Amino acid dipepetide frequency for Pseudoflavonifractor sp. An176

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.599AlaAla: 9.599 ± 0.149
1.325AlaCys: 1.325 ± 0.039
4.85AlaAsp: 4.85 ± 0.099
5.038AlaGlu: 5.038 ± 0.103
3.081AlaPhe: 3.081 ± 0.061
6.859AlaGly: 6.859 ± 0.097
1.713AlaHis: 1.713 ± 0.057
4.716AlaIle: 4.716 ± 0.092
4.186AlaLys: 4.186 ± 0.087
9.852AlaLeu: 9.852 ± 0.153
2.954AlaMet: 2.954 ± 0.064
2.602AlaAsn: 2.602 ± 0.067
3.375AlaPro: 3.375 ± 0.087
5.281AlaGln: 5.281 ± 0.107
4.246AlaArg: 4.246 ± 0.091
4.334AlaSer: 4.334 ± 0.089
4.548AlaThr: 4.548 ± 0.104
7.402AlaVal: 7.402 ± 0.108
0.932AlaTrp: 0.932 ± 0.041
2.821AlaTyr: 2.821 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
1.459CysAla: 1.459 ± 0.051
0.334CysCys: 0.334 ± 0.024
0.892CysAsp: 0.892 ± 0.034
0.766CysGlu: 0.766 ± 0.037
0.524CysPhe: 0.524 ± 0.026
1.614CysGly: 1.614 ± 0.061
0.417CysHis: 0.417 ± 0.024
0.747CysIle: 0.747 ± 0.035
0.563CysLys: 0.563 ± 0.026
1.369CysLeu: 1.369 ± 0.043
0.369CysMet: 0.369 ± 0.022
0.498CysAsn: 0.498 ± 0.029
0.801CysPro: 0.801 ± 0.037
0.634CysGln: 0.634 ± 0.032
0.892CysArg: 0.892 ± 0.041
0.922CysSer: 0.922 ± 0.044
0.921CysThr: 0.921 ± 0.037
1.21CysVal: 1.21 ± 0.043
0.157CysTrp: 0.157 ± 0.015
0.535CysTyr: 0.535 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.524AspAla: 4.524 ± 0.091
0.809AspCys: 0.809 ± 0.038
2.701AspAsp: 2.701 ± 0.077
3.695AspGlu: 3.695 ± 0.074
2.381AspPhe: 2.381 ± 0.062
5.163AspGly: 5.163 ± 0.11
1.189AspHis: 1.189 ± 0.037
3.206AspIle: 3.206 ± 0.065
2.719AspLys: 2.719 ± 0.074
5.339AspLeu: 5.339 ± 0.093
1.559AspMet: 1.559 ± 0.045
2.039AspAsn: 2.039 ± 0.068
2.568AspPro: 2.568 ± 0.056
2.469AspGln: 2.469 ± 0.068
2.647AspArg: 2.647 ± 0.069
2.782AspSer: 2.782 ± 0.076
3.502AspThr: 3.502 ± 0.086
4.168AspVal: 4.168 ± 0.08
0.694AspTrp: 0.694 ± 0.035
2.363AspTyr: 2.363 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.588GluAla: 5.588 ± 0.099
0.694GluCys: 0.694 ± 0.032
3.856GluAsp: 3.856 ± 0.078
5.878GluGlu: 5.878 ± 0.099
1.98GluPhe: 1.98 ± 0.052
4.965GluGly: 4.965 ± 0.08
1.39GluHis: 1.39 ± 0.048
3.569GluIle: 3.569 ± 0.07
3.856GluLys: 3.856 ± 0.089
6.495GluLeu: 6.495 ± 0.097
1.964GluMet: 1.964 ± 0.056
2.808GluAsn: 2.808 ± 0.072
2.148GluPro: 2.148 ± 0.058
3.418GluGln: 3.418 ± 0.083
3.462GluArg: 3.462 ± 0.09
2.715GluSer: 2.715 ± 0.063
3.583GluThr: 3.583 ± 0.083
4.479GluVal: 4.479 ± 0.085
0.634GluTrp: 0.634 ± 0.03
2.445GluTyr: 2.445 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.055PheAla: 3.055 ± 0.066
0.67PheCys: 0.67 ± 0.032
2.368PheAsp: 2.368 ± 0.056
1.984PheGlu: 1.984 ± 0.053
1.551PhePhe: 1.551 ± 0.054
2.859PheGly: 2.859 ± 0.073
0.892PheHis: 0.892 ± 0.039
1.691PheIle: 1.691 ± 0.053
1.101PheLys: 1.101 ± 0.041
3.6PheLeu: 3.6 ± 0.091
0.802PheMet: 0.802 ± 0.036
1.218PheAsn: 1.218 ± 0.048
1.442PhePro: 1.442 ± 0.044
1.591PheGln: 1.591 ± 0.051
1.798PheArg: 1.798 ± 0.044
2.495PheSer: 2.495 ± 0.066
2.202PheThr: 2.202 ± 0.062
2.678PheVal: 2.678 ± 0.067
0.431PheTrp: 0.431 ± 0.024
1.419PheTyr: 1.419 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
6.348GlyAla: 6.348 ± 0.095
1.386GlyCys: 1.386 ± 0.052
4.384GlyAsp: 4.384 ± 0.093
5.244GlyGlu: 5.244 ± 0.093
2.764GlyPhe: 2.764 ± 0.063
5.933GlyGly: 5.933 ± 0.12
1.555GlyHis: 1.555 ± 0.058
4.544GlyIle: 4.544 ± 0.071
4.355GlyLys: 4.355 ± 0.087
7.352GlyLeu: 7.352 ± 0.118
2.591GlyMet: 2.591 ± 0.068
2.764GlyAsn: 2.764 ± 0.08
1.895GlyPro: 1.895 ± 0.056
3.15GlyGln: 3.15 ± 0.077
3.807GlyArg: 3.807 ± 0.09
4.134GlySer: 4.134 ± 0.088
4.874GlyThr: 4.874 ± 0.116
6.744GlyVal: 6.744 ± 0.12
0.969GlyTrp: 0.969 ± 0.041
3.213GlyTyr: 3.213 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.467HisAla: 1.467 ± 0.046
0.381HisCys: 0.381 ± 0.022
0.927HisAsp: 0.927 ± 0.039
0.934HisGlu: 0.934 ± 0.035
0.809HisPhe: 0.809 ± 0.033
1.625HisGly: 1.625 ± 0.048
0.605HisHis: 0.605 ± 0.038
1.281HisIle: 1.281 ± 0.05
0.808HisLys: 0.808 ± 0.038
1.972HisLeu: 1.972 ± 0.061
0.634HisMet: 0.634 ± 0.029
0.702HisAsn: 0.702 ± 0.035
1.296HisPro: 1.296 ± 0.045
0.911HisGln: 0.911 ± 0.036
1.16HisArg: 1.16 ± 0.047
1.055HisSer: 1.055 ± 0.04
1.351HisThr: 1.351 ± 0.045
1.364HisVal: 1.364 ± 0.044
0.267HisTrp: 0.267 ± 0.018
0.776HisTyr: 0.776 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
4.699IleAla: 4.699 ± 0.097
0.959IleCys: 0.959 ± 0.039
2.799IleAsp: 2.799 ± 0.069
2.591IleGlu: 2.591 ± 0.064
1.933IlePhe: 1.933 ± 0.055
3.631IleGly: 3.631 ± 0.081
1.216IleHis: 1.216 ± 0.049
2.745IleIle: 2.745 ± 0.083
1.814IleLys: 1.814 ± 0.066
5.53IleLeu: 5.53 ± 0.112
1.149IleMet: 1.149 ± 0.04
1.822IleAsn: 1.822 ± 0.056
2.858IlePro: 2.858 ± 0.057
2.257IleGln: 2.257 ± 0.053
2.883IleArg: 2.883 ± 0.076
3.377IleSer: 3.377 ± 0.072
3.583IleThr: 3.583 ± 0.067
3.675IleVal: 3.675 ± 0.076
0.553IleTrp: 0.553 ± 0.03
1.812IleTyr: 1.812 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.282LysAla: 4.282 ± 0.088
0.466LysCys: 0.466 ± 0.031
2.387LysAsp: 2.387 ± 0.065
3.491LysGlu: 3.491 ± 0.082
1.24LysPhe: 1.24 ± 0.047
3.221LysGly: 3.221 ± 0.079
0.784LysHis: 0.784 ± 0.034
2.221LysIle: 2.221 ± 0.065
3.057LysLys: 3.057 ± 0.09
4.325LysLeu: 4.325 ± 0.078
1.358LysMet: 1.358 ± 0.047
1.763LysAsn: 1.763 ± 0.052
1.918LysPro: 1.918 ± 0.065
1.727LysGln: 1.727 ± 0.052
2.458LysArg: 2.458 ± 0.067
2.226LysSer: 2.226 ± 0.057
2.751LysThr: 2.751 ± 0.06
3.384LysVal: 3.384 ± 0.082
0.433LysTrp: 0.433 ± 0.026
1.73LysTyr: 1.73 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
9.182LeuAla: 9.182 ± 0.145
1.891LeuCys: 1.891 ± 0.059
6.019LeuAsp: 6.019 ± 0.097
7.02LeuGlu: 7.02 ± 0.112
3.615LeuPhe: 3.615 ± 0.087
7.4LeuGly: 7.4 ± 0.127
1.918LeuHis: 1.918 ± 0.056
4.482LeuIle: 4.482 ± 0.094
4.143LeuLys: 4.143 ± 0.085
9.933LeuLeu: 9.933 ± 0.202
2.769LeuMet: 2.769 ± 0.063
3.184LeuAsn: 3.184 ± 0.065
4.524LeuPro: 4.524 ± 0.094
3.055LeuGln: 3.055 ± 0.066
5.179LeuArg: 5.179 ± 0.108
7.0LeuSer: 7.0 ± 0.114
6.394LeuThr: 6.394 ± 0.104
7.36LeuVal: 7.36 ± 0.113
1.112LeuTrp: 1.112 ± 0.052
3.374LeuTyr: 3.374 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.934MetAla: 2.934 ± 0.068
0.355MetCys: 0.355 ± 0.024
1.92MetAsp: 1.92 ± 0.049
2.438MetGlu: 2.438 ± 0.051
0.799MetPhe: 0.799 ± 0.031
2.365MetGly: 2.365 ± 0.056
0.424MetHis: 0.424 ± 0.024
1.226MetIle: 1.226 ± 0.049
1.67MetLys: 1.67 ± 0.05
2.632MetLeu: 2.632 ± 0.053
0.74MetMet: 0.74 ± 0.031
1.138MetAsn: 1.138 ± 0.04
1.126MetPro: 1.126 ± 0.039
0.864MetGln: 0.864 ± 0.034
1.391MetArg: 1.391 ± 0.047
1.631MetSer: 1.631 ± 0.047
1.655MetThr: 1.655 ± 0.048
2.196MetVal: 2.196 ± 0.065
0.241MetTrp: 0.241 ± 0.017
0.747MetTyr: 0.747 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.031AsnAla: 3.031 ± 0.082
0.491AsnCys: 0.491 ± 0.027
1.737AsnAsp: 1.737 ± 0.053
1.759AsnGlu: 1.759 ± 0.053
1.2AsnPhe: 1.2 ± 0.038
3.034AsnGly: 3.034 ± 0.089
0.721AsnHis: 0.721 ± 0.029
2.061AsnIle: 2.061 ± 0.056
1.377AsnLys: 1.377 ± 0.054
3.49AsnLeu: 3.49 ± 0.062
0.899AsnMet: 0.899 ± 0.037
1.19AsnAsn: 1.19 ± 0.046
2.035AsnPro: 2.035 ± 0.058
1.496AsnGln: 1.496 ± 0.048
1.82AsnArg: 1.82 ± 0.055
1.738AsnSer: 1.738 ± 0.063
2.177AsnThr: 2.177 ± 0.062
2.467AsnVal: 2.467 ± 0.06
0.483AsnTrp: 0.483 ± 0.031
1.368AsnTyr: 1.368 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
3.596ProAla: 3.596 ± 0.077
0.621ProCys: 0.621 ± 0.031
2.797ProAsp: 2.797 ± 0.062
3.452ProGlu: 3.452 ± 0.071
1.508ProPhe: 1.508 ± 0.048
3.027ProGly: 3.027 ± 0.076
0.859ProHis: 0.859 ± 0.035
1.975ProIle: 1.975 ± 0.062
1.647ProLys: 1.647 ± 0.054
3.644ProLeu: 3.644 ± 0.085
1.121ProMet: 1.121 ± 0.038
1.545ProAsn: 1.545 ± 0.046
1.38ProPro: 1.38 ± 0.054
2.481ProGln: 2.481 ± 0.064
1.764ProArg: 1.764 ± 0.058
2.163ProSer: 2.163 ± 0.058
2.513ProThr: 2.513 ± 0.07
3.649ProVal: 3.649 ± 0.077
0.528ProTrp: 0.528 ± 0.032
1.481ProTyr: 1.481 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.685GlnAla: 4.685 ± 0.092
0.475GlnCys: 0.475 ± 0.029
2.152GlnAsp: 2.152 ± 0.062
3.487GlnGlu: 3.487 ± 0.088
1.329GlnPhe: 1.329 ± 0.045
3.366GlnGly: 3.366 ± 0.098
0.757GlnHis: 0.757 ± 0.035
2.009GlnIle: 2.009 ± 0.063
2.009GlnLys: 2.009 ± 0.05
4.747GlnLeu: 4.747 ± 0.101
1.304GlnMet: 1.304 ± 0.045
1.409GlnAsn: 1.409 ± 0.047
1.818GlnPro: 1.818 ± 0.057
2.224GlnGln: 2.224 ± 0.077
2.649GlnArg: 2.649 ± 0.074
2.03GlnSer: 2.03 ± 0.053
2.297GlnThr: 2.297 ± 0.066
3.781GlnVal: 3.781 ± 0.086
0.542GlnTrp: 0.542 ± 0.03
1.456GlnTyr: 1.456 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.78ArgAla: 3.78 ± 0.074
0.834ArgCys: 0.834 ± 0.038
2.815ArgAsp: 2.815 ± 0.066
3.846ArgGlu: 3.846 ± 0.082
1.939ArgPhe: 1.939 ± 0.055
3.547ArgGly: 3.547 ± 0.087
1.083ArgHis: 1.083 ± 0.045
2.769ArgIle: 2.769 ± 0.068
2.572ArgLys: 2.572 ± 0.071
5.039ArgLeu: 5.039 ± 0.1
1.659ArgMet: 1.659 ± 0.053
1.684ArgAsn: 1.684 ± 0.051
1.958ArgPro: 1.958 ± 0.053
2.47ArgGln: 2.47 ± 0.067
3.701ArgArg: 3.701 ± 0.088
2.614ArgSer: 2.614 ± 0.07
2.78ArgThr: 2.78 ± 0.064
3.708ArgVal: 3.708 ± 0.073
0.641ArgTrp: 0.641 ± 0.033
2.012ArgTyr: 2.012 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.743SerAla: 4.743 ± 0.083
0.821SerCys: 0.821 ± 0.036
2.833SerAsp: 2.833 ± 0.069
2.777SerGlu: 2.777 ± 0.07
2.287SerPhe: 2.287 ± 0.06
5.222SerGly: 5.222 ± 0.094
1.172SerHis: 1.172 ± 0.044
3.023SerIle: 3.023 ± 0.071
2.17SerLys: 2.17 ± 0.057
5.207SerLeu: 5.207 ± 0.104
1.683SerMet: 1.683 ± 0.05
1.877SerAsn: 1.877 ± 0.06
2.29SerPro: 2.29 ± 0.059
2.653SerGln: 2.653 ± 0.068
2.769SerArg: 2.769 ± 0.067
2.983SerSer: 2.983 ± 0.086
3.205SerThr: 3.205 ± 0.069
4.271SerVal: 4.271 ± 0.085
0.652SerTrp: 0.652 ± 0.029
2.111SerTyr: 2.111 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.792ThrAla: 5.792 ± 0.114
0.911ThrCys: 0.911 ± 0.043
3.217ThrAsp: 3.217 ± 0.081
2.903ThrGlu: 2.903 ± 0.072
2.24ThrPhe: 2.24 ± 0.054
4.875ThrGly: 4.875 ± 0.08
1.208ThrHis: 1.208 ± 0.039
3.335ThrIle: 3.335 ± 0.076
2.013ThrLys: 2.013 ± 0.055
6.272ThrLeu: 6.272 ± 0.113
1.585ThrMet: 1.585 ± 0.047
1.827ThrAsn: 1.827 ± 0.07
3.386ThrPro: 3.386 ± 0.076
2.998ThrGln: 2.998 ± 0.085
2.641ThrArg: 2.641 ± 0.064
2.964ThrSer: 2.964 ± 0.08
3.348ThrThr: 3.348 ± 0.097
5.618ThrVal: 5.618 ± 0.125
0.716ThrTrp: 0.716 ± 0.035
2.108ThrTyr: 2.108 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
7.064ValAla: 7.064 ± 0.099
1.463ValCys: 1.463 ± 0.055
4.871ValAsp: 4.871 ± 0.092
5.582ValGlu: 5.582 ± 0.1
2.828ValPhe: 2.828 ± 0.07
5.552ValGly: 5.552 ± 0.095
1.364ValHis: 1.364 ± 0.054
3.912ValIle: 3.912 ± 0.09
3.316ValLys: 3.316 ± 0.079
7.818ValLeu: 7.818 ± 0.142
2.163ValMet: 2.163 ± 0.059
2.597ValAsn: 2.597 ± 0.07
3.113ValPro: 3.113 ± 0.069
2.458ValGln: 2.458 ± 0.06
3.633ValArg: 3.633 ± 0.071
4.961ValSer: 4.961 ± 0.103
5.135ValThr: 5.135 ± 0.135
6.665ValVal: 6.665 ± 0.118
0.861ValTrp: 0.861 ± 0.036
2.733ValTyr: 2.733 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.897TrpAla: 0.897 ± 0.041
0.165TrpCys: 0.165 ± 0.014
0.659TrpAsp: 0.659 ± 0.036
0.826TrpGlu: 0.826 ± 0.03
0.449TrpPhe: 0.449 ± 0.025
0.877TrpGly: 0.877 ± 0.041
0.172TrpHis: 0.172 ± 0.016
0.499TrpIle: 0.499 ± 0.024
0.56TrpLys: 0.56 ± 0.027
1.23TrpLeu: 1.23 ± 0.045
0.389TrpMet: 0.389 ± 0.025
0.555TrpAsn: 0.555 ± 0.03
0.34TrpPro: 0.34 ± 0.022
0.578TrpGln: 0.578 ± 0.029
0.548TrpArg: 0.548 ± 0.028
0.702TrpSer: 0.702 ± 0.038
0.616TrpThr: 0.616 ± 0.035
0.768TrpVal: 0.768 ± 0.036
0.149TrpTrp: 0.149 ± 0.017
0.428TrpTyr: 0.428 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.99TyrAla: 2.99 ± 0.065
0.572TyrCys: 0.572 ± 0.03
2.331TyrAsp: 2.331 ± 0.067
2.214TyrGlu: 2.214 ± 0.057
1.39TyrPhe: 1.39 ± 0.044
2.868TyrGly: 2.868 ± 0.063
0.888TyrHis: 0.888 ± 0.034
1.876TyrIle: 1.876 ± 0.055
1.287TyrLys: 1.287 ± 0.043
3.708TyrLeu: 3.708 ± 0.078
0.798TyrMet: 0.798 ± 0.033
1.351TyrAsn: 1.351 ± 0.058
1.481TyrPro: 1.481 ± 0.046
1.812TyrGln: 1.812 ± 0.057
2.003TyrArg: 2.003 ± 0.06
1.924TyrSer: 1.924 ± 0.056
2.525TyrThr: 2.525 ± 0.074
2.502TyrVal: 2.502 ± 0.061
0.411TyrTrp: 0.411 ± 0.026
1.454TyrTyr: 1.454 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2212 proteins (726739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski