Amino acid dipepetide frequency for Dermatophagoides pteronyssinus (European house dust mite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.132AlaAla: 4.132 ± 0.07	0.763AlaCys: 0.763 ± 0.013	2.159AlaAsp: 2.159 ± 0.018	2.372AlaGlu: 2.372 ± 0.029	1.868AlaPhe: 1.868 ± 0.019	2.038AlaGly: 2.038 ± 0.023	0.907AlaHis: 0.907 ± 0.012	3.742AlaIle: 3.742 ± 0.027	2.956AlaLys: 2.956 ± 0.025	3.823AlaLeu: 3.823 ± 0.031	1.155AlaMet: 1.155 ± 0.015	2.961AlaAsn: 2.961 ± 0.026	1.547AlaPro: 1.547 ± 0.026	1.743AlaGln: 1.743 ± 0.018	1.94AlaArg: 1.94 ± 0.019	3.642AlaSer: 3.642 ± 0.035	3.184AlaThr: 3.184 ± 0.026	2.263AlaVal: 2.263 ± 0.022	0.344AlaTrp: 0.344 ± 0.007	1.371AlaTyr: 1.371 ± 0.019	0.001AlaXaa: 0.001 ± 0.0
Cys	0.69CysAla: 0.69 ± 0.012	0.506CysCys: 0.506 ± 0.011	1.151CysAsp: 1.151 ± 0.019	0.918CysGlu: 0.918 ± 0.017	0.865CysPhe: 0.865 ± 0.014	1.007CysGly: 1.007 ± 0.024	0.565CysHis: 0.565 ± 0.01	1.194CysIle: 1.194 ± 0.022	0.961CysLys: 0.961 ± 0.016	1.809CysLeu: 1.809 ± 0.021	0.354CysMet: 0.354 ± 0.008	1.011CysAsn: 1.011 ± 0.017	0.845CysPro: 0.845 ± 0.021	0.912CysGln: 0.912 ± 0.016	1.019CysArg: 1.019 ± 0.017	1.567CysSer: 1.567 ± 0.023	0.775CysThr: 0.775 ± 0.013	0.803CysVal: 0.803 ± 0.015	0.225CysTrp: 0.225 ± 0.006	0.639CysTyr: 0.639 ± 0.011	0.001CysXaa: 0.001 ± 0.0
Asp	1.986AspAla: 1.986 ± 0.02	1.111AspCys: 1.111 ± 0.019	7.071AspAsp: 7.071 ± 0.078	4.423AspGlu: 4.423 ± 0.033	2.332AspPhe: 2.332 ± 0.021	2.858AspGly: 2.858 ± 0.03	1.697AspHis: 1.697 ± 0.016	3.651AspIle: 3.651 ± 0.024	3.129AspLys: 3.129 ± 0.024	4.749AspLeu: 4.749 ± 0.033	1.085AspMet: 1.085 ± 0.012	4.811AspAsn: 4.811 ± 0.033	2.078AspPro: 2.078 ± 0.02	2.784AspGln: 2.784 ± 0.022	2.416AspArg: 2.416 ± 0.023	4.694AspSer: 4.694 ± 0.025	2.155AspThr: 2.155 ± 0.017	2.534AspVal: 2.534 ± 0.021	0.578AspTrp: 0.578 ± 0.01	2.242AspTyr: 2.242 ± 0.022	0.001AspXaa: 0.001 ± 0.0
Glu	2.125GluAla: 2.125 ± 0.023	1.053GluCys: 1.053 ± 0.024	2.76GluAsp: 2.76 ± 0.029	3.807GluGlu: 3.807 ± 0.046	2.439GluPhe: 2.439 ± 0.021	1.464GluGly: 1.464 ± 0.022	1.314GluHis: 1.314 ± 0.013	4.336GluIle: 4.336 ± 0.038	4.458GluLys: 4.458 ± 0.047	5.073GluLeu: 5.073 ± 0.04	1.596GluMet: 1.596 ± 0.017	4.05GluAsn: 4.05 ± 0.028	1.852GluPro: 1.852 ± 0.031	3.325GluGln: 3.325 ± 0.038	2.674GluArg: 2.674 ± 0.022	4.461GluSer: 4.461 ± 0.031	3.09GluThr: 3.09 ± 0.034	1.876GluVal: 1.876 ± 0.021	0.606GluTrp: 0.606 ± 0.012	1.833GluTyr: 1.833 ± 0.018	0.002GluXaa: 0.002 ± 0.001
Phe	2.059PheAla: 2.059 ± 0.021	0.867PheCys: 0.867 ± 0.012	3.044PheAsp: 3.044 ± 0.027	2.604PheGlu: 2.604 ± 0.024	2.045PhePhe: 2.045 ± 0.022	2.538PheGly: 2.538 ± 0.025	1.174PheHis: 1.174 ± 0.014	3.673PheIle: 3.673 ± 0.032	2.27PheLys: 2.27 ± 0.018	3.829PheLeu: 3.829 ± 0.034	0.923PheMet: 0.923 ± 0.013	2.778PheAsn: 2.778 ± 0.02	1.49PhePro: 1.49 ± 0.015	1.823PheGln: 1.823 ± 0.019	2.128PheArg: 2.128 ± 0.023	3.198PheSer: 3.198 ± 0.025	2.087PheThr: 2.087 ± 0.018	2.422PheVal: 2.422 ± 0.022	0.476PheTrp: 0.476 ± 0.008	1.686PheTyr: 1.686 ± 0.018	0.004PheXaa: 0.004 ± 0.001
Gly	1.881GlyAla: 1.881 ± 0.022	0.837GlyCys: 0.837 ± 0.018	2.394GlyAsp: 2.394 ± 0.028	2.013GlyGlu: 2.013 ± 0.025	2.025GlyPhe: 2.025 ± 0.02	4.252GlyGly: 4.252 ± 0.079	1.488GlyHis: 1.488 ± 0.018	3.008GlyIle: 3.008 ± 0.025	2.603GlyLys: 2.603 ± 0.025	3.508GlyLeu: 3.508 ± 0.03	0.927GlyMet: 0.927 ± 0.014	2.821GlyAsn: 2.821 ± 0.028	1.593GlyPro: 1.593 ± 0.027	2.288GlyGln: 2.288 ± 0.021	2.171GlyArg: 2.171 ± 0.022	3.921GlySer: 3.921 ± 0.036	2.335GlyThr: 2.335 ± 0.023	2.04GlyVal: 2.04 ± 0.019	0.495GlyTrp: 0.495 ± 0.011	1.819GlyTyr: 1.819 ± 0.021	0.001GlyXaa: 0.001 ± 0.0
His	0.783HisAla: 0.783 ± 0.012	0.618HisCys: 0.618 ± 0.011	1.25HisAsp: 1.25 ± 0.013	1.208HisGlu: 1.208 ± 0.014	1.156HisPhe: 1.156 ± 0.012	1.146HisGly: 1.146 ± 0.015	3.447HisHis: 3.447 ± 0.066	1.491HisIle: 1.491 ± 0.014	1.18HisLys: 1.18 ± 0.011	2.666HisLeu: 2.666 ± 0.022	0.497HisMet: 0.497 ± 0.009	1.929HisAsn: 1.929 ± 0.019	1.348HisPro: 1.348 ± 0.018	2.277HisGln: 2.277 ± 0.025	1.593HisArg: 1.593 ± 0.018	2.533HisSer: 2.533 ± 0.021	1.053HisThr: 1.053 ± 0.015	1.025HisVal: 1.025 ± 0.013	0.269HisTrp: 0.269 ± 0.007	1.277HisTyr: 1.277 ± 0.015	0.001HisXaa: 0.001 ± 0.0
Ile	3.538IleAla: 3.538 ± 0.024	1.462IleCys: 1.462 ± 0.019	5.496IleAsp: 5.496 ± 0.033	4.841IleGlu: 4.841 ± 0.035	3.338IlePhe: 3.338 ± 0.032	3.551IleGly: 3.551 ± 0.029	1.868IleHis: 1.868 ± 0.017	6.49IleIle: 6.49 ± 0.046	4.443IleLys: 4.443 ± 0.029	6.371IleLeu: 6.371 ± 0.042	1.815IleMet: 1.815 ± 0.019	5.336IleAsn: 5.336 ± 0.035	3.137IlePro: 3.137 ± 0.024	3.354IleGln: 3.354 ± 0.025	3.852IleArg: 3.852 ± 0.028	5.947IleSer: 5.947 ± 0.033	4.123IleThr: 4.123 ± 0.028	4.106IleVal: 4.106 ± 0.027	0.74IleTrp: 0.74 ± 0.01	2.48IleTyr: 2.48 ± 0.025	0.004IleXaa: 0.004 ± 0.001
Lys	2.295LysAla: 2.295 ± 0.023	1.249LysCys: 1.249 ± 0.022	2.85LysAsp: 2.85 ± 0.022	3.383LysGlu: 3.383 ± 0.041	2.833LysPhe: 2.833 ± 0.021	1.81LysGly: 1.81 ± 0.03	1.616LysHis: 1.616 ± 0.017	5.089LysIle: 5.089 ± 0.037	4.902LysLys: 4.902 ± 0.056	5.856LysLeu: 5.856 ± 0.044	1.638LysMet: 1.638 ± 0.015	4.601LysAsn: 4.601 ± 0.029	2.585LysPro: 2.585 ± 0.032	3.5LysGln: 3.5 ± 0.031	3.382LysArg: 3.382 ± 0.025	5.558LysSer: 5.558 ± 0.043	3.51LysThr: 3.51 ± 0.028	2.296LysVal: 2.296 ± 0.022	0.629LysTrp: 0.629 ± 0.01	2.176LysTyr: 2.176 ± 0.02	0.003LysXaa: 0.003 ± 0.001
Leu	4.653LeuAla: 4.653 ± 0.034	1.519LeuCys: 1.519 ± 0.018	4.582LeuAsp: 4.582 ± 0.031	4.706LeuGlu: 4.706 ± 0.039	4.237LeuPhe: 4.237 ± 0.035	3.157LeuGly: 3.157 ± 0.024	1.985LeuHis: 1.985 ± 0.022	7.189LeuIle: 7.189 ± 0.048	5.831LeuLys: 5.831 ± 0.042	8.582LeuLeu: 8.582 ± 0.053	2.372LeuMet: 2.372 ± 0.023	6.132LeuAsn: 6.132 ± 0.038	4.008LeuPro: 4.008 ± 0.034	3.952LeuGln: 3.952 ± 0.031	4.117LeuArg: 4.117 ± 0.029	7.847LeuSer: 7.847 ± 0.037	4.677LeuThr: 4.677 ± 0.029	3.917LeuVal: 3.917 ± 0.03	0.835LeuTrp: 0.835 ± 0.011	2.868LeuTyr: 2.868 ± 0.026	0.004LeuXaa: 0.004 ± 0.001
Met	1.73MetAla: 1.73 ± 0.019	0.28MetCys: 0.28 ± 0.007	1.444MetAsp: 1.444 ± 0.016	1.394MetGlu: 1.394 ± 0.016	1.061MetPhe: 1.061 ± 0.013	0.868MetGly: 0.868 ± 0.013	0.409MetHis: 0.409 ± 0.009	2.352MetIle: 2.352 ± 0.02	1.782MetLys: 1.782 ± 0.019	1.94MetLeu: 1.94 ± 0.021	1.188MetMet: 1.188 ± 0.018	2.09MetAsn: 2.09 ± 0.022	0.977MetPro: 0.977 ± 0.014	0.811MetGln: 0.811 ± 0.009	0.828MetArg: 0.828 ± 0.012	1.797MetSer: 1.797 ± 0.018	1.548MetThr: 1.548 ± 0.016	1.153MetVal: 1.153 ± 0.015	0.147MetTrp: 0.147 ± 0.005	0.571MetTyr: 0.571 ± 0.01	0.001MetXaa: 0.001 ± 0.0
Asn	2.472AsnAla: 2.472 ± 0.021	1.219AsnCys: 1.219 ± 0.017	6.139AsnAsp: 6.139 ± 0.039	4.557AsnGlu: 4.557 ± 0.031	2.729AsnPhe: 2.729 ± 0.022	4.048AsnGly: 4.048 ± 0.038	2.79AsnHis: 2.79 ± 0.028	4.921AsnIle: 4.921 ± 0.032	4.003AsnLys: 4.003 ± 0.031	5.603AsnLeu: 5.603 ± 0.034	1.288AsnMet: 1.288 ± 0.013	10.249AsnAsn: 10.249 ± 0.109	2.536AsnPro: 2.536 ± 0.021	4.138AsnGln: 4.138 ± 0.032	3.536AsnArg: 3.536 ± 0.024	6.126AsnSer: 6.126 ± 0.048	2.915AsnThr: 2.915 ± 0.023	3.649AsnVal: 3.649 ± 0.025	0.525AsnTrp: 0.525 ± 0.009	2.396AsnTyr: 2.396 ± 0.023	0.003AsnXaa: 0.003 ± 0.001
Pro	1.744ProAla: 1.744 ± 0.03	0.54ProCys: 0.54 ± 0.014	2.032ProAsp: 2.032 ± 0.02	2.283ProGlu: 2.283 ± 0.027	1.793ProPhe: 1.793 ± 0.019	1.736ProGly: 1.736 ± 0.047	0.942ProHis: 0.942 ± 0.014	3.408ProIle: 3.408 ± 0.027	2.594ProLys: 2.594 ± 0.027	3.572ProLeu: 3.572 ± 0.024	0.989ProMet: 0.989 ± 0.015	2.886ProAsn: 2.886 ± 0.026	3.385ProPro: 3.385 ± 0.074	1.809ProGln: 1.809 ± 0.023	1.513ProArg: 1.513 ± 0.018	4.379ProSer: 4.379 ± 0.045	2.824ProThr: 2.824 ± 0.026	2.003ProVal: 2.003 ± 0.021	0.322ProTrp: 0.322 ± 0.007	1.485ProTyr: 1.485 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	1.813GlnAla: 1.813 ± 0.018	0.874GlnCys: 0.874 ± 0.018	1.747GlnAsp: 1.747 ± 0.016	2.242GlnGlu: 2.242 ± 0.024	1.946GlnPhe: 1.946 ± 0.019	1.142GlnGly: 1.142 ± 0.016	1.769GlnHis: 1.769 ± 0.022	3.625GlnIle: 3.625 ± 0.026	3.02GlnLys: 3.02 ± 0.029	4.581GlnLeu: 4.581 ± 0.035	1.387GlnMet: 1.387 ± 0.014	3.468GlnAsn: 3.468 ± 0.026	2.64GlnPro: 2.64 ± 0.035	9.831GlnGln: 9.831 ± 0.146	2.561GlnArg: 2.561 ± 0.024	4.995GlnSer: 4.995 ± 0.038	3.074GlnThr: 3.074 ± 0.025	1.604GlnVal: 1.604 ± 0.018	0.502GlnTrp: 0.502 ± 0.009	1.666GlnTyr: 1.666 ± 0.016	0.002GlnXaa: 0.002 ± 0.001
Arg	1.776ArgAla: 1.776 ± 0.019	0.932ArgCys: 0.932 ± 0.02	1.955ArgAsp: 1.955 ± 0.02	2.301ArgGlu: 2.301 ± 0.025	2.363ArgPhe: 2.363 ± 0.022	1.627ArgGly: 1.627 ± 0.021	1.295ArgHis: 1.295 ± 0.016	3.672ArgIle: 3.672 ± 0.027	3.627ArgLys: 3.627 ± 0.027	4.733ArgLeu: 4.733 ± 0.033	1.248ArgMet: 1.248 ± 0.014	3.077ArgAsn: 3.077 ± 0.023	1.99ArgPro: 1.99 ± 0.026	2.605ArgGln: 2.605 ± 0.024	3.115ArgArg: 3.115 ± 0.03	4.044ArgSer: 4.044 ± 0.031	2.328ArgThr: 2.328 ± 0.022	1.783ArgVal: 1.783 ± 0.02	0.488ArgTrp: 0.488 ± 0.009	1.794ArgTyr: 1.794 ± 0.02	0.002ArgXaa: 0.002 ± 0.0
Ser	3.875SerAla: 3.875 ± 0.033	1.228SerCys: 1.228 ± 0.017	4.209SerAsp: 4.209 ± 0.027	3.629SerGlu: 3.629 ± 0.028	3.623SerPhe: 3.623 ± 0.028	4.056SerGly: 4.056 ± 0.039	1.89SerHis: 1.89 ± 0.02	7.181SerIle: 7.181 ± 0.039	5.315SerLys: 5.315 ± 0.034	7.939SerLeu: 7.939 ± 0.037	2.307SerMet: 2.307 ± 0.02	7.261SerAsn: 7.261 ± 0.052	4.041SerPro: 4.041 ± 0.044	3.462SerGln: 3.462 ± 0.031	3.309SerArg: 3.309 ± 0.028	16.094SerSer: 16.094 ± 0.167	7.181SerThr: 7.181 ± 0.058	3.525SerVal: 3.525 ± 0.023	0.641SerTrp: 0.641 ± 0.01	2.545SerTyr: 2.545 ± 0.024	0.003SerXaa: 0.003 ± 0.001
Thr	3.067ThrAla: 3.067 ± 0.027	0.826ThrCys: 0.826 ± 0.015	2.619ThrAsp: 2.619 ± 0.021	2.589ThrGlu: 2.589 ± 0.027	2.363ThrPhe: 2.363 ± 0.018	2.661ThrGly: 2.661 ± 0.023	0.918ThrHis: 0.918 ± 0.012	5.141ThrIle: 5.141 ± 0.034	3.667ThrLys: 3.667 ± 0.027	4.658ThrLeu: 4.658 ± 0.027	1.581ThrMet: 1.581 ± 0.015	4.795ThrAsn: 4.795 ± 0.032	2.405ThrPro: 2.405 ± 0.026	1.777ThrGln: 1.777 ± 0.019	1.937ThrArg: 1.937 ± 0.017	5.664ThrSer: 5.664 ± 0.052	7.715ThrThr: 7.715 ± 0.101	2.676ThrVal: 2.676 ± 0.025	0.408ThrTrp: 0.408 ± 0.008	1.479ThrTyr: 1.479 ± 0.017	0.002ThrXaa: 0.002 ± 0.001
Val	2.557ValAla: 2.557 ± 0.023	0.922ValCys: 0.922 ± 0.016	2.941ValAsp: 2.941 ± 0.021	2.621ValGlu: 2.621 ± 0.027	1.869ValPhe: 1.869 ± 0.018	2.106ValGly: 2.106 ± 0.021	1.123ValHis: 1.123 ± 0.011	3.35ValIle: 3.35 ± 0.025	2.69ValLys: 2.69 ± 0.035	3.607ValLeu: 3.607 ± 0.028	1.061ValMet: 1.061 ± 0.012	2.876ValAsn: 2.876 ± 0.023	1.916ValPro: 1.916 ± 0.018	1.93ValGln: 1.93 ± 0.019	2.098ValArg: 2.098 ± 0.021	3.306ValSer: 3.306 ± 0.026	2.503ValThr: 2.503 ± 0.024	2.532ValVal: 2.532 ± 0.025	0.49ValTrp: 0.49 ± 0.008	1.528ValTyr: 1.528 ± 0.015	0.002ValXaa: 0.002 ± 0.001
Trp	0.367TrpAla: 0.367 ± 0.008	0.181TrpCys: 0.181 ± 0.006	0.42TrpAsp: 0.42 ± 0.008	0.384TrpGlu: 0.384 ± 0.008	0.496TrpPhe: 0.496 ± 0.009	0.32TrpGly: 0.32 ± 0.008	0.237TrpHis: 0.237 ± 0.007	0.822TrpIle: 0.822 ± 0.013	0.672TrpLys: 0.672 ± 0.01	1.007TrpLeu: 1.007 ± 0.013	0.252TrpMet: 0.252 ± 0.006	0.697TrpAsn: 0.697 ± 0.012	0.449TrpPro: 0.449 ± 0.008	0.421TrpGln: 0.421 ± 0.009	0.47TrpArg: 0.47 ± 0.009	0.795TrpSer: 0.795 ± 0.014	0.508TrpThr: 0.508 ± 0.009	0.3TrpVal: 0.3 ± 0.008	0.14TrpTrp: 0.14 ± 0.004	0.336TrpTyr: 0.336 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.37TyrAla: 1.37 ± 0.017	0.83TyrCys: 0.83 ± 0.012	2.122TyrAsp: 2.122 ± 0.02	1.92TyrGlu: 1.92 ± 0.019	1.735TyrPhe: 1.735 ± 0.022	2.034TyrGly: 2.034 ± 0.025	1.309TyrHis: 1.309 ± 0.014	1.957TyrIle: 1.957 ± 0.017	1.655TyrLys: 1.655 ± 0.017	3.26TyrLeu: 3.26 ± 0.026	0.706TyrMet: 0.706 ± 0.011	2.007TyrAsn: 2.007 ± 0.021	1.417TyrPro: 1.417 ± 0.019	1.746TyrGln: 1.746 ± 0.02	2.094TyrArg: 2.094 ± 0.022	2.741TyrSer: 2.741 ± 0.021	1.361TyrThr: 1.361 ± 0.015	1.516TyrVal: 1.516 ± 0.015	0.413TyrTrp: 0.413 ± 0.01	1.665TyrTyr: 1.665 ± 0.016	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.005XaaPhe: 0.005 ± 0.001	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.004XaaIle: 0.004 ± 0.001	0.004XaaLys: 0.004 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.016XaaXaa: 0.016 ± 0.008

Statistics based on 12480 proteins (7101821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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