.082 ± 0.037
4.197GlyIle: 4.197 ± 0.056
2.195GlyLys: 2.195 ± 0.038
8.633GlyLeu: 8.633 ± 0.081
2.22GlyMet: 2.22 ± 0.036
1.892GlyAsn: 1.892 ± 0.041
4.495GlyPro: 4.495 ± 0.057
2.661GlyGln: 2.661 ± 0.049
6.542GlyArg: 6.542 ± 0.066
5.104GlySer: 5.104 ± 0.05
5.381GlyThr: 5.381 ± 0.067
7.953GlyVal: 7.953 ± 0.075
1.646GlyTrp: 1.646 ± 0.034
2.444GlyTyr: 2.444 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.383HisAla: 2.383 ± 0.035
0.215HisCys: 0.215 ± 0.011
1.359HisAsp: 1.359 ± 0.027
1.048HisGlu: 1.048 ± 0.024
0.736HisPhe: 0.736 ± 0.02
2.192HisGly: 2.192 ± 0.042
0.72HisHis: 0.72 ± 0.021
0.785HisIle: 0.785 ± 0.023
0.368HisLys: 0.368 ± 0.015
2.176HisLeu: 2.176 ± 0.037
0.359HisMet: 0.359 ± 0.016
0.463HisAsn: 0.463 ± 0.017
1.634HisPro: 1.634 ± 0.034
0.635HisGln: 0.635 ± 0.021
1.942HisArg: 1.942 ± 0.038
1.018HisSer: 1.018 ± 0.024
1.187HisThr: 1.187 ± 0.029
1.745HisVal: 1.745 ± 0.032
0.373HisTrp: 0.373 ± 0.015
0.544HisTyr: 0.544 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.253IleAla: 6.253 ± 0.062
0.407IleCys: 0.407 ± 0.016
3.351IleAsp: 3.351 ± 0.044
2.691IleGlu: 2.691 ± 0.043
1.066IlePhe: 1.066 ± 0.026
4.537IleGly: 4.537 ± 0.059
0.773IleHis: 0.773 ± 0.02
1.408IleIle: 1.408 ± 0.037
0.862IleLys: 0.862 ± 0.026
3.128IleLeu: 3.128 ± 0.045
0.663IleMet: 0.663 ± 0.02
1.068IleAsn: 1.068 ± 0.031
2.35IlePro: 2.35 ± 0.04
0.938IleGln: 0.938 ± 0.024
2.664IleArg: 2.664 ± 0.04
2.27IleSer: 2.27 ± 0.037
2.83IleThr: 2.83 ± 0.04
3.794IleVal: 3.794 ± 0.05
0.455IleTrp: 0.455 ± 0.02
0.794IleTyr: 0.794 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.573LysAla: 2.573 ± 0.048
0.112LysCys: 0.112 ± 0.008
1.103LysAsp: 1.103 ± 0.029
0.961LysGlu: 0.961 ± 0.025
0.657LysPhe: 0.657 ± 0.024
1.553LysGly: 1.553 ± 0.034
0.497LysHis: 0.497 ± 0.019
1.019LysIle: 1.019 ± 0.028
0.677LysLys: 0.677 ± 0.028
2.168LysLeu: 2.168 ± 0.042
0.49LysMet: 0.49 ± 0.018
0.521LysAsn: 0.521 ± 0.02
1.384LysPro: 1.384 ± 0.031
0.662LysGln: 0.662 ± 0.022
1.581LysArg: 1.581 ± 0.035
1.214LysSer: 1.214 ± 0.027
1.311LysThr: 1.311 ± 0.028
1.983LysVal: 1.983 ± 0.037
0.327LysTrp: 0.327 ± 0.013
0.451LysTyr: 0.451 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
13.438LeuAla: 13.438 ± 0.098
0.843LeuCys: 0.843 ± 0.022
6.647LeuAsp: 6.647 ± 0.064
4.571LeuGlu: 4.571 ± 0.049
2.748LeuPhe: 2.748 ± 0.049
8.792LeuGly: 8.792 ± 0.082
2.038LeuHis: 2.038 ± 0.038
4.11LeuIle: 4.11 ± 0.054
1.865LeuLys: 1.865 ± 0.033
9.579LeuLeu: 9.579 ± 0.097
1.833LeuMet: 1.833 ± 0.032
2.092LeuAsn: 2.092 ± 0.041
5.641LeuPro: 5.641 ± 0.058
2.538LeuGln: 2.538 ± 0.045
7.458LeuArg: 7.458 ± 0.077
5.601LeuSer: 5.601 ± 0.054
6.483LeuThr: 6.483 ± 0.069
8.512LeuVal: 8.512 ± 0.081
1.2LeuTrp: 1.2 ± 0.028
1.715LeuTyr: 1.715 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.683MetAla: 2.683 ± 0.039
0.197MetCys: 0.197 ± 0.011
0.911MetAsp: 0.911 ± 0.028
0.749MetGlu: 0.749 ± 0.023
0.712MetPhe: 0.712 ± 0.02
1.536MetGly: 1.536 ± 0.032
0.433MetHis: 0.433 ± 0.015
0.956MetIle: 0.956 ± 0.028
0.465MetLys: 0.465 ± 0.017
2.148MetLeu: 2.148 ± 0.04
0.466MetMet: 0.466 ± 0.017
0.544MetAsn: 0.544 ± 0.019
1.236MetPro: 1.236 ± 0.026
0.585MetGln: 0.585 ± 0.018
1.639MetArg: 1.639 ± 0.027
1.641MetSer: 1.641 ± 0.03
1.955MetThr: 1.955 ± 0.038
1.673MetVal: 1.673 ± 0.033
0.266MetTrp: 0.266 ± 0.013
0.359MetTyr: 0.359 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.585AsnAla: 2.585 ± 0.042
0.193AsnCys: 0.193 ± 0.01
1.207AsnAsp: 1.207 ± 0.034
1.003AsnGlu: 1.003 ± 0.025
0.668AsnPhe: 0.668 ± 0.023
2.005AsnGly: 2.005 ± 0.039
0.446AsnHis: 0.446 ± 0.016
0.946AsnIle: 0.946 ± 0.026
0.455AsnLys: 0.455 ± 0.018
2.086AsnLeu: 2.086 ± 0.037
0.431AsnMet: 0.431 ± 0.015
0.539AsnAsn: 0.539 ± 0.019
1.733AsnPro: 1.733 ± 0.031
0.614AsnGln: 0.614 ± 0.02
1.59AsnArg: 1.59 ± 0.026
1.09AsnSer: 1.09 ± 0.029
1.269AsnThr: 1.269 ± 0.029
1.8AsnVal: 1.8 ± 0.034
0.375AsnTrp: 0.375 ± 0.015
0.549AsnTyr: 0.549 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
7.239ProAla: 7.239 ± 0.068
0.285ProCys: 0.285 ± 0.015
4.547ProAsp: 4.547 ± 0.057
3.799ProGlu: 3.799 ± 0.05
1.754ProPhe: 1.754 ± 0.029
5.651ProGly: 5.651 ± 0.059
1.201ProHis: 1.201 ± 0.024
2.015ProIle: 2.015 ± 0.04
1.195ProLys: 1.195 ± 0.029
4.844ProLeu: 4.844 ± 0.059
1.253ProMet: 1.253 ± 0.027
1.2ProAsn: 1.2 ± 0.029
3.296ProPro: 3.296 ± 0.074
1.707ProGln: 1.707 ± 0.033
3.448ProArg: 3.448 ± 0.049
3.0ProSer: 3.0 ± 0.047
3.226ProThr: 3.226 ± 0.045
5.173ProVal: 5.173 ± 0.067
0.881ProTrp: 0.881 ± 0.026
1.213ProTyr: 1.213 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.33GlnAla: 3.33 ± 0.049
0.223GlnCys: 0.223 ± 0.013
1.304GlnAsp: 1.304 ± 0.026
1.161GlnGlu: 1.161 ± 0.025
0.993GlnPhe: 0.993 ± 0.026
2.027GlnGly: 2.027 ± 0.039
0.7GlnHis: 0.7 ± 0.02
1.547GlnIle: 1.547 ± 0.033
0.666GlnLys: 0.666 ± 0.021
3.225GlnLeu: 3.225 ± 0.049
0.703GlnMet: 0.703 ± 0.019
0.626GlnAsn: 0.626 ± 0.019
1.688GlnPro: 1.688 ± 0.036
1.279GlnGln: 1.279 ± 0.036
2.692GlnArg: 2.692 ± 0.043
1.439GlnSer: 1.439 ± 0.029
1.576GlnThr: 1.576 ± 0.035
2.391GlnVal: 2.391 ± 0.032
0.58GlnTrp: 0.58 ± 0.017
0.639GlnTyr: 0.639 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.07ArgAla: 8.07 ± 0.076
0.631ArgCys: 0.631 ± 0.02
4.54ArgAsp: 4.54 ± 0.055
4.025ArgGlu: 4.025 ± 0.056
2.491ArgPhe: 2.491 ± 0.039
5.212ArgGly: 5.212 ± 0.057
1.836ArgHis: 1.836 ± 0.032
3.549ArgIle: 3.549 ± 0.047
1.615ArgLys: 1.615 ± 0.035
7.361ArgLeu: 7.361 ± 0.081
1.896ArgMet: 1.896 ± 0.032
1.618ArgAsn: 1.618 ± 0.029
4.0ArgPro: 4.0 ± 0.054
2.265ArgGln: 2.265 ± 0.034
6.73ArgArg: 6.73 ± 0.073
3.973ArgSer: 3.973 ± 0.053
4.329ArgThr: 4.329 ± 0.053
5.675ArgVal: 5.675 ± 0.057
1.33ArgTrp: 1.33 ± 0.03
1.973ArgTyr: 1.973 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.759SerAla: 6.759 ± 0.074
0.42SerCys: 0.42 ± 0.017
3.21SerAsp: 3.21 ± 0.052
2.662SerGlu: 2.662 ± 0.042
1.753SerPhe: 1.753 ± 0.038
5.565SerGly: 5.565 ± 0.065
1.045SerHis: 1.045 ± 0.023
2.177SerIle: 2.177 ± 0.041
1.05SerLys: 1.05 ± 0.031
4.707SerLeu: 4.707 ± 0.049
1.368SerMet: 1.368 ± 0.027
1.035SerAsn: 1.035 ± 0.029
3.055SerPro: 3.055 ± 0.048
1.365SerGln: 1.365 ± 0.029
3.722SerArg: 3.722 ± 0.047
3.038SerSer: 3.038 ± 0.056
3.204SerThr: 3.204 ± 0.05
4.635SerVal: 4.635 ± 0.065
0.852SerTrp: 0.852 ± 0.022
1.23SerTyr: 1.23 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
7.941ThrAla: 7.941 ± 0.081
0.382ThrCys: 0.382 ± 0.014
3.899ThrAsp: 3.899 ± 0.051
3.391ThrGlu: 3.391 ± 0.048
2.001ThrPhe: 2.001 ± 0.042
5.959ThrGly: 5.959 ± 0.064
1.137ThrHis: 1.137 ± 0.027
2.363ThrIle: 2.363 ± 0.046
1.179ThrLys: 1.179 ± 0.029
5.654ThrLeu: 5.654 ± 0.061
1.233ThrMet: 1.233 ± 0.028
1.186ThrAsn: 1.186 ± 0.027
3.839ThrPro: 3.839 ± 0.054
1.402ThrGln: 1.402 ± 0.03
3.711ThrArg: 3.711 ± 0.053
3.098ThrSer: 3.098 ± 0.046
3.835ThrThr: 3.835 ± 0.063
6.345ThrVal: 6.345 ± 0.073
0.855ThrTrp: 0.855 ± 0.021
1.358ThrTyr: 1.358 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
11.641ValAla: 11.641 ± 0.086
0.794ValCys: 0.794 ± 0.023
6.077ValAsp: 6.077 ± 0.065
4.89ValGlu: 4.89 ± 0.057
2.734ValPhe: 2.734 ± 0.044
7.265ValGly: 7.265 ± 0.071
1.837ValHis: 1.837 ± 0.038
4.098ValIle: 4.098 ± 0.048
1.729ValLys: 1.729 ± 0.037
9.13ValLeu: 9.13 ± 0.083
1.712ValMet: 1.712 ± 0.034
2.13ValAsn: 2.13 ± 0.044
4.857ValPro: 4.857 ± 0.053
2.151ValGln: 2.151 ± 0.033
6.049ValArg: 6.049 ± 0.064
4.776ValSer: 4.776 ± 0.053
5.898ValThr: 5.898 ± 0.073
8.96ValVal: 8.96 ± 0.097
1.094ValTrp: 1.094 ± 0.027
1.7ValTyr: 1.7 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.528TrpAla: 1.528 ± 0.031
0.158TrpCys: 0.158 ± 0.011
0.828TrpAsp: 0.828 ± 0.025
0.684TrpGlu: 0.684 ± 0.02
0.546TrpPhe: 0.546 ± 0.021
1.054TrpGly: 1.054 ± 0.026
0.353TrpHis: 0.353 ± 0.016
0.651TrpIle: 0.651 ± 0.018
0.324TrpLys: 0.324 ± 0.013
1.66TrpLeu: 1.66 ± 0.035
0.338TrpMet: 0.338 ± 0.014
0.408TrpAsn: 0.408 ± 0.017
0.807TrpPro: 0.807 ± 0.021
0.595TrpGln: 0.595 ± 0.021
1.257TrpArg: 1.257 ± 0.027
0.897TrpSer: 0.897 ± 0.027
0.947TrpThr: 0.947 ± 0.025
1.155TrpVal: 1.155 ± 0.029
0.335TrpTrp: 0.335 ± 0.014
0.327TrpTyr: 0.327 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.384TyrAla: 2.384 ± 0.037
0.235TyrCys: 0.235 ± 0.012
1.42TyrAsp: 1.42 ± 0.029
1.094TyrGlu: 1.094 ± 0.028
0.806TyrPhe: 0.806 ± 0.02
2.084TyrGly: 2.084 ± 0.036
0.505TyrHis: 0.505 ± 0.019
0.705TyrIle: 0.705 ± 0.021
0.389TyrLys: 0.389 ± 0.015
2.348TyrLeu: 2.348 ± 0.041
0.303TyrMet: 0.303 ± 0.014
0.503TyrAsn: 0.503 ± 0.02
1.282TyrPro: 1.282 ± 0.029
0.685TyrGln: 0.685 ± 0.02
1.88TyrArg: 1.88 ± 0.039
1.128TyrSer: 1.128 ± 0.029
1.3TyrThr: 1.3 ± 0.032
1.714TyrVal: 1.714 ± 0.034
0.358TyrTrp: 0.358 ± 0.014
0.533TyrTyr: 0.533 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5363 proteins (1672165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski