Amino acid dipepetide frequency for Mycolicibacterium vanbaalenii (Mycobacterium vanbaalenii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.586AlaAla: 19.586 ± 0.165	1.001AlaCys: 1.001 ± 0.024	8.567AlaAsp: 8.567 ± 0.071	7.941AlaGlu: 7.941 ± 0.071	3.491AlaPhe: 3.491 ± 0.051	11.699AlaGly: 11.699 ± 0.086	2.498AlaHis: 2.498 ± 0.035	5.126AlaIle: 5.126 ± 0.054	2.772AlaLys: 2.772 ± 0.038	12.796AlaLeu: 12.796 ± 0.09	2.966AlaMet: 2.966 ± 0.043	2.47AlaAsn: 2.47 ± 0.036	6.332AlaPro: 6.332 ± 0.068	3.969AlaGln: 3.969 ± 0.046	8.432AlaArg: 8.432 ± 0.076	5.926AlaSer: 5.926 ± 0.054	7.306AlaThr: 7.306 ± 0.066	11.804AlaVal: 11.804 ± 0.092	1.591AlaTrp: 1.591 ± 0.03	2.205AlaTyr: 2.205 ± 0.033	0.014AlaXaa: 0.014 ± 0.004
Cys	1.077CysAla: 1.077 ± 0.024	0.099CysCys: 0.099 ± 0.007	0.567CysAsp: 0.567 ± 0.018	0.425CysGlu: 0.425 ± 0.013	0.221CysPhe: 0.221 ± 0.011	0.961CysGly: 0.961 ± 0.025	0.187CysHis: 0.187 ± 0.008	0.273CysIle: 0.273 ± 0.014	0.115CysLys: 0.115 ± 0.007	0.688CysLeu: 0.688 ± 0.02	0.141CysMet: 0.141 ± 0.007	0.174CysAsn: 0.174 ± 0.01	0.481CysPro: 0.481 ± 0.017	0.226CysGln: 0.226 ± 0.011	0.603CysArg: 0.603 ± 0.017	0.5CysSer: 0.5 ± 0.015	0.505CysThr: 0.505 ± 0.016	0.673CysVal: 0.673 ± 0.019	0.136CysTrp: 0.136 ± 0.007	0.199CysTyr: 0.199 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.742AspAla: 7.742 ± 0.07	0.49AspCys: 0.49 ± 0.016	4.643AspAsp: 4.643 ± 0.067	4.16AspGlu: 4.16 ± 0.051	1.828AspPhe: 1.828 ± 0.033	6.125AspGly: 6.125 ± 0.065	1.473AspHis: 1.473 ± 0.03	2.639AspIle: 2.639 ± 0.039	1.278AspLys: 1.278 ± 0.026	6.097AspLeu: 6.097 ± 0.051	1.109AspMet: 1.109 ± 0.023	1.285AspAsn: 1.285 ± 0.028	4.558AspPro: 4.558 ± 0.05	1.833AspGln: 1.833 ± 0.027	4.674AspArg: 4.674 ± 0.053	3.181AspSer: 3.181 ± 0.042	3.407AspThr: 3.407 ± 0.051	5.553AspVal: 5.553 ± 0.053	1.015AspTrp: 1.015 ± 0.023	1.383AspTyr: 1.383 ± 0.03	0.001AspXaa: 0.001 ± 0.001
Glu	6.279GluAla: 6.279 ± 0.072	0.388GluCys: 0.388 ± 0.014	2.703GluAsp: 2.703 ± 0.037	2.591GluGlu: 2.591 ± 0.043	1.939GluPhe: 1.939 ± 0.028	3.466GluGly: 3.466 ± 0.051	1.57GluHis: 1.57 ± 0.029	2.612GluIle: 2.612 ± 0.036	1.304GluLys: 1.304 ± 0.03	6.6GluLeu: 6.6 ± 0.058	1.142GluMet: 1.142 ± 0.023	1.168GluAsn: 1.168 ± 0.025	3.175GluPro: 3.175 ± 0.046	2.339GluGln: 2.339 ± 0.038	4.346GluArg: 4.346 ± 0.059	2.873GluSer: 2.873 ± 0.041	2.812GluThr: 2.812 ± 0.041	4.617GluVal: 4.617 ± 0.046	0.794GluTrp: 0.794 ± 0.022	1.112GluTyr: 1.112 ± 0.025	0.002GluXaa: 0.002 ± 0.001
Phe	3.93PheAla: 3.93 ± 0.046	0.338PheCys: 0.338 ± 0.013	2.531PheAsp: 2.531 ± 0.035	1.604PheGlu: 1.604 ± 0.031	1.001PhePhe: 1.001 ± 0.024	3.406PheGly: 3.406 ± 0.048	0.64PheHis: 0.64 ± 0.019	1.129PheIle: 1.129 ± 0.024	0.552PheLys: 0.552 ± 0.019	2.597PheLeu: 2.597 ± 0.036	0.498PheMet: 0.498 ± 0.018	0.741PheAsn: 0.741 ± 0.021	1.464PhePro: 1.464 ± 0.028	0.698PheGln: 0.698 ± 0.016	1.716PheArg: 1.716 ± 0.026	1.775PheSer: 1.775 ± 0.031	2.147PheThr: 2.147 ± 0.034	2.647PheVal: 2.647 ± 0.043	0.46PheTrp: 0.46 ± 0.016	0.721PheTyr: 0.721 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.148GlyAla: 10.148 ± 0.08	0.82GlyCys: 0.82 ± 0.022	5.255GlyAsp: 5.255 ± 0.054	4.535GlyGlu: 4.535 ± 0.049	3.117GlyPhe: 3.117 ± 0.041	7.822GlyGly: 7.822 ± 0.097	1.995GlyHis: 1.995 ± 0.033	4.007GlyIle: 4.007 ± 0.045	2.141GlyLys: 2.141 ± 0.035	8.483GlyLeu: 8.483 ± 0.076	2.223GlyMet: 2.223 ± 0.04	1.951GlyAsn: 1.951 ± 0.037	4.525GlyPro: 4.525 ± 0.055	2.83GlyGln: 2.83 ± 0.039	6.3GlyArg: 6.3 ± 0.057	5.282GlySer: 5.282 ± 0.052	5.24GlyThr: 5.24 ± 0.055	7.791GlyVal: 7.791 ± 0.063	1.675GlyTrp: 1.675 ± 0.035	2.366GlyTyr: 2.366 ± 0.034	0.004GlyXaa: 0.004 ± 0.002
His	2.405HisAla: 2.405 ± 0.035	0.216HisCys: 0.216 ± 0.011	1.356HisAsp: 1.356 ± 0.026	1.064HisGlu: 1.064 ± 0.025	0.69HisPhe: 0.69 ± 0.019	2.079HisGly: 2.079 ± 0.035	0.712HisHis: 0.712 ± 0.023	0.798HisIle: 0.798 ± 0.021	0.349HisLys: 0.349 ± 0.013	2.202HisLeu: 2.202 ± 0.036	0.351HisMet: 0.351 ± 0.014	0.45HisAsn: 0.45 ± 0.015	1.624HisPro: 1.624 ± 0.03	0.692HisGln: 0.692 ± 0.021	1.93HisArg: 1.93 ± 0.034	1.109HisSer: 1.109 ± 0.025	1.221HisThr: 1.221 ± 0.023	1.701HisVal: 1.701 ± 0.03	0.378HisTrp: 0.378 ± 0.014	0.509HisTyr: 0.509 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.165IleAla: 6.165 ± 0.053	0.401IleCys: 0.401 ± 0.016	3.364IleAsp: 3.364 ± 0.042	2.666IleGlu: 2.666 ± 0.034	1.024IlePhe: 1.024 ± 0.024	4.401IleGly: 4.401 ± 0.051	0.752IleHis: 0.752 ± 0.018	1.458IleIle: 1.458 ± 0.03	0.883IleLys: 0.883 ± 0.024	3.081IleLeu: 3.081 ± 0.045	0.63IleMet: 0.63 ± 0.019	1.168IleAsn: 1.168 ± 0.023	2.39IlePro: 2.39 ± 0.035	0.914IleGln: 0.914 ± 0.019	2.624IleArg: 2.624 ± 0.037	2.321IleSer: 2.321 ± 0.037	2.774IleThr: 2.774 ± 0.039	3.732IleVal: 3.732 ± 0.046	0.496IleTrp: 0.496 ± 0.014	0.777IleTyr: 0.777 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.53LysAla: 2.53 ± 0.043	0.118LysCys: 0.118 ± 0.008	1.046LysAsp: 1.046 ± 0.023	0.932LysGlu: 0.932 ± 0.025	0.618LysPhe: 0.618 ± 0.015	1.502LysGly: 1.502 ± 0.031	0.47LysHis: 0.47 ± 0.017	0.969LysIle: 0.969 ± 0.023	0.64LysLys: 0.64 ± 0.02	2.071LysLeu: 2.071 ± 0.032	0.51LysMet: 0.51 ± 0.017	0.522LysAsn: 0.522 ± 0.015	1.343LysPro: 1.343 ± 0.027	0.668LysGln: 0.668 ± 0.019	1.589LysArg: 1.589 ± 0.032	1.215LysSer: 1.215 ± 0.022	1.305LysThr: 1.305 ± 0.027	1.894LysVal: 1.894 ± 0.031	0.321LysTrp: 0.321 ± 0.014	0.451LysTyr: 0.451 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	13.665LeuAla: 13.665 ± 0.103	0.85LeuCys: 0.85 ± 0.018	6.587LeuAsp: 6.587 ± 0.064	4.568LeuGlu: 4.568 ± 0.048	2.655LeuPhe: 2.655 ± 0.038	8.632LeuGly: 8.632 ± 0.067	2.027LeuHis: 2.027 ± 0.03	4.126LeuIle: 4.126 ± 0.057	1.769LeuLys: 1.769 ± 0.035	9.469LeuLeu: 9.469 ± 0.082	1.774LeuMet: 1.774 ± 0.032	2.18LeuAsn: 2.18 ± 0.036	5.639LeuPro: 5.639 ± 0.055	2.604LeuGln: 2.604 ± 0.037	7.443LeuArg: 7.443 ± 0.077	5.754LeuSer: 5.754 ± 0.055	6.378LeuThr: 6.378 ± 0.052	8.371LeuVal: 8.371 ± 0.071	1.211LeuTrp: 1.211 ± 0.028	1.668LeuTyr: 1.668 ± 0.028	0.007LeuXaa: 0.007 ± 0.002
Met	2.702MetAla: 2.702 ± 0.037	0.189MetCys: 0.189 ± 0.01	0.923MetAsp: 0.923 ± 0.02	0.754MetGlu: 0.754 ± 0.022	0.693MetPhe: 0.693 ± 0.02	1.587MetGly: 1.587 ± 0.03	0.418MetHis: 0.418 ± 0.014	0.952MetIle: 0.952 ± 0.023	0.492MetLys: 0.492 ± 0.015	2.109MetLeu: 2.109 ± 0.034	0.471MetMet: 0.471 ± 0.018	0.537MetAsn: 0.537 ± 0.017	1.271MetPro: 1.271 ± 0.025	0.585MetGln: 0.585 ± 0.017	1.578MetArg: 1.578 ± 0.026	1.633MetSer: 1.633 ± 0.028	1.925MetThr: 1.925 ± 0.03	1.734MetVal: 1.734 ± 0.029	0.293MetTrp: 0.293 ± 0.01	0.358MetTyr: 0.358 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.596AsnAla: 2.596 ± 0.037	0.184AsnCys: 0.184 ± 0.01	1.261AsnAsp: 1.261 ± 0.029	1.072AsnGlu: 1.072 ± 0.022	0.662AsnPhe: 0.662 ± 0.018	1.989AsnGly: 1.989 ± 0.036	0.496AsnHis: 0.496 ± 0.016	0.933AsnIle: 0.933 ± 0.022	0.438AsnLys: 0.438 ± 0.015	2.066AsnLeu: 2.066 ± 0.036	0.417AsnMet: 0.417 ± 0.016	0.601AsnAsn: 0.601 ± 0.019	1.793AsnPro: 1.793 ± 0.029	0.641AsnGln: 0.641 ± 0.019	1.589AsnArg: 1.589 ± 0.029	1.177AsnSer: 1.177 ± 0.027	1.371AsnThr: 1.371 ± 0.029	1.804AsnVal: 1.804 ± 0.03	0.392AsnTrp: 0.392 ± 0.014	0.538AsnTyr: 0.538 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.404ProAla: 7.404 ± 0.073	0.303ProCys: 0.303 ± 0.012	4.525ProAsp: 4.525 ± 0.042	3.827ProGlu: 3.827 ± 0.049	1.669ProPhe: 1.669 ± 0.033	5.581ProGly: 5.581 ± 0.066	1.232ProHis: 1.232 ± 0.03	2.117ProIle: 2.117 ± 0.033	1.192ProLys: 1.192 ± 0.03	4.835ProLeu: 4.835 ± 0.061	1.266ProMet: 1.266 ± 0.025	1.258ProAsn: 1.258 ± 0.023	3.725ProPro: 3.725 ± 0.081	1.82ProGln: 1.82 ± 0.027	3.416ProArg: 3.416 ± 0.047	3.164ProSer: 3.164 ± 0.042	3.496ProThr: 3.496 ± 0.046	5.121ProVal: 5.121 ± 0.061	0.858ProTrp: 0.858 ± 0.022	1.138ProTyr: 1.138 ± 0.027	0.003ProXaa: 0.003 ± 0.002
Gln	3.526GlnAla: 3.526 ± 0.043	0.223GlnCys: 0.223 ± 0.01	1.296GlnAsp: 1.296 ± 0.027	1.198GlnGlu: 1.198 ± 0.023	1.003GlnPhe: 1.003 ± 0.024	2.101GlnGly: 2.101 ± 0.031	0.713GlnHis: 0.713 ± 0.02	1.561GlnIle: 1.561 ± 0.03	0.608GlnLys: 0.608 ± 0.018	3.486GlnLeu: 3.486 ± 0.039	0.759GlnMet: 0.759 ± 0.017	0.62GlnAsn: 0.62 ± 0.018	1.847GlnPro: 1.847 ± 0.037	1.322GlnGln: 1.322 ± 0.029	2.805GlnArg: 2.805 ± 0.039	1.589GlnSer: 1.589 ± 0.026	1.673GlnThr: 1.673 ± 0.029	2.514GlnVal: 2.514 ± 0.033	0.61GlnTrp: 0.61 ± 0.019	0.675GlnTyr: 0.675 ± 0.018	0.001GlnXaa: 0.001 ± 0.001
Arg	8.078ArgAla: 8.078 ± 0.069	0.623ArgCys: 0.623 ± 0.019	4.306ArgAsp: 4.306 ± 0.051	3.853ArgGlu: 3.853 ± 0.051	2.414ArgPhe: 2.414 ± 0.034	5.21ArgGly: 5.21 ± 0.049	1.818ArgHis: 1.818 ± 0.033	3.421ArgIle: 3.421 ± 0.043	1.537ArgLys: 1.537 ± 0.031	7.272ArgLeu: 7.272 ± 0.075	1.812ArgMet: 1.812 ± 0.03	1.658ArgAsn: 1.658 ± 0.029	3.957ArgPro: 3.957 ± 0.049	2.328ArgGln: 2.328 ± 0.041	6.502ArgArg: 6.502 ± 0.068	4.22ArgSer: 4.22 ± 0.047	4.263ArgThr: 4.263 ± 0.043	5.595ArgVal: 5.595 ± 0.054	1.367ArgTrp: 1.367 ± 0.027	1.858ArgTyr: 1.858 ± 0.031	0.002ArgXaa: 0.002 ± 0.001
Ser	7.135SerAla: 7.135 ± 0.061	0.436SerCys: 0.436 ± 0.016	3.478SerAsp: 3.478 ± 0.05	2.868SerGlu: 2.868 ± 0.04	1.665SerPhe: 1.665 ± 0.028	5.803SerGly: 5.803 ± 0.058	1.055SerHis: 1.055 ± 0.024	2.231SerIle: 2.231 ± 0.034	1.152SerLys: 1.152 ± 0.025	4.908SerLeu: 4.908 ± 0.047	1.451SerMet: 1.451 ± 0.027	1.103SerAsn: 1.103 ± 0.026	3.144SerPro: 3.144 ± 0.044	1.581SerGln: 1.581 ± 0.027	3.86SerArg: 3.86 ± 0.04	3.367SerSer: 3.367 ± 0.061	3.425SerThr: 3.425 ± 0.04	4.722SerVal: 4.722 ± 0.052	0.899SerTrp: 0.899 ± 0.026	1.22SerTyr: 1.22 ± 0.025	0.001SerXaa: 0.001 ± 0.001
Thr	8.042ThrAla: 8.042 ± 0.075	0.4ThrCys: 0.4 ± 0.015	3.909ThrAsp: 3.909 ± 0.046	3.346ThrGlu: 3.346 ± 0.041	1.939ThrPhe: 1.939 ± 0.032	5.843ThrGly: 5.843 ± 0.05	1.111ThrHis: 1.111 ± 0.023	2.393ThrIle: 2.393 ± 0.036	1.193ThrLys: 1.193 ± 0.025	5.688ThrLeu: 5.688 ± 0.049	1.294ThrMet: 1.294 ± 0.027	1.246ThrAsn: 1.246 ± 0.025	3.871ThrPro: 3.871 ± 0.047	1.553ThrGln: 1.553 ± 0.03	3.718ThrArg: 3.718 ± 0.042	3.423ThrSer: 3.423 ± 0.047	4.04ThrThr: 4.04 ± 0.061	6.022ThrVal: 6.022 ± 0.061	0.868ThrTrp: 0.868 ± 0.022	1.303ThrTyr: 1.303 ± 0.024	0.003ThrXaa: 0.003 ± 0.001
Val	11.684ValAla: 11.684 ± 0.086	0.772ValCys: 0.772 ± 0.021	5.947ValAsp: 5.947 ± 0.052	4.658ValGlu: 4.658 ± 0.052	2.676ValPhe: 2.676 ± 0.036	7.257ValGly: 7.257 ± 0.06	1.852ValHis: 1.852 ± 0.034	3.946ValIle: 3.946 ± 0.046	1.599ValLys: 1.599 ± 0.026	8.891ValLeu: 8.891 ± 0.076	1.721ValMet: 1.721 ± 0.032	2.022ValAsn: 2.022 ± 0.035	4.694ValPro: 4.694 ± 0.051	2.171ValGln: 2.171 ± 0.033	5.874ValArg: 5.874 ± 0.06	4.879ValSer: 4.879 ± 0.05	5.748ValThr: 5.748 ± 0.066	8.632ValVal: 8.632 ± 0.085	1.076ValTrp: 1.076 ± 0.023	1.586ValTyr: 1.586 ± 0.032	0.002ValXaa: 0.002 ± 0.001
Trp	1.527TrpAla: 1.527 ± 0.03	0.162TrpCys: 0.162 ± 0.01	0.821TrpAsp: 0.821 ± 0.022	0.709TrpGlu: 0.709 ± 0.02	0.529TrpPhe: 0.529 ± 0.015	1.055TrpGly: 1.055 ± 0.025	0.357TrpHis: 0.357 ± 0.013	0.657TrpIle: 0.657 ± 0.02	0.32TrpLys: 0.32 ± 0.011	1.744TrpLeu: 1.744 ± 0.032	0.358TrpMet: 0.358 ± 0.014	0.415TrpAsn: 0.415 ± 0.014	0.86TrpPro: 0.86 ± 0.023	0.642TrpGln: 0.642 ± 0.02	1.246TrpArg: 1.246 ± 0.03	0.979TrpSer: 0.979 ± 0.024	0.938TrpThr: 0.938 ± 0.019	1.13TrpVal: 1.13 ± 0.022	0.351TrpTrp: 0.351 ± 0.016	0.337TrpTyr: 0.337 ± 0.013	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.26TyrAla: 2.26 ± 0.036	0.238TyrCys: 0.238 ± 0.01	1.39TyrAsp: 1.39 ± 0.025	1.055TyrGlu: 1.055 ± 0.027	0.762TyrPhe: 0.762 ± 0.02	1.984TyrGly: 1.984 ± 0.033	0.46TyrHis: 0.46 ± 0.014	0.674TyrIle: 0.674 ± 0.019	0.381TyrLys: 0.381 ± 0.016	2.289TyrLeu: 2.289 ± 0.036	0.31TyrMet: 0.31 ± 0.014	0.45TyrAsn: 0.45 ± 0.014	1.254TyrPro: 1.254 ± 0.027	0.715TyrGln: 0.715 ± 0.019	1.848TyrArg: 1.848 ± 0.031	1.133TyrSer: 1.133 ± 0.022	1.227TyrThr: 1.227 ± 0.028	1.63TyrVal: 1.63 ± 0.028	0.345TyrTrp: 0.345 ± 0.015	0.513TyrTyr: 0.513 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.003	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.0XaaPhe: 0.0 ± 0.001	0.005XaaGly: 0.005 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.006XaaLeu: 0.006 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.002

Statistics based on 6378 proteins (2015758 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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