Amino acid dipepetide frequency for Wenzhou sobemo-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.25AlaAla: 2.25 ± 0.195
0.0AlaCys: 0.0 ± 0.0
2.25AlaAsp: 2.25 ± 1.439
5.624AlaGlu: 5.624 ± 0.33
2.25AlaPhe: 2.25 ± 1.439
1.125AlaGly: 1.125 ± 0.719
0.0AlaHis: 0.0 ± 0.0
3.375AlaIle: 3.375 ± 1.109
4.499AlaLys: 4.499 ± 2.023
5.624AlaLeu: 5.624 ± 0.33
4.499AlaMet: 4.499 ± 0.39
3.375AlaAsn: 3.375 ± 1.109
6.749AlaPro: 6.749 ± 2.683
5.624AlaGln: 5.624 ± 0.33
0.0AlaArg: 0.0 ± 0.0
0.0AlaSer: 0.0 ± 0.0
4.499AlaThr: 4.499 ± 1.244
3.375AlaVal: 3.375 ± 0.525
0.0AlaTrp: 0.0 ± 0.0
4.499AlaTyr: 4.499 ± 2.023
0.0AlaXaa: 0.0 ± 0.0
Cys
2.25CysAla: 2.25 ± 0.195
2.25CysCys: 2.25 ± 1.828
0.0CysAsp: 0.0 ± 0.0
1.125CysGlu: 1.125 ± 0.914
0.0CysPhe: 0.0 ± 0.0
1.125CysGly: 1.125 ± 0.914
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.25CysLeu: 2.25 ± 1.828
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
1.125CysGln: 1.125 ± 0.719
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
2.25CysTrp: 2.25 ± 1.828
1.125CysTyr: 1.125 ± 0.914
0.0CysXaa: 0.0 ± 0.0
Asp
3.375AspAla: 3.375 ± 0.525
0.0AspCys: 0.0 ± 0.0
2.25AspAsp: 2.25 ± 0.195
4.499AspGlu: 4.499 ± 0.39
1.125AspPhe: 1.125 ± 0.914
4.499AspGly: 4.499 ± 1.244
2.25AspHis: 2.25 ± 1.439
2.25AspIle: 2.25 ± 0.195
3.375AspLys: 3.375 ± 1.109
0.0AspLeu: 0.0 ± 0.0
1.125AspMet: 1.125 ± 0.719
3.375AspAsn: 3.375 ± 0.525
2.25AspPro: 2.25 ± 1.828
3.375AspGln: 3.375 ± 0.525
2.25AspArg: 2.25 ± 1.828
3.375AspSer: 3.375 ± 0.525
3.375AspThr: 3.375 ± 1.109
4.499AspVal: 4.499 ± 0.39
2.25AspTrp: 2.25 ± 1.828
4.499AspTyr: 4.499 ± 1.244
0.0AspXaa: 0.0 ± 0.0
Glu
8.999GluAla: 8.999 ± 0.779
1.125GluCys: 1.125 ± 0.914
1.125GluAsp: 1.125 ± 0.914
7.874GluGlu: 7.874 ± 1.768
3.375GluPhe: 3.375 ± 2.742
3.375GluGly: 3.375 ± 1.109
1.125GluHis: 1.125 ± 0.719
1.125GluIle: 1.125 ± 0.719
2.25GluLys: 2.25 ± 1.439
4.499GluLeu: 4.499 ± 0.39
2.25GluMet: 2.25 ± 0.427
2.25GluAsn: 2.25 ± 1.439
6.749GluPro: 6.749 ± 3.851
2.25GluGln: 2.25 ± 0.195
3.375GluArg: 3.375 ± 0.525
3.375GluSer: 3.375 ± 2.158
2.25GluThr: 2.25 ± 0.195
4.499GluVal: 4.499 ± 1.244
0.0GluTrp: 0.0 ± 0.0
3.375GluTyr: 3.375 ± 2.158
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
4.499PheGlu: 4.499 ± 3.656
0.0PhePhe: 0.0 ± 0.0
1.125PheGly: 1.125 ± 0.719
0.0PheHis: 0.0 ± 0.0
3.375PheIle: 3.375 ± 1.109
2.25PheLys: 2.25 ± 1.439
1.125PheLeu: 1.125 ± 0.914
1.125PheMet: 1.125 ± 0.719
3.375PheAsn: 3.375 ± 2.158
0.0PhePro: 0.0 ± 0.0
2.25PheGln: 2.25 ± 0.195
2.25PheArg: 2.25 ± 0.195
2.25PheSer: 2.25 ± 0.195
2.25PheThr: 2.25 ± 0.195
4.499PheVal: 4.499 ± 2.023
1.125PheTrp: 1.125 ± 0.914
1.125PheTyr: 1.125 ± 0.914
0.0PheXaa: 0.0 ± 0.0
Gly
2.25GlyAla: 2.25 ± 0.195
2.25GlyCys: 2.25 ± 1.828
2.25GlyAsp: 2.25 ± 0.195
3.375GlyGlu: 3.375 ± 2.158
2.25GlyPhe: 2.25 ± 0.195
3.375GlyGly: 3.375 ± 0.525
0.0GlyHis: 0.0 ± 0.0
5.624GlyIle: 5.624 ± 0.33
7.874GlyLys: 7.874 ± 5.035
2.25GlyLeu: 2.25 ± 0.195
1.125GlyMet: 1.125 ± 0.719
1.125GlyAsn: 1.125 ± 0.914
2.25GlyPro: 2.25 ± 1.828
0.0GlyGln: 0.0 ± 0.0
2.25GlyArg: 2.25 ± 1.828
7.874GlySer: 7.874 ± 3.402
5.624GlyThr: 5.624 ± 0.33
2.25GlyVal: 2.25 ± 0.195
2.25GlyTrp: 2.25 ± 0.195
3.375GlyTyr: 3.375 ± 2.158
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.125HisCys: 1.125 ± 0.914
1.125HisAsp: 1.125 ± 0.914
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
3.375HisLeu: 3.375 ± 2.158
1.125HisMet: 1.125 ± 0.719
0.0HisAsn: 0.0 ± 0.0
2.25HisPro: 2.25 ± 0.195
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
1.125HisThr: 1.125 ± 0.719
2.25HisVal: 2.25 ± 1.439
0.0HisTrp: 0.0 ± 0.0
2.25HisTyr: 2.25 ± 0.195
0.0HisXaa: 0.0 ± 0.0
Ile
3.375IleAla: 3.375 ± 1.109
0.0IleCys: 0.0 ± 0.0
3.375IleAsp: 3.375 ± 2.742
1.125IleGlu: 1.125 ± 0.914
0.0IlePhe: 0.0 ± 0.0
3.375IleGly: 3.375 ± 2.742
0.0IleHis: 0.0 ± 0.0
1.125IleIle: 1.125 ± 0.719
5.624IleLys: 5.624 ± 1.304
3.375IleLeu: 3.375 ± 0.525
5.624IleMet: 5.624 ± 2.937
1.125IleAsn: 1.125 ± 0.914
3.375IlePro: 3.375 ± 0.525
3.375IleGln: 3.375 ± 2.742
4.499IleArg: 4.499 ± 0.39
2.25IleSer: 2.25 ± 0.195
3.375IleThr: 3.375 ± 0.525
2.25IleVal: 2.25 ± 0.195
0.0IleTrp: 0.0 ± 0.0
1.125IleTyr: 1.125 ± 0.719
0.0IleXaa: 0.0 ± 0.0
Lys
3.375LysAla: 3.375 ± 2.158
0.0LysCys: 0.0 ± 0.0
1.125LysAsp: 1.125 ± 0.914
2.25LysGlu: 2.25 ± 0.195
3.375LysPhe: 3.375 ± 2.158
7.874LysGly: 7.874 ± 3.402
1.125LysHis: 1.125 ± 0.914
4.499LysIle: 4.499 ± 3.656
4.499LysLys: 4.499 ± 1.244
3.375LysLeu: 3.375 ± 0.525
0.0LysMet: 0.0 ± 0.0
2.25LysAsn: 2.25 ± 1.439
4.499LysPro: 4.499 ± 1.244
1.125LysGln: 1.125 ± 0.914
3.375LysArg: 3.375 ± 0.525
4.499LysSer: 4.499 ± 2.023
3.375LysThr: 3.375 ± 0.525
4.499LysVal: 4.499 ± 2.023
1.125LysTrp: 1.125 ± 0.914
1.125LysTyr: 1.125 ± 0.719
0.0LysXaa: 0.0 ± 0.0
Leu
3.375LeuAla: 3.375 ± 0.525
1.125LeuCys: 1.125 ± 0.914
4.499LeuAsp: 4.499 ± 0.39
4.499LeuGlu: 4.499 ± 2.877
6.749LeuPhe: 6.749 ± 2.218
6.749LeuGly: 6.749 ± 1.049
0.0LeuHis: 0.0 ± 0.0
5.624LeuIle: 5.624 ± 0.33
3.375LeuLys: 3.375 ± 2.742
8.999LeuLeu: 8.999 ± 4.046
1.125LeuMet: 1.125 ± 0.914
1.125LeuAsn: 1.125 ± 0.719
4.499LeuPro: 4.499 ± 1.244
6.749LeuGln: 6.749 ± 2.218
3.375LeuArg: 3.375 ± 1.109
4.499LeuSer: 4.499 ± 1.244
4.499LeuThr: 4.499 ± 0.39
3.375LeuVal: 3.375 ± 1.109
0.0LeuTrp: 0.0 ± 0.0
2.25LeuTyr: 2.25 ± 0.195
0.0LeuXaa: 0.0 ± 0.0
Met
2.25MetAla: 2.25 ± 0.195
0.0MetCys: 0.0 ± 0.0
4.499MetAsp: 4.499 ± 2.023
3.375MetGlu: 3.375 ± 0.525
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
1.125MetHis: 1.125 ± 0.719
1.125MetIle: 1.125 ± 0.719
2.25MetLys: 2.25 ± 1.828
2.25MetLeu: 2.25 ± 0.195
4.499MetMet: 4.499 ± 2.877
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
1.125MetGln: 1.125 ± 0.914
2.25MetArg: 2.25 ± 0.195
3.375MetSer: 3.375 ± 2.158
3.375MetThr: 3.375 ± 2.742
3.375MetVal: 3.375 ± 1.109
0.0MetTrp: 0.0 ± 0.0
1.125MetTyr: 1.125 ± 0.914
0.0MetXaa: 0.0 ± 0.0
Asn
2.25AsnAla: 2.25 ± 0.195
0.0AsnCys: 0.0 ± 0.0
1.125AsnAsp: 1.125 ± 0.719
3.375AsnGlu: 3.375 ± 0.525
1.125AsnPhe: 1.125 ± 0.719
1.125AsnGly: 1.125 ± 0.719
0.0AsnHis: 0.0 ± 0.0
1.125AsnIle: 1.125 ± 0.914
2.25AsnLys: 2.25 ± 1.439
5.624AsnLeu: 5.624 ± 1.304
0.0AsnMet: 0.0 ± 0.0
2.25AsnAsn: 2.25 ± 1.439
3.375AsnPro: 3.375 ± 0.525
2.25AsnGln: 2.25 ± 1.439
2.25AsnArg: 2.25 ± 0.195
6.749AsnSer: 6.749 ± 1.049
3.375AsnThr: 3.375 ± 0.525
3.375AsnVal: 3.375 ± 2.158
0.0AsnTrp: 0.0 ± 0.0
1.125AsnTyr: 1.125 ± 0.914
0.0AsnXaa: 0.0 ± 0.0
Pro
2.25ProAla: 2.25 ± 0.195
0.0ProCys: 0.0 ± 0.0
4.499ProAsp: 4.499 ± 1.244
5.624ProGlu: 5.624 ± 2.937
1.125ProPhe: 1.125 ± 0.914
6.749ProGly: 6.749 ± 1.049
1.125ProHis: 1.125 ± 0.719
0.0ProIle: 0.0 ± 0.0
2.25ProLys: 2.25 ± 0.195
4.499ProLeu: 4.499 ± 2.877
1.125ProMet: 1.125 ± 0.719
3.375ProAsn: 3.375 ± 0.525
5.624ProPro: 5.624 ± 1.963
2.25ProGln: 2.25 ± 0.195
1.125ProArg: 1.125 ± 0.719
5.624ProSer: 5.624 ± 0.33
7.874ProThr: 7.874 ± 1.768
5.624ProVal: 5.624 ± 1.304
0.0ProTrp: 0.0 ± 0.0
3.375ProTyr: 3.375 ± 0.525
0.0ProXaa: 0.0 ± 0.0
Gln
3.375GlnAla: 3.375 ± 1.109
1.125GlnCys: 1.125 ± 0.719
3.375GlnAsp: 3.375 ± 1.109
1.125GlnGlu: 1.125 ± 0.719
1.125GlnPhe: 1.125 ± 0.914
2.25GlnGly: 2.25 ± 0.195
1.125GlnHis: 1.125 ± 0.719
3.375GlnIle: 3.375 ± 1.109
1.125GlnLys: 1.125 ± 0.914
3.375GlnLeu: 3.375 ± 0.525
1.125GlnMet: 1.125 ± 0.914
3.375GlnAsn: 3.375 ± 0.525
1.125GlnPro: 1.125 ± 0.719
1.125GlnGln: 1.125 ± 0.914
3.375GlnArg: 3.375 ± 0.525
1.125GlnSer: 1.125 ± 0.914
3.375GlnThr: 3.375 ± 0.525
3.375GlnVal: 3.375 ± 1.109
1.125GlnTrp: 1.125 ± 0.719
2.25GlnTyr: 2.25 ± 1.828
0.0GlnXaa: 0.0 ± 0.0
Arg
2.25ArgAla: 2.25 ± 0.195
0.0ArgCys: 0.0 ± 0.0
0.0ArgAsp: 0.0 ± 0.0
5.624ArgGlu: 5.624 ± 1.304
1.125ArgPhe: 1.125 ± 0.914
2.25ArgGly: 2.25 ± 0.195
2.25ArgHis: 2.25 ± 1.439
3.375ArgIle: 3.375 ± 2.742
5.624ArgLys: 5.624 ± 1.963
4.499ArgLeu: 4.499 ± 2.023
2.25ArgMet: 2.25 ± 0.195
2.25ArgAsn: 2.25 ± 1.439
1.125ArgPro: 1.125 ± 0.719
2.25ArgGln: 2.25 ± 0.195
4.499ArgArg: 4.499 ± 2.877
3.375ArgSer: 3.375 ± 0.525
4.499ArgThr: 4.499 ± 1.244
1.125ArgVal: 1.125 ± 0.914
1.125ArgTrp: 1.125 ± 0.914
4.499ArgTyr: 4.499 ± 0.39
0.0ArgXaa: 0.0 ± 0.0
Ser
2.25SerAla: 2.25 ± 0.195
2.25SerCys: 2.25 ± 0.195
8.999SerAsp: 8.999 ± 0.854
2.25SerGlu: 2.25 ± 0.195
0.0SerPhe: 0.0 ± 0.0
5.624SerGly: 5.624 ± 0.33
0.0SerHis: 0.0 ± 0.0
3.375SerIle: 3.375 ± 2.742
3.375SerLys: 3.375 ± 0.525
5.624SerLeu: 5.624 ± 0.33
1.125SerMet: 1.125 ± 0.604
6.749SerAsn: 6.749 ± 4.316
3.375SerPro: 3.375 ± 0.525
2.25SerGln: 2.25 ± 1.439
3.375SerArg: 3.375 ± 2.158
2.25SerSer: 2.25 ± 0.195
4.499SerThr: 4.499 ± 2.877
2.25SerVal: 2.25 ± 1.439
2.25SerTrp: 2.25 ± 1.439
6.749SerTyr: 6.749 ± 0.584
0.0SerXaa: 0.0 ± 0.0
Thr
6.749ThrAla: 6.749 ± 2.683
0.0ThrCys: 0.0 ± 0.0
4.499ThrAsp: 4.499 ± 2.877
1.125ThrGlu: 1.125 ± 0.719
4.499ThrPhe: 4.499 ± 2.023
3.375ThrGly: 3.375 ± 2.158
1.125ThrHis: 1.125 ± 0.719
2.25ThrIle: 2.25 ± 1.828
3.375ThrLys: 3.375 ± 1.109
4.499ThrLeu: 4.499 ± 2.023
2.25ThrMet: 2.25 ± 0.195
1.125ThrAsn: 1.125 ± 0.914
5.624ThrPro: 5.624 ± 0.33
1.125ThrGln: 1.125 ± 0.719
5.624ThrArg: 5.624 ± 1.304
3.375ThrSer: 3.375 ± 0.525
6.749ThrThr: 6.749 ± 1.049
6.749ThrVal: 6.749 ± 2.683
2.25ThrTrp: 2.25 ± 0.195
3.375ThrTyr: 3.375 ± 2.158
0.0ThrXaa: 0.0 ± 0.0
Val
5.624ValAla: 5.624 ± 0.33
0.0ValCys: 0.0 ± 0.0
5.624ValAsp: 5.624 ± 1.304
3.375ValGlu: 3.375 ± 1.109
3.375ValPhe: 3.375 ± 0.525
2.25ValGly: 2.25 ± 0.195
2.25ValHis: 2.25 ± 1.828
2.25ValIle: 2.25 ± 0.195
3.375ValLys: 3.375 ± 0.525
4.499ValLeu: 4.499 ± 0.39
1.125ValMet: 1.125 ± 0.914
2.25ValAsn: 2.25 ± 0.195
7.874ValPro: 7.874 ± 3.402
1.125ValGln: 1.125 ± 0.914
4.499ValArg: 4.499 ± 0.39
8.999ValSer: 8.999 ± 0.854
3.375ValThr: 3.375 ± 2.158
5.624ValVal: 5.624 ± 1.963
0.0ValTrp: 0.0 ± 0.0
4.499ValTyr: 4.499 ± 0.39
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.125TrpCys: 1.125 ± 0.914
1.125TrpAsp: 1.125 ± 0.914
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.125TrpGly: 1.125 ± 0.719
0.0TrpHis: 0.0 ± 0.0
1.125TrpIle: 1.125 ± 0.719
0.0TrpLys: 0.0 ± 0.0
2.25TrpLeu: 2.25 ± 1.828
0.0TrpMet: 0.0 ± 0.0
2.25TrpAsn: 2.25 ± 1.828
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
2.25TrpArg: 2.25 ± 0.195
0.0TrpSer: 0.0 ± 0.0
1.125TrpThr: 1.125 ± 0.914
3.375TrpVal: 3.375 ± 0.525
1.125TrpTrp: 1.125 ± 0.914
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.375TyrAla: 3.375 ± 0.525
1.125TyrCys: 1.125 ± 0.914
2.25TyrAsp: 2.25 ± 1.439
5.624TyrGlu: 5.624 ± 3.597
1.125TyrPhe: 1.125 ± 0.719
2.25TyrGly: 2.25 ± 0.195
1.125TyrHis: 1.125 ± 0.914
3.375TyrIle: 3.375 ± 1.109
0.0TyrLys: 0.0 ± 0.0
4.499TyrLeu: 4.499 ± 0.39
3.375TyrMet: 3.375 ± 2.742
1.125TyrAsn: 1.125 ± 0.914
3.375TyrPro: 3.375 ± 0.525
3.375TyrGln: 3.375 ± 1.109
3.375TyrArg: 3.375 ± 0.525
5.624TyrSer: 5.624 ± 1.963
1.125TyrThr: 1.125 ± 0.914
5.624TyrVal: 5.624 ± 0.33
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski